Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity
SELECT
SELECT - Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity
3 other identifiers
interventional
17,604
40 countries
820
Brief Summary
The researchers are doing the study to see if semaglutide may reduce the risk of having cardiovascular events in patients with overweight or obesity and with prior cardiovascular disease. The participant will either get semaglutide (active medicine) or placebo ("dummy" medicine). Which treatment the participants get is decided by chance. The participant's chance of getting semaglutide or placebo is the same. The participant will get the study medicine in a pen. The participants will need to use the pen to inject the study medicine in a skinfold once a week. The study will last for about 2.5 to 5 years. Participants will have up to 25 clinic visits with the study doctor.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Oct 2018
Longer than P75 for phase_3
820 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 21, 2018
CompletedFirst Posted
Study publicly available on registry
July 2, 2018
CompletedStudy Start
First participant enrolled
October 24, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 21, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
June 29, 2023
CompletedResults Posted
Study results publicly available
August 30, 2024
CompletedAugust 30, 2024
August 1, 2024
4.7 years
June 21, 2018
June 18, 2024
August 6, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
Participants From Time of Randomization to First Occurrence of a Composite Outcome Measure Consisting of: Cardiovascular (CV) Death, Non-fatal Myocardial Infarction (MI), or Non-fatal Stroke
Number of participants with first occurrence of composite outcome measure consisted of CV death (undetermined cause of death presumed CV death), non-fatal MI, or non-fatal stroke are presented. The outcome measure was evaluated based on data from in-trial observation period. In-trial observation period defined as the period from date of randomisation to one of the following dates, whichever comes first: date of follow-up visit, date when participant withdrew consent, date of last contact with participant for participants who were lost to follow-up (participant did not complete the trial and did not withdraw consent), date of death.
From randomisation (week 0) up to 240 weeks
Secondary Outcomes (28)
Participants From Time of Randomisation to CV Death
From randomisation (week 0) up to 240 weeks
Participants From Time of Randomisation to First Occurrence of a Composite Heart Failure (HF) Outcome Measure Consisting of: HF Hospitalisation, Urgent HF Visit or CV Death
From randomisation (week 0) up to 240 weeks
Participants From Time of Randomisation to All-cause Death
From randomisation (week 0) up to 240 weeks
Participants From Time of Randomisation to First Occurrence of an Expanded Composite CV Outcome Measure Consisting of: CV Death, Non-fatal MI, Non-fatal Stroke, Coronary Revascularisation or Unstable Angina Pectoris (UAP) Requiring Hospitalisation
From randomisation (week 0) up to 240 weeks
Participants From Time of Randomisation to First Occurrence of a Composite Outcome Measure Consisting of: All-cause Death, Non-fatal MI, or Non-fatal Stroke
From randomisation (week 0) up to 240 weeks
- +23 more secondary outcomes
Study Arms (2)
Semaglutide
EXPERIMENTALParticipants will receive semaglutide as an adjunct to standard-of-care. Estimated trial duration for an individual subject is from 31 to 59 months.
Placebo (semaglutide)
PLACEBO COMPARATORParticipants will receive placebo (semaglutide) as an adjunct to standard-of-care. Estimated trial duration for an individual subject is from 31 to 59 months.
Interventions
Semaglutide will be injected into a skin fold, in the stomach, thigh or upper arm once a week at the same day of the week (to the extent possible) throughout the trial. Subjects will start semaglutide treatment at 0.24 mg; dose will gradually be increased every 4 weeks up to 2.4 mg.
Placebo will be injected into a skin fold, in the stomach, thigh or upper arm once a week at the same day of the week (to the extent possible) throughout the trial. Participants will receive placebo at an equivalent dose to semaglutide.
Eligibility Criteria
You may qualify if:
- Informed consent obtained before any trial-related activities. Trial-related activities are any procedures that are carried out as part of the trial, including activities to determine suitability for the trial
- Male or female, age greater than or equal to 45 years at the time of signing informed consent
- Body mass index (BMI) greater than or equal to 27 kg/m\^2
- Have established cardiovascular (CV) disease as evidenced by at least one of the following: prior myocardial infarction; prior stroke (ischemic or haemorrhagic stroke); or symptomatic peripheral arterial disease (PAD), as evidenced by intermittent claudication with ankle-brachial index (ABI) less than 0.85 (at rest), or peripheral arterial revascularization procedure, or amputation due to atherosclerotic disease
You may not qualify if:
- Cardiovascular-related:
- Any of the following: myocardial infarction, stroke, hospitalisation for unstable angina pectoris or transient ischaemic attack within the past 60 days prior to the day of screening
- Planned coronary, carotid or peripheral artery revascularisation known on the day of screening
- Presently classified as being in New York Heart Association (NYHA) Class IV heart failure
- Glycaemia-related:
- HbA1c greater than or equal to 48 mmol/mol (6.5 %) as measured by the central laboratory at screening
- History of type 1 or type 2 diabetes (history of gestational diabetes is allowed)
- Treatment with glucose-lowering agents within 90 days before screening
- Treatment with any glucagon-like-peptide-1 receptor agonist (GLP-1 RA) within 90 days before screening
- General safety:
- History or presence of chronic pancreatitis
- Presence of acute pancreatitis within the past 180 days prior to the day of screening
- Personal or first degree relative(s) history of multiple endocrine neoplasia type 2 or medullary thyroid carcinoma
- End stage renal disease or chronic or intermittent haemodialysis or peritoneal dialysis
- Presence or history of malignant neoplasms within the past 5 years prior to the day of screening. Basal and squamous cell skin cancer and any carcinoma in-situ are allowed
- +6 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Novo Nordisk A/Slead
Study Sites (833)
Central Alabama Research
Birmingham, Alabama, 35209, United States
Univ of Alabama Birmingham
Birmingham, Alabama, 35294, United States
Healthscan Clinical Trials,LLC.
Montgomery, Alabama, 36106, United States
Synexus Clinical Research US, Inc./Tatum
Glendale, Arizona, 85306, United States
Synexus Clinical Research
Glendale, Arizona, 85308, United States
Synexus Rsch /Cnt Phnx Med C
Phoenix, Arizona, 85050, United States
National Heart Institute Cal
Beverly Hills, California, 90211, United States
FDRC
Costa Mesa, California, 92627, United States
Valley Clinical Trials
Covina, California, 91723, United States
Scripps Whittier Diabetes Inst
La Jolla, California, 92037, United States
First Valley Medical Group
Lancaster, California, 93534, United States
Torrance Clin Res Inst, Inc.
Lomita, California, 90717, United States
Long Beach VA healthcare System
Long Beach, California, 90822, United States
Angel City Research, Inc.
Los Angeles, California, 90010, United States
VAGLAHS Clinical Research Center (CRC)
Los Angeles, California, 90073, United States
Riverside University Health System Medical Center
Moreno Valley, California, 92555, United States
Valley Clinical Trials, Inc.
Northridge, California, 91325, United States
Desert Oasis Hlthcr Med Group
Palm Springs, California, 92262, United States
Western University of Health Sciences
Pomona, California, 91766, United States
Quartz Hill Walk-in Medical Group, inc.
Quartz Hill, California, 93536, United States
TriWest Research Associates
San Diego, California, 92108, United States
San Diego Family Care
San Diego, California, 92111, United States
Mills-Peninsula Medical Center
San Mateo, California, 94401, United States
NorCal Endocrinology and Internal Medicine
San Ramon, California, 94583, United States
Encompass Clinical Research_Spring Valley
Spring Valley, California, 91978, United States
Lundquist Inst-Biomed Innovtn
Torrance, California, 90502, United States
Synexus Clinical Research US, Inc._Horsham
Vista, California, 92083, United States
University of Colorado Hospital
Aurora, Colorado, 80045, United States
Optumcare Colorado Springs, LLC
Colorado Springs, Colorado, 80906, United States
Optumcare Colorado Springs
Colorado Springs, Colorado, 80906, United States
New West Physicians,Inc.
Golden, Colorado, 80401, United States
Optumcare Colorado Springs, LLC_Monument
Monument, Colorado, 80132, United States
Bridgeport Hospital
Bridgeport, Connecticut, 06610, United States
Yale University School Of Medicine
New Haven, Connecticut, 06510, United States
Chase Medical Research LLC
Waterbury, Connecticut, 06708, United States
Excel Med Ctr Clinical Trials
Boca Raton, Florida, 33434, United States
Bradenton Research Center
Bradenton, Florida, 34205, United States
Clearwater Cardiovascular Consultants
Clearwater, Florida, 33756, United States
Nature Coast Clin Rsrch_Crystal River
Crystal River, Florida, 34429, United States
Florida Premier Cardiology
Delray Beach, Florida, 33445, United States
Fleming Island Center for Clinical Research
Fleming Island, Florida, 32003, United States
Northeast Research Institute
Fleming Island, Florida, 32003, United States
Integrative Research Assoc Inc
Fort Lauderdale, Florida, 33312, United States
Clinical Research of Hollywood_Hollywood
Hollywood, Florida, 33024, United States
Est Cst Inst for Rsrch,Jksnvil
Jacksonville, Florida, 32216, United States
Jacksonville Ctr For Clin Res
Jacksonville, Florida, 32216, United States
Clinical Neuroscience Solutions, Inc.
Jacksonville, Florida, 32256, United States
Baptist Heart Specialists_Jacksonville
Jacksonville, Florida, 32258, United States
Baptist Heart Specialists_Jacksonville Beach
Jacksonville Beach, Florida, 32250, United States
Reyes Clinical Research, Inc
Miami, Florida, 33175, United States
International Research Associates, LLC_Miami
Miami, Florida, 33183, United States
AdventHealth Diab Inst
Orlando, Florida, 32804, United States
Oviedo Medical Research, LLC
Oviedo, Florida, 32765, United States
East Coast Institute for Research LLC
Saint Augustine, Florida, 32086, United States
Intercoastal Medical Group
Sarasota, Florida, 34239, United States
Cardio Partners Clin Res Inst
Wellington, Florida, 33449, United States
Ellipsis Group
Alpharetta, Georgia, 30022, United States
NSC Research, Inc
Johns Creek, Georgia, 30024, United States
Endocrine Research Solutions
Roswell, Georgia, 30076, United States
Family Health Care Center
Statesboro, Georgia, 30461, United States
Herman Clinical Research LLC
Suwanee, Georgia, 30024, United States
Atlanta Heart Specialists, LLC
Tucker, Georgia, 30084, United States
Northwest Heart Clinical Research, LLC
Arlington Heights, Illinois, 60005, United States
Apex Medical Research Inc
Chicago, Illinois, 60607, United States
Mercy Hospital and Medical Center
Chicago, Illinois, 60616, United States
Macoupin Research Group
Gillespie, Illinois, 62033, United States
Chicago Medical Research LLC
Hazel Crest, Illinois, 60429, United States
Lemah Creek Clinical Research
Oakbrook Terrace, Illinois, 60181, United States
Evanston Premier Hlthcr Res
Skokie, Illinois, 60077, United States
NorthShore Univ Hlth Sys
Skokie, Illinois, 60077, United States
Central Illinois Diabetes and Clinical Research
Springfield, Illinois, 62711, United States
Community Clinical Research_Anderson
Anderson, Indiana, 46011, United States
American Health Network of Indiana, LLC_Avon_0
Avon, Indiana, 46123, United States
MediSphere Medical Research Center, LLC
Evansville, Indiana, 47714, United States
American Health Network of IN LLC_Franklin
Franklin, Indiana, 46131, United States
American Health Network of Indiana, LLC_Greenfield
Greenfield, Indiana, 46140, United States
Franciscan Health Michigan City
Michigan City, Indiana, 46360, United States
American Health Network of IN LLC
Muncie, Indiana, 47304, United States
American Health Network of Indiana, LLC
New Albany, Indiana, 47150, United States
Velocity Clinical_Valparaiso
Valparaiso, Indiana, 46383, United States
University of Iowa Prev Inter Ctr
Iowa City, Iowa, 52242, United States
The University Of Kansas Medical Center - Cray Dia
Kansas City, Kansas, 66160, United States
Midwest Heart & Vasc Spec
Overland Park, Kansas, 66211, United States
Cotton O'Neil Clin Research Ctr
Topeka, Kansas, 66606, United States
Robley Rex VA Medical Center
Louisville, Kentucky, 40206, United States
L-MARC Research Center
Louisville, Kentucky, 40213, United States
Norton Clinical Research Group
Louisville, Kentucky, 40213, United States
Cambridge Medical Trials
Alexandria, Louisiana, 71301, United States
Louisiana Heart Center
Hammond, Louisiana, 70403, United States
Barnum Medical Research, Inc.
Natchitoches, Louisiana, 71457-5881, United States
Louisiana Heart Center_Slidell
Slidell, Louisiana, 70458, United States
Anne Arundel Medical Center
Annapolis, Maryland, 21401, United States
University Of Maryland School of Medicine
Baltimore, Maryland, 21201, United States
Ascension Saint Agnes Heart Ca
Baltimore, Maryland, 21229, United States
MedStar Good Samaritan Hosp
Baltimore, Maryland, 21239, United States
Johns Hopkins University
Columbia, Maryland, 21044, United States
Centennial Medical Group
Elkridge, Maryland, 21075-6437, United States
MD Medical Research
Oxon Hill, Maryland, 20745, United States
Endo And Metab Cons
Rockville, Maryland, 20852, United States
Brigham & Women's Hospital
Boston, Massachusetts, 02115-5804, United States
Michigan Medicine
Ann Arbor, Michigan, 48109, United States
ClinSite LLC.
Canton, Michigan, 48187, United States
Henry Ford Health System
Detroit, Michigan, 48202, United States
Aa Mrc Llc
Flint, Michigan, 48504, United States
Trinity Health Michigan Heart
Ypsilanti, Michigan, 48197, United States
Belzoni Clinical Research
Belzoni, Mississippi, 39038, United States
Amicis Centers of Clinical Research
St Louis, Missouri, 63128, United States
St Louis Heart & Vascular, P.C.
St Louis, Missouri, 63136, United States
Mercury Street Medical Group, PLLC_Butte
Butte, Montana, 59701, United States
VA NEB - Western IA Health Stm
Omaha, Nebraska, 68105, United States
University of NE Med Ctr
Omaha, Nebraska, 68198, United States
Synexus Clinical Research US
Henderson, Nevada, 89052, United States
Palm Research Center Inc-Vegas
Las Vegas, Nevada, 89128, United States
Southern NH Diabetes and Endo_Nashua
Nashua, New Hampshire, 03060, United States
UniMed Center
East Brunswick, New Jersey, 08816, United States
Holy Name Medical Center
Teaneck, New Jersey, 07666, United States
Albany Medical College - Endo
Albany, New York, 12203, United States
Dr. Alexander Perkelvald
Brooklyn, New York, 11229, United States
Long Island Cardiovascular Consultants PC
Lake Success, New York, 11042, United States
NYU Grossman School of Med
New York, New York, 10016, United States
NYU School of Medicine
New York, New York, 10016, United States
Comprehensive Weight Ctrl Prog
New York, New York, 10021, United States
Saratoga Clinical Research
Saratoga Springs, New York, 12866, United States
Southgate Medical Group, LLP
West Seneca, New York, 14224, United States
Great Lakes Medical Research
Westfield, New York, 14787, United States
UNC Eastowne Clinical Trials Unit
Chapel Hill, North Carolina, 27514, United States
OnSite Clinical Solutions, LLC
Charlotte, North Carolina, 28226, United States
Duke University_Durham
Durham, North Carolina, 27705, United States
Durham VA Medical Center - Duke University
Durham, North Carolina, 27705, United States
WakeMed Garner Hlthplx
Garner, North Carolina, 27529, United States
Physician's East Endocrinology
Greenville, North Carolina, 27834, United States
Duke University - S.E Cardio
Lumberton, North Carolina, 28358, United States
Burke Primary Care
Morganton, North Carolina, 28655, United States
Accellacare
Wilmington, North Carolina, 28401, United States
PMG Research of Winston-Salem
Winston-Salem, North Carolina, 27103, United States
The Carl & Edyth Lindner Center
Cincinnati, Ohio, 45219, United States
Cleveland Clinic_Cleveland
Cleveland, Ohio, 44195, United States
Providence Health Partners Ctr
Dayton, Ohio, 45439, United States
Advanced Med Res Maumee
Maumee, Ohio, 43537, United States
New Venture Medical Research
Wadsworth, Ohio, 44281, United States
Corvallis Clinic PC Clinical Research Department
Corvallis, Oregon, 97330-3737, United States
Oregon Health & Science Uni
Portland, Oregon, 97239, United States
Geisinger Clinic
Danville, Pennsylvania, 17822-2111, United States
Doylestown Hospital Pharmacy
Doylestown, Pennsylvania, 18901, United States
Harleysville Medical Associates
Harleysville, Pennsylvania, 19438, United States
Richard M Kastelic MD Assoc
Johnstown, Pennsylvania, 15905, United States
Hospital of the Univ PA
Philadelphia, Pennsylvania, 19104-4206, United States
Tristar Clin Investigations, PC
Philadelphia, Pennsylvania, 19114, United States
Parkside Family Medicine
Philadelphia, Pennsylvania, 19144, United States
Preferred Primary Care Physicians Inc.
Pittsburgh, Pennsylvania, 15243, United States
Internal Medicine Associates of Anderson
Anderson, South Carolina, 29621, United States
Synexus Clin Res US-Anderson
Anderson, South Carolina, 29621, United States
Medical Uni of SC Charleston
Charleston, South Carolina, 29425, United States
Palmetto Clinical Research
Greenville, South Carolina, 29615, United States
Accellacare US Inc._SC
Mt. Pleasant, South Carolina, 29464, United States
Holston Medical Group Pc
Bristol, Tennessee, 37620-7352, United States
The Stern Cardiovascular Group
Germantown, Tennessee, 38138, United States
Holston Medical Group
Kingsport, Tennessee, 37660, United States
Clinical Neuroscience Solutions
Memphis, Tennessee, 38119, United States
InvestiClin Research
Nashville, Tennessee, 37203, United States
MidState Endocrine Associates
Nashville, Tennessee, 37203, United States
Trinity Clinical Research LLC
Tullahoma, Tennessee, 37388, United States
Amarillo Med Spec LLP
Amarillo, Texas, 79106, United States
Arlington Family Res. Ctr Inc
Arlington, Texas, 76012-4637, United States
Texas Diab & Endo, P.A.
Austin, Texas, 78749, United States
UT Health University of Texas
Bellaire, Texas, 77401, United States
Thyroid, Endocrinology, and Diabetes, PA
Dallas, Texas, 75208, United States
Texas Health Physicians Group_Dallas
Dallas, Texas, 75231, United States
UT Southwestern Med Cntr
Dallas, Texas, 75390-9302, United States
Northwest Houston Cardiology, P.A.
Houston, Texas, 77070, United States
PlanIt Research, PLLC
Houston, Texas, 77079, United States
DCOL Ctr for Clin Res
Longview, Texas, 75605, United States
Research Institute Of Dallas
Plano, Texas, 75093, United States
Quality Research Inc
San Antonio, Texas, 78209, United States
Sun Research Institute
San Antonio, Texas, 78215, United States
San Antonio Prem Int Med
San Antonio, Texas, 78220, United States
Physician PrimeCare Research Institute, PLLC dba
San Antonio, Texas, 78228-6205, United States
Audie L. Murphy Va Hospital, Stvhcs
San Antonio, Texas, 78229, United States
VIP Trials
San Antonio, Texas, 78230, United States
Simcare Medical Research, LLC
Sugar Land, Texas, 77478, United States
Houston Center for Clinical Research LLC
Sugar Land, Texas, 77479, United States
Christus Heart and Vascular Institute
Tyler, Texas, 75701, United States
Hillcrest Family Health Center
Waco, Texas, 76708, United States
Wade Family Medicine
Bountiful, Utah, 84010, United States
Kalo Clinical Research
West Valley City, Utah, 84120, United States
U. of Vermont Med Ctr Burlington
South Burlington, Vermont, 05403-7205, United States
Inova Cardiology - Mt. Vernon
Alexandria, Virginia, 23306, United States
Cardiology Consultants of Danville Inc.
Danville, Virginia, 24541, United States
Inova Cardiology-Fairfax
Fairfax, Virginia, 22031, United States
Virginia Research Center
Midlothian, Virginia, 23114, United States
York Clinical Research LLC
Norfolk, Virginia, 23504, United States
Strelitz Diabetes Of Eastern V.
Norfolk, Virginia, 23510, United States
Dominion Medical Associates
Richmond, Virginia, 23219, United States
Clinical Research Partners, LLC
Richmond, Virginia, 23226, United States
National Clin Res Inc.
Richmond, Virginia, 23294, United States
VA Medical Center_Salem
Salem, Virginia, 24153-6404, United States
Bayview Physician Services
Virginia Beach, Virginia, 23454, United States
Sentara Medical Group_Norfolk
Virginia Beach, Virginia, 23454, United States
Selma Medical Associates
Winchester, Virginia, 22601-3834, United States
Amherst Family Practice P.C.
Winchester, Virginia, 22601, United States
Capital Clin Res Ctr,LLC
Olympia, Washington, 98502, United States
Confluence Health Hospital
Wenatchee, Washington, 98801, United States
St. Vincent Hosp-Prevea Health
Green Bay, Wisconsin, 54303, United States
Clinical Inv Spec, Inc.Kenosha
Kenosha, Wisconsin, 53144, United States
Aspirus Research Institute
Wausau, Wisconsin, 54401, United States
Cardiology department CHU Mustapha Pacha. Algiers
Algiers, 16000, Algeria
Centre National De la Médecine du Sport
Algiers, 16000, Algeria
CHU Issad Hassani, Beni Messous, Cardiology department
Algiers, 16000, Algeria
CHU - Hussein dey Cardiology department Nafissa Hamoud
Algiers, 16040, Algeria
Cardiology department, Benaouda Benzerdjeb CHU Oran
Oran, 31000, Algeria
Instituto de Cardiología de Corrientes
Corrientes, Buenos Aires, W3400AMZ, Argentina
Fundacion Favaloro
CABA, Buenos Aires, Argentina, C1093AAS, Argentina
Sanatorio Güemes
CABA, City of Buenos Aires, C1180AAX, Argentina
Centro de Investigación y Prevención Cardiovascular
CABA, C1061AAS., Argentina
Centro Médico MEDEOS
CABA, C1426EGQ, Argentina
Glenny Corp. S.A
CABA, C1430CKE, Argentina
Clínica Adventista Belgrano
CABA, C1430EGF, Argentina
Medical Center of Diabetes and Nutrition
CABA, C1440AAD, Argentina
Instituto Médico DAMIC
Córdoba, X5003DCE, Argentina
Sanatorio Plaza
Rosario, S2000, Argentina
The Canberra Hospital_Garran
Garran, Australian Capital Territory, 2605, Australia
Gosford Hospital
Gosford, New South Wales, 2250, Australia
Liverpool Hospital
Liverpool, New South Wales, 2170, Australia
Hunter Diabetes Centre
Merewether, New South Wales, 2291, Australia
Advara HeartCare
Milton, Queensland, 4064, Australia
Core Research Centre
Milton, Queensland, 4064, Australia
Cholesterol Care Australia
Wollongabba, Queensland, 4102, Australia
Royal Adelaide Hospital Cardiovascular Clinical Trials
Adelaide, South Australia, 5000, Australia
Lyell McEwin Hospital
Elizabeth Vale, South Australia, 5112, Australia
Monash Cardiovascular Research Centre
Clayton, Victoria, 3168, Australia
Geelong Cardiology Research Unit
Geelong, Victoria, 3220, Australia
Austin Health, Metabolic Disorders Centre
Heidelberg Heights, Victoria, 3081, Australia
HeartCare WA (Joondalup)
Joondalup, Western Australia, 6027, Australia
Universitätsklinik für Innere Medizin
Graz, 8036, Austria
Univ.-Klinik für Innere Medizin I
Innsbruck, 6020, Austria
LKH Salzburg Universitätsklinikum
Salzburg, 5020, Austria
Klinik Landstraße
Vienna, 1030, Austria
Ordination Dr. Hanusch
Vienna, 1060, Austria
Universitätsklinikum AKH Wien
Vienna, 1090, Austria
Klinik Hietzing
Vienna, 1130, Austria
Algemeen Stedelijk Ziekenhuis - Aalst - Interventional Cardiology
Aalst, 9300, Belgium
Imeldaziekenhuis - Bonheiden - Department of Endocrinology
Bonheiden, 2820, Belgium
CUB Hôpital Erasme_Brussels_1
Brussels, 1070, Belgium
Ziekenhuis Oost-Limburg AV - Cardiology
Genk, 3600, Belgium
UZ Gent - Cardiology
Ghent, 9000, Belgium
UZ Gent_Gent_4
Ghent, 9000, Belgium
Jessa Ziekenhuis - Hasselt - Cardiology
Hasselt, 3500, Belgium
Cárdio Pulmonar da Bahia
Salvador, Estado de Bahia, 40170130, Brazil
Hospital do Coração do Brasil
Brasília, Federal District, 70390-700, Brazil
Eurolatino Medical Research Center
Uberlândia, Minas Gerais, 38400-500, Brazil
Cline Research Center
Curitiba, Paraná, 80030-480, Brazil
Núcleo de Pesquisa Clínica S/S
Curitiba, Paraná, 80730-150, Brazil
Hospital São Vicente de Paulo
Passo Fundo, Rio Grande do Sul, 99010-080, Brazil
AngioCor Blumenau
Blumenau, Santa Catarina, 89020-430, Brazil
Instituto de Pesquisa Clínica de Campinas
Campinas, São Paulo, 13060-080, Brazil
CIP Centro Integrado de Pesquisas do Hospital de Base
São José do Rio Preto, São Paulo, 15090-000, Brazil
CPQuali Pesquisa Clínica Ltda
São Paulo, São Paulo, 01228-000, Brazil
CPCLIN - Centro de Pesquisas Clínicas
São Paulo, São Paulo, 01228-200, Brazil
Instituto Dante Pazzanese de Cardiologia
São Paulo, São Paulo, 04012-909, Brazil
Departamento de Gastroenterologia - HCFMUSP
São Paulo, São Paulo, 05403-000, Brazil
Instituto do Coração - HCFMUSP
São Paulo, São Paulo, 05403-000, Brazil
Instituto Brasil de Pesquisa Clinica
Rio de Janeiro, 20241-180, Brazil
Medical Centre Diamedical-2013
Dimitrovgrad, 6400, Bulgaria
MHAT Lukovit, Department of Internal Diseases
Lukovit, 5770, Bulgaria
"MHAT - Pazardzhik" AD, Second Department of Internal Diseas
Pazardzhik, 4400, Bulgaria
"UMBAL-Dr. Georgi Stranski" EAD, First Clinic of cardiology
Pleven, 5800, Bulgaria
"UMHAT "Sveti Georgi" EAD
Plovdiv, 4002, Bulgaria
Medical centre Razgrad OOD
Razgrad, 7200, Bulgaria
"MHAT "NCH" EAD, Cardiology clinic, Noninvasive diag. dep.
Sofia, 1309, Bulgaria
"MHAT "NCH" EAD, Clinic of Cardiology, Depart. of Cardiology
Sofia, 1309, Bulgaria
"Acibadem City Clinic MHAT Tokuda" EAD,Cardiology department
Sofia, 1407, Bulgaria
"Acibadem City Clinic UMHAT" EOOD, Sofia, Cardiology clinic
Sofia, 1407, Bulgaria
"Diagnostic - Consulting Center Aleksandrovska" EOOD
Sofia, 1431, Bulgaria
"UMHAT "Aleksandrovska" EAD, Cardiology clinic
Sofia, 1431, Bulgaria
"UMHAT "Tsaritsa Yoanna-ISUL"" EAD, Clinic of Cardiology
Sofia, 1527, Bulgaria
"UMHATEM N.I. Pirogov" EAD
Sofia, 1606, Bulgaria
"UMHAT "Sveta Anna" Sofia" AD, Clinic of Cardiology
Sofia, 1750, Bulgaria
"Diagnostic - Consulting Center "Ekvita"" EOOD
Varna, 9002, Bulgaria
University of Calgary
Calgary, Alberta, T2T 5C7, Canada
C-endo Diab Endo Clin Calgery
Calgary, Alberta, T2V 4J2, Canada
Synergy Wellness Clinic
Sherwood Park, Alberta, T8H 0N2, Canada
G.A. Research Associates Ltd.
Moncton, New Brunswick, E1G 1A7, Canada
Manna Research Inc. (Burlington N)
Burlington, Ontario, L7M 4Y1, Canada
Cambridge Cardiac Care Centre
Cambridge, Ontario, N1R 6V6, Canada
St. Joseph's Health Care
London, Ontario, N6A 4V2, Canada
Manna Research Ottawa
Nepean, Ontario, K2J 4A7, Canada
North York Diagn & Cardiac Ctr
North York, Ontario, M6B 3H7, Canada
Dr. James Cha
Oshawa, Ontario, L1J 2K1, Canada
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2, Canada
Medical Associates of Port Perry
Port Perry, Ontario, L9L 1L9, Canada
HHI Research Inc.
Scarborough Village, Ontario, M1B 4Z8, Canada
Manna Research Stoney Creek
Stoney Creek, Ontario, L8J 3W2, Canada
The Port Arthur Clinic Research Program
Thunder Bay, Ontario, P7A 4V7, Canada
Manna Research Inc._Toronto
Toronto, Ontario, M9W 4L6, Canada
ViaCar Recherche Clinique Inc
Brossard, Quebec, J4Z 2K9, Canada
Manna Research Quebec
Lévis, Quebec, G6W 0M5, Canada
Manna Research Mirabel
Mirabel, Quebec, J7J 2K8, Canada
Clinique Sante Cardio MC
Montreal, Quebec, H1T 3Y7, Canada
IRCM
Montreal, Quebec, H2W 1R7, Canada
Applied Med Inf Res
Montreal, Quebec, H4A 3T2, Canada
Centricity Res Pointe-Claire
Pointe-Claire, Quebec, H9R 4S5, Canada
Clin des Mal Lipid de Quebec
Québec, Quebec, G1V 4W2, Canada
Ctr Méd. et pro d l'Ost d port
Saint-Marc-des-Carrieres, Quebec, G0A 4B0, Canada
Centre de recherché du CHUS
Sherbrooke, Quebec, J1H 5N4, Canada
Centre de santé et de services
Terrebonne, Quebec, J6V 2H2, Canada
Institut universitaire de cardiologie
Québec, G1V 4G5, Canada
Rodrigo Botero S.A.S
Medellín, Antioquia, 050021, Colombia
IPS Centro Cientifico Asistencial Jose Luis Accini SAS
Barranquilla, Atlántico, 080001, Colombia
Unidad de Estudios Clínicos de la Fundación Cardiovascular de Colombia
Bucaramanga-piedecuesta, Valle Del Menzuli - Santander, Santander Department, 681012, Colombia
Fundacion del Caribe para la Investigacion Biomedica-BIOS
Barranquilla, 080020, Colombia
Clinica de la Costa
Barranquilla, 80020, Colombia
Centro de Investigacion Clinica Avanzada y Multidisciplinari
Medellín, 050021, Colombia
CardiovidCentro Cardiovascular Colombiano ClinicaSantaMaria
Medellín, 050034, Colombia
Poliklinika Solmed
Zagreb, City of Zagreb, 10000, Croatia
Specijalna bolnica Krapinske Toplice - Kardiologija
Krapinske Toplice, Krapinsko Zagorska County, 49217, Croatia
Klinicki bolnicki centar Osijek
Osijek, 31 000, Croatia
KBC Rijeka, Zavod za kardiomiopatije
Rijeka, 51000, Croatia
KBC "Sestre milosrdnice", Kardiologija
Zagreb, 10000, Croatia
KBC Zagreb, Klinika za bolesti srca i krvnih zila
Zagreb, 10000, Croatia
Klinicka bolnica Sveti Duh
Zagreb, 10000, Croatia
Fakultni poliklinika
Prague, Czech Republic, 128 08, Czechia
Edumed Broumov
Broumov, 550 01, Czechia
Ordinace pro choroby srdce
Chomutov, 430 02, Czechia
Fakultni nemocnice Hradec Kralove_Hradec Kralove_0
Hradec Králové, 500 05, Czechia
Nemocnice Jihlava Kardiologie
Jihlava, 586 33, Czechia
Kardiologické centrum
Liberec, 460 63, Czechia
Policska nemocnice
Polička, 572 01, Czechia
Endocare
Prague, 140 00, Czechia
ResTrial
Prague, 181 00, Czechia
Nemocnice Slany Kardiologie
Slaný, 274 01, Czechia
Svitavska nemocnice Kardiologie
Svitavy, 568 25, Czechia
Vseobecna kardiologicka ambulance
Tábor, 39003, Czechia
Herlev og Gentofte Hospital
Hellerup, Capital Region, 2900, Denmark
Aalborg Universitetshospital Kardiologisk Afdeling
Aalborg, 9000, Denmark
Aarhus Universitetshospital, Skejby Hjertesygdomme
Aarhus N, 8200, Denmark
Regionshospitalet Gødstrup, Hjertesygdomme
Herning, 7400, Denmark
Hvidovre Hospital Hjertemedicinsk
Hvidovre, 2650, Denmark
Kardiologisk Odense & Svendborg
Svendborg, 5700, Denmark
StudyCor
Jyväskylä, 40620, Finland
Health Step Finland Oy
Kuopio, 70210, Finland
Päijät-Häme Central Hospital
Lahti, 15850, Finland
OYS Sisätautien tutkimusyksikkö
Oulu, 90220, Finland
Seinäjoen keskussairaala
Seinäjoki, 60220, Finland
TAYS Sydänsairaala
Tampere, 33520, Finland
TYKS Sydänkeskus
Turku, 20520, Finland
CHRU Besançon
Besançon, 25030, France
Hôpital Jean Verdier
Bondy, 93143, France
Centre Hospitalier Sud Francilien
Corbeil-Essonnes, 91106, France
Centre Hospitalier Universitaire de Dijon-Hopital Le Bocage
Dijon, 21079, France
Chu Du Bocage
Dijon, 21079, France
Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon-1
La Tronche, 38700, France
Les Hopitaux de Chartres-Hopital Louis Pasteur
Le Coudray, 28630, France
Centre Hospitalier de Narbonne
Narbonne, 11100, France
CHU de Nice
Nice, 06000, France
Aphp-Hopital La Pitie Salpetriere-2
Paris, 75013, France
Ap-Hp-Hopital Europeen Georges Pompidou
Paris, 75015, France
Hôpital Européen Georges Pompidou
Paris, 75015, France
Ap-Hp-Hopital Bichat-Claude Bernard-2
Paris, 75877, France
Centre Hospitalier Universitaire de Bordeaux-Hopital Haut Leveque-2
Pessac, 33600, France
Centre Hospitalier Universitaire de Nantes-Hopital Nord Laennec-1
Saint-Herblain, 44800, France
Les Hopitaux Universitaires de Strasbourg-Hopital Civil-2
Strasbourg, 67091, France
Centre de Recherche Clinique Portes Du Sud
Vénissieux, 69200, France
Universitaetsklinikum Aachen AöR
Aachen, 52074, Germany
Kardiologische Praxis
Bad Homburg, 61348, Germany
Klinische Forschung Berlin (kfgn)
Berlin, 10117, Germany
Emovis GmbH
Berlin, 10629, Germany
Synexus Berlin
Berlin, 12627, Germany
Synexus Bochum
Bochum, 44787, Germany
Klinische Forschung Dresden
Dresden, 01069, Germany
Hausaerztlich-Kardiologisches MVZ Am Felsenkeller GmbH
Dresden, 01277, Germany
Zentrum fuer klinische Studien Suedbrandenburg GmbH
Elsterwerda, 04910, Germany
InnoDiab Forschung GmbH
Essen, 45136, Germany
Synexus Frankfurt
Frankfurt, 60313, Germany
MVZ CCB Frankfurt Und Main-Taunus GbR
Frankfurt, 60389, Germany
Denger, Friedrichsthal
Friedrichsthal, 66299, Germany
Klinische Forschung Hamburg
Hamburg, 20253, Germany
Wendisch/Dahl Hamburg
Hamburg, 22607, Germany
Klinische Forschung Hannover
Hanover, 30159, Germany
Chevts
Karlsruhe, 76137, Germany
Appel
Kassel, 34121, Germany
Universitätsklinikum Leipzig, Endokrinologie und Nephrologie
Leipzig, 04103, Germany
AmBeNet GmbH
Leipzig, 04107, Germany
Die Praxis am Ludwigsplatz
Ludwigshafen, 67059, Germany
Universitätsklinikum Schleswig-Holstein
Lübeck, 23562, Germany
RED-Institut für medizinische Forschung und Fortbildung GmbH
Oldenburg in Holstein, 23758, Germany
Dr. Axthelm Christoph, Pirna
Pirna, 01796, Germany
Zentrum für klinische Studien Alexander Segner
Saint Ingbert-Oberwürzbach, 66386, Germany
Steindorf, Schkeuditz
Schkeuditz, 04435, Germany
Klinische Forschung Schwerin
Schwerin, 19055, Germany
Jacob, Villingen-Schwenningen
Villingen-Schwenningen, 78048, Germany
Zentrum für klinische Studien Allgäu Oberschwaben
Wangen, 88239, Germany
Al-Zoebi
Wermsdorf, 04779, Germany
Forschungszentrum Ruhr KliFoCenter GmbH, Dr. med. Kahrmann
Witten, 58455, Germany
University Hospital of Athens ATTIKON
Haidari-Athens, Attica, GR-12462, Greece
Onassis Cardiac Surgery Center
Athens, 17674, Greece
"Laiko" General Hospital of Athens
Athens, GR-11527, Greece
Hippokration Hospital
Athens, GR-11527, Greece
Alexandra General Hospital, Therapeutic Clinic
Athens, GR-11528, Greece
Konstantopouleio G.H. of Athens, "Agia Olga"
Athens, GR-14233, Greece
"Hygeia" General Hospital of Athens
Athens, GR-15123, Greece
Iatriko Athinon (Athens Medical Canter)
Athens, GR-15125, Greece
General Hospital of Chios "Skilitsio"
Chios, GR82100, Greece
University General Hospital of Ioannina,Internal Medicine
Ioannina, 45500, Greece
General Hospital of Lamia
Lamia, GR35100, Greece
Univ Gen Hospital Larisa, Cardiology Medicine Clinic
Larissa, GR-41110, Greece
AHEPA General University Hospital
Thessaloniki, GR-54636, Greece
"Thermi" Private Hosital
Thessaloniki, GR-57001, Greece
Lausmed Kft.
Baja, Bács-Kiskun county, 6500, Hungary
Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ
Szeged, Csongrád-Csanád, H-6725, Hungary
Léda Platán Magánklinika
Zalaegerszeg, Zala County, 8900, Hungary
Debreceni Egyetem Klinikai Központ Belgyógyászati Klinika
Debrecen, H-4032, Hungary
Bugát Pál Kórház
Gyöngyös, 3200, Hungary
Markusovszky Egyetemi Oktatókórház
Szombathely, H-9700, Hungary
Ramesh Hospitals
Vijayawada, Andhra Pradesh, 520008, India
Apex Heart Institute
Ahmedabad, Gujarat, 380054, India
CIMS- Care Institute of Medical Sciences
Ahmedabad, Gujarat, 380060, India
Shri B. D. Mehta Mahavir Heart Institute
Surat, Gujarat, 395001, India
Unicare heart institute and research centre
Surat, Gujarat, 395001, India
Nirmal Hospital Pvt. Ltd.
Surat, Gujarat, 395002, India
Medanta - The Medicity Multi-Speciality Hospital, Gurugram
Gurgaon, Haryana, 122001, India
Sri Jayadeva Institute of Cardiovascular Sciences & Research
Bangalore, Karnataka, 560069, India
St John's Medical College Hospital
Bengaluru, Karnataka, 560034, India
Kamalnayan Bajaj Hospital
Aurangabad, Maharashtra, 431010, India
Seth GS medical college and KEM Hospital
Mumbai, Maharashtra, 400012, India
Lokmanya Tilak Municipal Medical College & General Hospital
Mumbai, Maharashtra, 400022, India
Holy Family Hospital and Medical Research Centre
Mumbai, Maharashtra, 400050, India
Arneja Heart & Multispeciality Hospital
Nagpur, Maharashtra, 440010, India
Shri Krishna Hrudayalaya & Critical Care Centre
Nagpur, Maharashtra, 440012, India
Vijan Hospital & Research Centre
Nashik, Maharashtra, 422005, India
Grant Medical Foundation
Pune, Maharashtra, 411001, India
Batra Hospital and Medical Research Center
New Delhi, National Capital Territory of Delhi, 110062, India
Maulana Azad Medical College
Delhi, New Delhi, 110002, India
All India Institute of Medical Sciences
New Dehli, New Delhi, 110029, India
VMMC & Safdarjung Hospital
New Dehli, New Delhi, 110029, India
Dayanand Medical College & Hospital
Ludhiana, Punjab, 141001, India
SP Medical College
Bikaner, Rajasthan, 334003, India
The Madras Medical Mission
Chennai, Tamil Nadu, 600037, India
G Kuppuswamy Naidu Memorial Hospital
Coimbatore, Tamil Nadu, 641037, India
Christian Medical College Hospital, Vellore
Vellore, Tamil Nadu, 632004, India
Osmania General Hospital
Hyderabad, Telangana, 500 012, India
Guru Nanak CARE Hospitals
Hyderabad, Telangana, 500020, India
Gandhi Memorial Hospital- King George's Medical University
Lucknow, Uttar Pradesh, 226003, India
B M Birla Heart Research Centre
Kolkata, West Bengal, 700027, India
Narayana Hrudayalya Institute of Cardiac Sciences
Bangalore, 560 099, India
St John's Medical College and Hospital
Bangalore, 560034, India
Dr. BL Kapur Memorial Hospital
New Delhi, 110005, India
Sir Ganga Ram Hospital
New Delhi, 110060, India
Mater Miscericordiae Hospital
Dublin, Leinster, D07 XAO9, Ireland
Connolly Hospital
Dublin, Leinster, DUBLIN 15, Ireland
The Heartbeat Trust
Dublin, A96 D628, Ireland
St Vincent's Private Hospital
Dublin, D04 T6F4, Ireland
Tallaght Hospital - Cardiology
Dublin, D24NR0A, Ireland
Mallow Primary Healthcare Centre
Mallow, P51Y8EC, Ireland
Outpatient Diabetes Clinic Soroka MC
Beersheba, 84101, Israel
Diabetes and obesity center of excellence, Rambam MC
Haifa, 31096, Israel
Diabetes Unit Hadassah Ein Karem MC
Jerusalem, 91120, Israel
Hadassah Ein Kerem MC - Cardio
Jerusalem, 91120, Israel
Clinical Research Unit Meir Medical Center
Kfar Saba, 44281, Israel
Institute of Diabetes, Western Galilee MC Nahariya
Nahariya, 22100, Israel
Rabin Medical Center - Hasharon Hospital, Dept. D
Petah Tikva, 49372, Israel
Kaplan MC
Rehovot, 76100, Israel
Cardio Vascular Research Center Sourasky MC
Tel Aviv, 6423906, Israel
Institute of Endocrinology, metabolism and hypertension
Tel Aviv, 64239, Israel
Endrocrinolgy Clinic - Sheba Medical Center
Tel Litwinsky, 52621, Israel
Sheba Medica Center - Clinical Research Unit
Tel Litwinsky, 5265601, Israel
Ospedale Santa Maria Goretti - UOD Diabetologia
Latina, LT, 04100, Italy
Centro di Alta Spec. Diet., Educ. Alim. e Prev. Cardio Metab
San Donato Milanese (MI), MI, 20097, Italy
Pol. Uni. Campus Biomedico UOC Endocrinologia e Diabetologia
Roma, RM, 00128, Italy
AO Papa Giovanni XXIII USS Dietologia Clinica
Bergamo, 24127, Italy
A. O. Universitaria S.ORSOLA-MALPIGHI - U. O. Endocrinologia
Bologna, 40138, Italy
ARNAS Ospedale Garibaldi
Catania, 95122, Italy
Università degli studi G. D'Annunzio Chieti Pescara - CAST
Chieti Scalo, 66100, Italy
Ospedale di San Fermo della Battaglia
Como, 22042, Italy
Azienda Osp-Univ Ferrara-Dip Scienze Mediche-Endocrinologia
Cona - Ferrara, 44124, Italy
AOU Careggi Dipartimento Medico Geriatrico SOD Diabetologia
Florence, 50134, Italy
U.O.D. Dietetica e Nutrizione Clinica
Genova, 16132, Italy
Azienda Ospedaliera Universitaria Federico II di Napoli
Napoli, 80131, Italy
Azienda Ospedaliera di Padova Clin.Med.3
Padua, 35128, Italy
Unità Funzionale di nutrizione clinica cod 58.01.3
Palermo, 90127, Italy
IRCCS Fondazione "S. Maugeri" U.O. Medicina Interna ed Endo
Pavia, 27100, Italy
Azienda Ospedaliero Universitaria Pisana Ospedale Cisanello
Pisa, 56124, Italy
UOC di Medicina Interna - Centro Medico dell'Obesità
Roma, 00133, Italy
Policlinico Universitario AGemelli DH Patologie dell'Obesità
Rome, 00168, Italy
Ist.Clinico Humanitas Endocrinologia e Malattie del ricambio
Rozzano (MI), 20089, Italy
Centro di Alta Spec. Diet., Educ. Alim. e Prev. Cardio Metab
San Donato Milanese (MI), 20097, Italy
Osp. Santissima Annunziata ASL CN1 Endocrinol. Diabetol.
Savigliano (CN), 12038, Italy
IRCCS Multimedica
Sesto San Giovanni (MI), 20099, Italy
A.O.U. Senese Policlinico "Le Scotte" , U.O.C. Diabetologia
Siena, 53100, Italy
A.O.U. Città della Salute e della Scienza di Torino
Torino, 10126, Italy
Seiwa Clinic
Adachi-ku, Tokyo, 123-0845, Japan
Toyooka Chuo Hospital
Asahikawa, Hokkaido, 078-8237, Japan
The Univ. of Tokyo Hp., Dept. of Cardiovascular Medicine
Bunkyo-ku, Tokyo, 113-8655, Japan
New Tokyo Heart Clinic_Matsudo-shi, Chiba,
Chiba, 271-0077, Japan
Fukuokaken Saiseikai Futsukaichi Hospital_Cardiovascular Medicine
Chikushino-shi, Fukuoka, 818-8516, Japan
Ehime Prefectural Central Hospital
Ehime, 790-0024, Japan
Chiba Tokushukai Hospital
Funabashi-shi, Chiba, 274-8503, Japan
Gifu Heart Center
Gifu-city, Gifu, 500-8384, Japan
Hirakata Kohsai Hospital
Hirakata-shi, Osaka, 573-0153, Japan
Medical Corporation JR Hiroshima Hospital
Hiroshima-shi, Hiroshima, 732-0057, Japan
Hiroshi Yamaguchi Clinic
Kagoshima-shi, Kagoshima, 892-0828, Japan
H.E.C Science Clinic
Kanagawa, 235-0045, Japan
Kasugai Municipal Hospital
Kasugai-shi, Aichi, 486-8510, Japan
Sugiura Clinic
Kawaguchi-shi, Saitama, 332-0012, Japan
Steel Memorial Yawata Hospital
Kitakyushu-shi, Fukuoka, 805-8508, Japan
Chikamori Hospital
Kochi-shi, Kochi, 780-8522, Japan
Saiseikai Kumamoto Hospital
Kumamoto-shi, Kumamoto, 861-4193, Japan
Uji Tokushukai Medical Center
Kyoto, 611-0041, Japan
Koseikai Takeda Hospital
Kyoto-shi, Kyoto, 600-8558, Japan
Ijinkai Takeda General Hospital, Cardiovascular Medicine
Kyoto-shi,Kyoto, 601-1495, Japan
Ijinkai Takeda General Hospital, Neurosurgery
Kyoto-shi,Kyoto, 601-1495, Japan
Medical Corporation Matsuyama-heartcenter Yotsuba Circulatio
Matsuyama-shi, Ehime, 790-0062, Japan
Shinden Higashi Clinic_Miyagi
Miyagi, 983-0039, Japan
Shiga General Hospital
Moriyama-shi, Shiga, 524-8524, Japan
Nagoya Ekisaikai Hospital
Nagoya-shi, Aichi, 454-8502, Japan
Naha City Hospital
Naha-shi, Okinawa, 902-8511, Japan
Takagi hospital, Internal Medicine
Okawa-shi, Fukuoka, 831-0016, Japan
Okayama Medical Center
Okayama-shi, Okayama, 701-1192, Japan
Takatsuki Red Cross Hospital
Osaka, 569-1045, Japan
Sakurabashi Watanabe Advanced Healthcare Hospital
Osaka-city, Osaka, 530-0005, Japan
Saga University Hospital, Department of Cardiology
Saga-shi, Saga, 849-8501, Japan
Shinsapporo Seiryou Hospital, Intenal Medicine
Sapporo-shi, Hokkaido, 004-0004, Japan
Hanaoka Seishu Memorial Hospital
Sapporo-shi, Hokkaido, 062-0003, Japan
Medical corporation Sanseikai Miyanomori Memorial Hospital
Sapporo-shi, Hokkaido, 064-8570, Japan
Sendai Kousei Hospital_Sendai-shi, Miyagi
Sendai-shi, Miyagi, 980-0873, Japan
National Center for Global Health and Medicine
Shinjuku-ku, Tokyo, 162-8655, Japan
Japan Community Health care Organization Ritsurin Hospital
Takamatsu-shi, Kagawa, 760-0073, Japan
Kagawa Prefectural Central Hospital, Cardiovascular Medicine
Takamatsu-shi, Kagawa, 760-8557, Japan
Kagawa Prefectural Central Hospital
Takamatsu-shi, Kagawa, 760-8557, Japan
Kan-etsu chu-oh Hospital
Takasaki-shi, Gunma, 370-3513, Japan
Tokorozawa Heart Center
Tokorozawa-shi, Saitama, 356-1142, Japan
Saino Clinic
Tokorozawa-shi,Saitama, 359-1141, Japan
Tokyo-Eki Center-building Clinic
Tokyo, 103-0027, Japan
Fukuwa Clinic
Tokyo, 104-0031, Japan
Tokyo Shinagawa Hospital Social Medical Corporation Association Tokyokyojuno-kai
Tokyo, 140-8522, Japan
Minamino Cardiovascular Hospital
Tokyo, 192-0918, Japan
National Hospital Organization Saitama National Hospital
Wako-city, Saitama, 351-0102, Japan
Nagata Hospital
Yanagawa-shi, Fukuoka, 832-0059, Japan
Yokosuka General Hospital Uwamachi, Cardiology
Yokosuka-shi, Kanagawa, 238-856, Japan
Ari Med
Daugavpils, LV5401, Latvia
Meissana Ltd
Liepāja, LV-3414, Latvia
Teterovska practice
Ogre, LV-5001, Latvia
Stradini Cardiology
Riga, LV-1002, Latvia
Medical Centre Pulss 5
Riga, LV-1011, Latvia
Adoria
Riga, LV1011, Latvia
Health Centre-4
Riga, LV1012, Latvia
Ziemelkurzeme Regional Hospital
Ventspils, LV3601, Latvia
Hospital Universiti Sains Malaysia
Kota Bharu, Kelantan, 16150, Malaysia
Hospital Tengku Ampuan Afzan
Kuantan, Pahang, 25100, Malaysia
Hospital Seri Manjung
Seri Manjung, Perak, 32040, Malaysia
Sarawak Heart Centre
Kota Samarahan, Sarawak, 94300, Malaysia
University Technology MARA (UiTM) - Puncak Alam
Sungai Buloh, Selangor, 47000, Malaysia
Klinik Kesihatan Masjid Tanah
Alor Gajah, 78300, Malaysia
Hospital Sultanah Bahiyah
Alor Star, 05460, Malaysia
Sarawak Heart Centre
Kota Samarahan, 94300, Malaysia
National Heart Institute
Kuala Lumpur, 50400, Malaysia
University Malaya Medical Centre
Kuala Lumpur, 59100, Malaysia
Hospital Tengku Ampuan Afzan
Kuantan, 25100, Malaysia
Hospital Putrajaya
Putrajaya, 62250, Malaysia
Hospital Queen Elizabeth II
Sabak Bernam, 88300, Malaysia
CIMAB SA de CV
Torreón, Coahuila, 27000, Mexico
Centro de Investigacion Clinica Endocrinologica de Jalisco
Guadalajara, Jalisco, 44670, Mexico
Instituto Nacional de Cardiología Ignacio Chavez
Mexico City, México, D.F., 14080, Mexico
Hospital Universitario Dr. José Eleuterio González_Monterrey
Monterrey, Nuevo León, 64460, Mexico
Unidad Biomedica Avanzada Monterrey
Monterrey, Nuevo León, 64460, Mexico
Centro de atención e investigación cardiovascular del Potosí
San Luis Potosí City, San Luis Potosí, 78200, Mexico
Centro para el Desarrollo de la Medicina y la Asistencia
Culiacán, Sinaloa, 80230, Mexico
Centro de Investigación Cardiometabólica de Aguascalientes
Aguascalientes, 20230, Mexico
Lahoja Asociación para la Investigación y Farmacovigilancia
Durango, 34000, Mexico
Gelre Ziekenhuizen Apeldoorn
Apeldoorn, 7334 DZ, Netherlands
Amphia Ziekenhuis
Breda, 4818 CK, Netherlands
Deventer Ziekenhuis
Deventer, 7416 SE, Netherlands
UMC Groningen
Groningen, 9713 GZ, Netherlands
Medisch Centrum Leeuwarden
Leeuwarden, 8934 AD, Netherlands
Alrijne Leiderdorp
Leiderdorp, 2353 GA, Netherlands
Bravis Ziekenhuis
Roosendaal, 4708 AE, Netherlands
Franciscus Gasthuis en Vlietland
Rotterdam, 3045 PM, Netherlands
D & A Research B.V.
Sneek, 8601 ZR, Netherlands
Ziekenhuis Rivierenland Tiel
Tiel, 4002 WP, Netherlands
Ålesund Sjukehus - Hjertemedisinsk poliklinikk
Ålesund, 6017, Norway
Haukeland Universitetssykehus
Bergen, 5021, Norway
Falck Norge AS
Hamar, 2317, Norway
Sykehuset Innlandet Lillehammer
Lillehammer, 2609, Norway
Akershus Universitetssykehus
Nordbyhagen, 1474, Norway
Rikshospitalet - Kardiologisk forskning
Oslo, 0372, Norway
Oslo universitetssykehus HF Ullevål
Oslo, 0450, Norway
Oslo universitetssykehus Aker
Oslo, 0586, Norway
Senter for sykelig overvekt i Helse Sør-Øst
Tønsberg, 3117, Norway
NZOZ "CenterMed Lublin" Sp. z o.o.
Lublin, Lublin Voivodeship, 20-044, Poland
ETG Siedlce
Siedlce, Masovian Voivodeship, 08-110, Poland
ETG Warszawa
Warsaw, Masovian Voivodeship, 02-677, Poland
Gabinet Leczenia Otylosci i Chorob Dietozaleznych
Bialystok, Podlaskie Voivodeship, 15-281, Poland
Kresmed Sp. z o. o.
Bialystok, Podlaskie Voivodeship, 15-481, Poland
Centrum Medyczne Pratia Gdynia
Gdynia, Pomeranian Voivodeship, 81-338, Poland
PRATIA Centrum Medyczne
Gdynia, Pomeranian Voivodeship, 81-338, Poland
Centrum Zdrowia Metabolicznego
Poznan, Wielkopolskie Voivodeship, 60-589, Poland
Poradnia Kardiologiczna Jaroslaw Jurowiecki
Gdansk, 80-286, Poland
Centrum Badan Klinicznych PI-House
Gdansk, 80-546, Poland
Grazyna Pulka Specjalistyczny Osrodek "All-Med"
Krakow, 30-033, Poland
UniCardia & UniMedica & UniEstetica
Krakow, 31-271, Poland
Centrum Terapii Wspolczesnej
Lodz, 90-338, Poland
ETG Lowicz
Lowicz, 99-400, Poland
Centrum Medyczne HCP Sp. z o.o.
Poznan, 61-485, Poland
Velocity Nova Sp. z o.o.
Puławy, 24-100, Poland
Gabinety Lekarskie LabMed
Szczecin, 71-531, Poland
Przychodnia Lekarzy Specjalistow Serce
Warsaw, 00-416, Poland
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych I Administracji
Warsaw, 02-507, Poland
Velocity Zamość
Zamość, 22-400, Poland
Klimed Lomza
Łomża, 18-404, Poland
Clinmedica Research sp. z o.o.
Skierniewice, Łódź Voivodeship, 96-100, Poland
Hospital Garcia de Orta
Almada, 2805-267, Portugal
Centro Hospitalar e Universitário de Coimbra
Coimbra, 3000-459, Portugal
Hospital da Luz
Lisbon, 1500-650, Portugal
Centro Hospitalar Lisboa Norte
Lisbon, 1649-035, Portugal
Unidade Local de Saúde de Matosinhos
Matosinhos Municipality, 4464-513, Portugal
Centro Hospitalar de São João
Porto, 4200-319, Portugal
San Miguel Medical
Trujillo Alto, 00976, Puerto Rico
SC Grand Med SRL
Oradea, Bihor County, 410025, Romania
S.C. Endodigest S.R.L.
Oradea, Bihor County, 410151, Romania
SC Ames Research Center SRL
Clarasi, Calaras, 910103, Romania
S.C. Centrul Medical Unirea S.R.L.
Cluj-Napoca, Cluj, 400349, Romania
S.C. Top Diabet Srl
Craiova, Dolj, 200515, Romania
County Hospital Deva
Deva, Hunedoara County, 330084, Romania
CMI Dr Pop Lavinia
Baia Mare, Maramureş, 430222, Romania
Sc Mediab Srl
Târgu Mureş, Mureș County, 540142, Romania
3rd Clinic for Nutrition-Spitalulul Județean de Urgenta
Timișoara, Timiș County, 300736, Romania
Minimed S.R.L.
Bacau, 600238, Romania
Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed
Brasov, 500283, Romania
Sc Nicodiab Srl
Bucharest, 010507, Romania
"Carol Davila" Military Emergency Hospital
Bucharest, 010825, Romania
Sana Monitoring SRL
Bucharest, 011025, Romania
Institutul National de Endocrinologie C.I. Parhon
Bucharest, 011863, Romania
SC Eco-Diagnosis SRL
Bucharest, 031818, Romania
S.C. Medcon S.R.L
Buzău, 120203, Romania
S.C Milena Sante SRL
Galati, 800001, Romania
SC Diamed Obesity SRL
Galati, 800291, Romania
SC Consultmed SRL
Iași, 700547, Romania
SC Cardiomed SRL
Iași, 700687, Romania
Centrul Medical Bella Praxis
Paşcani, 700502, Romania
Bella Praxis S.R.L.
Paşcani, 705200, Romania
S.C. Dianutrilife Medica S.R.L.
Ploieşti, 100561, Romania
County Emergency Hospital Satu Mare
Satu Mare, 440055, Romania
SC Gensan SRL, Policlinica ASTRA
Sibiu, 550371, Romania
Tumen State Medical University
Tyumen, Russia, 625023, Russia
Volosevich First City Clinical Hospital
Arkhangelsk, 163001, Russia
Reg. State Budget Healthc. Inst. Regional Clinical Hospital
Barnaul, 656024, Russia
City Hospital #5
Barnaul, 656045, Russia
RBSHI "Altay Regional Cardiology Dispensary"
Barnaul, 656055, Russia
Belgorod regional clinical hospital of the St. Ioasaph
Belgorod, 308007, Russia
Cardiological dispensary
Ivanovo, 153012, Russia
KSFMU, Inrereginal Clinical Diagnostic center
Kazan', 420010, Russia
Institute of Complex Problems of Cardio-Vascular Diseases
Kemerovo, 650002, Russia
Medical Center CAPITAL-HEALTH
Moscow, 109369, Russia
Moscow City Clinical Hospital #15
Moscow, 111539, Russia
Friendship University of Russia
Moscow, 117292, Russia
Moscow State University n.a. M.V. Lomonosov
Moscow, 119991, Russia
National Medical Research Center of Cardiology
Moscow, 121552, Russia
City Clinical Hospital №52
Moscow, 123182, Russia
Federal Bureau for Medical and Social Expertise
Moscow, 127486, Russia
PHI "Central Clinical Hospital RZD- Medicine"
Moscow, 129128, Russia
Moscow City Clinical Hospital n.a. A.K. Eramishantseva
Moscow, 129327, Russia
LLC RC Medical
Novosibirsk, 630005, Russia
Limited Law Company "Healthy Family" Medicine Center"
Novosibirsk, 630099, Russia
LLC Reafan
Novosibirsk, 630099, Russia
Scientific Research Institute of neuroscience and Medicine
Novosibirsk, 630117, Russia
Orenburg Regional Clinical Hospital
Orenburg, 460018, Russia
Penza Regional Clinical Hospital named after N.N. Burdenko
Penza, 440052, Russia
Rostov State Medical University_Rostov-on-Don
Rostov-on-Don, 344068, Russia
City policlinic #28
Saint Petersburg, 190013, Russia
Joint Stock Company "Modern Medical Technologies"
Saint Petersburg, 190121, Russia
SPb SBHI City Outpatient clinic #37
Saint Petersburg, 191119, Russia
SPb SBHI City Outpatient clinic #109
Saint Petersburg, 192283, Russia
Limited Liability Company "Energiya Zdoroviya"
Saint Petersburg, 194156, Russia
SPb SBHI City Multifield Hospital #2
Saint Petersburg, 194354, Russia
SPb SBHI City polyclinic #117
Saint Petersburg, 194358, Russia
FSPbSMU n.a. Academic I.P. Pavlov
Saint Petersburg, 197022, Russia
Consultative & Diagnostic Center with a Outpatient Hospital
Saint Petersburg, 197110, Russia
Saint-Petersburg "City Policlinic # 74"
Saint Petersburg, 197762, Russia
Astarta Clinic LLC
Saint Petersburg, 199226, Russia
SPb SBHI City Hospital #38 n.a. N.A. Semashko
Saint-Petersburg, Pushkin, 196601, Russia
Regional Clinical cardiological dispensary n.a. Polyakov
Samara, 443070, Russia
City Hospital #4, Sochi
Sochi, 354057, Russia
SAHI of Komi Republic "Consultative Diagnostic Center"
Syktyvkar, 167981, Russia
Tomsk National Research Medical Center of the RAS
Tomsk, 634012, Russia
Tomsk Regional Clinical Hospital
Tomsk, 634041, Russia
Siberian State Medical University_Tomsk
Tomsk, 634050, Russia
Regional Clinical Hospital of Tver
Tver', 170036, Russia
Tumen State Medical University - RIMBB
Tyumen, 625023, Russia
Ulianovsk Regional Clinical Hospital
Ulyanovsk, 432063, Russia
Voronezh Regional Clinical Consultive-diagnostic Centre
Voronezh, 394018, Russia
Solovyov Clinical Emergency Hospital
Yaroslavl, 150003, Russia
Urals State Medical University
Yekaterinburg, 620026, Russia
Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.
Novi Sad, Vojvodina, 21000, Serbia
Clinical centre of Serbia, Clinic for cardiology
Belgrade, 11000, Serbia
Clinical Centre of Serbia, Emergency Centre, Department of Cardiology
Belgrade, 11000, Serbia
Emergency Internal Medicine Clinic
Belgrade, 11000, Serbia
Endocrinology, Diabetes and Metabolism Diseases Clinic
Belgrade, 11000, Serbia
Special Hospital "Sveti Sava"
Belgrade, 11000, Serbia
Phoenix Pharma
Port Elizabeth, Eastern Cape, 6001, South Africa
Cardiology Research_Bloemfontein
Bloemfontein, Free State, 9301, South Africa
IATROS International
Bloemfontein, Free State, 9301, South Africa
Josha Research
Bloemfontein, Free State, 9301, South Africa
Cardiology Clinical Research
Alberton, Gauteng, 1450, South Africa
Dr Iftikhar Osman Ebrahim
Centurion, Gauteng, 0157, South Africa
CRISMO
Germiston, Gauteng, 1401, South Africa
Wits Bara Clinical Trial Site
Johannesburg, Gauteng, 2013, South Africa
Tickerdoc Research (Pty) LTD
Johannesburg, Gauteng, 2157, South Africa
WITS Clinical Research
Johannesburg, Gauteng, 2193, South Africa
Dr Moosa's Rooms
Lenasia, Gauteng, 1827, South Africa
Lenasia Clinical Trial Centre
Lenasia, Gauteng, 1827, South Africa
Jongaie Research
Pretoria, Gauteng, 0183, South Africa
Synexus Watermeyer Clinical Research Centre
Pretoria, Gauteng, 0184, South Africa
Clinical Trial Systems (CTC)
Pretoria, Gauteng, 0186, South Africa
Roodepoort Medicross Clinical Research Centre
Roodepoort, Gauteng, 1724, South Africa
Dr Jugnundan's Rooms
Durban, KwaZulu-Natal, 4091, South Africa
Dr S Dawood
Cape Town, Western Cape, 7405, South Africa
Dr Corbett
Cape Town, Western Cape, 7500, South Africa
Tread Research (Pty)Ltd
Cape Town, Western Cape, 7500, South Africa
UCT Lung institute
Cape Town, Western Cape, 7700, South Africa
Cape Town Medical Research Centre
Kuilsriver, Western Cape, 7580, South Africa
Paarl Research Centre
Paarl, Western Cape, 7646, South Africa
Synexus Helderberg Clinical Research Centre
Somerset West, Western Cape, 7130, South Africa
Clinical Projects Research
Worcester, Western Cape, 6850, South Africa
Complejo Hospitalario Universitario A Coruña
A Coruña, 15006, Spain
Centro Periférico de Especialidades Bola Azul
Almería, 04009, Spain
Hospital Gregorio Marañón
Madrid, 28009, Spain
Hospital Ramón y Cajal
Madrid, 28034, Spain
Hospital Universitario La Paz
Madrid, 28046, Spain
Hospital Clínico Virgen de la Victoria
Málaga, 29010, Spain
Hospital Son Llatzer
Palma de Mallorca, 07198, Spain
Clínica Nuevas Tecnologías en Diabetes y Endocrinología
Seville, 41003, Spain
Hospital Virgen de la Macarena
Seville, 41009, Spain
Hospital Infanta Luisa
Seville, 41010, Spain
Hospital La Fe - Endocrinología y Nutrición
Valencia, 46026, Spain
Lundberglab for Diab Research
Gothenburg, 413 45, Sweden
Centralsjukhuset, Kristianstad
Kristianstad, 291 85, Sweden
Clemenstorgets Hjärtmottagning
Lund, 222 21, Sweden
Enheten för Kliniska Studier (EKS), Örebro
Örebro, 703 62, Sweden
Hjärtenheten
Östersund, 831 83, Sweden
Karolinska Universitetssjukhuset Solna,FOU Tema Hjärta Kärl
Stockholm, 171 76, Sweden
HsinChu MacKay Memorial Hospital
Hsinchu, 300, Taiwan
E-DA Hosiptal
Kaohsiung City, 82445, Taiwan
MacKay Memorial Hospital-Tamsui Branch
New Taipei City, 25160, Taiwan
National Taiwan University Hospital
Taipei, 100, Taiwan
Chang Gung Memorial Hospital Linkou
Taoyuan, 333, Taiwan
Thammasat University Hospital
Klong Luang, Pathumthani, Changwat Pathum Thani, 12120, Thailand
Maharaj Nakorn Chiang Mai Hospital
Chiang Mai, Mueang Chiang Mai District, 50200, Thailand
King Chulalongkorn Memorial Hospital_Bangkok
Bangkok, 10330, Thailand
Phramongkutklao Hospital-cardio
Bangkok, 10400, Thailand
Phramongkutklao Hospital-neuro
Bangkok, 10400, Thailand
Ramathibodi Hospital-Cardiovascular metabolic Center
Bangkok, 10400, Thailand
Siriraj Hospital_Bangkok_1
Bangkok, 10700, Thailand
Maharaj Nakorn Chiang Mai Hospital-cardio
Chiang Mai, 50200, Thailand
Srinakarind Hospital-Division of Cardiology
Khon Kaen, 40002, Thailand
Baskent Universitesi Adana
Adana, 01250, Turkey (Türkiye)
Cukurova University School of Medicine Balcali Hospital
Adana, 01330, Turkey (Türkiye)
Gulhane Egitim Arastirma Hastanesi
Ankara, 06010, Turkey (Türkiye)
Hacettepe Universitesi Tip Fakultesi Hastanesi
Ankara, 06100, Turkey (Türkiye)
Akdeniz University Tip Fakultesi Hastanesi
Antalya, 07058, Turkey (Türkiye)
Adnan Menderes Universitesi Uygulama ve Arastirma Hastanesi
Aydin, 09010, Turkey (Türkiye)
Eskisehir Osmangazi University-Cardio
Eskişehir, 26040, Turkey (Türkiye)
Gaziantep Universitesi Tip Fakultesi Hastanesi
Gaziantep, 27070, Turkey (Türkiye)
Koc University Hospital
Istanbul, 34010, Turkey (Türkiye)
Seyrantepe Hamidiye Etfal Egitim ve Arastirma Hastanesi
Istanbul, 34371, Turkey (Türkiye)
Istanbul Universitesi Istanbul Tip Fakultesi - Endokrinoloji
Istanbul, 34390, Turkey (Türkiye)
TC SB Ist.İl Sag.Müd.Prof.Dr.Cemil Tascioglu Sehir Hastanesi
Istanbul, 34400, Turkey (Türkiye)
Fatih Sultan Mehmet Hastanesi
Istanbul, 34752, Turkey (Türkiye)
Umraniye Egitim ve Arastirma Hastanesi
Istanbul, 34760, Turkey (Türkiye)
T.C. Saglik Bakanligi Pendik Egitim ve Arastirma Hastanesi
Istanbul, 34899, Turkey (Türkiye)
Ege University School of Medicine, Cardiology Department
Izmir, 35100, Turkey (Türkiye)
Izmir Tepecik Training and Research Hospital
Izmir, 35180, Turkey (Türkiye)
Dokuz Eylul University School of Medicine, Cardiology
Izmir, 35340, Turkey (Türkiye)
Erciyes University Cardiology
Kayseri, 38039, Turkey (Türkiye)
Mersin University Cardiology
Mersin, 33343, Turkey (Türkiye)
Cumhuriyet University School of Medicine-Cardiology
Sivas, 58140, Turkey (Türkiye)
CMI City Clinical Hospital #3
Chernivtsi, 58000, Ukraine
CNPI "Kharkiv City Clinical Hospital #27"
Kharkiv, 61002, Ukraine
NI of Therapy na LT Malaya of NAMSU - Chr. Non-Communicable
Kharkiv, 61039, Ukraine
Oleksandrivska Clinical Hospital - cardio rehabilitation dep
Kyiv, 01023, Ukraine
Medical Center of LLC 'Harmoniya Krasy'
Kyiv, 01135, Ukraine
Medical Center 'Ok!Clinic+' of II of Clinical Studies LLC
Kyiv, 02091, Ukraine
Kyiv City Clinical Hospital of Emergency Care - Infarction
Kyiv, 02660, Ukraine
Clinical Hosp on the railway line №2 branch PHC JSC Ukrzaliz
Kyiv, 03049, Ukraine
MD Strazheska Institute of Cardiology of NAMSU - Resuscitati
Kyiv, 03151, Ukraine
Kyiv Regional Hospital
Kyiv, 04053, Ukraine
City Clinical Emergency Hospital - Cardiology department
Lviv, 79059, Ukraine
Odesa Regional Clinical Hospital
Odesa, 65025, Ukraine
Odessa Clinical Railway Hospital - Outpatient department
Odesa, 65059, Ukraine
City Clinical Hospital #1 - Therapy department
Vinnytsia, 21000, Ukraine
Vinnytsia Regional Clinical Hospital - Cardiology department
Vinnytsia, 21018, Ukraine
Central City Hospital #1 - Scientific-Research center
Zhytomyr, 10002, Ukraine
Zhytomir Regional Clinical Hospital - Cardio-Arrhytm. centre
Zhytomyr, 10002, Ukraine
Harrogate District Hospital
Harrogate, North Yorkshire, HG2 7SX, United Kingdom
Clifton Medical Centre
Rotherham, South Yorkshire, S65 1DA, United Kingdom
St. Richards Hospital
Chichester, West Sussex, PO19 6SE, United Kingdom
Crouch Oak Family Practice
Addlestone, KT15 2BH, United Kingdom
Stroke Trials Office
Airdrie, ML6 0JS, United Kingdom
Antrim Area Hospital
Antrim, BT42 2RL, United Kingdom
Axbridge & Wedmore Medical Practice
Axbridge, BS26 2BJ, United Kingdom
Bermuda Practice
Basingstoke, RG24 9GT, United Kingdom
Sea Road Surgery
Bexhill-on-Sea, TN40 1JJ, United Kingdom
Birmingham Heartlands Hospital
Birmingham, B9 5SS, United Kingdom
Layton Medical Centre
Blackpool, FY3 7EN, United Kingdom
Bollington Medical Centre
Bollington, SK10 5JH, United Kingdom
The Health Centre
Bradford-on-Avon, BA15 1DQ, United Kingdom
Southmead Hospital
Bristol, BS10 5NB, United Kingdom
Ely Bridge Surgery
Cardiff, CF5 4AD, United Kingdom
St Peters Hospital, Chertsey
Chertsey, KT16 0PZ, United Kingdom
Countess Of Chester NHS Foundation Trust
Chester, CH2 1UL, United Kingdom
WISDEM Centre
Coventry, CV2 2DX, United Kingdom
Ninewells Hospital
Dundee, DD1 9SY, United Kingdom
Royal Devon University Healthcare NHS Foundation Trust
Exeter, EX2 5DW, United Kingdom
Department Of Cardiac Research
Harrow, HA1 3UJ, United Kingdom
Wycombe General Hospital
High Wycombe, HP11 2TT, United Kingdom
Hull Royal Infirmary
Hull, HU3 2JZ, United Kingdom
Cardiology
Leicester, LE3 9QP, United Kingdom
Lincoln County Hospital
Lincoln, LN2 5QY, United Kingdom
University Hospital Aintree
Liverpool, L9 7AL, United Kingdom
Guys Hospital
London, SE1 9RT, United Kingdom
Kings College Hospital
London, SE5 9RS, United Kingdom
Imperial College London
London, W12 0HS, United Kingdom
Diabetes Centre North Manchester General Hospital
Manchester, M8 5RB, United Kingdom
Cardio Research
Middlesbrough, TS4 3BW, United Kingdom
University Dept of Medicine, Derriford Hospital, Plymouth
Plymouth, PL6 8DH, United Kingdom
Clarence Medical Centre
Rhyl, LL18 1DA, United Kingdom
Ashfields Primary Care Centre
Sandbach, CW11 1EQ, United Kingdom
Clinical Research Unit
Somerset, BA21 4AT, United Kingdom
Moorgreen Hospital
Southampton, SO30 3JB, United Kingdom
Lister Hospital
Stevenage, SG1 4AB, United Kingdom
Sunderland Royal Hospital
Sunderland, SR4 7TP, United Kingdom
Musgrove Park Hospital
Taunton, TA1 5DA, United Kingdom
Cardiology Department
Torquay, TQ2 7AA, United Kingdom
Royal Cornwall Hospital (Treliske)
Truro, TR1 3LJ, United Kingdom
University Hospital Wishaw
Wishaw, ML2 0DP, United Kingdom
Related Publications (18)
Ryan DH, Lingvay I, Colhoun HM, Deanfield J, Emerson SS, Kahn SE, Kushner RF, Marso S, Plutzky J, Brown-Frandsen K, Gronning MOL, Hovingh GK, Holst AG, Ravn H, Lincoff AM. Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (SELECT) rationale and design. Am Heart J. 2020 Nov;229:61-69. doi: 10.1016/j.ahj.2020.07.008. Epub 2020 Jul 17.
PMID: 32916609RESULTWilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021 Mar 18;384(11):989-1002. doi: 10.1056/NEJMoa2032183. Epub 2021 Feb 10.
PMID: 33567185RESULTLincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, Lingvay I, Oral TK, Michelsen MM, Plutzky J, Tornoe CW, Ryan DH; SELECT Trial Investigators. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. N Engl J Med. 2023 Dec 14;389(24):2221-2232. doi: 10.1056/NEJMoa2307563. Epub 2023 Nov 11.
PMID: 37952131RESULTNicholls SJ, Ryan DH, Deanfield J, Ferreira D, Lang CC, Lincoff AM, Lingvay I, Lubker C, Terns PP, Rasmussen S, Stensen S, Weeke PE, Kahn SE; SELECT Trial Investigators. Semaglutide and Hospitalizations in Patients With Obesity and Established Cardiovascular Disease: An Exploratory Analysis of the SELECT Randomized Clinical Trial. JAMA Cardiol. 2025 Dec 23:e254824. doi: 10.1001/jamacardio.2025.4824. Online ahead of print.
PMID: 41433034DERIVEDDeanfield J, Lincoff AM, Kahn SE, Emerson SS, Lingvay I, Scirica BM, Plutzky J, Kushner RF, Colhoun HM, Hovingh GK, Stensen S, Weeke PE, Jeppesen OK, Bravo R, Wu CC, Komuro I, Santini F, Hjelmesaeth J, Urina-Triana M, Buscemi S, Ryan DH. Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial. Lancet. 2025 Nov 8;406(10516):2257-2268. doi: 10.1016/S0140-6736(25)01375-3. Epub 2025 Oct 22.
PMID: 41138739DERIVEDLubker C, Bhavsar J, Duque do Vale R, Emerson SS, Nortoft E, Plutzky J, Roberts G, Tarp JM, Lincoff AM. The Composite Number Needed to Treat for Semaglutide in Populations with Overweight or Obesity and Established Cardiovascular Disease Without Diabetes. Adv Ther. 2025 May;42(5):2513-2525. doi: 10.1007/s12325-025-03176-w. Epub 2025 Mar 29.
PMID: 40156748DERIVEDMcEwan P, Bog M, Faurby M, Foos V, Lingvay I, Lubker C, Miller R, Toliver JC, Yeates F, Lincoff AM. Cost-effectiveness of semaglutide in people with obesity and cardiovascular disease without diabetes. J Med Econ. 2025 Dec;28(1):268-278. doi: 10.1080/13696998.2025.2459529. Epub 2025 Feb 12.
PMID: 39882599DERIVEDBadve SV, Bilal A, Lee MMY, Sattar N, Gerstein HC, Ruff CT, McMurray JJV, Rossing P, Bakris G, Mahaffey KW, Mann JFE, Colhoun HM, Tuttle KR, Pratley RE, Perkovic V. Effects of GLP-1 receptor agonists on kidney and cardiovascular disease outcomes: a meta-analysis of randomised controlled trials. Lancet Diabetes Endocrinol. 2025 Jan;13(1):15-28. doi: 10.1016/S2213-8587(24)00271-7. Epub 2024 Nov 25.
PMID: 39608381DERIVEDMendonca L, Moura H, Chaves PC, Neves JS, Ferreira JP. The Impact of Glucagon-Like Peptide-1 Receptor Agonists on Kidney Outcomes: A Meta-Analysis of Randomized Placebo-Controlled Trials. Clin J Am Soc Nephrol. 2024 Oct 8;20(2):159-68. doi: 10.2215/CJN.0000000584. Online ahead of print.
PMID: 39480988DERIVEDKosiborod MN, Deanfield J, Pratley R, Borlaug BA, Butler J, Davies MJ, Emerson SS, Kahn SE, Kitzman DW, Lingvay I, Mahaffey KW, Petrie MC, Plutzky J, Rasmussen S, Ronnback C, Shah SJ, Verma S, Weeke PE, Lincoff AM; SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM Trial Committees and Investigators. Semaglutide versus placebo in patients with heart failure and mildly reduced or preserved ejection fraction: a pooled analysis of the SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM randomised trials. Lancet. 2024 Sep 7;404(10456):949-961. doi: 10.1016/S0140-6736(24)01643-X. Epub 2024 Aug 30.
PMID: 39222642DERIVEDScirica BM, Lincoff AM, Lingvay I, Bogdanski P, Buscemi S, Colhoun H, Craciun AE, Ezhov M, Hardt-Lindberg S, Kleist Jeppesen O, Matos ALSA, Node K, Schiele F, Toplak H, van Beek A, Weeke PE, Wiviott SD, Deanfield J, Ryan D. The Effect of Semaglutide on Mortality and COVID-19-Related Deaths: An Analysis From the SELECT Trial. J Am Coll Cardiol. 2024 Oct 22;84(17):1632-1642. doi: 10.1016/j.jacc.2024.08.007. Epub 2024 Aug 30.
PMID: 39217559DERIVEDDeanfield J, Verma S, Scirica BM, Kahn SE, Emerson SS, Ryan D, Lingvay I, Colhoun HM, Plutzky J, Kosiborod MN, Hovingh GK, Hardt-Lindberg S, Frenkel O, Weeke PE, Rasmussen S, Goudev A, Lang CC, Urina-Triana M, Pietila M, Lincoff AM; SELECT Trial Investigators. Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial. Lancet. 2024 Aug 24;404(10454):773-786. doi: 10.1016/S0140-6736(24)01498-3.
PMID: 39181597DERIVEDColhoun HM, Lingvay I, Brown PM, Deanfield J, Brown-Frandsen K, Kahn SE, Plutzky J, Node K, Parkhomenko A, Ryden L, Wilding JPH, Mann JFE, Tuttle KR, Idorn T, Rathor N, Lincoff AM. Long-term kidney outcomes of semaglutide in obesity and cardiovascular disease in the SELECT trial. Nat Med. 2024 Jul;30(7):2058-2066. doi: 10.1038/s41591-024-03015-5. Epub 2024 May 25.
PMID: 38796653DERIVEDRyan DH, Lingvay I, Deanfield J, Kahn SE, Barros E, Burguera B, Colhoun HM, Cercato C, Dicker D, Horn DB, Hovingh GK, Jeppesen OK, Kokkinos A, Lincoff AM, Meyhofer SM, Oral TK, Plutzky J, van Beek AP, Wilding JPH, Kushner RF. Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial. Nat Med. 2024 Jul;30(7):2049-2057. doi: 10.1038/s41591-024-02996-7. Epub 2024 May 13.
PMID: 38740993DERIVEDRowe IA, Allen AM. Hepatic steatosis provides the terroir that promotes the development of cardiovascular risk factors and disease. Hepatology. 2023 Jun 1;77(6):1843-1845. doi: 10.1097/HEP.0000000000000327. Epub 2023 Feb 6. No abstract available.
PMID: 36738088DERIVEDLeite AR, Angelico-Goncalves A, Vasques-Novoa F, Borges-Canha M, Leite-Moreira A, Neves JS, Ferreira JP. Effect of glucagon-like peptide-1 receptor agonists on cardiovascular events in overweight or obese adults without diabetes: A meta-analysis of placebo-controlled randomized trials. Diabetes Obes Metab. 2022 Aug;24(8):1676-1680. doi: 10.1111/dom.14707. Epub 2022 May 3.
PMID: 35373878DERIVEDMares AC, Chatterjee S, Mukherjee D. Semaglutide for weight loss and cardiometabolic risk reduction in overweight/obesity. Curr Opin Cardiol. 2022 Jul 1;37(4):350-355. doi: 10.1097/HCO.0000000000000955. Epub 2022 Feb 16.
PMID: 35175229DERIVEDKanie T, Mizuno A, Takaoka Y, Suzuki T, Yoneoka D, Nishikawa Y, Tam WWS, Morze J, Rynkiewicz A, Xin Y, Wu O, Providencia R, Kwong JS. Dipeptidyl peptidase-4 inhibitors, glucagon-like peptide 1 receptor agonists and sodium-glucose co-transporter-2 inhibitors for people with cardiovascular disease: a network meta-analysis. Cochrane Database Syst Rev. 2021 Oct 25;10(10):CD013650. doi: 10.1002/14651858.CD013650.pub2.
PMID: 34693515DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Clinical Reporting Office (2834)
- Organization
- Novo Nordisk A/S
Study Officials
- STUDY DIRECTOR
Clinical Transparency (dept.2834)
Novo Nordisk A/S
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Masking Details
- Sponsor staff involved in the clinical trial is masked according to company standard procedures
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 21, 2018
First Posted
July 2, 2018
Study Start
October 24, 2018
Primary Completion
June 21, 2023
Study Completion
June 29, 2023
Last Updated
August 30, 2024
Results First Posted
August 30, 2024
Record last verified: 2024-08
Data Sharing
- IPD Sharing
- Will share
According to the Novo Nordisk disclosure commitment on novonordisk-trials.com