The Effect of Dietary Nitrate Supplementation on Linear Running Sprint Performance, Agility and Vertical Jump Performance in a Rested and Fatigued State

NCT03565523 | Completed

• 1 other identifier: PEP-1607
• Study Type: interventional
• Target: 32
• Locations: 0 countries
• Sites: N/A

Brief Summary

Dietary nitrate (NO3-) supplementation has been shown to improve skeletal muscle contractility and fatigue resistance, particularly in fast-twitch (type II) muscle fibers. Furthermore, NO3- supplementation has been shown to speed reaction time. Taken together, these findings suggest that NO3- ingestion may be ergogenic during all-out sprint running and reactive agility tasks. Moreover, increasing muscle force production at high contraction speeds would be expected to translate into improved muscle power and, subsequently, improved performance in very explosive forms of exercise, such as vertical jumping. Therefore, the purpose of this investigation is to assess the effect of short term (5 days) NO3- supplementation on linear running sprint performance, reactive agility and vertical jump performance in a rested and fatigued state.

Conditions

Exercise Performance

Outcome Measures

Primary Outcomes (1)

• Linear running sprint time

  Linear running sprint in a rested and fatigued state

  5 days

Study Arms (2)

Test Beet shot

EXPERIMENTAL

Containing 385 mg nitrate

Other: Beetroot

Placebo beverage

PLACEBO COMPARATOR

\<0.1 mmol nitrate in sucrose solution with beet coloring

Other: Placebo beverage

Interventions

Beetroot OTHER

Containing 385 mg nitrate

Test Beet shot

Placebo beverage OTHER

\<0.1 mmol nitrate in sucrose solution with beet coloring

Placebo beverage

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male and female participants in self-reported good general health as assessed by the standard procedures described below and specifically meeting normal blood pressure range (systolic: 100-135, diastolic: 60-90) and body mass index (BMI) range (16.0-29.9)
• Range of 18-45 years of age
• Participants must participate in an intermittent exercise based sport (e.g. soccer, rugby, hockey), at a competitive level (i.e. competes in officiated matches/games).
• Understanding of the procedures to be undertaken as part of the study
• Willingness to participate in exercise testing and follow supplementation guidelines and other instructions provided by the experimenter
• Informed, voluntary, written consent to participate in the study

You may not qualify if:

• Known pulmonary, cardiovascular or metabolic disease
• Food allergies including phenylketonurea (PKU)
• Current regular use of any dietary supplement (excluding macronutrient based supplements) or previous use of any dietary supplement in the past 6 months that is known to have a lasting effect.
• Blood donation within 3 months prior to the start of the study
• Substance abuse within 2 years of the start of the study
• Smoking
• Any prescription and non-prescription medication which may impact saliva production (antidepressants, diuretics, analgesics, antihistamines, anti-hyper/hypo-tensives, anti-anxiety, appetite suppressants).
• Current or previous use of phosphodiesterase 5 (PDE5) inhibitors.
• Participation in another clinical trial within past 4 weeks.

Sponsors & Collaborators

• PepsiCo Global R&D: lead

Study Officials

• Andy Jones, PhD

  University of Exeter, Sport and Health Sciences department

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 6, 2018
• First Posted: June 21, 2018
• Study Start: September 1, 2016
• Primary Completion: March 31, 2017
• Study Completion: April 30, 2017
• Last Updated: June 21, 2018

Record last verified: 2018-06

Data Sharing

• IPD Sharing: Will not share