Effects of High-Intensity Interval Training (HIT) While in a Hyperoxic-Hyperbaric Environment on Exercise Performance

NCT02941939 | Completed

• 1 other identifier: 1050188
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Hyperbaric oxygen has previously been tested as a possible means for pre-conditioning to enhance exercise performance. This study is designed to examine the effects of exercising in a hyperbaric chamber for improving fitness when combined with high-intensity training.

Conditions

Exercise Performance

Keywords

high intensity interval training; hyperbaric oxygen

Outcome Measures

Primary Outcomes (1)

• Change in maximum VO2 at 2 weeks compared to baseline

  Comparison of post-training VO2 results with baseline in the two HIT groups (performed at ambient conditions in Salt Lake City, UT and hyperbarichyperoxic conditions); the results of HIT at Salt Lake City, UT altitude will be compared with those performed at sea-level altitude in Durham, NC.

  2 weeks

Secondary Outcomes (6)

• Change in VO2 measured at anaerobic threshold (in mL O2/kg/min) at 2 weeks compared to baseline

  2 weeks

• ΔVO2/ΔWR (in mL O2/kg/min/Watt; a measure of exercise efficiency)

  2 weeks

• Change in peak work rate (in Watts) at 2 weeks compared to baseline

  2 weeks

• Change in heart rate response to exercise at 2 weeks compared with baseline

  2 weeks

• Change in level of perceived exertion at 2 weeks compared with baseline

  2 weeks

Study Arms (2)

Ambient pressure arm

ACTIVE COMPARATOR

High intensity training will be completed while the subjects are breathing normal air.

Other: Ambient pressure

Hyperoxic-hyperbaric arm

EXPERIMENTAL

The high intensity training program will be carried out in a hyperbaric chamber.

Other: Hyperbaric chamber

Interventions

Hyperbaric chamber OTHER

Hyperoxic-hyperbaric arm

Ambient pressure OTHER

Ambient pressure arm

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy individuals, ages 18-40 years that are sedentary or recreationally active but not involved in any structured endurance training will be eligible for the study. This level of activity will be defined as performing mild-moderate aerobic exercise 0-3 times per week.
• VO2 max within normal limits (defined as 84-120% predicted using Wasserman reference equations48).
• Spirometry within predicted limits.

You may not qualify if:

• Subjects unable to complete a satisfactory VO2 max test
• Individuals with chronic cardiovascular disease such as hypertension, valve disease, coronary artery disease, cardiac conduction abnormalities, etc.
• History of pneumothorax or chronic lung disease such as asthma, COPD, bronchiectasis
• Active Smokers
• Pregnant women
• Persons unable to read or understand English, not in full mental capacity or suffer from blindness.

Sponsors & Collaborators

• Intermountain Health Care, Inc.: lead

Study Sites (1)

Intermountain Medical Center

Murray, Utah, 84107, United States

Location

Study Officials

• Matt Hegewald, MD

  Intermountain Health Care, Inc.

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 10, 2016
• First Posted: October 21, 2016
• Study Start: April 14, 2016
• Primary Completion: April 8, 2017
• Study Completion: June 8, 2017
• Last Updated: May 22, 2018

Record last verified: 2018-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)