From Brain Currents to Interpersonal Flow: Investigating the Social Processing Stream of Schizophrenia

NCT03543553 | Not Yet Recruiting

• 1 other identifier: ecoval
• Study Type: observational
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

The overall objective of this project is to identify the neural signature of the impaired ability to relate socially seen in individuals with schizophrenia. A hypothesized path from the neural processes of social cognition, to social cognition assessed behaviorally, to real-life social interactions is examined. Secondary aims are to compare electrophysiological measures of high vs low level social cognition; to develop assessment methods of real-life behavior; and to increase the ecological validity of schizophrenia research. Much research within the field is devoid of personal meaning and interpersonal context. This project's use of personalized assessment allows for an ecologically valid approach to the social deficits of schizophrenia.

Conditions

Schizophrenia; Cognitive Impairment; Social Competence

Outcome Measures

Primary Outcomes (13)

• Neurophysiology: EEG

  EEG mu suppression paradigm using point-light displays

  1 day (when assessed)

• Neurophysiology: ERP

  ERP mentalizing paradigm (perspective taking)

  1 day (when assessed)

• Cognition

  Matrics Consensus Cognitive Battery

  1 day (when assessed)

• Negative symptoms: clinician-rated

  Positive and Negative Syndrome Scale (PANSS) 2. Objectively assessed using computerized software (FaceReader, PRAAT) of video-taped personal narratives produced by the participants

  1 day (when assessed)

• Negative symptoms: objective 1

  FaceReader

  1 day (when assessed)

• Negative symptoms: objective 2

  PRAAT

  1 day (when assessed)

• Social cognition: complex ToM

  Movie for the Assessment of Social Cognition

  1 day (when assessed)

• Social cognition: low level ToM

  The Hinting Task

  1 day (when assessed)

• Social cognition: facial emotion perception

  Pictures of Facial Affect

  1 day (when assessed)

• Social cognition: body language reading

  Emotion in Biological Motion test

  1 day (when assessed)

• Functioning

  Social Functioning Scale (SFS). Seven scales that can be combined into a total score. Mean score in a schizophrenia population = 100, SD = 15. For both the seven scales and the total score.

  1 day (when assessed)

• Real-world behaviour

  Day Reconstruction Method

  1 day (when assessed)

• Real-world social interactions

  Video-ethnography

  1 day (when assessed)

Study Arms (2)

SZ

Individuals with a diagnosis of schizophrenia

Other: This is not an intervention study

HC

Healthy control participants

Other: This is not an intervention study

Interventions

This is not an intervention study OTHER

This is not an intervention study

HC; SZ

Eligibility Criteria

• Age: 17 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Individuals with a diagnosis of schizophrenia will be compared to healthy control participants

You may qualify if:

• schizophrenia
• schizoaffective disorder

You may not qualify if:

• diabetes
• Hyperthyroidism
• severe head trauma
• neurological disease

Sponsors & Collaborators

• Oslo University Hospital: lead

MeSH Terms

Conditions

Schizophrenia; Cognitive Dysfunction; Social Skills

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Cognition Disorders; Neurocognitive Disorders; Social Behavior; Behavior

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: April 17, 2018
• First Posted: June 1, 2018
• Study Start: January 1, 2025
• Primary Completion (Estimated): March 31, 2027
• Study Completion (Estimated): March 31, 2027
• Last Updated: November 28, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share