Functional Magnetic Resonance Imaging Study in Schizophrenia Patients and Correlation With Cognitive Impairments

NCT06471179 | Not Yet Recruiting

• 1 other identifier: fMRI in schizophrenia
• Study Type: observational
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

1. 1.Comparison of functional activity at different brain areas related to different cognitive domains e.g. Memory, visuospatial abilities, executive functions, attention, concentration, language, orientation in schizophrenia to healthy subjects.
2. 2.Correlation with resting functional activity at brain areas with clinical deterioration in cognitive functions.

Conditions

Schizophrenia; Cognitive Impairment

Keywords

Functional MRI; Schizophrenia

Outcome Measures

Primary Outcomes (1)

• functional Magnetic Resonance Imaging

  different regional brain activity among schizophrenic and healthy subjects and correlation with cognitive function

  baseline

Study Arms (2)

group A Patients

Schizophrenic patients according to diagnostic criteria

Device: Functional MRI

group B Control

healthy subjects not suffering from any Psychiatric illness

Device: Functional MRI

Interventions

Functional MRI DEVICE

Functional Magnetic Resonance Imaging during rest for minutes and analysis of data obtained from resting fMRI

group A Patients; group B Control

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

twenty subjects will be chosen from psychiatric inpatient unit from assiut university hospitals diagnosed with schizophrenia and 20 subjects as control to be investigated for affection of brain activity in case of schizophrenia

You may qualify if:

• Diagnosis according to Diagnostic and statistical manual of mental of mental disorders -5 (DSM-5) and confirmed by the Structured Clinical Interview for DSM-5 (SCID -I)

You may not qualify if:

• History of head injury.
• History of intellectual disability or neurological diseases e.g. cerebrovascular stroke, dementia Parkinsonism, etc.
• History of alcohol and/or substance abuse in the previous six months.
• Inability to provide informed consent.

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Schizophrenia; Cognitive Dysfunction

Interventions

Magnetic Resonance Imaging

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Cognition Disorders; Neurocognitive Disorders

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Wageeh A Hassan, MD

  Assiut University

  STUDY CHAIR

• Hossam E Khalifa

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

waleed A Hamdy

CONTACT

01030968160; waleedashraf7@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: June 18, 2024
• First Posted: June 24, 2024
• Study Start: October 1, 2024
• Primary Completion (Estimated): July 1, 2026
• Study Completion (Estimated): January 1, 2027
• Last Updated: July 31, 2024

Record last verified: 2024-07