Dementia Phenotypes in Primary Care, Hospital, and National Mortality Registries

NCT02549872 | Unknown DMC

• 1 other identifier: 15_138
• Study Type: observational
• Target: 51,000
• Locations: 1 country
• Sites: 1

Brief Summary

Most patients with dementia in the UK use their local hospitals and general (family) practices throughout their illness. Linked electronic health records from primary care, hospital and death certificates records therefore provide useful information about the diagnosis and prognosis of patients who develop dementia. In this study we will assess the validity of dementia diagnoses in linked primary care, hospital and death records, by examining the timing of important health transitions in patients with recorded dementia, and we will estimate the lifetime risk of recorded dementia in different age and sex groups

Conditions

Dementia

Keywords

Dementia; Validity; Mortality; Electronic health records

Outcome Measures

Primary Outcomes (9)

• Proportion of patients with dementia diagnosis (any type) in primary care that also are recorded in secondary care

  10 years

• Factors associated with dementia diagnosis (any type) recording in mortality data only

  These will be estimated from multivariable logistic regression models

  10 years

• Symptoms associated with subsequent diagnosis of dementia

  These will be estimated from multivariable logistic regression models

  10 years

• Lifetime risk of dementia (any type)

  10 years

• Lifetime risk of mortality associated with dementia (any time)

  10 years

• Factors associated with dementia diagnosis (any type) recording in secondary care only

  These will be estimated from multivariable logistic regression models

  10 years

• Factors associated with dementia diagnosis (any type) recording in primary care only

  These will be estimated from multivariable logistic regression models

  10 years

• Proportion of patients with dementia diagnosis (any type) in primary care that also are recorded in mortality data

  10 years

• Proportion of patients with dementia diagnosis (any type) in secondary care that also are recorded in mortality data

  10 years

Secondary Outcomes (9)

• Proportion of patients with Alzheimer's disease in primary care that are also diagnosed in secondary care

  10 years

• Proportion of patients with vascular dementia in primary care that are also diagnosed in secondary care

  10 years

• Lifetime risk of Alzheimer's disease

  10 years

• Lifetime risk of vascular dementia

  10 years

• Lifetime risk of mortality associated with Alzheimer's disease

  10 years

Study Arms (2)

Dementia

Patients with a recorded diagnosis of dementia in primary or secondary care

Other: This is not an intervention study

Non-dementia

Patients without a recorded diagnosis of dementia in primary or secondary care

Other: This is not an intervention study

Interventions

This is not an intervention study OTHER

This study is based on the retrospective analysis of linked electronic health records.

Dementia; Non-dementia

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients registered in English general practices contributing with data to the CALIBER research platform from 1997 onward.

You may qualify if:

• Patients aged 18 years and over
• Registered with a participating general practice during the study period
• Minimum one year of records prior to study entry meeting CPRD data quality criteria
• Followed on or after 1 January 1997

You may not qualify if:

• Patients without recorded gender
• Less than 1 year of follow-up between study entry and date of administrative censoring

Sponsors & Collaborators

• University College, London: lead
• University of Edinburgh: collaborator
• University of Leeds: collaborator
• Medical Research Council: collaborator

Study Sites (1)

London Farr Institute of Health Informatics

London, United Kingdom

Location

MeSH Terms

Conditions

Dementia

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Epidemiology and Public Health

Study Record Dates

• First Submitted: September 3, 2015
• First Posted: September 15, 2015
• Study Start: September 1, 2015
• Primary Completion: October 1, 2015
• Study Completion: December 1, 2015
• Last Updated: September 15, 2015

Record last verified: 2015-09

Locations

GB (1)