Simultaneous PET/MR Imaging of Human Brain Plasticity
Multimodal Associations of Human Brain Plasticity Investigated With Simultaneous PET/MR Imaging
1 other identifier
interventional
40
1 country
1
Brief Summary
Background: Neuronal plasticity is the brain's ability to continuously adapt to experiences and learning of new skills. Although this affects multiple characteristics of the brain such as structure, function and metabolism, direct interactions between these aspects are largely missing. Aim: Using recent advancements in neuroimaging we aim to identify novel relationships how neuronal plasticity is related across these characteristics. Design: 40 healthy subjects will undergo two simultaneous PET/MR measurements at baseline and after 4 weeks. During the measurements a cognitively challenging task will be performed and the training group (20 subjects) will practice during the 4-week period. Implications: We combine simultaneous PET/MR and novel task-specific PET imaging to study brain metabolism, structure and function in a single measurement session. This provides optimal sensitivity for assessment of multimodal neuroplasticity associations. Knowledge how cognitive training affects multiple characteristics of the brain will also increase our understanding of disorders like depression, dementia and brain injuries, since these are diagnosed with cognitive evaluations. Considering the vast usage of the applied imaging procedures in diagnosis and therapy monitoring, the thorough investigation of multimodal associations offers benefit for the interpretability of neuroimaging in clinical routine.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started May 2017
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 28, 2017
CompletedStudy Start
First participant enrolled
May 1, 2017
CompletedFirst Posted
Study publicly available on registry
April 2, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2020
CompletedSeptember 23, 2019
September 1, 2019
3.5 years
April 28, 2017
September 19, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Training induced changes in imaging parameters
Imaging parameters are glucose metabolism (\[18F\]FDG PET), cerebral blood flow (arterial spin labeling MRI), functional connectivity (resting-state and task fMRI), gray matter volume (T1-weighted MRI) and white matter structure (diffusion weighted MRI)
4 weeks
Secondary Outcomes (1)
Cognitive performance
4 weeks
Study Arms (2)
Training
EXPERIMENTAL20 healthy participants, 4 week training of a challenging cognitive task (Tetris) between PET/MR measurements
Control
NO INTERVENTION20 healthy participants, no training between PET/MR measurements
Interventions
The video game Tetris is a cognitively challenging task, which requires mental rotation, problem solving and fast visuo-spatial and motor coordination.
Eligibility Criteria
You may qualify if:
- Age range 21-30 years
- Right-handedness
- Willingness and competence to sign the informed consent form
You may not qualify if:
- History of or current physical, neurological or psychiatric disorder
- History of or current substance abuse or medication including antipsychotic, antidepressant and antianxiety agents
- Pregnancy or current breastfeeding
- Contraindications for MRI-scanning (e.g., metal implants, steel grafts, etc), including dental implants causing signal artifacts
- For subjects participating in earlier studies using ionizing radiation, the total radiation exposure of 30mSv over the last 10 years must not be exceeded, as specified in the Austrian legislation on radiation protection
- Regular players of the video game Tetris (3 years before scanning).
- Failure to comply with the study protocol or to follow the instructions of the investigating team
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Psychiatry and Psychotherapy, Medical University of Vienna
Vienna, Austria
Related Publications (1)
Hahn A, Breakspear M, Rischka L, Wadsak W, Godbersen GM, Pichler V, Michenthaler P, Vanicek T, Hacker M, Kasper S, Lanzenberger R, Cocchi L. Reconfiguration of functional brain networks and metabolic cost converge during task performance. Elife. 2020 Apr 21;9:e52443. doi: 10.7554/eLife.52443.
PMID: 32314956DERIVED
Related Links
Study Officials
- STUDY DIRECTOR
Rupert Lanzenberger, Assoc Prof
Department of Psychiatry and Psychotherapy, Medical University of Vienna
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Assoc.Prof. PD MD, Head of Neuroimaging Labs
Study Record Dates
First Submitted
April 28, 2017
First Posted
April 2, 2018
Study Start
May 1, 2017
Primary Completion
November 1, 2020
Study Completion
November 1, 2020
Last Updated
September 23, 2019
Record last verified: 2019-09