Effect of Balance Training on White Matter Tracts in Healthy Elderly Population

NCT05539690 | Unknown DMC

• 1 other identifier: SC22FISI0069
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Balance impairment increases the risk of falling and is associated with a fear of falling and immobility. Balance impairment can ultimately affect the morbidity of cardiovascular disease, cognitive impairment, and mortality, especially in an older population. Among the multiple types of exercise, balance training is the most effective in preventing falls. This study aims to investigate white matter plasticity in healthy elderly population, based on stepwise balance training. Healthy elderly participants will undergo four weeks of balance training. The investigators will analyze longitudinal changes in the microstructural integrity of the white matter tracts pre- and post-training.

Conditions

Postural Balance; Neuronal Plasticity; Elderly Population

Keywords

Postural Balance; White Matter; Neuronal Plasticity; Elderly Population; Rehabilitation; Diffusion Tensor Imaging

Outcome Measures

Primary Outcomes (2)

• Fractional anisotropy of the motor-related white matter tracts

  Measurement of the change of DTI-derived parameter before and after balance training 1. Tracts of interest * Corticospinal tract (CST) * Cortico-ponto-cerebellar tract (CPCT) * Dentato-rubro-thalamo-cortical tract (DRTCT) * Dorsal spinocerebellar tract (DSCT) 2. Measurement of DTI-derived parameter * Fractional anisotropy (FA) values of the CST, CPCT, DRTCT, and DSCT 3. Units and scoring of the Measurement * FA * No unit. * The measurement ranges from 0 to 1 * Higher scores indicate better microstructural integrity.

  4 weeks

• Community Balance & Mobility Scale

  Performance measure before and after balance training 1. Measurement * 13 domain * Unilateral stance, Tandem walking, 180° tandem pivot, Lateral foot scooting, Hopping forward, Crouch and walk, Lateral dodging, Walking \& looking, Running with controlled stop, Forward to backward walking, Walk look and carry, Descending stairs, Step-ups x 1 step 2. Scoring of the Measurement * No units. * The measurement ranges from 0 to 96 * Higher scores indicate better postural balance and mobility.

  4 weeks

Secondary Outcomes (2)

• Mean diffusivity of the motor-related white matter tracts

  4 weeks

• Tract volume of the motor-related white matter tracts

  4 weeks

Study Arms (1)

Balance training group

EXPERIMENTAL

A single training group

Behavioral: Balance training

Interventions

Balance training BEHAVIORAL

* Step-by-step training (5 levels) * 30 minute per training * 3 times per week * 4 weeks

Balance training group

Eligibility Criteria

• Age: 60 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Mini-mental state examination ≥ 26
• Independent outdoor ambulator

You may not qualify if:

• Men/women with any metal implants in their body
• A prior history of psychopathology or a neurological disorders
• A prior history of osteoporosis, advanced osteoarthritis (K-L grade \>=3), surgical history of hip or knee arthroplasty
• If any structural abnormalities are detected on their scan

Sponsors & Collaborators

• The Catholic University of Korea: lead

Study Sites (1)

Yeouido St. Mary's Hospital

Seoul, Yeongdeungpo-gu, 07345, South Korea

RECRUITING

Related Publications (5)

• Sherrington C, Fairhall NJ, Wallbank GK, Tiedemann A, Michaleff ZA, Howard K, Clemson L, Hopewell S, Lamb SE. Exercise for preventing falls in older people living in the community. Cochrane Database Syst Rev. 2019 Jan 31;1(1):CD012424. doi: 10.1002/14651858.CD012424.pub2.

  PMID: 30703272 RESULT

• Surgent OJ, Dadalko OI, Pickett KA, Travers BG. Balance and the brain: A review of structural brain correlates of postural balance and balance training in humans. Gait Posture. 2019 Jun;71:245-252. doi: 10.1016/j.gaitpost.2019.05.011. Epub 2019 May 6.

  PMID: 31082657 RESULT

• Scholz J, Klein MC, Behrens TE, Johansen-Berg H. Training induces changes in white-matter architecture. Nat Neurosci. 2009 Nov;12(11):1370-1. doi: 10.1038/nn.2412. Epub 2009 Oct 11.

  PMID: 19820707 RESULT

• Kim JS, Kim SH, Lim SH, Im S, Hong BY, Oh J, Kim Y. Degeneration of the Inferior Cerebellar Peduncle After Middle Cerebral Artery Stroke: Another Perspective on Crossed Cerebellar Diaschisis. Stroke. 2019 Oct;50(10):2700-2707. doi: 10.1161/STROKEAHA.119.025723. Epub 2019 Aug 26.

  PMID: 31446886 RESULT

• Kim Y, Kim SH, Hong BY, Oh J, Chang SY. Integrity of the Inferior Cerebellar Peduncle Correlates with Ambulatory Function after Hemorrhagic Stroke. J Stroke Cerebrovasc Dis. 2021 Dec;30(12):106164. doi: 10.1016/j.jstrokecerebrovasdis.2021.106164. Epub 2021 Oct 13.

  PMID: 34655972 RESULT

Study Officials

• Youngkook Kim, MD, PhD

  Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Youngkook Kim, MD, PhD

CONTACT

+8237791383; england2@hamail.net

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: September 11, 2022
• First Posted: September 14, 2022
• Study Start: August 24, 2022
• Primary Completion: August 31, 2023
• Study Completion: February 29, 2024
• Last Updated: September 15, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)