The Effect of Aging on Value Based Decision-making

NCT03341611 | Completed

• 1 other identifier: 1R21AG046917-01A1
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators propose to study the effect of aging on the neural circuitry involved in valuation and value reasoning and to relate it to choice anomalies and inconsistencies. Quantifying and characterizing valuation-based decision-making deficits in older adults, and their relationship to the aging brain, can inform and facilitate intervention - both at the level of the individual and at the level of policy.

Conditions

Healthy Aging

Outcome Measures

Primary Outcomes (2)

• Computerized behavioral choice task

  The task consists in 450 trials. In each trial, the participant needs to choose between food items presented on a computer screen. Frequency of choices is used to assess the ranking (or value) of these food items and inconsistencies in choices are recorded. Food items vary in complexity (from single items to complex bundles).

  2 hours

• Brain imaging to track brain regions involving in value

  fMRI images are collected during part of the behavioral choice task. Behavioral measures are used to track value encoding as well as inconsistent choices in the brain (as a function of item complexity). These data are eventually aggregated across participants in each condition (using standard methods) to identify the regions of interest involved in our experiment.

  1 hour

Study Arms (2)

Adults 55 and younger

Behavioral: Neuro-imaging during behavioral decision-making task

Adults 55 and older

Behavioral: Neuro-imaging during behavioral decision-making task

Interventions

Neuro-imaging during behavioral decision-making task BEHAVIORAL

All participants will make simple decisions while in a scanner.

Adults 55 and older; Adults 55 and younger

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy adults above 18yo

You may qualify if:

• Healthy adults

You may not qualify if:

• Subjects under 18yo . 2- Subjects with known cognitive disorders 3- Subjects with visual or auditory deficits that would interfere with the ability to complete the experimental tasks.
• Subjects reporting having metal implants 5- Subjects with a history of major anxiety disorder or other major psychiatric condition, 6- Subjects with a documented or subjectively reported claustrophobia. 7- Subjects thinking they are or may be pregnant. 8- Subjects with a history of head trauma that resulted in loss of consciousness for more than 5 minutes.
• Hx of seizures 10-Left Handed 11- On any medications affecting cognition 12- For tasks involving foods: a) Currently on diet and or b) any known food allergies

Sponsors & Collaborators

• University of Southern California: lead

Study Sites (1)

LABEL

Los Angeles, California, 90089, United States

Location

Study Officials

• Isabelle Brocas, PhD

  University of Southern California

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Economics

Study Record Dates

• First Submitted: November 6, 2017
• First Posted: November 14, 2017
• Study Start: January 1, 2016
• Primary Completion: April 30, 2018
• Study Completion: April 30, 2018
• Last Updated: May 22, 2019

Record last verified: 2019-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ANALYTIC CODE
• Time Frame: After publication

Locations

US (1)