Using Teleneuropsychology to Optimize Cognition in Healthy Aging: the Web-based Breakfast Game

NCT05506852 | Completed Results

• 2 other identifiers: AAAT47731K99AG078561-01
• Study Type: interventional
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

Executive control processes involve initiate, coordinate, synchronize, and regulate elemental cognitive functions for the conduct of goal-directed behavior. The proposed research investigates whether exposure to a web-based training protocol designed to enhance executive control processes will improve cognitive performance in cognitively healthy older adults.

Conditions

Healthy Aging

Keywords

cognition; cognitive training; non-pharmacological intervention; video game; cognitive enhancement; computer-based; teleneuropsychology; computerized; attention control; executive control; cognitive decline; multi-tasking

Outcome Measures

Primary Outcomes (4)

• Changes in the Breakfast Game Performance: Number of Tables Set Score

  Change in the total number of tables set. In the computerized task, participants are asked to set tables for four guests. When finished, one point is given. Higher scores represent a better outcome. This metric represents a change in the score = the higher means improvement in the performance. The total score ranges between 0 and 12; the total change score ranged from -3 to +3.

  Assessed at training session 1, week 1; training session 12, approximately 6 weeks. Data is reported for the change between session 1 and 12

• Changes in the Breakfast Game Performance: Cooking Time Range of Stop Times Scores

  Change in cooking time (milliseconds) between food items. In the computerized task, participants are asked to cook different food types. Scores reflect the difference between the first and last food item that was stopped cooking. Lower scores (closest to zero) represent a better outcome. This metric represents a change in the score = the lower means improvement on the performance. The total score ranges between 0.3 and 315; the total change score ranges from -40 to +40.

  Assessed at training session 1, week 1; training session 12, approximately 6 weeks. Data is reported for the change between session 1 and 12

• Change in Breakfast Game Performance: Cooking Time Discrepancy Scores

  Change in cooking time (milliseconds) in each food type. In the computerized task, participants are asked to cook different food types. Scores reflect the average absolute values of the difference between the required and actual cooking time of each item. Lower scores (closest to zero) represent a better outcome. This metric represents a change in the score = the lower means improvement in the performance. The total score ranges between 0.3 and 175; The total change score ranges from -20 to +20.

  Assessed at training session 1, week 1; training session 12, approximately 6 weeks. Data is reported for the change between session 1 and 12

• Transfer to Complex Executive/Attention Control Measure (Proximal Outcome).

  Accuracy on the Alphanumeric Task. This metric represents a change in the score. The higher the means more improvement in the performance. The total change score ranged from -0.1 to +0.1

  Within the 2 weeks before intervention starts; and the 6th week, after the last (12th) training session. (Measure represent change between pre and post training)

Secondary Outcomes (5)

• Transfer to Executive Functions Composite Z-Score (Distal Outcome)

  Within the 2 weeks before intervention starts; and the 6th week, after the last (12th) training session. (Measure represent change between pre and post training)

• Transfer to the General Self-efficacy Scale (Distal Outcome)

  Within the 2 weeks before intervention starts; and the 6th week, after the last (12th) training session. (Measure represent change between pre and post training)

• Transfer to Beck Depression Inventory (Distal Outcome)

  Within the 2 weeks before intervention starts; and the 6th week, after the last (12th) training session. (Measure represent change between pre and post training)

• Transfer to Beck Anxiety Inventory (Distal Outcome)

  Within the 2 weeks before intervention starts, and the 6th week, after the last (13th) training session. (Measure represent the change between pre and post training)

• Transfer to Cognition-Leisure Questionnaire (Distal Outcome)

  Within the 2 weeks before intervention starts, and the 6th week, after the last (12th) training session. (Measure represent the change between pre and post training)

Study Arms (2)

Strategy Training

EXPERIMENTAL

Participants will play the Breakfast Game with training strategy.

Behavioral: Web-based training strategy

Regular Approach

ACTIVE COMPARATOR

Participants will play the Breakfast Game without training strategy.

Behavioral: Web-based regular training (no strategy)

Interventions

Web-based training strategy BEHAVIORAL

Participants will undergo a web-based training protocol where they will play an online game that simulates a breakfast environment and will perform everyday activities as "cooking" and "setting tables" in a multi-tasking fashion. Participants will learn to play the game using specific strategies, in order to optimize the performance.

Also known as: Experimental intervention

Strategy Training

Web-based regular training (no strategy) BEHAVIORAL

Participants will undergo a web-based training protocol where they will play an online game that simulates a breakfast environment and will perform everyday activities as "cooking" and "setting tables" in a multi-tasking fashion. Participants will learn to play the game under regular game instructions.

Also known as: Control intervention

Regular Approach

Eligibility Criteria

• Age: 60 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 60-75
• Willingness to adhere to training protocol
• Adequate English proficiency

You may not qualify if:

• Low test scores (below 26 on the Montreal Cognitive Assessment)
• Known history of cognitive impairment, dementia, stroke, seizure disorder, or other neuropsychiatric condition judged to impact cognitive performance.
• Taking medications known to influence cognitive performance.
• Sensory (e.g. visual, auditory) or physical (e.g. severe arthritic, orthopedic, neurologic) impairment incompatible with use of a standard computer workstation.
• Enrolled in a concurrent study that could affect the outcome of this study.

Sponsors & Collaborators

• National Institute on Aging (NIA): collaborator
• Columbia University: lead

Study Sites (1)

Columbia University Irving Medical Center

New York, New York, 10032, United States

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Results Point of Contact

• Title: Dr. Sharon Sanz Simon
• Organization: Columbia University (previous); Rutgers University (current)

sharon.sanzsimon@rutgers.edu

973-972-2977

Study Officials

• Sharon Sanz Simon, PhD

  Columbia University

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Participants will not be aware of the difference across the two conditions.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 25, 2022
• First Posted: August 18, 2022
• Study Start: January 17, 2023
• Primary Completion: July 30, 2024
• Study Completion: July 30, 2024
• Last Updated: March 19, 2026
• Results First Posted: March 19, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: Data will be available within 6 months of study completion.
• Access Criteria: Data access requests will be reviewed by the principal investigator.

Locations

US (1)