NCT03270475

Brief Summary

The aim of the study is to investigate skeletal muscle proteome signature changes induced by exercise training in young men

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
8

participants targeted

Target at below P25 for not_applicable healthy

Timeline
Completed

Started Aug 2017

Shorter than P25 for not_applicable healthy

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 28, 2017

Completed
Same day until next milestone

Study Start

First participant enrolled

August 28, 2017

Completed
4 days until next milestone

First Posted

Study publicly available on registry

September 1, 2017

Completed
1 month until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 15, 2017

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 15, 2017

Completed
Last Updated

January 15, 2021

Status Verified

January 1, 2021

Enrollment Period

2 months

First QC Date

August 28, 2017

Last Update Submit

January 12, 2021

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

  • Skeletal muscle proteome signature

    proteomics

    Change from baseline proteome signature at 5 weeks

Other Outcomes (3)

  • Skeletal muscle acetylome signature

    Change from baseline acetylome signature at 5 weeks

  • Skeletal muscle mitochondrial respiration

    Change from baseline at 5 weeks

  • Maximal oxygen uptake

    Change from baseline at 5 weeks

Study Arms (1)

Exercise

EXPERIMENTAL

12-15 training sessions of 30 min over 4-5 weeks

Other: exercise training

Interventions

exercise trainingOTHER

subjects complete 4-5 weeks of training

Exercise

Eligibility Criteria

Age18 Years - 40 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy
  • VO2max of 45-55 ml/kg/min (+/- SD) / 3000-4000 ml/min (+/- SD)
  • Body mass index (BMI) of 19-26 kg/m2
  • Normal ECG (electrocardiography)

You may not qualify if:

  • Serious adverse effects to exercise
  • Chronic disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Nutrition, Exercise and Sports

Copenhagen, 2100, Denmark

Location

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Assistant Professor, PhD

Study Record Dates

First Submitted

August 28, 2017

First Posted

September 1, 2017

Study Start

August 28, 2017

Primary Completion

October 15, 2017

Study Completion

October 15, 2017

Last Updated

January 15, 2021

Record last verified: 2021-01

Locations

DK(1)