NCT00426881

Brief Summary

Primary Objectives: 1\. To ascertain whether a 12-month, twice-weekly or once-weekly resistance training (RT) program will significantly improve executive function in community-dwelling women aged 65 to 75 years old compared with a 12-month, twice-weekly stretch and relax (S \& R) program (shame exercise). We will assess executive function by standard neuropsychological tests. Secondary Objectives:

  1. 1.To describe the neural mechanisms that underpin the observed changes in executive function associated with a 12-month, twice-weekly or once-weekly RT training (by using functional magnetic resonance imaging (fMRI)).
  2. 2.To investigate whether RT-induced changes in executive function are independently associated with changes in physiological fall risk profile.
  3. 3.To investigate the dose response of RT (resistance training) on bone health as measured by dual energy x-ray and peripheral quantitative computed tomography.
  4. 4.To conduct a one-year follow-up after the formal cessation of the resistance training programs to determine the persisting effect of resistance training on cognitive performance, cortical plasticity, physiological falls risk, and bone health.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
155

participants targeted

Target at P75+ for not_applicable healthy

Timeline
Completed

Started Jan 2007

Typical duration for not_applicable healthy

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2007

Completed
22 days until next milestone

First Submitted

Initial submission to the registry

January 23, 2007

Completed
2 days until next milestone

First Posted

Study publicly available on registry

January 25, 2007

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2008

Completed
Last Updated

October 4, 2017

Status Verified

October 1, 2017

Enrollment Period

1.4 years

First QC Date

January 23, 2007

Last Update Submit

October 2, 2017

Conditions

Healthy

Keywords

ExerciseResistance training

Outcome Measures

Primary Outcomes (1)

  • Cognitive Performance of Executive Function

    12 months

Secondary Outcomes (1)

  • Functional MRI and physiological falls risk

    12 months

Study Arms (3)

1

EXPERIMENTAL

Twice weekly resistance training for 52 weeks.

Behavioral: Exercise Training

2

EXPERIMENTAL

Once weekly resistance training for 52 weeks.

Behavioral: Exercise training

3

EXPERIMENTAL

Twice weekly balance and tone training for 52 weeks.

Behavioral: Exercise training

Interventions

Exercise trainingBEHAVIORAL

Twice weekly resistance training for 52 weeks.

1

Eligibility Criteria

Age65 Years - 75 Years
Sexfemale
Healthy VolunteersYes
Age GroupsOlder Adult (65+)

You may qualify if:

  • Sedentary (less than twice weekly exercising) women aged 65-75 years old without conditions restricting them from exercising.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

YMCA

Vancouver, British Columbia, V5Y 2Z5, Canada

Location

Vancouver Coastal Health Research Institute Research Pavilion

Vancouver, British Columbia, V5Z 1L8, Canada

Location

Related Publications (9)

  • Bolandzadeh N, Tam R, Handy TC, Nagamatsu LS, Hsu CL, Davis JC, Dao E, Beattie BL, Liu-Ambrose T. Resistance Training and White Matter Lesion Progression in Older Women: Exploratory Analysis of a 12-Month Randomized Controlled Trial. J Am Geriatr Soc. 2015 Oct;63(10):2052-60. doi: 10.1111/jgs.13644. Epub 2015 Oct 12.

    PMID: 26456233DERIVED

  • Davis JC, Nagamatsu LS, Hsu CL, Beattie BL, Liu-Ambrose T. Self-efficacy is independently associated with brain volume in older women. Age Ageing. 2012 Jul;41(4):495-501. doi: 10.1093/ageing/afs029. Epub 2012 Mar 21.

    PMID: 22436405DERIVED

  • Nagamatsu LS, Hsu CL, Handy TC, Liu-Ambrose T. Functional neural correlates of reduced physiological falls risk. Behav Brain Funct. 2011 Aug 16;7:37. doi: 10.1186/1744-9081-7-37.

    PMID: 21846395DERIVED

  • Davis JC, Marra CA, Robertson MC, Najafzadeh M, Liu-Ambrose T. Sustained economic benefits of resistance training in community-dwelling senior women. J Am Geriatr Soc. 2011 Jul;59(7):1232-7. doi: 10.1111/j.1532-5415.2011.03474.x. Epub 2011 Jun 30.

    PMID: 21718265DERIVED

  • Davis JC, Marra CA, Liu-Ambrose TY. Falls-related self-efficacy is independently associated with quality-adjusted life years in older women. Age Ageing. 2011 May;40(3):340-6. doi: 10.1093/ageing/afr019. Epub 2011 Mar 24.

    PMID: 21436152DERIVED

  • Davis JC, Marra CA, Beattie BL, Robertson MC, Najafzadeh M, Graf P, Nagamatsu LS, Liu-Ambrose T. Sustained cognitive and economic benefits of resistance training among community-dwelling senior women: a 1-year follow-up study of the Brain Power study. Arch Intern Med. 2010 Dec 13;170(22):2036-8. doi: 10.1001/archinternmed.2010.462. No abstract available.

    PMID: 21149764DERIVED

  • Liu-Ambrose T, Davis JC, Nagamatsu LS, Hsu CL, Katarynych LA, Khan KM. Changes in executive functions and self-efficacy are independently associated with improved usual gait speed in older women. BMC Geriatr. 2010 May 19;10:25. doi: 10.1186/1471-2318-10-25.

    PMID: 20482830DERIVED

  • Davis JC, Marra CA, Najafzadeh M, Liu-Ambrose T. The independent contribution of executive functions to health related quality of life in older women. BMC Geriatr. 2010 Apr 1;10:16. doi: 10.1186/1471-2318-10-16.

    PMID: 20359355DERIVED

  • Liu-Ambrose T, Nagamatsu LS, Graf P, Beattie BL, Ashe MC, Handy TC. Resistance training and executive functions: a 12-month randomized controlled trial. Arch Intern Med. 2010 Jan 25;170(2):170-8. doi: 10.1001/archinternmed.2009.494.

    PMID: 20101012DERIVED

MeSH Terms

Conditions

Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Teresa Liu-Ambrose, Ph.D

    University of British Columbia

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
PREVENTION
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

January 23, 2007

First Posted

January 25, 2007

Study Start

January 1, 2007

Primary Completion

June 1, 2008

Study Completion

June 1, 2008

Last Updated

October 4, 2017

Record last verified: 2017-10

Locations

CA(2)