Effects of Exercise on Fructose-induced Postprandial Lipemia

NCT03173495 | Completed

• 1 other identifier: 48763715.3.0000.5347
• Study Type: interventional
• Target: 12
• Locations: 0 countries
• Sites: N/A

Brief Summary

Cardiovascular Diseases (CVDs) are the leading causes of death in the world and in Brazil. In 2001, 12.45 million deaths on the globe (21% of the total) were caused by some CVD. The composition of modern man's diet has changed drastically with the industrialization of food, resulting in the transition from a diet rich in fibers and complex carbohydrates to one with a high content of sugars and fats. Since the current dietary pattern is characterized by the consumption of three or more meals a day, containing a quantity of fat in the range of 20 to 70 g, individuals spend a large part of the day in the postprandial state, with continuous fluctuation of lipemia Over 18 hours. Food intake (postprandial state) is the dynamic, unstable response of the body that refers to rapid hormonal and lipoprotein remodeling. It is well established in the literature that high-fat meals (lipid overload) cause an increase in plasma triglycerides. Hypertriglyceridemia and / or elevated triglyceride-rich lipoproteins (LRT) (chylomicrons, VLDL and their remnants) in the postprandial state induces endothelial dysfunction via increased oxidative stress and is an independent risk factor for CVDs. Therefore, Postprandial Lipemia (PPL) is counted as an early marker of atherosclerotic process, metabolic abnormalities and endothelial dysfunction. High-carbohydrate (CHO) diets may promote increased LDL-c, TG, VLDL and HDL-c reduction, as well as PPL, generating a lipid profile associated with an increased risk of CVDs. This effect appears to be more pronounced with the inclusion of simple carbohydrates (mono and disaccharides), although it also occurs with diets rich in complex carbohydrates (polysaccharides). High fructose diets (HFDs) are a known model of induction of insulin resistance, dyslipidemia and DM2 in primates and humans. The chronic effect of fructose consumption has been well studied in the last decades due to its connection with obesity, resistance to Insulin, accumulation of visceral fat and dyslipidemia. As the consumption of fructose is progressively increasing in society and its chronic exposure can generate a phenotypic effect of dyslipidemia and, consequently, the increased risk of CVDs, prevention and treatment strategies should be seen as an important public health issue . Thus, the objective of this study is to understand the effects of exercise on fat metabolism, since there is a lack of robust evidence about the possible cardioprotective and hypolipemic role of the same on HFD.

Conditions

Sedentary Lifestyle; Dyslipidemias; Lipid Metabolism Disorders; Carbohydrate Inducible Hyperlipemia

Keywords

fat metabolism; fructose; exercise

Outcome Measures

Primary Outcomes (2)

• Triglycerides

  Parameter was analyzed by Cobas C111

  4 hour postprandial test

• VLDL

  Parameter was analyzed by ELISA

  4 hour postprandial test

Secondary Outcomes (4)

• Glycemia

  4 hour postprandial test

• Insulin

  4 hour postprandial test

• HDL

  4 hour postprandial test

• Non-HDL cholesterol

  4 hour postprandial test

Study Arms (3)

FRUCTOSE

EXPERIMENTAL

Day 0, 45 min in rest position. Day 1, High Fat Meal (HFM) consisted of macronutrients (50% fat, 40% carbohydrate and 10% protein) with a fructose-rich beverage (0.5 g / kg). Day 2, High Fat Meal (HFM) consisted of macronutrients (50% fat, 40% carbohydrate and 10% protein) with a dextrose-rich beverage (0.5 g / kg).

Dietary Supplement: FRUCTOSE

DEXTROSE

PLACEBO COMPARATOR

Day 0, 45 min in rest position. Day 1, High Fat Meal (HFM) consisted of macronutrients (50% fat, 40% carbohydrate and 10% protein) with a dextrose-rich beverage (0.5 g / kg). Day 2, High Fat Meal (HFM) consisted of macronutrients (50% fat, 40% carbohydrate and 10% protein) with a dextrose-rich beverage (0.5 g / kg).

Dietary Supplement: DEXTROSE

FRUCTEX

ACTIVE COMPARATOR

Day 0, 45 min of 60%VO2peak aerobic exercise . Day 1, High Fat Meal (HFM) consisted of macronutrients (50% fat, 40% carbohydrate and 10% protein) with a fructose-rich beverage (0.5 g / kg). Day 2, High Fat Meal (HFM) consisted of macronutrients (50% fat, 40% carbohydrate and 10% protein) with a dextrose-rich beverage (0.5 g / kg).

Dietary Supplement: FRUCTOSE; Dietary Supplement: EXERCISE

Interventions

FRUCTOSE DIETARY_SUPPLEMENT

Fructose-rich beverage with a high fat meal, without exercise.

Also known as: High fat meal

FRUCTEX; FRUCTOSE

DEXTROSE DIETARY_SUPPLEMENT

Dextrose-rich beverage with a high fat meal (control), without exercise.

Also known as: High fat meal

DEXTROSE

EXERCISE DIETARY_SUPPLEMENT

45 minutes of 60% VO2peak aerobic exercise

FRUCTEX

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• BMI (18,5 to 24,9 kg/m²)
• Sedentary lifestyle (\< 150 minutes exercise per week)
• Fructose intake \< 25g per day
• Otherwise healthy

You may not qualify if:

• Smoker
• Drug user
• Using some medicine
• Fat metabolism disorders
• Orthopedic disorders

Sponsors & Collaborators

• Federal University of Rio Grande do Sul: lead

MeSH Terms

Conditions

Sedentary Behavior; Dyslipidemias; Lipid Metabolism Disorders; Hyperlipoproteinemia Type IV; Motor Activity

Interventions

Fructose; Glucose; Exercise

Condition Hierarchy (Ancestors)

Behavior; Metabolic Diseases; Nutritional and Metabolic Diseases; Lipid Metabolism, Inborn Errors; Metabolism, Inborn Errors; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hyperlipoproteinemias; Hyperlipidemias; Hypertriglyceridemia

Intervention Hierarchy (Ancestors)

Hexoses; Monosaccharides; Sugars; Carbohydrates; Ketoses; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 4, 2017
• First Posted: June 1, 2017
• Study Start: January 10, 2016
• Primary Completion: December 15, 2016
• Study Completion: December 15, 2016
• Last Updated: June 1, 2017

Record last verified: 2017-05

Data Sharing

• IPD Sharing: Will not share