Postprandial Glucose, Insulin Response to Meal Sequence Among Healthy UAE Adults

NCT05878301 | Completed

• 1 other identifier: REC-22-10-18-S
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

the goal of this Randomized controlled cross over trial is to compare the effects of meal sequences VPF meal vs. SMM on the incremental area under the curve of postprandial glucose response among healthy adults in the UAE. the main question it aims to answer is what is the effect of meal sequence of vegetable and protein first followed by carbohydrates (VPF) compared to a standard mixed meal (SMM) on the postprandial glucose level and insulin response among healthy adults in the UAE. Participants will consume two is caloric test meals in random order (SMM and VPF meal sequences) separated by a 7-10-day washout period then blood sample will be collected at fasting ,30min,60min and 120mon for glucose and insulin and hunger ration will be done as well .Researchers will compare the effect of the two meals on postprandial blood glucose, insuline and hunger rating.

Conditions

Postprandial Hyperglycemia

Outcome Measures

Primary Outcomes (1)

• To compare the effects of meal sequences VPF meal vs. SMM on the incremental area under the curve of postprandial glucose response among healthy adults in the UAE.

  incremental area under the curve

  7-10 days

Secondary Outcomes (2)

• To compare the effects of the VPF meal sequence vs. SMM sequence on the incremental area under the curve of postprandial insulin response.

  2 month

• To compare the postprandial hunger response of the VPF meal sequence vs SMM sequence on the area under the curve using a validated visual analog scale for hunger and fullness (VAS)

  7-10 days

Study Arms (1)

standard mixed meal (SMM)

OTHER

standard mixed meal (SMM) consumed within 15 min to compared to the vegetable protein first followed 10 min later by carbohydrates it with the effect on postprandial glucose ,insulin and hunger rating

Other: vegetable and protein first followed by carbohydrates (VPF) meal sequence

Interventions

vegetable and protein first followed by carbohydrates (VPF) meal sequence OTHER

vegetable and protein first followed10 min later by carbohydrates (VPF) meal sequence

Also known as: VPF

standard mixed meal (SMM)

Eligibility Criteria

• Age: 18 Years - 59 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Emirati, Gulf Cooperation Council (GCC), and Arabs ethnicity
• BMI: 18.5-29.9 kg/m2
• Fasting blood glucose level less than 100 mg/dL
• Non-smoker
• no genetic or metabolic diseases
• no known medical condition.

You may not qualify if:

• any participants with pre-existing diabetes
• Pregnant and breastfeeding women
• Participants with behaviors or/and health conditions that are known to affect glucose or -- insulin concentrations, such as smoking, gastrointestinal conditions, bariatric surgery, gastroparesis and reactive hypoglycemia
• Participants who consumed medication that might affect glucose or insulin response
• Participants with reported allergy or intolerance to any of the meal components (White Basmati rice, grilled chicken, cucumber, tomato, and lettuce salad with lemon olive oil dressing).

Sponsors & Collaborators

• University of Sharjah: lead

Study Sites (1)

Diabetes center ,university of sharjah

Sharjah city, United Arab Emirates

Location

Related Publications (1)

• Shukla AP, Andono J, Touhamy SH, Casper A, Iliescu RG, Mauer E, Shan Zhu Y, Ludwig DS, Aronne LJ. Carbohydrate-last meal pattern lowers postprandial glucose and insulin excursions in type 2 diabetes. BMJ Open Diabetes Res Care. 2017 Sep 14;5(1):e000440. doi: 10.1136/bmjdrc-2017-000440. eCollection 2017.

  PMID: 28989726 BACKGROUND

MeSH Terms

Conditions

Hyperglycemia

Interventions

Vegetables

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: clinical dietitian

Study Record Dates

• First Submitted: May 17, 2023
• First Posted: May 26, 2023
• Study Start: June 9, 2023
• Primary Completion: August 14, 2023
• Study Completion: August 14, 2023
• Last Updated: August 15, 2023

Record last verified: 2023-08

Locations

AE (1)