Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer
monarchE
A Randomized, Open-Label, Phase 3 Study of Abemaciclib Combined With Standard Adjuvant Endocrine Therapy Versus Standard Adjuvant Endocrine Therapy Alone in Patients With High Risk, Node Positive, Early Stage, Hormone Receptor Positive, Human Epidermal Receptor 2 Negative, Breast Cancer
4 other identifiers
interventional
5,637
37 countries
612
Brief Summary
The purpose of this study is to evaluate the safety and efficacy of the study drug abemaciclib in participants with high risk, node positive, early stage, hormone receptor positive (HR+), human epidermal receptor 2 negative (HER2-), breast cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 breast-cancer
Started Jul 2017
Longer than P75 for phase_3 breast-cancer
612 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 15, 2017
CompletedFirst Posted
Study publicly available on registry
May 16, 2017
CompletedStudy Start
First participant enrolled
July 12, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 16, 2020
CompletedResults Posted
Study results publicly available
April 9, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2029
ExpectedApril 24, 2026
April 1, 2026
2.7 years
May 15, 2017
March 15, 2021
April 7, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Invasive Disease Free Survival (IDFS)
IDFS, as defined by the STEEP System, was measured from the date of randomization to the date of first occurrence of one of the following events: ipsilateral invasive breast tumor recurrence, regional invasive breast cancer recurrence, distant recurrence, contralateral invasive breast cancer, second primary non-breast invasive cancer, death attributable to any cause.
Baseline to Recurrence or Death from Any Cause (Up to 32 Months)
Secondary Outcomes (8)
IDFS for Participants With Ki-67 Index ≥20%
Baseline to Recurrence or Death from Any Cause (Approximately 10 Years)
Distant Relapse-Free Survival (DRFS)
Baseline to Distant Recurrence or Death from Any Cause (Up to 32 Months)
Overall Survival (OS)
Baseline to Death from Any Cause (Approximately 10 Years)
Pharmacokinetics (PK): Minimum Steady State Concentration (Cmin,ss) of Abemaciclib
Day 1 (2 hours post-dose), Days 30, 60, 90 post-dose
Change From Baseline on the Functional Assessment of Cancer Therapy - Breast (FACT-B)
Baseline, Follow Up (Approximately 3 Years)
- +3 more secondary outcomes
Study Arms (2)
150 mg Abemaciclib + Endocrine Therapy
EXPERIMENTALParticipants received Abemaciclib orally at 150 milligrams (mg) twice daily with at least 6 hours between doses for up to 2 years or until evidence of disease recurrence or other discontinuation criteria were met, whichever occurs first. Endocrine therapy (physicians' choice) standard-of-care was administered according to package label until discontinuation criteria were met.
Endocrine Therapy
OTHEREndocrine therapy (physicians' choice) standard-of-care was administered according to package label until discontinuation criteria were met.
Interventions
Administered according to label instructions.
Eligibility Criteria
You may qualify if:
- Women (regardless of menopausal status) or men ≥18 years of age (or per local regulations).
- The participant has confirmed HR+, HER2-, early stage resected invasive breast cancer without evidence of distant metastases.
- The participant must have undergone definitive surgery of the primary breast tumor.
- The participant must have tumor tissue from breast (preferred) or lymph node for exploratory biomarker analysis available prior to randomization.
- Pathologic lymph node involvement and at least one of the following indicating a higher risk of recurrence:
- or more positive axillary lymph nodes
- Tumor size of at least 5 centimeters
- Grade 3 defined as at least 8 points on the Bloom Richardson grading system
- Ki-67 index by central analysis of ≥20% on untreated breast tissue
- The participant must be randomized within 16 months from the time of definitive breast cancer surgery.
- The participant may receive up to 12 weeks of endocrine therapy until randomization following the last non-endocrine therapy (surgery, chemotherapy, or radiation) whichever is last.
- Participants must have recovered (grade ≤1) from the acute effects of chemotherapy and radiotherapy and from surgical side effects following definitive breast surgery.
- Women of reproductive potential must have a negative blood pregnancy test and agree to use highly effective contraceptive methods.
- The participant has a Eastern Cooperative Oncology Group (ECOG) performance status ≤1.
- The participant has adequate organ function.
- +1 more criteria
You may not qualify if:
- Metastatic disease (including contralateral axillary lymph nodes) or node-negative disease.
- Participants with inflammatory breast cancer.
- Participants with a history of previous breast cancer, with the exception of ipsilateral ductal carcinoma in situ (DCIS) treated by locoregional therapy alone ≥5 years ago. Participants with a history of contralateral DCIS treated by local regional therapy at any time may be eligible. Participants with a history of any other cancer (except non-melanoma skin cancer or carcinoma in situ of the cervix), unless in complete remission with no therapy for a minimum of 5 years from the date of randomization are excluded.
- Females who are pregnant or lactating.
- The participant has previously received treatment with any CDK4 and CDK6 inhibitor.
- The participant is receiving concurrent exogenous reproductive hormone therapy (for example, birth control pills, hormone replacement therapy, or megestrol acetate).
- The participant has previously received endocrine therapy for breast cancer prevention (tamoxifen or aromatase inhibitors) or raloxifene.
- The participant has serious preexisting medical condition(s) that, in the judgment of the investigator, would preclude participation in this study.
- The participant has a personal history of any of the following conditions: syncope of cardiovascular etiology, ventricular arrhythmia of pathological origin or sudden cardiac arrest. Any participant with a history of venous thromboembolism (VTE).
- The participant has active systemic infections or viral load.
- The participant has received an experimental treatment in a clinical trial within the last 30 days or 5 half-lives, whichever is longer.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Eli Lilly and Companylead
- NSABP Foundation Inccollaborator
Study Sites (619)
University of Alabama Birmingham
Birmingham, Alabama, 32594, United States
Providence Alaska Medical Center
Anchorage, Alaska, 99508, United States
Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
Arizona Oncology Associates, P.C. - HOPE
Goodyear, Arizona, 85395, United States
St. Joseph's Hospital and Medical Center
Phoenix, Arizona, 85013, United States
Mayo Clinic Hospital
Phoenix, Arizona, 85054, United States
The University of Arizona Cancer Center
Tucson, Arizona, 85719, United States
Yuma Regional Cancer Center
Yuma, Arizona, 85364, United States
St. Bernards Medical Center
Jonesboro, Arkansas, 72401, United States
Highlands Oncology Group
Springdale, Arkansas, 72762, United States
Beverly Hills Cancer Center
Beverly Hills, California, 90211, United States
Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center
Burbank, California, 91505, United States
City of Hope National Medical Center
Duarte, California, 91010-0269, United States
California Cancer Associates Research and Excellence
Fresno, California, 93720, United States
Kaiser Permanente
Harbor City, California, 92505, United States
Loma Linda University School of Medicine
Loma Linda, California, 92354, United States
Cedars-Sinai Medical Center
Los Angeles, California, 90048, United States
Pacific Cancer Care
Monterey, California, 93940, United States
St. Joseph Hospital
Orange, California, 92868, United States
University of California Davis (UC Davis) Comprehensive Cancer Center
Sacramento, California, 95817, United States
UCSF Medical Center at Mission Bay
San Francisco, California, 94158, United States
California Cancer Associates in Research and Excellence
San Marcos, California, 92069, United States
Dignity Health Dominican Oncology and Hematology
Santa Cruz, California, 95065, United States
Kaiser Permanente
Vallejo, California, 94589, United States
USO-Rocky Mountain Cancer Center
Boulder, Colorado, 80303, United States
USO-Rocky Mountain Cancer Center
Thornton, Colorado, 80260, United States
Yale-New Haven Hospital
New Haven, Connecticut, 06510, United States
Florida Cancer Specialists - South
Fort Myers, Florida, 37203, United States
University of Florida College of Medicine
Gainesville, Florida, 32610, United States
Millennium Oncology - Hollywood
Hollywood, Florida, 33024, United States
Mayo Clinic in Florida
Jacksonville, Florida, 32224, United States
Cancer Specialists of North Florida
Jacksonville, Florida, 32256, United States
Florida Cancer Specialists - North
Lecanto, Florida, 34461, United States
Ocala Oncology, P.A.
Ocala, Florida, 34474, United States
Tallahassee Memorial Cancer Center
Tallahassee, Florida, 32308, United States
Moffitt Cancer Center, Richard M. Shulze Family Foundation Outpatient Center
Tampa, Florida, 33612, United States
University Cancer & Blood Center, LLC
Athens, Georgia, 30607, United States
Northside Hospital
Atlanta, Georgia, 30342, United States
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital
Marietta, Georgia, 30060, United States
Summit Cancer Care DBA Candler Medical Oncology Practice
Savannah, Georgia, 31405, United States
University of Hawaii Cancer Center
Honolulu, Hawaii, 96813, United States
John H. Stroger Hospital of Cook County
Chicago, Illinois, 60612, United States
Rush University Medical Center
Chicago, Illinois, 60612, United States
Edward Cancer Center
Naperville, Illinois, 60540, United States
Quincy Medical Group
Quincy, Illinois, 62301, United States
Franciscan St. Francis Health
Indianapolis, Indiana, 46237, United States
Community Howard Oncology Center
Kokomo, Indiana, 46902, United States
Cancer Center of Kansas
Wichita, Kansas, 67214, United States
Univ of Louisville School of Medicine
Louisville, Kentucky, 40202, United States
Mary Bird Perkins Cancer Center - Baton Rouge
Baton Rouge, Louisiana, 70817, United States
Terrebonne General Medical Center
Houma, Louisiana, 70360, United States
Cancer Care of Maine
Brewer, Maine, 04412, United States
New England Cancer Specialists - Kennebunk
Kennebunk, Maine, 04043, United States
Central Maine Medical Center
Lewiston, Maine, 04240, United States
Meritus John Marsh Cancer Center
Hagerstown, Maryland, 21742, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
Reliant Medical Group, Inc.
Worcester, Massachusetts, 01606, United States
Mayo Clinic in Rochester, Minnesota
Rochester, Minnesota, 55905, United States
Jackson Oncology Associates PLLC
Jackson, Mississippi, 39202, United States
HCA Midwest Kansas City, MidAmerica Division, Inc.
Kansas City, Missouri, 37203, United States
Cancer Alliance of Nebraska
Omaha, Nebraska, 68106, United States
Nebraska Methodist Hospital
Omaha, Nebraska, 68114, United States
Tennessee Cancer Specialists
Omaha, Nebraska, 68130, United States
Renown Regional Medical Center
Reno, Nevada, 89502, United States
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, 03756, United States
Memorial Sloan Kettering - Basking Ridge
Basking Ridge, New Jersey, 07920, United States
Summit Medical Group Cancer Center
Florham Park, New Jersey, 07932, United States
Newark Beth Israel Medical Center
Newark, New Jersey, 07112, United States
The Valley Hospital, Inc.
Paramus, New Jersey, 07652, United States
Community Medical Center
Toms River, New Jersey, 08755, United States
Broome Oncology
Binghamton, New York, 13905, United States
Weill Cornell Medical College
New York, New York, 10065, United States
Vassar Brothers Medical Center
Poughkeepsie, New York, 12601, United States
SUNY At Stony Brook
Stony Brook, New York, 11794, United States
White Plains Hospital
White Plains, New York, 10601, United States
WakeMed Cancer Care - Waverly Hematology & Medical Oncology
Cary, North Carolina, 27518, United States
Margaret R. Pardee Memorial Hospital
Hendersonville, North Carolina, 28739, United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States
Aultman Hospital
Canton, Ohio, 44710, United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
Columbus Community Clinical Oncology Program
Columbus, Ohio, 43215, United States
Asante Rogue Regional Medical Center
Medford, Oregon, 97504, United States
Oregon Health and Science University
Portland, Oregon, 97239, United States
Abington Medical Specialists
Abington, Pennsylvania, 19001, United States
St. Luke's Hospital & Health Network
Bethlehem, Pennsylvania, 18015, United States
Albert Einstein Healthcare Network
Philadelphia, Pennsylvania, 19141, United States
AHN Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212, United States
NSABP Foundation
Pittsburgh, Pennsylvania, 15213, United States
PinnacleHealth Cancer Institute
Pittsburgh, Pennsylvania, 15213, United States
Univ of Pittsburgh Cancer Inst. (UPCI)
Pittsburgh, Pennsylvania, 15213, United States
WellSpan Health/York Cancer Center Oncology Research
York, Pennsylvania, 17403, United States
McLeod Regional Medical Center
Florence, South Carolina, 29502, United States
St Francis Cancer Center
Greenville, South Carolina, 29607, United States
Spartanburg Regional Medical Center
Spartanburg, South Carolina, 29303, United States
Sanford USD Medical Center
Sioux Falls, South Dakota, 57105, United States
Erlanger Health System
Chattanooga, Tennessee, 37403, United States
Chattanooga Research and Medicine
Chattanooga, Tennessee, 37404, United States
The West Clinic, PLLC dba West Cancer Center
Germantown, Tennessee, 38138, United States
Urology Associates of Kingsport
Kingsport, Tennessee, 37660, United States
Tennessee Cancer Specialists
Knoxville, Tennessee, 37909, United States
University of Tennessee Medical Center
Knoxville, Tennessee, 37920, United States
Baptist Cancer Center
Memphis, Tennessee, 38120, United States
Florida Cancer Specialists
Nashville, Tennessee, 37203, United States
Sarah Cannon Cancer Center
Nashville, Tennessee, 37203, United States
Tennessee Oncology Nashville
Nashville, Tennessee, 37203, United States
Texas Oncology Cancer Care and Research Center
Austin, Texas, 78731, United States
Texas Oncology-Baylor Charles A. Sammons Cancer Center
Dallas, Texas, 75246, United States
University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, 75390, United States
Texas Oncology Fort Worth
Fort Worth, Texas, 76104, United States
Oncology Consultants, P.A.
Houston, Texas, 77030, United States
Texas Oncology P.A.
Lewisville, Texas, 75056, United States
University of Texas Health Science Center - San Antonio
San Antonio, Texas, 78229, United States
Arizona Oncology Associates, P.C. - HOPE
The Woodlands, Texas, 77380, United States
Comprehensive Cancer Centers of Nevada
The Woodlands, Texas, 77380, United States
Illinois Cancer Specialists
The Woodlands, Texas, 77380, United States
Miami Cancer Institute at Baptist Health, Inc.
The Woodlands, Texas, 77380, United States
Minnesota Oncology/Hematology PA
The Woodlands, Texas, 77380, United States
Northwest Cancer Specialists PC
The Woodlands, Texas, 77380, United States
Oncology and Hematology Associates of Southwest Virginia Inc
The Woodlands, Texas, 77380, United States
Oncology Hematology Care Inc
The Woodlands, Texas, 77380, United States
Oncology Hematology West
The Woodlands, Texas, 77380, United States
Sansum Clinic
The Woodlands, Texas, 77380, United States
Shenandoah Oncology, P.C.
The Woodlands, Texas, 77380, United States
Texas Oncology - Dallas Presbyterian Hospital
The Woodlands, Texas, 77380, United States
Texas Oncology - Denison
The Woodlands, Texas, 77380, United States
Texas Oncology - McAllen
The Woodlands, Texas, 77380, United States
Texas Oncology - McKinney
The Woodlands, Texas, 77380, United States
Texas Oncology - Medical City Dallas
The Woodlands, Texas, 77380, United States
Texas Oncology - Methodist Dallas Cancer Center
The Woodlands, Texas, 77380, United States
Texas Oncology - Paris
The Woodlands, Texas, 77380, United States
Texas Oncology - San Antonio Medical Center
The Woodlands, Texas, 77380, United States
Texas Oncology - The Woodlands
The Woodlands, Texas, 77380, United States
Texas Oncology - Tyler
The Woodlands, Texas, 77380, United States
Texas Oncology - West Texas
The Woodlands, Texas, 77380, United States
Texas Oncology Cancer Care and Research Center
The Woodlands, Texas, 77380, United States
Texas Oncology Denton
The Woodlands, Texas, 77380, United States
Texas Oncology Fort Worth
The Woodlands, Texas, 77380, United States
Texas Oncology P.A.
The Woodlands, Texas, 77380, United States
Texas Oncology- Mesquite
The Woodlands, Texas, 77380, United States
Texas Oncology-Arlington South
The Woodlands, Texas, 77380, United States
Texas Oncology-Baylor Charles A. Sammons Cancer Center
The Woodlands, Texas, 77380, United States
Texas Oncology-Deke Slayton Cancer Center
The Woodlands, Texas, 77380, United States
Texas Oncology-Plano East
The Woodlands, Texas, 77380, United States
Texas Oncology-Plano West
The Woodlands, Texas, 77380, United States
US Oncology
The Woodlands, Texas, 77380, United States
USO - Texas Oncology, P. A.
The Woodlands, Texas, 77380, United States
USO-Maryland Oncology Hematology, P.A.
The Woodlands, Texas, 77380, United States
USO-New York Oncology Hematology, P.C
The Woodlands, Texas, 77380, United States
USO-Rocky Mountain Cancer Center
The Woodlands, Texas, 77380, United States
USO-Southern Cancer Center, P.C.
The Woodlands, Texas, 77380, United States
USO-Virginia Oncology Associates
The Woodlands, Texas, 77380, United States
Virginia Cancer Specialists
The Woodlands, Texas, 77380, United States
Willamette Valley Cancer Institute & Research Ctr.
The Woodlands, Texas, 77380, United States
Texas Oncology - Paris
Tyler, Texas, 75702, United States
Texas Oncology - Tyler
Tyler, Texas, 75702, United States
Utah Cancer Specialists
Salt Lake City, Utah, 84106, United States
The University of Vermont Medical Center Inc.
Burlington, Vermont, 05401, United States
Hematology Oncology Associates of Fredericksburg Inc.
Fredericksburg, Virginia, 22408, United States
Virginia Commonwealth University (VCU) Medical Center
Richmond, Virginia, 23219, United States
MultiCare Regional Cancer Center - Auburn
Auburn, Washington, 98001, United States
Swedish Medical Center
Seattle, Washington, 98104, United States
Centro de Oncologia e Investigacion Buenos Aires
Berazategui, Buenos Aires, B1884BBF, Argentina
Instituto de Investigaciones Clinicas Mar del Plata
Mar del Plata, Buenos Aires, 7600, Argentina
Hospital Universitario Austral
Pilar, Buenos Aires, 1629, Argentina
Hospital Aleman
Buenos Aires, Buenos Aires F.D., C1118AAT, Argentina
Fundacion CENIT para la Investigacion en Neurociencias
CABA, Ciudad Autonoma Buenos Aires, 1125, Argentina
Clinica Viedma
Viedma, Río Negro Province, R8500ACE, Argentina
Instituto de Oncologia de Rosario
Rosario, Santa Fe Province, S2000KZE, Argentina
Centro Para la Atención Integral del Paciente Oncologico (CAIPO)
San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Instituto Alexander Fleming
Buenos Aires, 1426, Argentina
IDIM - Instituto de Diagnóstico e Investigaciones Metabólicas
Buenos Aires, C1012AAR, Argentina
Clinica Adventista de Belgrano
Ciudad Autonoma Buenos Aires, C1430EGF, Argentina
Fundación CORI para la Investigación y Prevención del Cáncer
La Rioja, F5300COE, Argentina
Consultorio Dr. Miguel Ángel Escudero
Salta, 4400, Argentina
CER San Juan
San Juan, 5400, Argentina
Centro Medico San Roque
San Miguel de Tucumán, 4000, Argentina
Chris O'Brien Lifehouse
Camperdown, New South Wales, 2050, Australia
St Vincent's Hospital
Darlinghurst, New South Wales, 2010, Australia
Lismore Base Hospital
Lismore, New South Wales, 2480, Australia
Liverpool Hospital
Liverpool, New South Wales, 2170, Australia
Mater Hospital Sydney
Sydney, New South Wales, 2060, Australia
Calvary Mater Newcastle
Waratah, New South Wales, 2298, Australia
Westmead Hospital
Westmead, New South Wales, 2145, Australia
Southern Medical Day Care Centre
Wollongong, New South Wales, 2500, Australia
Mater Misericordiae Limited
Brisbane, Queensland, 4101, Australia
Gold Coast University Hospital
Southport, Queensland, 4215, Australia
The Townsville Hospital
Townsville, Queensland, 4814, Australia
Lyell McEwin Hospital
Elizabeth Vale, South Australia, 5112, Australia
Ashford Cancer Centre Research
Kurralta Park, South Australia, 5037, Australia
Launceston General Hospital
Launceston, Tasmania, 7250, Australia
Box Hill Hospital
Box Hill, Victoria, 3128, Australia
Epworth Hospital
East Melbourne, Victoria, 3121, Australia
Peter MacCallum Cancer Centre
Melbourne, Victoria, 3050, Australia
Maroondah Hospital
Melbourne, Victoria, 3135, Australia
Breast Cancer Research Centre WA
Nedlands, Western Australia, 6009, Australia
St John of God Subiaco Hospital
Subiaco, Western Australia, 6008, Australia
Medizinische Universität Wien
Vienna, State of Vienna, 1090, Austria
Universitaetsklinikum Allgemeines Krankenhaus Wien
Vienna, State of Vienna, 1090, Austria
Klinik Hietzing
Vienna, State of Vienna, 1130, Austria
Medizinische Universität Graz
Graz, Styria, 8036, Austria
Medizinische Universitaet Innsbruck
Innsbruck, Tyrol, 6020, Austria
Private Practice - Dr. Hubalek
Schwaz, Tyrol, 6130, Austria
Universitätsklinikum Salzburg
Salzburg, 5020, Austria
Algemeen Ziekenhuis klina
Brasschaat, Antwerpen, 2930, Belgium
Antwerp University Hospital
Edegem, Antwerpen, 2650, Belgium
Cliniques Universitaires Saint-Luc
Brussels, Bruxelles-Capitale, Région de, 1200, Belgium
CHU de Charleroi - Hopital Civil Marie Curie
Lodelinsart, Hainaut, 6042, Belgium
Jessa Ziekenhuis
Hasselt, Limburg, 3500, Belgium
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
Liège, Liège, 4000, Belgium
Centre Hospitalier D'Ardenne - Forget
Libramont, Luxembourg, 6800, Belgium
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne
Yvoir, Namur, 5000, Belgium
AZ Nikolaas
Sint-Niklaas, Oost-Vlaanderen, B-9100, Belgium
UZ Leuven
Leuven, Vlaams-Brabant, 3000, Belgium
Groupe Jolimont
La Louvière, Wallonne, Région, 7100, Belgium
Clinical Chc Montlégia
Liège, Wallonne, Région, 4000, Belgium
Clinique Saint Pierre
Ottignies, Wallonne, Région, 1340, Belgium
AZ Sint-Jan Brugge-Oostende AV
Bruges, West-Vlaanderen, 8000, Belgium
Jan Yperman ziekenhuis
Ieper, West-Vlaanderen, 8900, Belgium
AZ Groeninge Campus Kennedylaan
Kortrijk, West-Vlaanderen, 8500, Belgium
CHU UCL Namur/Site Sainte Elisabeth
Namur, 5000, Belgium
Centro de Pesquisa Clínica do Instituto do Câncer do Ceará
Fortaleza, Ceará, 60430-230, Brazil
Sírio-Libanês Brasilia-Centro de Oncologia-Asa Sul
Brasília, Federal District, 70200-730, Brazil
Hospital Araújo Jorge
Goiânia, Goiás, 74605-070, Brazil
CIONC - Centro Integrado de Oncologia de Curitiba
Curitiba, Paraná, 80810-050, Brazil
Hospital de Cancer de Londrina
Londrina, Paraná, 86015-520, Brazil
Instituto de Educação, Pesquisa e Gestão em Saúde
Rio de Janeiro, Rio de Janeiro, 22775-002, Brazil
ONCOSITE - Centro de Pesquisa Clinica em Oncologia
Ijuí, Rio Grande do Sul, 98700 000, Brazil
Hospital Bruno Born
Lajeado, Rio Grande do Sul, 95900-000, Brazil
Hospital São Lucas da PUCRS
Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Fundação Pio XII - Hospital de Câncer de Barretos
Barretos, São Paulo, 14784-400, Brazil
Hospital de Clínicas de Ribeirão Preto
Ribeirão Preto, São Paulo, 14051-140, Brazil
Faculdade de Medicina do ABC
Santo André, São Paulo, 09060-650, Brazil
Hospital de Base de São José do Rio Preto
Sao Jose Rio Preto, São Paulo, 15091-000, Brazil
Instituto do Cancer do Estado de Sao Paulo - ICESP
São Paulo, São Paulo, 01246-000, Brazil
INCA - Instituto Nacional Do Cancer
Rio de Janeiro, 20560121, Brazil
Hospital Sírio Libanês
São Paulo, 01308-060, Brazil
Pérola Centro de Pesquisa em Oncologia
São Paulo, 01317-000, Brazil
IBCC - Núcleo de Pesquisa e Ensino
São Paulo, 04014-002, Brazil
Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE/HSPE-FMO Conhecer Centro de Oncolog -T
São Paulo, 04038-034, Brazil
Instituto D'Or de Pesquisa e Ensino (IDOR)
São Paulo, 04543-000, Brazil
The Ottawa Hospital - General Campus
Ottawa, Ontario, K1H 8L6, Canada
North York General Hospital
Toronto, Ontario, M2K 1E1, Canada
Humber River Hospital
Toronto, Ontario, M3M 0B2, Canada
Unity Health Toronto, St. Michael's Hospital
Toronto, Ontario, M5B 1W8, Canada
Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, H2X 3E4, Canada
Jewish General Hospital
Montreal, Quebec, H3T 1E2, Canada
Hopital du Sacre-Coeur de Montreal
Montreal, Quebec, H4J 1C5, Canada
CHU de Quebec-Hopital de Saint-Sacrement
Québec, Quebec, G1S 4L8, Canada
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitair -T
Sherbrooke, Quebec, J1J 3H5, Canada
The Fifth Medical Center of PLA General Hospital
Beijing, Beijing Municipality, 100039, China
Beijing Cancer Hospital
Beijing, Beijing Municipality, 100142, China
Fujian Medical University Union Hospital-1 Bingfanglou
Fuzhou, Fujian, 350001, China
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, 510080, China
The First Affiliated Hospital, Sun-Yat Sen University
Guangzhou, Guangdong, 510080, China
Sun Yat-Sen University
Guangzhou, Guangdong, 510120, China
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, 150081, China
Henan Cancer Hospital
Zhengzhou, Henan, 450008, China
Hunan Cancer Hospital
Changsha, Hunan, 410013, China
Jiangsu Cancer Hospital
Nanjing, Jiangsu, 210009, China
Jiangsu Province Hospital
Nanjing, Nanjing, 210029, China
Shandong Cancer Hospital
Jinan, Shandong, 250117, China
Shanghai Jiaotong University School of Medicine Ruijin Hospital
Shanghai, Shanghai Municipality, 200025, China
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, 200032, China
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, 310022, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310052, China
Nemocnice Horovice
Hořovice, Beroun, 268 31, Czechia
Masarykuv onkologicky ustav
Brno, Brno-město, 656 53, Czechia
Fakultni Nemocnice Ostrava
Ostrava, Moravian-Silesian Region, 708 52, Czechia
Multiscan
Pardubice, Pardubice Region, 532 03, Czechia
Fakultni Thomayerova nemocnice
Prague, Praha 4, 14059, Czechia
FN Plzen Lochotin
Pilsen, 30460, Czechia
Herlev and Gentofte Hospital
Copenhagen, Capital Region, 2730, Denmark
Rigshospitalet
København Ø, Capital Region, 2100, Denmark
Aarhus Universitetshospital, Skejby
Aarhus, Central Jutland, 8200, Denmark
Regionshospitalet Herning
Herning, Central Jutland, 7400, Denmark
Aalborg Universitetshospital, Syd
Aalborg, North Denmark, 9000, Denmark
Næstved Sygehus
Næstved, Region Sjælland, 4700, Denmark
Sydvestjysk Sygehus Esbjerg
Esbjerg, Region Syddanmark, 6700, Denmark
Odense Universitetshospital
Odense, Region Syddanmark, 5000, Denmark
Sygehus Soenderjylland
Sønderborg, Region Syddanmark, 6400, Denmark
Vejle Sygehus
Vejle, Region Syddanmark, 7100, Denmark
Keski-Suomen Keskussairaala
Jyväskylä, Central Finland, 40620, Finland
Oulun yliopistollinen sairaala
Oulu, North Ostrobothnia, 90220, Finland
Kuopion Yliopistollinen Sairaala
Kuopio, Northern Savonia, 70210, Finland
Tampereen yliopistollinen sairaala
Tampere, Pirkanmaa, 33520, Finland
Vaasan Keskussairaala
Vaasa, Pohjanmaa, Finland
Satakunnan Keskussairaala
Pori, Satakunta, 28500, Finland
Turku University Central Hospital
Turku, Southwest Finland, 20520, Finland
Docrates Syöpäsairaala
Helsinki, Uusimaa, 00029, Finland
Päijät-Häme Central hospital
Lahti, 15850, Finland
Centre Leon Berard
Lyon, Auvergne-Rhône-Alpes, 69008, France
Centre Hospitalier Régional Universitaire de Brest - Hôpital Morvan
Brest, Brittany Region, 29200, France
Polyclinique De Blois
La Chaussée-Saint-Victor, Centre-Val de Loire, 41260, France
Centre Georges Francois Leclerc
Dijon, Côte-d'Or, 21079, France
Hôpital Privé des Côtes d'Armor- HPCA
Plérin, Côtes-d'Armor, 22190, France
CHU de Besancon Hopital Jean Minjoz
Besançon, Doubs, 25000, France
Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer
Rennes, Ille-et-Vilaine, 35042, France
Centre de Cancérologie du Grand Montpellier
Montpellier, Languedoc-Roussillon, 34070, France
Institut de Cancérologie de l'Ouest
Saint-Herblain, Loire-Atlantique, 44805, France
Polyclinique de Gentilly
Nancy, Meurthe-et-Moselle, 54519, France
Clinique Victor Hugo Le Mans
Le Mans, Pays de la Loire Region, 72000, France
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne
Clermont-Ferrand, Puy-de-Dôme, 63011, France
Henri Mondor Hospital
Créteil, Seine-et-Marne, 94000, France
Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen
Rouen, Seine-Maritime, 76038, France
Sainte Catherine Institut du Cancer Avignon Provence
Avignon, Vaucluse, 84918, France
Centre Hospitalier de Vendee Les Oudairies
La Roche-sur-Yon, Vendée, 85000, France
Institut Curie
Paris, 75248, France
Praxis für interdisziplinäre Onkologie & Hämatologie
Freiburg im Breisgau, Baden-Wurttemberg, 69126, Germany
Universitätsklinikum Freiburg
Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
Private Practice - Dr. Helmut Oettle und Prof.Dr.med. Frank Mayer
Friedrichshafen, Baden-Wurttemberg, 88045, Germany
Klinikum Ludwigsburg
Ludwigsburg, Baden-Wurttemberg, 71640, Germany
Universitätsklinikum Tübingen
Tübingen, Baden-Wurttemberg, 72076, Germany
Universitätsklinikum Ulm
Ulm, Baden-Wurttemberg, 89075, Germany
Klinikum St. Marien Amberg
Amberg, Bavaria, 92224, Germany
Gemeinschaftspraxis hop-augsburg
Augsburg, Bavaria, 86150, Germany
Universitätsklinikum Erlangen
Erlangen, Bavaria, 91054, Germany
Klinikum der Ludwig-Maximilians-Universitaet Muenchen
München, Bavaria, 80336, Germany
Klinikum Rechts Der Isar Der Technischen Universität München
München, Bavaria, 81675, Germany
Rotkreuzklinikum München gemeinnützige GmbH
München, Bavaria, 81675, Germany
Agaplesion Markus Krankenhaus
Frankfurt am Main, Hesse, 60431, Germany
Private Practice - Dres. Andreas Köhler und Roswitha Fuchs
Langen, Hesse, 63225, Germany
Sana Klinikum Offenbach
Offenbach, Hesse, 63069, Germany
Franziskus-Hospital Harderberg
Georgsmarienhütte, Lower Saxony, 49124, Germany
Gynäkologisch-Onkologische Praxis am Pelikanplatz
Hanover, Lower Saxony, 30177, Germany
Medizinische Hochschule Hannover
Hanover, Lower Saxony, 30625, Germany
Universitätsklinikum Bonn
Bonn, North Rhine-Westphalia, 53127, Germany
Universitätsklinikum Düsseldorf
Düsseldorf, North Rhine-Westphalia, 40225, Germany
Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung
Essen, North Rhine-Westphalia, 45136, Germany
Zentrum fuer ambulante gynaekologische Onkologie (ZAGO)
Krefeld, North Rhine-Westphalia, 47805, Germany
Evangelisches Krankenhaus Bethesda Mönchengladbach gGmbH
Mönchengladbach, North Rhine-Westphalia, 41061, Germany
Universitätsklinikum Münster - Albert Schweitzer Campus
Münster, North Rhine-Westphalia, 52074, Germany
Marien Hospital Witten
Witten, North Rhine-Westphalia, 58452, Germany
Universitätsklinikum Carl Gustav Carus
Dresden, Saxony, 1307, Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel
Kiel, Schleswig-Holstein, 24105, Germany
SRH Wald-Klinikum Gera gGmbH
Gera, Thuringia, 07548, Germany
Helios Klinikum Berlin-Buch
Berlin, 13125, Germany
Medizinisches Versorgungszentrum Onkologischer Schwerpunkt am Oskar-Helene-Heim
Berlin, 14195, Germany
Mammazentrum HH - Krankenhaus Jerusalem
Hamburg, 20246, Germany
Kath. Marienkrankenhaus gGmbH
Hamburg, 22087, Germany
Asklepios Kliniken Hamburg
Hamburg, 22307, Germany
University Hospital of Patras
Pátrai, Achaia, 26504, Greece
Errikos Dunant Hospital Center
Athens, Attikí (Region), 11526, Greece
Alexandra Hospital
Athens, Attikí, 115 28, Greece
Agios Savvas Regional Cancer Hospital
Athens, Attikí, 11522, Greece
Metropolitan Hospital
Athens, Attikí, 18547, Greece
Attikon General University Hospital
Chaïdári, Attikí, 12462, Greece
General Oncology Hospital of Kifissia "Agioi Anargiroi"
Nea Kifissia, Attikí, 14564, Greece
Bioclinic of Thessaloniki
Thessaloniki, Kentrikí Makedonía, 54622, Greece
University General Hospital of Heraklion
Heraklion, Krítí, 71110, Greece
European Interbalkan Medical Center
Thessaloniki, Thessaloníki, 570 01, Greece
Euromedica - General Clinic of Thessaloniki
Thessaloniki, 54645, Greece
Papageorgiou General Hospital of Thessaloniki
Thessaloniki, 564 29, Greece
University Hospital of Ioannina
Ioannina, Ípeiros, 45500, Greece
Pamela Youde Nethersole Eastern Hospital
Chai Wan, 999077, Hong Kong
Queen Mary Hospital
Hksar, Hong Kong
Tuen Mun Hospital
Tuenmen, 999077, Hong Kong
Queen Elizabeth Hospital
Yau Ma Tei, 999077, Hong Kong
Bacs-Kiskun Varmegyei Oktatokorhaz
Kecskemét, Bács-Kiskun county, 6000, Hungary
Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz
Szolnok, Jász-Nagykun-Szolnok, 5004, Hungary
Szent Margit Kórház
Budapest, 1032, Hungary
Magyar Honvedseg Egeszsegugyi Kozpont
Budapest, 1062, Hungary
Semmelweis University
Budapest, 1088, Hungary
Szent Imre Egyetemi Oktatokorhaz
Budapest, 1115, Hungary
Uzsoki Utcai Kórház
Budapest, 1145, Hungary
MNJ Institute of Oncology
Hyderabad, Andhra Pradesh, 500004, India
HCG Cancer Centre
Ahmedabad, Gujarat, 380060, India
HCG Cancer Centre
Vadodara, Gujarat, 390012, India
Artemis Hospital
Gurgaon, Haryana, 122003, India
Manipal Hospital
Bangalore, Karmnataka, 560017, India
Regional Cancer Centre
Trivandrum, Kerala, 695 011, India
Tata Memorial Hospital
Mumbai, Maharashtra, 400012, India
HCG Manavata Cancer Centre
Nashik, Maharashtra, 422001, India
Grant Medical Foundation - Ruby Hall Clinic
Pune, Maharashtra, 411001, India
Deenanth Mangeshkar Hospital and Research Centre
Pune, Maharashtra, 411004, India
Dr. B. L. Kapur Memorial Hospital
New Delhi, National Capital Territory of Delhi, 110005, India
Apollo Speciality Hospital - Teynampet
Chennai, Tamil Nadu, 600035, India
Apollo Gleneagles Hospitals
Kolkata, West Bengal, 700054, India
Medica Superspecialty Hospital
Kolkata, West Bengal, 700099, India
Post Graduate Institute of Medical Education & Research
Chandigarh, 160012, India
Meir Medical Center
Kfar Saba, Central District, 4428164, Israel
Rabin Medical Center
Petah Tikva, Central District, 49100, Israel
Sheba Medical Center
Ramat Gan, Central District, 5265601, Israel
Kaplan Medical Center
Rehovot, Central District, 7610001, Israel
Yitzhak Shamir Medical Center
Ẕerifin, Central District, 6093000, Israel
Shaare Zedek Medical Center
Jerusalem, Jerusalem, 9013102, Israel
Hadassah Medical Center
Jerusalem, Jerusalem, 9112001, Israel
Soroka Medical Center
Beersheba, Southern District, 8400000, Israel
Rambam Health Care Campus
Haifa, Ḥeifā, 3109601, Israel
University of Naples Federico II
Naples, Campania, 80131, Italy
Azienda Ospedaliero Universitaria S.Anna
Cona, Emilia-Romagna, 44124, Italy
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
Meldola, Emilia-Romagna, 47014, Italy
Fondazione IRCCS San Gerardo dei Tintori
Monza, Lombardy, 20900, Italy
Ospedale Fatebenefratelli-Oftalmico
Milan, Milano, 20121, Italy
Humanitas
Rozzano, Milano, 20141, Italy
Istituto Nazionale Tumori Regina Elena
Rome, Roma, 00144, Italy
Azienda Ospedaliera Sant'Andrea
Rome, Roma, 00157, Italy
Azienda Ospedaliera Santa Maria
Terni, TR, 05100, Italy
Ospedale Bellaria - Azienda USL di Bologna
Bologna, 40139, Italy
Ospedale Antonio Perrino
Brindisi, 72100, Italy
Ospedale San Martino
Genova, 16132, Italy
Azienda Ospedaliero Universitaria
Modena, 41125, Italy
Istituto Nazionale Tumori IRCCS Fondazione Pascale
Naples, 80131, Italy
Istituto Oncologico Veneto IRCCS
Padova, 35128, Italy
Azienda Ospedaliera Di Parma
Parma, 43126, Italy
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino
Torino, 10126, Italy
APSS - Presidio Ospedaliero Santa Chiara
Trento, 38122, Italy
Aichi Cancer Center Hospital
Nagoya, Aichi-ken, 464-8681, Japan
Chiba Cancer Center
Chiba, Chiba, 260-8717, Japan
National Cancer Center Hospital East
Kashiwa, Chiba, 277 8577, Japan
National Hospital Organization Shikoku Cancer Center
Matsuyama, Ehime, 791-0280, Japan
Kurume General Hospital
Kurume, Fukuoka, 830-0013, Japan
Gunma Prefectural Cancer Center
Ōta, Gunma, 373-0828, Japan
Hiroshima University Hospital
Hiroshima, Hiroshima, 734-8551, Japan
National Hospital Organization Hokkaido Cancer Center
Sapporo, Hokkaido, 003-0804, Japan
Hyogo College of Medecine
Nishinomiya, Hyōgo, 663-8501, Japan
University of tsukuba hospital
Tsukuba, Ibaragi, 305-8576, Japan
Tokai University Hospital- Isehara Campus
Isehara, Kanagawa, 259-1143, Japan
St Marianna University School of Medicine Hospital
Kawasaki, Kanagawa, 216-8511, Japan
Kanagawa Cancer Center
Yokohama, Kanagawa, 241 8515, Japan
KKR Tohoku Kosai Hospital
Aoba-ku, Sendai-shi, Miyagi, 980-0803, Japan
Niigata Cancer Center Hospital
Niigata, Niigata, 951-8566, Japan
Kindai University Hospital- Osakasayama Campus
Osaka Sayama-shi, Osaka, 589 8511, Japan
Saitama Medical University International Medical Center
Hidaka, Saitama, 350-1298, Japan
Saitama Prefectural Cancer Center
Ina-machi, Saitama, 362-0806, Japan
Shizuoka Cancer Center
Nakatogari, Shizuoka, 411-8777, Japan
Jichi Medical University Hospital
Shimotsuke, Tochigi, 329-0498, Japan
Tochigi Cancer Center
Utsunomiya, Tochigi, 320-0834, Japan
Juntendo University Hospital
Bunkyō-Ku, Tokyo, 113-8431, Japan
National Cancer Center Hospital
Chuo Ku, Tokyo, 104-0045, Japan
St. Lukes International Hospital
Chuo-Ku, Tokyo, 104 8560, Japan
Japanese Foundation for Cancer Research
Koto, Tokyo, 135-8550, Japan
Showa University Hospital
Shinagawa-ku, Tokyo, 142-8555, Japan
Tokyo Medical University Hospital
Shinjuku-ku, Tokyo, 160-0023, Japan
National Center for Global Health and Medicine
Shinjuku-ku, Tokyo, 162-8655, Japan
National Hospital Organization Kyushu Cancer Center
Fukuoka, 811-1395, Japan
Sagara Hospital
Kagoshima, 892-0833, Japan
Kumamoto University Hospital
Kumamoto, 860-8556, Japan
Kumamoto Shinto General hospital
Kumamoto, 862-8655, Japan
Kyoto University Hospital
Kyoto, 606-8507, Japan
National Hospital Organization Osaka Medical Center
Osaka, 540-0006, Japan
Osaka International Cancer Institute
Osaka, 541-8567, Japan
CIMAB S.A. de C.V.
Torreón, Coahuila, 27000, Mexico
Health Pharma Professional Research, S.A. de C.V.
Mexico City, Federal District, 3100, Mexico
Hospital Civil Fray Antonio Alcalde
Guadalajara, Jalisco, 44280, Mexico
Centro Oncológico Internacional (COI)
Guadalajara, Jalisco, 45647, Mexico
Grupo Medico Camino S.C.
Mexico City, Mexico City, 3310, Mexico
Centro Regiomontano de Investigacion
Monterrey, Nuevo León, 64060, Mexico
Private Practice - Dr. Joaquin Reinoso
Monterrey, Nuevo León, 64320, Mexico
Filios Alta Medicina
Monterrey, Nuevo León, 64460, Mexico
Centro de Estudios y Prevencion del Cancer
Juchitán de Zaragoza, Oaxaca, 70020, Mexico
Neurociencias Estudios Clinicos S.C.
Culiacán, Sinaloa, 80020, Mexico
Centro Hemato Oncologico Privado
Toluca, Toluca, 50120, Mexico
Medical Care and Research, S.A. de C.V.
Mérida, Yucatán, 97070, Mexico
Centro de Atención e Investigación Clínica en Oncología
Mérida, Yucatán, 97134, Mexico
Unidad de Investigacion en Salud
Chihuahua City, 31203, Mexico
Oaxaca Site Management Organization SC
Oaxaca City, 68000, Mexico
Unidad Médica Onco-hematológica
Puebla City, 72424, Mexico
Oncológico Potosino
San Luis Potosí City, 78209, Mexico
Maastricht UMC+
Maastricht, Limburg, 6229 HX, Netherlands
Onze Lieve Vrouwe Gasthuis (OLVG)
Amsterdam, North Holland, 1091AC, Netherlands
Albert Schweitzer Ziekenhuis, locatie Dordwijk
Dordrecht, South Holland, 3318 AT, Netherlands
Haga Ziekenhuis locatie Leyweg
The Hague, South Holland, 2545 AA, Netherlands
Waikato Hospital
Hamilton, Waikato Region, 3240, New Zealand
Palmerston North Hospital
Palmerston North, Wanganui, 4414, New Zealand
Auckland City Hospital
Auckland, 1023, New Zealand
Przychodnia Lekarska "Komed"
Konin, Greater Poland Voivodeship, 62-500, Poland
Wielkopolskie Centrum Onkologii
Poznan, Greater Poland Voivodeship, 61-866, Poland
Dolnośląskie Centrum Onkologii we Wrocławiu
Wroclaw, Lower Silesian Voivodeship, 53-413, Poland
Centrum Onkologii Ziemii Lubelskiej
Lublin, Lublin Voivodeship, 20-081, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
Warsaw, Masovian Voivodeship, 02-781, Poland
Luxmed Onkologia sp. z o. o.
Warsaw, Masovian Voivodeship, 07-100, Poland
Opolskie Centrum Onkologii w Opolu im. prof. Tadeusza Koszarowskiego
Opole, Opole Voivodeship, 45-061, Poland
Uniwersyteckie Centrum Kliniczne
Gdansk, Pomeranian Voivodeship, 80-214, Poland
Szpitale Pomorskie Sp. z o. o.
Gdynia, Pomeranian Voivodeship, 81-519, Poland
Olsztyński Ośrodek Onkologiczny Kopernik
Olsztyn, Warmian-Masurian Voivodeship, 82-300, Poland
Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna
Lodz, Łódź Voivodeship, 90338, Poland
Instituto Portugês de Oncologia de Coimbra Francisco Gentil
Coimbra, 3000-075, Portugal
Champalimaud Foundation
Lisbon, 1400-038, Portugal
Centro Hospitalar Lisboa Norte, E.P.E. - Hospital de Santa Maria
Lisbon, 1649-028, Portugal
Centro Hospitalar do Porto - Hospital de Santo António
Porto, 4099-001, Portugal
IPOFG - Porto
Porto, 4200-072, Portugal
Puerto Rico Hematology/Oncology Group
Bayamón, PR, 00961, Puerto Rico
UPR Comprehensive Cancer Center
San Juan, PR, 00935, Puerto Rico
Institutul Oncologic
Bucharest, Bucharest, 22328, Romania
Institutul Oncologic
Cluj-Napoca, Cluj, 400015, Romania
Ovidius Clinical Hospital OCH
Ovidiu, Constanța County, 905900, Romania
Centrul de Oncologie "Sfântul Nectarie"
Craiova, Dolj, 200542, Romania
Radiology Therapeutic Center
Otopeni, Ilfov, 75100, Romania
Oncopremium Team
Baia Mare, Maramureş, 430291, Romania
Spitalul Clinic Filantropia
Bucharest, 11171, Romania
Chelyabinsk Regional Oncology Dispensary
Chelyabinsk, Chelyabinsk Oblast, 454087, Russia
Kaluga Regional Clinical Oncology Center
Kaluga, Kalužskaja Oblast', 248007, Russia
Kursk Regional Oncology Dispensary
Kursk, Kursk Oblast, 305524, Russia
Fed State Budgetary Inst "N.N. Blokhin Med Center of Oncology" MHRF
Moscow, Moscow, 115478, Russia
Burdenko Main Military Hospital
Moscow, Moscow, 117198, Russia
Orenburg Regional Clinical Oncology Dispensary
Orenburg, Orenburg Oblast, 460021, Russia
Samara Regional Clinical Oncology Center
Samara, Samara Oblast, 443031, Russia
Leningrad Regional Oncology Dispensary
Saint Petersburg, Sankt-Peterburg, 188663, Russia
North-Western State Medical University named after I.I.Mechnikov
Saint Petersburg, Sankt-Peterburg, 191015, Russia
St. Petersburg City Oncological Dispensary - Berezovaya Avenue
Saint Petersburg, Sankt-Peterburg, 197022, Russia
N.N.Petrov Research Institute of Oncology
Saint Petersburg, Sankt-Peterburg, 197758, Russia
Saint-Petersburg Scientific-Practical Center of Specialized Kinds of Medical Care (oncological) named afte -T
Saint Petersburg, Sankt-Peterburg, 197758, Russia
Republican Clinical Oncology Dispensary
Kazan', Tatarstan Republic, 420029, Russia
Volgograd Regional Oncological Dispensary No. 3
Volzhsky, Volgograd Oblast, 404130, Russia
Yaroslavl Regional Cancer Hospital
Yaroslavl, Yaroslavl Oblast, 150054, Russia
Blokhin Cancer Research Center
Moscow, 115478, Russia
King Fahad Specialist Hospital-Dammam
Dammam, Eastern Province, 31444, Saudi Arabia
King Abdulaziz Medical City - National Guard Hospital
Riyadh, Riyadh Region, 11426, Saudi Arabia
King Fahad Medical City
Riyadh, Riyadh Region, 11525, Saudi Arabia
King Faisal Specialist Hospital & Research Center
Riyadh, 11211, Saudi Arabia
National Cancer Center
Singapore, Central Singapore, 168583, Singapore
National University Hospital
Singapore, 119074, Singapore
Cancercare Langenhoven Drive Oncology Centre
Port Elizabeth, Eastern Cape, 6055, South Africa
Life Groenkloof
Pretoria, Gauteng, 181, South Africa
Eastleigh Breast Care Center
Pretoria, Gauteng, 81, South Africa
Sandton Oncology Medical Group (Pty) Ltd
Sandton, Gauteng, 2196, South Africa
Cancercare Rondebosch Oncology
Cape Town, Western Cape, 7700, South Africa
GVI Oncology
George, Western Cape, 7764, South Africa
Chungbuk National University Hospital
Cheongju-si, Chungcheongbuk-do [Chungbuk], 28644, South Korea
Soon chun hyang University Cheonan Hospital
Cheonan-si, Chungcheongnam-do [Chungnam], 31151, South Korea
Inha University Hospital
Incheon, Incheon-gwangyeoksi [Incheon], 22332, South Korea
Gachon University Gil Medical Center
Namdong-gu, Incheon-gwangyeoksi [Incheon], 21565, South Korea
National Cancer Center
Goyang-si, Kyǒnggi-do, 10408, South Korea
Seoul National University Bundang Hospital
Seongnam, Kyǒnggi-do, 13620, South Korea
Dongnam Institute of Radiological and Medical Sciences
Busan, Pusan-Kwangyǒkshi, 46033, South Korea
Inje University Haeundae Paik Hospital
Haeundae-gu, Pusan-Kwangyǒkshi, 48108, South Korea
Korea University Anam Hospital
Seoul, Seoul-teukbyeolsi [Seoul], 2841, South Korea
Seoul National University Hospital
Seoul, Seoul-teukbyeolsi [Seoul], 3080, South Korea
Severance Hospital Yonsei University Health System
Seoul, Seoul-teukbyeolsi [Seoul], 3722, South Korea
Asan Medical Center
Seoul, Seoul-teukbyeolsi [Seoul], 5505, South Korea
Samsung Medical Center
Seoul, Seoul-teukbyeolsi [Seoul], 6351, South Korea
Korea University Guro Hospital
Seoul, Seoul-teukbyeolsi [Seoul], 8308, South Korea
Ewha Womans University Mokdong Hospital
Seoul, Seoul-teukbyeolsi [Seoul], South Korea
Kyungpook National University Chilgok Hospital
Daegu, Taegu-Kwangyǒkshi, 41404, South Korea
Hospital Universitario Reina Sofia
Córdoba, Andalusia, 14004, Spain
Hospital Quiron Barcelona
Barcelona, Barcelona [Barcelona], 8023, Spain
Hospital Clínic de Barcelona
Barcelona, Catalunya [Cataluña], 08908, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, Catalunya [Cataluña], 8041, Spain
CHUS - Hospital Clinico Universitario
Santiago de Compostela, La Coruna, 15706, Spain
Hospital Universitario Arnau de Vilanova de Lleida
Lleida, Lleida [Lérida], 25198, Spain
Hospital Universitario Quironsalud Madrid
Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitario Fundacion ALcorcon
Alcorcón, Madrid, Comunidad de, 28922, Spain
Hospital Universitario Ramón y Cajal
Madrid, Madrid, Comunidad de, 28034, Spain
Hospital Universitario 12 de Octubre
Madrid, Madrid, Comunidad de, 28041, Spain
Hospital Universitario Virgen de la Victoria
Málaga, Málaga, 29010, Spain
Hospital Universitario Central de Asturias
Oviedo, Principality of Asturias, 33011, Spain
Hospital Universitario de Canarias
San Cristóbal de La Laguna, Santa Cruz De Tenerife, 38320, Spain
Hospital Clínico de Valencia
Valencia, Valenciana, Comunitat, 46010, Spain
Parc de Salut Mar - Hospital del Mar
Barcelona, 8003, Spain
Hospital Universitari Vall d'Hebron
Barcelona, 8035, Spain
Hospital Universitario San Cecilio
Granada, 18016, Spain
Complejo Hospitalario de Jaén
Jaén, 23007, Spain
Hospital La Princesa
Madrid, 28006, Spain
Hospital General Universitario Gregorio Marañon
Madrid, 28009, Spain
Hospital Clinico San Carlos
Madrid, 28040, Spain
Hospital Universitario HM Sanchinarro
Madrid, 28050, Spain
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
Salamanca, 37007, Spain
Hospital Universitario Virgen Macarena
Seville, 41009, Spain
Hospital Universitario Virgen del Rocio
Seville, 41013, Spain
Hospital Universitario Virgen de Valme
Seville, 41014, Spain
Hospital Quirón Salud Valencia
Valencia, 46010, Spain
Hospital Universitario Miguel Servet
Zaragoza, 50009, Spain
Skånes universitetssjukhus Lund
Malmo, Skåne Län [se-12], 205 02, Sweden
Norrlands universitetssjukhus
Umeå, Västerbottens Län [se-24], 90185, Sweden
Sundsvalls Sjukhus
Sundsvall, Västernorrlands Län [se-22], 856 43, Sweden
Västmanlands sjukhus Västerås
Västerås, Västmanlands Län [se-19], 721 89, Sweden
Växjö Centrallasarettet
Vaxjo, 35234, Sweden
Chang Gung Memorial Hospital - Kaohsiung
Kaohsiung Niao Sung Dist, Kaohsiung, 83301, Taiwan
Tri-Service General Hospital
Taipei City, Taipei, 114, Taiwan
Changhua Christian Hospital
Changhua, 50006, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 80756, Taiwan
Taipei Medical University Hospital
New Taipei City, 235, Taiwan
China Medical University Hospital
Taichung, 40447, Taiwan
National Taiwan University Hospital
Taipei, 10002, Taiwan
MacKay Memorial Hospital
Taipei, 10449, Taiwan
Taipei Veterans General Hospital
Taipei, 11217, Taiwan
Koo Foundation Sun Yat-Sen Cancer Center
Taipei, 112, Taiwan
Chang Gung Medical Foundation-Linkou Branch
Taoyuan, 333, Taiwan
Istanbul Universitesi Cerrahpasa
Istanbul- Fatih, Istanbul, 34098, Turkey (Türkiye)
Acibadem Altunizade Hospital
Üsküdar/stanbul, Istanbul, 34662, Turkey (Türkiye)
Ege University Medicine of Faculty
Bornova, İzmir, 35100, Turkey (Türkiye)
Izmir Medical Park Hospital
Izmir, Karsiyaka, İzmir, 9035575, Turkey (Türkiye)
Ankara Gülhane Eitim ve Aratrma Hastanesi
Ankara, Kecioren, 6010, Turkey (Türkiye)
Abdurrahman Yurtaslan Ankara Oncology, education and Research Hospital
Ankara, Turkey, 6200, Turkey (Türkiye)
Baskent University Dr. Turgut Noyan Research and Training Center
Adana, 01250, Turkey (Türkiye)
Ankara Universitesi Tip Fakultesi Hastanesi
Ankara, 06100, Turkey (Türkiye)
Hacettepe Universitesi
Ankara, 6230, Turkey (Türkiye)
Akdeniz Universitesi Hastanesi
Antalya, 7070, Turkey (Türkiye)
Trakya University Faculty of Medicine
Edirne, 22030, Turkey (Türkiye)
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
Istanbul, 34090, Turkey (Türkiye)
Kocaeli Üniversitesi
Kocaeli, 41380, Turkey (Türkiye)
İnönü Üniversitesi Turgut Özal Tıp Merkezi
Malatya, 44280, Turkey (Türkiye)
Municipal Non-profit Enterprise "City Clinical Hospital #4" of Dnipro City Council
Dnipro, Dnipropetrovsk Oblast, 49102, Ukraine
Communal Enterprise 'Kryvyi Rih Oncology Dispensary' of the Dnipropetrovsk Regional Council
Kryvyi Rih, Dnipropetrovsk Oblast, 50048, Ukraine
Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council
Odesa, Odesa Oblast, 65025, Ukraine
Poltava Regional Clinical Oncology Center
Poltava, Poltava Oblast, 36011, Ukraine
Communal Noncommercial Enterprise "Podillia Regional Oncology Center Of Vinnytsia Regional Council"
Vinnytsia, Vinnytsia Oblast, 21029, Ukraine
Municipal Enterprise "Volyn Regional Medical Oncology Centre" of the Volyn Regional Council
Lutsk, Volyn Oblast, 43018, Ukraine
Uzhgorod Central City Clinical Hospital
Uzhhorod, Zakarpattia Oblast, 88000, Ukraine
The Royal Cornwall Hospital
Truro, England, TR1 3LJ, United Kingdom
Mid Essex Hospital Services NHS Trust
Chelmsford, Essex, CM1 7ET, United Kingdom
North Middlesex Hospital
London, Greater London, N18 1QX, United Kingdom
Charing Cross Hospital
London, Hammersmith and Fulham, W6 8RF, United Kingdom
Mount Vernon Hospital
Northwood, Hertfordshire, HA6 2RN, United Kingdom
Victoria Hospital
Blackpool, Lancashire, FY3 8NR, United Kingdom
Royal Preston Hospital
Preston, Lancashire, PR2 9HT, United Kingdom
Boston Pilgrim Hospital
Boston, Lincolnshire, PE21 9QS, United Kingdom
Sarah Canon Research Institute UK
London, London, City of, NW1 2PG, United Kingdom
Guy's & St Thomas' NHS Foundation Trust
London, London, City of, SE1 9RT, United Kingdom
James Cook University Hospital
Central Middlesbrough, Middlesbrough, TS4 3BW, United Kingdom
Western General Hospital
Edinburgh, Midlothian, EH4 2XU, United Kingdom
Nottingham City Hospital
Nottingham, Nottinghamshire, NG5 1PB, United Kingdom
The Churchill Hospital
Oxford, Oxfordshire, OX3 7LE, United Kingdom
Musgrove Park Hospital
Taunton, Somerset, TA1 5DA, United Kingdom
Royal Surrey County Hospital
Guildford, Surrey, GU2 7XX, United Kingdom
Royal Marsden Hospital
London, Sutton, SM2 5PT, United Kingdom
Airedale General Hospital
Bradford, BD20 6TD, United Kingdom
The Christie
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Related Publications (12)
Zhang Q, Shen K, Song CG, Ouyang Q, Liu Z, Liu Q, Feng J, Chiu JWY, Tang J, Jiang Z, Tseng LM, Wang X, Yang L, Qian C, Shao Z. Abemaciclib combined with endocrine therapy as adjuvant treatment for hormone-receptor-positive, HER2-, high-risk early breast cancer: 5-year Chinese population analysis of the phase III randomized monarchE study. Ther Adv Med Oncol. 2024 Oct 23;16:17588359241286775. doi: 10.1177/17588359241286775. eCollection 2024.
PMID: 39463748DERIVEDJohnston SRD, Rugo HS, Tolaney SM, Munoz Fernandez M, Wei R, Martin M. Abemaciclib plus endocrine therapy for HR+, HER2-, node-positive, high-risk early breast cancer: a plain language summary of the monarchE study. Future Oncol. 2024;20(28):2037-2048. doi: 10.1080/14796694.2024.2362095. Epub 2024 Jul 18.
PMID: 39023253DERIVEDRastogi P, O'Shaughnessy J, Martin M, Boyle F, Cortes J, Rugo HS, Goetz MP, Hamilton EP, Huang CS, Senkus E, Tryakin A, Cicin I, Testa L, Neven P, Huober J, Shao Z, Wei R, Andre V, Munoz M, San Antonio B, Shahir A, Harbeck N, Johnston S. Adjuvant Abemaciclib Plus Endocrine Therapy for Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative, High-Risk Early Breast Cancer: Results From a Preplanned monarchE Overall Survival Interim Analysis, Including 5-Year Efficacy Outcomes. J Clin Oncol. 2024 Mar 20;42(9):987-993. doi: 10.1200/JCO.23.01994. Epub 2024 Jan 9. Erratum In: J Clin Oncol. 2024 Jun 10;42(17):2111. doi: 10.1200/JCO.24.00711. J Clin Oncol. 2025 Jan;43(1):113. doi: 10.1200/JCO-24-02469.
PMID: 38194616DERIVEDGanfornina Andrades A, Fenix Caballero S, Salguero Olid A, Alegre Del-Rey Emilio J. Abemaciclib as adjuvant treatment for high-risk early breast cancer. Farm Hosp. 2024 Mar-Apr;48(2):75-78. doi: 10.1016/j.farma.2023.08.006. Epub 2023 Sep 19. English, Spanish.
PMID: 37735004DERIVEDJohnston SRD, Toi M, O'Shaughnessy J, Rastogi P, Campone M, Neven P, Huang CS, Huober J, Jaliffe GG, Cicin I, Tolaney SM, Goetz MP, Rugo HS, Senkus E, Testa L, Del Mastro L, Shimizu C, Wei R, Shahir A, Munoz M, San Antonio B, Andre V, Harbeck N, Martin M; monarchE Committee Members. Abemaciclib plus endocrine therapy for hormone receptor-positive, HER2-negative, node-positive, high-risk early breast cancer (monarchE): results from a preplanned interim analysis of a randomised, open-label, phase 3 trial. Lancet Oncol. 2023 Jan;24(1):77-90. doi: 10.1016/S1470-2045(22)00694-5. Epub 2022 Dec 6.
PMID: 36493792DERIVEDToi M, Boyle F, Im YH, Reinisch M, Molthrop D, Jiang Z, Wei R, Sapunar F, Grimes BR, Nabinger SC, Johnston SRD. Adjuvant Abemaciclib Combined with Endocrine Therapy: Efficacy Results in monarchE Cohort 1. Oncologist. 2023 Jan 18;28(1):e77-e81. doi: 10.1093/oncolo/oyac234.
PMID: 36342342DERIVEDMartin M, Hegg R, Kim SB, Schenker M, Grecea D, Garcia-Saenz JA, Papazisis K, Ouyang Q, Lacko A, Oksuzoglu B, Reeves J, Okera M, Testa L, Shimizu C, Denduluri N, Adamchuk H, Dakhil S, Wei R, Forrester T, Fernandez MM, Zimmermann A, Headley D, Johnston SRD. Treatment With Adjuvant Abemaciclib Plus Endocrine Therapy in Patients With High-risk Early Breast Cancer Who Received Neoadjuvant Chemotherapy: A Prespecified Analysis of the monarchE Randomized Clinical Trial. JAMA Oncol. 2022 Aug 1;8(8):1190-1194. doi: 10.1001/jamaoncol.2022.1488.
PMID: 35653145DERIVEDPerachino M, Poggio F, Arecco L, Blondeaux E, Spinaci S, Marrocco C, Levaggi A, Lambertini M. Update on Pregnancy Following Breast Cancer Diagnosis and Treatment. Cancer J. 2022 May-Jun 01;28(3):176-182. doi: 10.1097/PPO.0000000000000599.
PMID: 35594464DERIVEDPolewski MD, Nielsen GB, Gu Y, Weaver AT, Gegg G, Tabuena-Frolli S, Cajaiba M, Hanks D, Method M, Press MF, Gottstein C, Gruver AM. A Standardized Investigational Ki-67 Immunohistochemistry Assay Used to Assess High-Risk Early Breast Cancer Patients in the monarchE Phase 3 Clinical Study Identifies a Population With Greater Risk of Disease Recurrence When Treated With Endocrine Therapy Alone. Appl Immunohistochem Mol Morphol. 2022 Apr 1;30(4):237-245. doi: 10.1097/PAI.0000000000001009.
PMID: 35384873DERIVEDRugo HS, O'Shaughnessy J, Boyle F, Toi M, Broom R, Blancas I, Gumus M, Yamashita T, Im YH, Rastogi P, Zagouri F, Song C, Campone M, San Antonio B, Shahir A, Hulstijn M, Brown J, Zimmermann A, Wei R, Johnston SRD, Reinisch M, Tolaney SM; monarchE Committee Members. Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: safety and patient-reported outcomes from the monarchE study. Ann Oncol. 2022 Jun;33(6):616-627. doi: 10.1016/j.annonc.2022.03.006. Epub 2022 Mar 23.
PMID: 35337972DERIVEDRoyce M, Osgood C, Mulkey F, Bloomquist E, Pierce WF, Roy A, Kalavar S, Ghosh S, Philip R, Rizvi F, Mixter BD, Tang S, Pazdur R, Beaver JA, Amiri-Kordestani L. FDA Approval Summary: Abemaciclib With Endocrine Therapy for High-Risk Early Breast Cancer. J Clin Oncol. 2022 Apr 10;40(11):1155-1162. doi: 10.1200/JCO.21.02742. Epub 2022 Jan 27.
PMID: 35084948DERIVEDJohnston SRD, Harbeck N, Hegg R, Toi M, Martin M, Shao ZM, Zhang QY, Martinez Rodriguez JL, Campone M, Hamilton E, Sohn J, Guarneri V, Okada M, Boyle F, Neven P, Cortes J, Huober J, Wardley A, Tolaney SM, Cicin I, Smith IC, Frenzel M, Headley D, Wei R, San Antonio B, Hulstijn M, Cox J, O'Shaughnessy J, Rastogi P; monarchE Committee Members and Investigators. Abemaciclib Combined With Endocrine Therapy for the Adjuvant Treatment of HR+, HER2-, Node-Positive, High-Risk, Early Breast Cancer (monarchE). J Clin Oncol. 2020 Dec 1;38(34):3987-3998. doi: 10.1200/JCO.20.02514. Epub 2020 Sep 20.
PMID: 32954927DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Chief Medical Officer
- Organization
- Eli Lilly and Company
Study Officials
- STUDY DIRECTOR
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
Eli Lilly and Company
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- GT60
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
- Expanded Access
- Yes
Study Record Dates
First Submitted
May 15, 2017
First Posted
May 16, 2017
Study Start
July 12, 2017
Primary Completion
March 16, 2020
Study Completion (Estimated)
May 1, 2029
Last Updated
April 24, 2026
Results First Posted
April 9, 2021
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, CSR
- Time Frame
- Data are available 6 months after the primary publication and approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.
- Access Criteria
- A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.
Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.