Success Metrics

Clinical Success Rate
69.9%

Based on 51 completed trials

Completion Rate
70%(51/73)
Active Trials
102(53%)
Results Posted
108%(55 trials)
Terminated
22(11%)

Phase Distribution

Ph phase_3
21
11%
Ph phase_2
79
41%
Ph phase_4
5
3%
Ph phase_1
73
38%
Ph early_phase_1
5
3%
Ph not_applicable
1
1%

Phase Distribution

78

Early Stage

79

Mid Stage

26

Late Stage

Phase Distribution184 total trials
Early Phase 1First-in-human
5(2.7%)
Phase 1Safety & dosage
73(39.7%)
Phase 2Efficacy & side effects
79(42.9%)
Phase 3Large-scale testing
21(11.4%)
Phase 4Post-market surveillance
5(2.7%)
N/ANon-phased studies
1(0.5%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

63.7%

51 of 80 finished

Non-Completion Rate

36.3%

29 ended early

Currently Active

102

trials recruiting

Total Trials

193

all time

Status Distribution
Active(107)
Completed(51)
Terminated(29)
Other(6)

Detailed Status

Recruiting62
Completed51
Active, not recruiting40
Terminated22
Withdrawn7
unknown6

Development Timeline

Analytics

Development Status

Total Trials
193
Active
102
Success Rate
69.9%
Most Advanced
Phase 4

Trials by Phase

Early Phase 15 (2.7%)
Phase 173 (39.7%)
Phase 279 (42.9%)
Phase 321 (11.4%)
Phase 45 (2.7%)
N/A1 (0.5%)

Trials by Status

completed5126%
active_not_recruiting4021%
unknown63%
recruiting6232%
terminated2211%
enrolling_by_invitation11%
not_yet_recruiting42%
withdrawn74%

Recent Activity

Clinical Trials (193)

Showing 20 of 193 trialsScroll for more
NCT04616183Phase 1

LY3214996 and Cetuximab Alone or in Combination With Abemaciclib for the Treatment of Unresectable or Metastatic Colorectal Cancer

Active Not Recruiting
NCT05563220Phase 1

Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Participants With Metastatic Breast Cancer

Active Not Recruiting
NCT05372640Phase 1

Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

Recruiting
NCT06025747Phase 1

A Phase 1 Study of Neoadjuvant Abemaciclib in Combination With Radiation Therapy for Liposarcomas

Recruiting
NCT07209449Phase 2

A Study of Elacestrant Alone or in Combination With Abemaciclib in People With Endometrial Cancer

Recruiting
NCT04802759Phase 1

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

Recruiting
NCT02846987Phase 2

Study of Abemaciclib in Dedifferentiated Liposarcoma

Active Not Recruiting
NCT04931342Phase 2

A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors

Active Not Recruiting
NCT04750928Phase 1

Cyclin-Dependent Kinase (CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type I (NF1) Related Atypical Neurofibromas

Recruiting
NCT06570031Phase 1

ONO-4578-06:Phase I Study of ONO-4578 and Letrozole Plus CDK4 /6 Inhibitors in Breast Cancer

Completed
NCT06065748Phase 3

A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

Recruiting
NCT07174336Phase 3

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Recruiting
NCT05386108Phase 1

Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

Recruiting
NCT05768139Phase 1

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

Recruiting
NCT07492641Phase 3

BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

Recruiting
NCT02523014Phase 2

Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas

Recruiting
NCT03939897Phase 1

Testing the Addition of Copanlisib to Usual Treatment (Fulvestrant and Abemaciclib) in Metastatic Breast Cancer

Active Not Recruiting
NCT02693535Phase 2

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Recruiting
NCT06678269Phase 1

A Study of Abemaciclib and Radiation Therapy in People With Metastatic Breast Cancer

Recruiting
NCT05952557Phase 3

An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
193