Study of Olfaction / Vision Interactions in Expert and Novice Populations

NCT03058172 | Unknown

• 1 other identifier: 69HCL16_0685
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this research project is to better understand the reciprocal influence of visual and olfactory systems on cerebral activity evoked by odors and visual stimuli. Given the importance of olfacto-visual learning in expert situations, the degree of expertise in olfaction will also be considered. In addition, the investigators will try to better understand the differences between expert and non-expert populations in olfaction through different levels of approach: sensory, genetic and cerebral. To achieve this, the investigators will use psychophysical tests, genetic analyzes and a non-invasive technique, functional magnetic resonance imaging (fMRI) to measure the brain activity of human subjects - novices or experts in olfaction - in response to different visual and olfactory stimuli.

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

• Brain activity

  fMRI 3T scanner in CERMEP imaging center (Bron - see web link at the end of the document), allowing anatomical measures, connectivity between olfactory and other regions (DTI), activation pattern in olfactory and visual areas.

  During the 2-hour testing session (one session per participant)

Secondary Outcomes (4)

• Genotyping

  Sampling during the 2-hour testing session (one session per participant), analyses within 6 years after sampling

• Olfactory abilities

  During the 2-hour testing session (one session per participant)

• Perception

  During the 2-hour testing session (one session per participant)

• Response times

  During the 2-hour testing session (one session per participant)

Study Arms (2)

Odors (food and non-food)

OTHER

Odorants diluted in mineral oil.

Other: Odor presentation (for participants' perception)

Pictures (food and non-food)

OTHER

Pictures of objects or scenes.

Other: Image presentation (for participants' perception)

Interventions

Odor presentation (for participants' perception) OTHER

Several different odors will be diffused by an olfactometer under the participants' nostrils, though a controlled airflow, and synchronously with the participants' respiration. fMRI designs require repeated stimulus presentation. Odors will also be presented (in flasks or in odor pens) outside the scanner.

Odors (food and non-food)

Image presentation (for participants' perception) OTHER

Several different pictures will be displayed in front of the participants' face, though a through a mirror system in the scanner, or on a computer screen outside the scanner.

Pictures (food and non-food)

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• healthy volunteers
• men and women, aged 18-85 years old
• subjects with social security cover
• expertise in olfaction for half of the subjects (60)

You may not qualify if:

• subjects younger than 18 and older than 85
• subjects with contraindications to fMRI, i.e. with pacemaker / insulin pump / metal prosthesis / intracerebral clip / neurosensory stimulator / implantable defibrillator / cochlear implants / ferromagnetic ocular or cerebral foreign body close to the nerve structures / ventriculoperitoneal neurosurgical bypass valves / braces and other non-removable metallic dental device / claustrophobic, non-cooperating or agitated subjects.
• pregnant or breastfeeding women
• subjects with known olfactory disorder
• subjects with known neurological disorder

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Infirmerie Protestante

Caluire-et-Cuire, 69300, France

RECRUITING

Study Officials

• Frédéric FAURE, MD

  Infirmerie Protestante

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Frédéric FAURE, MD

CONTACT

04 26 29 40 53; famillefaure@bbox.fr

Moustafa BENSAFI, PhD

CONTACT

04 37 28 74 97; moustafa.bensafi@cnrs.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 8, 2017
• First Posted: February 20, 2017
• Study Start: April 15, 2016
• Primary Completion: March 15, 2022
• Study Completion: April 15, 2022
• Last Updated: July 21, 2021

Record last verified: 2021-07

Locations

FR (1)