Study Stopped
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Induction Study #1 of Oral Ozanimod as Induction Therapy for Moderately to Severely Active Crohn's Disease
Induction Study #1 - A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Oral Ozanimod as Induction Therapy for Moderately to Severely Active Crohn's Disease
3 other identifiers
interventional
625
34 countries
400
Brief Summary
This is a study to explore the effect of oral ozanimod as an induction treatment for participants with moderately to severely active Crohn's Disease.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Feb 2018
Longer than P75 for phase_3
400 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 14, 2018
CompletedFirst Posted
Study publicly available on registry
February 22, 2018
CompletedStudy Start
First participant enrolled
February 27, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2024
CompletedResults Posted
Study results publicly available
November 4, 2025
CompletedNovember 4, 2025
October 1, 2025
6.6 years
February 14, 2018
September 18, 2025
October 21, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Percent of Participants With a Crohn's Disease Activity Index (CDAI) Score < 150 at Week 12
Crohn's Disease Activity Index (CDAI) is a composite score used to measure the clinical activity of Crohn's disease. CDAI uses 8 variables: number of soft/liquid stools, severity of abdominal pain (0=none to 3=severe), general well-being (0=well to 4=terrible), presence of complications, need for antidiarrheal drugs, presence of abdominal mass, hematocrit, and change in body weight. Scores for stool number, abdominal pain, and well-being are summed over the 7 days before each visit. The other factors are also recorded and weighted to create a total CDAI score, which ranges from 0-600, with higher scores indicating worse disease (score 150-219 = mild, 220-450 = moderate, \>450 = severe). This measure reports the percentage of participants whose CDAI score was below 150 at 12 weeks.
At Week 12
Secondary Outcomes (11)
Percent of Participants With Average Daily Abdominal Pain Score ≤ 1 Point, and Average Daily Stool Frequency Score ≤ 3 Points With Abdominal Pain and Stool Frequency no Worse Than Baseline at Week 12
At Week 12
Percent of Participants With a Simple Endoscopic Score for Crohn's Disease (SES-CD) Score Decrease From Baseline of ≥ 50% at Week 12
At Week 12
Percent of Participants With Crohn's Disease Activity Index (CDAI) Reduction From Baseline of ≥ 100 Points or CDAI Score < 150 at Week 12
At Week 12
Percent of Participants With Crohn's Disease Activity Index (CDAI) Reduction From Baseline of ≥ 100 Points or CDAI Score < 150 and Simple Endoscopic Score for Crohn's Disease (SES-CD) Decrease From Baseline of ≥ 50% at Week 12
At Week 12
Percent of Participants With Crohn's Disease Activity Index (CDAI) Score < 150 at Week 12 and Simple Endoscopic Score for Crohn's Disease (SES-CD) Decrease From Baseline of ≥ 50% at Week 12
At Week 12
- +6 more secondary outcomes
Study Arms (2)
Administration of oral Ozanimod
EXPERIMENTALAdministration of Placebo
PLACEBO COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- Crohn's disease for ≥ 3 months on endoscopy and on histological exam
- Inadequate response or loss of response to corticosteroids, immunomodulators, and/or biologic therapies
- Crohn's Disease Activity Index (CDAI) score ≥ 220 and ≤ 450
- An average daily stool frequency ≥ 4 points and/or an abdominal pain of ≥ 2 points
- Has Simple Endoscopic Score for Crohn's Disease (SES-CD) score of ≥ 6 (or SES-CD ≥ 4 in participants with isolated ileal disease)
You may not qualify if:
- Has a diagnosis of ulcerative colitis, indeterminate colitis, radiation colitis, or ischemic colitis, or has strictures with prestenotic dilatation requiring procedural intervention
- Has extensive small bowel resection (\>100cm) or known diagnosis of short bowel syndrome, or requires total parenteral nutrition
- Current stoma, ileal-anal pouch anastomosis, or fistula
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Celgenelead
Study Sites (408)
Holland Center for Family Health
Peoria, Arizona, 85381, United States
Local Institution - 026
North Little Rock, Arkansas, 72117, United States
Local Institution - 284
Camarillo, California, 93012, United States
Local Institution - 165
Chula Vista, California, 91911, United States
Local Institution - 039
Garden Grove, California, 92843, United States
San Diego Clinical Trials
La Mesa, California, 91942, United States
Local Institution - 061
Los Angeles, California, 90027, United States
Local Institution - 110
Los Angeles, California, 90067, United States
Local Institution - 140
Mission Viejo, California, 92691, United States
Alliance Clinical Research
Oceanside, California, 92056, United States
Local Institution - 027
Orange, California, 92868, United States
Palo Alto Center-Palo Alto Medical Foundation Research Institute
Palo Alto, California, 94304, United States
Local Institution - 006
Rialto, California, 92377, United States
Local Institution - 003
San Diego, California, 92123, United States
Local Institution - 297
Lakewood, Colorado, 80228, United States
Local Institution - 225
Bristol, Connecticut, 06010, United States
Local Institution - 091
New Haven, Connecticut, 06510, United States
Local Institution - 062
Clearwater, Florida, 33756-3839, United States
Local Institution - 218
Gainesville, Florida, 32608, United States
Local Institution - 203
Hialeah, Florida, 33010, United States
Harmony Medical Research Institute
Hialeah, Florida, 33016, United States
Local Institution - 078
Hialeah, Florida, 33016, United States
Local Institution - 179
Hollywood, Florida, 33021, United States
Local Institution - 101
Homestead, Florida, 33033, United States
Local Institution - 016
Largo, Florida, 33777, United States
Local Institution - 199
Miami, Florida, 33125, United States
LCC Medical Research Institute, LLC
Miami, Florida, 33126, United States
Local Institution - 169
Miami, Florida, 33156, United States
Local Institution - 090
Naples, Florida, 34109, United States
Local Institution - 214
New Smyrna Beach, Florida, 32168, United States
Local Institution - 076
Orlando, Florida, 32819, United States
Local Institution - 098
Port Orange, Florida, 32127, United States
Local Institution - 226
Tampa, Florida, 33612, United States
Local Institution - 149
Tampa, Florida, 33614, United States
Local Institution - 114
Weeki Wachee, Florida, 34607, United States
Local Institution - 205
Atlanta, Georgia, 30308, United States
Local Institution - 222
Atlanta, Georgia, 30322, United States
Local Institution - 019
Atlanta, Georgia, 30342, United States
Local Institution - 063
Atlanta, Georgia, 30342, United States
Local Institution - 074
Columbus, Georgia, 31904, United States
Local Institution - 028
Macon, Georgia, 31201, United States
Local Institution - 194
Chicago, Illinois, 60612, United States
Local Institution - 036
Chicago, Illinois, 60622, United States
Local Institution - 146
Urbana, Illinois, 61801, United States
Iowa Digestive Disease Center
Clive, Iowa, 50325, United States
Local Institution - 155
Lexington, Kentucky, 40536-0298, United States
CroNOLA LLC
Houma, Louisiana, 70360, United States
Local Institution - 053
Lake Charles, Louisiana, 70601, United States
Local Institution - 104
New Orleans, Louisiana, 70125, United States
Local Institution - 278
Baltimore, Maryland, 21224, United States
Local Institution - 129
Catonsville, Maryland, 21228, United States
Local Institution - 282
Glen Burnie, Maryland, 21061, United States
Local Institution - 142
Chestnut Hill, Massachusetts, 02467, United States
Local Institution - 228
North Worcester, Massachusetts, 01655, United States
Local Institution - 286
Springfield, Massachusetts, 01199, United States
Local Institution - 191
Caro, Michigan, 48723, United States
Local Institution - 108
Southfield, Michigan, 48034, United States
Local Institution - 301
Wyoming, Michigan, 49519, United States
Local Institution - 300
Ypsilanti, Michigan, 48197, United States
Local Institution - 274
Jackson, Mississippi, 39216, United States
Local Institution - 029
St Louis, Missouri, 63110, United States
Local Institution - 215
Englewood, New Jersey, 07631, United States
Local Institution - 144
Brooklyn, New York, 11235, United States
Local Institution - 009
Great Neck, New York, 11021, United States
Local Institution - 105
New York, New York, 10021, United States
Local Institution - 043
New York, New York, 10075, United States
Local Institution - 094
Orchard Park, New York, 14127, United States
Advantage Clinical Trials
The Bronx, New York, 10468, United States
Local Institution - 017
Asheville, North Carolina, 28801, United States
Local Institution - 152
Charlotte, North Carolina, 28204, United States
Local Institution - 055
Charlotte, North Carolina, 28207, United States
Local Institution - 133
Greenville, North Carolina, 27834, United States
Local Institution - 302
Raleigh, North Carolina, 27612, United States
Local Institution - 210
Beachwood, Ohio, 44122, United States
Local Institution - 291
Cincinnati, Ohio, 45219, United States
Local Institution - 018
Cleveland, Ohio, 44195, United States
Local Institution - 177
Mentor, Ohio, 44060, United States
Local Institution - 211
Warren, Ohio, 44483, United States
Local Institution - 208
Oklahoma City, Oklahoma, 73104, United States
Local Institution - 131
Oklahoma City, Oklahoma, 73112, United States
Local Institution - 113
Portland, Oregon, 97239, United States
Local Institution - 197
Hershey, Pennsylvania, 17033, United States
Penn State University Milton S Hershey Medical Center
State College, Pennsylvania, 16803, United States
Local Institution - 253
Providence, Rhode Island, 02904, United States
Local Institution - 289
Charleston, South Carolina, 29425, United States
Local Institution - 121
Nashville, Tennessee, 37211, United States
Vanderbilt University Medical Center
Nashville, Tennessee, 37212, United States
Advanced Gastroenterology
Union City, Tennessee, 38261, United States
Local Institution - 158
Austin, Texas, 78742, United States
Local Institution - 056
Houston, Texas, 77030, United States
Local Institution - 150
Houston, Texas, 77030, United States
Local Institution - 102
Houston, Texas, 77043, United States
Local Institution - 082
Houston, Texas, 77070, United States
Local Institution - 303
Houston, Texas, 77074, United States
Local Institution - 088
Houston, Texas, 77084, United States
Local Institution - 085
San Antonio, Texas, 78215, United States
Local Institution - 223
San Antonio, Texas, 78229, United States
Local Institution - 007
Southlake, Texas, 76092, United States
Local Institution - 073
Tyler, Texas, 75701, United States
Local Institution - 025
Salt Lake City, Utah, 84132, United States
Local Institution - 189
Gainesville, Virginia, 20155, United States
Local Institution - 298
Manassas, Virginia, 20110, United States
Local Institution - 139
Petersburg, Virginia, 23805, United States
Virginia Gastroenterology Institute PC
Suffolk, Virginia, 23434, United States
Local Institution - 296
Williamsburg, Virginia, 23188, United States
Local Institution - 125
Spokane, Washington, 99204, United States
Aurora Health Care Aurora Research
Grafton, Wisconsin, 53024, United States
Local Institution - 501
Buenos Aires, 0, Argentina
Local Institution - 494
Buenos Aires, 1180, Argentina
Local Institution - 571
Buenos Aires, 1702, Argentina
Local Institution - 500
Buenos Aires, B1878, Argentina
Local Institution - 570
CĂ³rdoba, X5003DCE, Argentina
Local Institution - 495
CĂ³rdoba, X5016, Argentina
Local Institution - 569
Mar del Plata, B7600, Argentina
Local Institution - 496
Rosario, 2000, Argentina
Local Institution - 497
Rosario, 2000, Argentina
Local Institution - 502
Rosario, Santa Fe, S2002, Argentina
Local Institution - 492
San Miguel de TucumĂ¡n, 4000, Argentina
Local Institution - 310
Concord, New South Wales, 2139, Australia
Local Institution - 319
Kingswood, New South Wales, 2747, Australia
Local Institution - 323
Wollongong, New South Wales, 2500, Australia
Local Institution - 707
Maroochydore, Queensland, 4558, Australia
Local Institution - 311
Woolloongabba, Queensland, 4102, Australia
Local Institution - 308
Adelaide, South Australia, 5000, Australia
Local Institution - 708
Adelaide, South Australia, 5112, Australia
Local Institution - 320
Woodville South, South Australia, 5011, Australia
Local Institution - 709
Melbourne, Victoria, 3004, Australia
Local Institution - 316
Murdoch, Western Australia, 6150, Australia
Local Institution - 325
Bankstown, 2200, Australia
Local Institution - 330
Box Hill, 3128, Australia
Local Institution - 324
Sydney, NSW, NSW 2050, Australia
Local Institution - 745
Grodno, 230026, Belarus
Local Institution - 737
Vitebsk, 210604, Belarus
Local Institution - 943
Brasschaat, Antwerpen, 2930, Belgium
Local Institution - 940
Brussels, 1090, Belgium
Local Institution - 939
Edegem, 2650, Belgium
Local Institution - 937
Ghent, 9000, Belgium
Local Institution - 942
Leuven, 3000, Belgium
Local Institution - 936
Liège, 4000, Belgium
Local Institution - 938
Seraing, 4100, Belgium
Local Institution - 941
Tournai, 7500, Belgium
Local Institution - 743
Banja Luka, 78000, Bosnia and Herzegovina
Local Institution - 741
Mostar, 88000, Bosnia and Herzegovina
Local Institution - 738
Sarajevo, 71000, Bosnia and Herzegovina
Local Institution - 742
Sarajevo, 71000, Bosnia and Herzegovina
Local Institution - 456
Blagoevgrad, 2700, Bulgaria
Local Institution - 746
Plovdiv, 4002, Bulgaria
Local Institution - 747
Sofia, 1202, Bulgaria
Local Institution - 627
Sofia, 1527, Bulgaria
Local Institution - 749
Sofia, 1606, Bulgaria
Local Institution - 748
Sofia, 1784, Bulgaria
Local Institution - 553
Stara Zagora, 6000, Bulgaria
Local Institution - 754
Varna, 9002, Bulgaria
Local Institution - 273
Calgary, Alberta, T2N 4Z6, Canada
Local Institution - 227
Edmonton, Alberta, T5R 1W2, Canada
Local Institution - 263
Kelowna, British Columbia, V1Y 1Z9, Canada
Local Institution - 255
Vancouver, British Columbia, V5Z1M9, Canada
Local Institution - 261
Winnipeg, Manitoba, R3CON2, Canada
Local Institution - 268
Bridgewater, Nova Scotia, B4V 3N2, Canada
Local Institution - 252
London, Ontario, N6A 5A5, Canada
Local Institution - 251
London, Ontario, N6A 5W9, Canada
Local Institution - 275
Toronto, Ontario, M5G 1X8, Canada
Local Institution - 271
Vaughan, Ontario, L4L 4Y7, Canada
Local Institution - 389
ConcepciĂ³n, 4070038, Chile
Local Institution - 392
Santiago, 7500010, Chile
Local Institution - 387
Santiago, 7500571, Chile
Local Institution - 391
Santiago, 7550000, Chile
Local Institution - 390
Santiago, 8320000, Chile
Local Institution - 453
Koprivnica, 48000, Croatia
Local Institution - 763
Osijek, 31000, Croatia
Local Institution - 764
Rijeka, 51000, Croatia
Local Institution - 765
Split, HR-21000, Croatia
Local Institution - 452
Zagreb, 10000, Croatia
Local Institution - 761
Zagreb, 10000, Croatia
Local Institution - 762
Zagreb, 10000, Croatia
Local Institution - 766
Zagreb, 10000, Croatia
Local Institution - 767
Brno, 615 00, Czechia
Local Institution - 772
Brno, 656 91, Czechia
Local Institution - 773
Hradec KrĂ¡lovĂ©, 500 12, Czechia
Local Institution - 775
Most, 43401, Czechia
Local Institution - 771
Olomouc, 77900, Czechia
Local Institution - 774
Pardubice, 532 03, Czechia
Local Institution - 769
Pilsen, 30460, Czechia
Local Institution - 573
Prague, 120 00, Czechia
Local Institution - 368
Prague, 14000, Czechia
Local Institution - 776
Prague, 14021, Czechia
Local Institution - 768
Prague, 150 06, Czechia
Local Institution - 770
Prague, 190 00, Czechia
Local Institution - 611
Copenhagen, 2400, Denmark
Local Institution - 610
Holbæk, 4300, Denmark
Local Institution - 609
Nykøbing Falster, 4800, Denmark
Local Institution - 614
Turku, FI-20521, Finland
Local Institution - 638
Amiens, 80054, France
Local Institution - 711
Créteil, 94010, France
Local Institution - 616
Dijon, 21079, France
Local Institution - 615
Grenoble, 38700, France
Local Institution - 633
Lillie Cedex, 59037, France
Local Institution - 646
Marseille, 13915, France
Local Institution - 507
Montpellier, 34295, France
Local Institution - 641
Rennes, 35033, France
Local Institution - 612
Rouen, 76031, France
Local Institution - 643
Toulouse, 31059, France
Local Institution - 248
Tbilisi, 0101, Georgia
Local Institution - 247
Tbilisi, 0112, Georgia
Local Institution - 249
Tbilisi, 0180, Georgia
Local Institution - 626
Berlin, 10117, Germany
Local Institution - 665
Berlin, 10825, Germany
Local Institution - 650
Berlin, 14050, Germany
Local Institution - 662
Frankfurt, 60431, Germany
Local Institution - 654
Frankfurt, 60594, Germany
Local Institution - 659
Hamburg, 20246, Germany
Local Institution - 651
Leipzig, 04103, Germany
Local Institution - 655
Ludwigshafen am Rhein, 67067, Germany
Local Institution - 730
Ludwigshafen am Rhein, 67067, Germany
Local Institution - 661
Stuttgart, 70376, Germany
Local Institution - 666
TĂ¼bingen, 72076, Germany
Local Institution - 663
Ulm, 89081, Germany
Local Institution - 444
Hyderabad, Andhra Pradesh, 500084, India
Local Institution - 407
Surat, Gujarat, 395002, India
Local Institution - 332
Gurgaon, Haryana, 122002, India
Local Institution - 445
Kochi, Kerala, 682041, India
Local Institution - 446
Ludhiana, Punjab, 141001, India
Local Institution - 443
Jaipur, Rajasthan, 302004, India
Local Institution - 399
Jaipur, Rajasthan, 302006, India
Local Institution - 408
Coimbatore, Tamil Nadu, 641044, India
Local Institution - 331
Hyderabad, Telangana, 500032, India
Local Institution - 457
Delhi, 110002, India
Local Institution - 411
New Delhi, 110029, India
Local Institution - 975
Dublin, Dublin, DO4 T6F4, Ireland
Local Institution - 973
Dublin, D09 V2N0, Ireland
Local Institution - 345
Bat Yam, 5962025, Israel
Local Institution - 339
Jerusalem, 91031, Israel
Local Institution - 344
Nahariya, 22100, Israel
Local Institution - 342
Ramat Gan, 52621, Israel
Local Institution - 338
Rehovot, 76100, Israel
Local Institution - 677
Bologna, 40138, Italy
Local Institution - 684
Brescia, 25123, Italy
Local Institution - 688
Brescia, 25124, Italy
Local Institution - 689
Castellana Grotte, 70013, Italy
Local Institution - 679
Catanzaro, 88100, Italy
Local Institution - 687
Chieti, 66100, Italy
Local Institution - 674
Messina, 98125, Italy
Local Institution - 672
Milan, 20089, Italy
Local Institution - 686
Milan, 20122, Italy
Local Institution - 334
Milan, 20132, Italy
Local Institution - 678
Monza, 20900, Italy
Local Institution - 685
Padua, 35128, Italy
Local Institution - 682
Palermo, 90146, Italy
Local Institution - 673
Pavia, 27100, Italy
Local Institution - 681
Roma, 00133, Italy
Local Institution - 675
Roma, 00168, Italy
Local Institution - 671
Rome, 00152, Italy
Local Institution - 680
Udine, 33100, Italy
Local Institution - 670
Varese, 21100, Italy
Local Institution - 676
Verona, 37024, Italy
Local Institution - 602
Riga, LV-1002, Latvia
Local Institution - 601
Riga, LV-1006, Latvia
Local Institution - 600
Riga, LV-1038, Latvia
Local Institution - 526
Zapapan, Jalisco, 45030, Mexico
Local Institution - 532
Monterrey, Nuevo LeĂ³n, 64610, Mexico
Local Institution - 525
Monterrey, Nuevo LeĂ³n, 64718, Mexico
Local Institution - 447
Monterrey, Nuevo LeĂ³n, C.P 64000, Mexico
Local Institution - 449
Monterrey, Nuevo LeĂ³n, C.P 64060, Mexico
Local Institution - 529
Querétaro City, Querétaro, 76070, Mexico
Local Institution - 528
Chihuahua City, 31020, Mexico
Local Institution - 448
Mexico City, 6700, Mexico
Local Institution - 527
MĂ©xico, 07020, Mexico
Local Institution - 530
Tlalpan, 14080, Mexico
Local Institution - 811
Chisinau, MD-2068, Moldova
Local Institution - 810
Chisinau, MD2005, Moldova
Local Institution - 809
Chisinau, MD2025, Moldova
Local Institution - 812
Chisinau, MD2025, Moldova
Local Institution - 813
Chisinau, MD2025, Moldova
Local Institution - 403
Zamość, Lublin Voivodeship, 22-400, Poland
Local Institution - 597
Zamość, Lublin Voivodeship, 22-400, Poland
Local Institution - 820
Bialystok, 15-276, Poland
Local Institution - 818
Bochnia, 32-700, Poland
Local Institution - 238
Katowice, 40-040, Poland
Local Institution - 828
Katowice, 40-660, Poland
Local Institution - 819
Katowice, 40-752, Poland
Local Institution - 815
Krakow, 30-363, Poland
Local Institution - 823
Krakow, 31-156, Poland
Local Institution - 826
Krakow, 31-501, Poland
Local Institution - 817
KÅ‚odzko, 57-300, Poland
Local Institution - 829
Lodz, 90-302, Poland
Local Institution - 888
Lodz, 91-839, Poland
Local Institution - 760
Lublin, 20-049, Poland
Local Institution - 830
Olsztyn, 10-561, Poland
Local Institution - 402
Opole, 45-819, Poland
Local Institution - 400
Oświęcim, 32-600, Poland
Local Institution - 758
Poznan, 60-529, Poland
Local Institution - 575
Poznan, 60-702, Poland
Local Institution - 401
Poznan, 61-293, Poland
Local Institution - 239
Sopot, 81756, Poland
Local Institution - 235
Szczecin, 71434, Poland
Local Institution - 822
Torun, 87-100, Poland
Local Institution - 824
Tychy, 43-100, Poland
Local Institution - 827
Ul. Piotrkowska 177, 90-447, Poland
Local Institution - 410
Warsaw, 00-189, Poland
Local Institution - 576
Warsaw, 01-192, Poland
Local Institution - 825
Warsaw, 03-580, Poland
Local Institution - 236
Warsaw, 04-501, Poland
Local Institution - 808
Bucharest, 010719, Romania
Local Institution - 836
Bucharest, 010719, Romania
Local Institution - 499
Bucharest, 013823, Romania
Local Institution - 795
Bucharest, 021494, Romania
Local Institution - 837
Bucharest, 022328, Romania
Local Institution - 839
Bucharest, 050098, Romania
Local Institution - 842
Bucharest, 10825, Romania
Local Institution - 838
Cluj-Napoca, 400001, Romania
Local Institution - 843
Craiova, 200642, Romania
Local Institution - 840
TĂ¢rgu MureÅŸ, 540136, Romania
Local Institution - 598
Chita, 672090, Russia
Local Institution - 848
Irkutsk, 664049, Russia
Local Institution - 892
Kazan', 420103, Russia
Local Institution - 599
Khanty-Mansiysk, 628012, Russia
Local Institution - 927
Krasnoyarsk, 660037, Russia
Local Institution - 851
Moscow, 111123, Russia
Local Institution - 594
Novosibirsk, 630007, Russia
Local Institution - 858
Petrozavodsk, 185019, Russia
Local Institution - 859
Pushkin, 196603, Russia
Local Institution - 960
Pyatigorsk, 357502, Russia
Local Institution - 846
Pyatigorsk, 357538, Russia
Local Institution - 883
Rostov-on-Don, 344022, Russia
Local Institution - 862
Saint Petersburg, 194044, Russia
Local Institution - 847
Saint Petersburg, 194354, Russia
Local Institution - 857
Saint Petersburg, 195009, Russia
Local Institution - 845
Saint Petersburg, 195067, Russia
Local Institution - 856
Saint Petersburg, 195257, Russia
Local Institution - 844
Samara, 443041, Russia
Local Institution - 806
Tula, 300053, Russia
Local Institution - 861
Ufa, 450071, Russia
Local Institution - 855
Veliky Novgorod, 173008, Russia
Local Institution - 935
Vladimir, 600023, Russia
Local Institution - 999
Vladivostok, 690091, Russia
Local Institution - 986
Vladivostok, 690922, Russia
Local Institution - 534
Dammam, 32253, Saudi Arabia
Local Institution - 537
Jeddah, 22252, Saudi Arabia
Local Institution - 536
Riyadh, 12746, Saudi Arabia
Local Institution - 535
Riyadh, 14611, Saudi Arabia
Local Institution - 241
Belgrade, 11 000, Serbia
Local Institution - 245
Belgrade, 11 080, Serbia
Local Institution - 246
Belgrade, 11000, Serbia
Local Institution - 437
Ansan, 152-703, South Korea
Local Institution - 441
Busan, 49201, South Korea
Local Institution - 435
Guri-si, 11923, South Korea
Local Institution - 436
Seongnam-si, 13620, South Korea
Local Institution - 433
Seoul, 06351, South Korea
Local Institution - 440
Seoul, 06591, South Korea
Local Institution - 430
Seoul, 120-752, South Korea
Local Institution - 442
Seoul, 138-736, South Korea
Local Institution - 427
Seoul, 3181, South Korea
Local Institution - 439
Seoul, 7985, South Korea
Local Institution - 703
Alicante, 03010, Spain
Local Institution - 690
Badalona, 08916, Spain
Local Institution - 691
Madrid, 28006, Spain
Local Institution - 692
Madrid, 28046, Spain
Local Institution - 698
San CristĂ³bal de La Laguna, 38320, Spain
Local Institution - 696
Seville, 41009, Spain
Local Institution - 705
Seville, 41013, Spain
Local Institution - 700
Viladecans, 08840, Spain
Local Institution - 967
Bern, 3001, Switzerland
Local Institution - 968
Sankt Gallen, 9007, Switzerland
Local Institution - 969
Zurich, 8091, Switzerland
Local Institution - 363
Kozlu, 67000, Taiwan
Local Institution - 356
Ankara, 06590, Turkey (TĂ¼rkiye)
Local Institution - 360
Bursa, 16059, Turkey (TĂ¼rkiye)
Local Institution - 362
Istanbul, 34093, Turkey (TĂ¼rkiye)
Local Institution - 355
Istanbul, 34840, Turkey (TĂ¼rkiye)
Local Institution - 354
Izmit/Kocaeli, 41380, Turkey (TĂ¼rkiye)
Local Institution - 359
Trabzon, 61080, Turkey (TĂ¼rkiye)
Local Institution - 914
Chernivtsi, 58001, Ukraine
Local Institution - 950
Dnipropetrovsk, 49074, Ukraine
Local Institution - 229
Ivano-Frankivsk, 76008, Ukraine
Local Institution - 912
Ivano-Frankivsk, 76018, Ukraine
Local Institution - 919
Kharkiv, 61018, Ukraine
Local Institution - 901
Kyiv, 01030, Ukraine
Local Institution - 915
Kyiv, 02000, Ukraine
Local Institution - 243
Kyiv, 02002, Ukraine
Local Institution - 911
Kyiv, 02175, Ukraine
Local Institution - 244
Kyiv, 03037, Ukraine
Local Institution - 918
Kyiv, 04053, Ukraine
Local Institution - 908
Kyiv, 04107, Ukraine
Local Institution - 562
Kyiv, 4210, Ukraine
Local Institution - 240
Lutsk, 43005, Ukraine
Local Institution - 234
Lviv, 79010, Ukraine
Local Institution - 910
Lviv, 79059, Ukraine
Local Institution - 242
Odesa, 65025, Ukraine
Local Institution - 905
Poltava, 36011, Ukraine
Local Institution - 934
Ternopil, 46008, Ukraine
Local Institution - 909
Vinnytsia, 02029, Ukraine
Local Institution - 224
Vinnytsia, 21018, Ukraine
Local Institution - 971
Vinnytsia, 21018, Ukraine
Local Institution - 723
Southampton, Hampshire, SO16 6YD, United Kingdom
Local Institution - 729
London, LND, NW1 2BU, United Kingdom
Local Institution - 557
Birmingham, B15 2SQ, United Kingdom
Local Institution - 714
Bristol, BS2 8HW, United Kingdom
Local Institution - 560
Cardiff, CF15 9SS, United Kingdom
Local Institution - 558
Chorley, PR7 7NA, United Kingdom
Local Institution - 559
Corbridge Road, NE46 1QJ, United Kingdom
Local Institution - 712
Dundonald, BT16 1RH, United Kingdom
Local Institution - 713
Glasgow, G51 4TF, United Kingdom
Local Institution - 716
Lancashire Blackpool, FY3 8NR, United Kingdom
Local Institution - 722
London, E1 1BB, United Kingdom
Local Institution - 715
London, SE1 9RT, United Kingdom
Local Institution - 561
North Manchester Science Park, M15 6SX, United Kingdom
Local Institution - 593
Shrewsbury, SY38XQ, United Kingdom
Local Institution - 718
Torquay, TQ2 7AA, United Kingdom
Related Publications (1)
Feagan BG, Schreiber S, Afzali A, Rieder F, Hyams J, Kollengode K, Pearlman J, Son V, Marta C, Wolf DC, D'Haens GG. Ozanimod as a novel oral small molecule therapy for the treatment of Crohn's disease: The YELLOWSTONE clinical trial program. Contemp Clin Trials. 2022 Nov;122:106958. doi: 10.1016/j.cct.2022.106958. Epub 2022 Oct 5.
PMID: 36208720DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Bristol-Myers Squibb Study Director
- Organization
- Bristol-Myers Squibb
Study Officials
- STUDY DIRECTOR
Bristol-Myers Squibb
Bristol-Myers Squibb
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 14, 2018
First Posted
February 22, 2018
Study Start
February 27, 2018
Primary Completion
October 1, 2024
Study Completion
October 1, 2024
Last Updated
November 4, 2025
Results First Posted
November 4, 2025
Record last verified: 2025-10