NCT03440385

Brief Summary

This is a study to explore the effect of oral ozanimod as an induction treatment for participants with moderately to severely active Crohn's Disease.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
606

participants targeted

Target at P75+ for phase_3

Timeline
Completed

Started Mar 2018

Longer than P75 for phase_3

Geographic Reach
27 countries

344 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 14, 2018

Completed
8 days until next milestone

First Posted

Study publicly available on registry

February 22, 2018

Completed
13 days until next milestone

Study Start

First participant enrolled

March 7, 2018

Completed
5.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 21, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 21, 2023

Completed
1 year until next milestone

Results Posted

Study results publicly available

December 5, 2024

Completed
Last Updated

December 5, 2024

Status Verified

November 1, 2024

Enrollment Period

5.7 years

First QC Date

February 14, 2018

Results QC Date

November 11, 2024

Last Update Submit

November 11, 2024

Conditions

Keywords

Crohn's DiseaseCrohn DiseaseOralOzanimodModerately activeSeverely activeRPC01RPC01-3202

Outcome Measures

Primary Outcomes (1)

  • Percentage of Participants With Crohn's Disease Activity Index (CDAI) Score < 150

    The CDAI is a composite score that is used to measure the clinical activity of Crohn's disease (CD). The CDAI uses a questionnaire with 8 disease activity variables: number of soft/liquid stools, severity of abdominal pain, general well-being, presence of complications, need for antidiarrheal drugs, presence of an abdominal mass, hematocrit, and deviation in body weight. The sub scores of number of soft/liquid stool, severity of abdominal pain (0 \[none\] to 3 \[Severe\]), general well-being (0 \[well\] to 4 \[terrible\] were summed over the 7 days prior to each visit. Additionally, the remaining predictors were also noted and weighted to create the total CDAI score which ranged from 0-600 with a higher score indicating a worse outcome.

    Week 12

Secondary Outcomes (12)

  • Percentage of Participants With Abdominal Pain and Stool Frequency Clinical Remission

    Week 12

  • Percentage of Participants With a Simple Endoscopic Score for Crohn's Disease (SES-CD) Score Decrease From Baseline of ≥ 50%

    Week 12

  • Percentage of Participants With Reduction From Baseline in the Crohn's Disease Activity Index (CDAI) Score of >= 100 Points or a Total CDAI Score < 150

    Week 12

  • Percentage of Participants With Crohn's Disease Activity Index (CDAI) Score Reduction From Baseline of ≥ 100 Points or CDAI Score < 150 and SES-CD Decrease From Baseline of ≥ 50%

    Week 12

  • Percentage of Participants With Crohn's Disease Activity Index (CDAI) Score < 150 and Simple Endoscopic Score for Crohn's Disease (SES-CD) Score Decrease From Baseline of ≥ 50%

    Week 12

  • +7 more secondary outcomes

Study Arms (2)

Administration of oral Ozanimod

EXPERIMENTAL
Drug: Ozanimod

Administration of Placebo

PLACEBO COMPARATOR
Other: Placebo

Interventions

Specified dose on specified days

Administration of oral Ozanimod
PlaceboOTHER

Specified dose on specified days

Administration of Placebo

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Crohn's disease for ≥ 3 months on endoscopy and on histological exam
  • Inadequate response or loss of response to corticosteroids, immunomodulators, and/or biologic therapy
  • Crohn's Disease Activity Index (CDAI) score ≥ 220 and ≤ 450
  • Average daily stool frequency ≥ 4 points and/or an abdominal pain of ≥ 2 points
  • Simple Endoscopic Score for Crohn's Disease (SES-CD) score of ≥ 6 (or SES-CD ≥ 4 in participants with isolated ileal disease)

You may not qualify if:

  • Diagnosis of ulcerative colitis, indeterminate colitis, radiation colitis, or ischemic colitis, or has strictures with prestenotic dilatation requiring procedural intervention
  • Extensive small bowel resection (\>100cm) or known diagnosis of short bowel syndrome, or requires total parenteral nutrition
  • Current stoma, ileal-anal pouch anastomosis, or fistula

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (368)

Local Institution - 202

Scottsdale, Arizona, 85258, United States

Location

Ucsd Medical Center

La Jolla, California, 92037, United States

Location

Local Institution - 010

Lancaster, California, 93534, United States

Location

Southern California Research Institute Medical Group, Inc.

Los Angeles, California, 90045, United States

Location

Matrix Clinical Research Inc

Los Angeles, California, 90048, United States

Location

Facey Medical Foundation (Parent)

Mission Hills, California, 91345, United States

Location

Local Institution - 093

Pasadena, California, 91105, United States

Location

Sutter Medical Group

Roseville, California, 95661, United States

Location

Local Institution - 280

Sacramento, California, 95817, United States

Location

Local Institution - 281

San Francisco, California, 94158, United States

Location

Local Institution - 124

West Covina, California, 91790, United States

Location

Local Institution - 065

Colorado Springs, Colorado, 80907, United States

Location

Local Institution - 182

Bristol, Connecticut, 06010, United States

Location

Local Institution - 166

Clearwater, Florida, 33765, United States

Location

Local Institution - 084

Clermont, Florida, 34711, United States

Location

American Research Institute Inc

Cutler Bay, Florida, 33157, United States

Location

Local Institution - 112

Doral, Florida, 33166, United States

Location

Riverside Clinical Research

Edgewater, Florida, 32132, United States

Location

SIH Research

Kissimmee, Florida, 34759, United States

Location

Local Institution - 067

Lighthouse PT, Florida, 33064, United States

Location

Center For Advanced Gastroenterology

Maitland, Florida, 32751, United States

Location

LMG Research

Miami, Florida, 33125, United States

Location

Local Institution - 175

Miami, Florida, 33166, United States

Location

Local Institution - 081

Miami, Florida, 33176, United States

Location

Local Institution - 044

Miami Springs, Florida, 33166, United States

Location

Local Institution - 192

New Port Richey, Florida, 34655, United States

Location

Local Institution - 200

Orlando, Florida, 32810, United States

Location

Local Institution - 002

Palmetto Bay, Florida, 33157, United States

Location

Theia Clinical Research, LLC

Pinellas Park, Florida, 33781, United States

Location

Precision Clinical Research, LLC.

Sunrise, Florida, 33351, United States

Location

Local Institution - 183

Tampa, Florida, 33612-4799, United States

Location

Apex Clinical Research

Tampa, Florida, 33612, United States

Location

Local Institution - 107

Tampa, Florida, 33614, United States

Location

Local Institution - 037

Atlanta, Georgia, 30322, United States

Location

Local Institution - 220

Atlanta, Georgia, 30322, United States

Location

Local Institution - 143

Decatur, Georgia, 30030, United States

Location

Local Institution - 115

Idaho Falls, Idaho, 83404, United States

Location

Local Institution - 022

Chicago, Illinois, 60637, United States

Location

Local Institution - 092

Evansville, Indiana, 47714, United States

Location

Local Institution - 033

Indianapolis, Indiana, 46202, United States

Location

Local Institution - 070

Topeka, Kansas, 66606, United States

Location

Local Institution - 020

Baton Rouge, Louisiana, 70809, United States

Location

Clinical Trials of SW Louisiana LLC

Lake Charles, Louisiana, 70601, United States

Location

Tandem Clinical Research, LLC

Marrero, Louisiana, 70072, United States

Location

Local Institution - 024

Worcester, Massachusetts, 01655, United States

Location

Local Institution - 167

Kalamazoo, Michigan, 49008, United States

Location

Local Institution - 005

Novi, Michigan, 48377, United States

Location

Local Institution - 095

Minneapolis, Minnesota, 55455, United States

Location

Local Institution - 045

Rochester, Minnesota, 55905, United States

Location

Local Institution - 198

Kansas City, Missouri, 64111, United States

Location

Internal Medicine Specialists

Las Vegas, Nevada, 89145, United States

Location

Local Institution - 040

Lebanon, New Hampshire, 03756, United States

Location

Local Institution - 054

Hartsdale, New York, 10530, United States

Location

Weill Cornell Medical College

New York, New York, 10010, United States

Location

Concorde Medical Group

New York, New York, 10016, United States

Location

TrialSpark

New York, New York, 10024, United States

Location

Local Institution - 060

North Massapequa, New York, 11758-1802, United States

Location

Local Institution - 156

Charlotte, North Carolina, 28209, United States

Location

Local Institution - 052

Winston-Salem, North Carolina, 27103, United States

Location

Local Institution - 170

Dayton, Ohio, 45417, United States

Location

Local Institution - 049

Hilliard, Ohio, 43026, United States

Location

Paramount Medical Research & Consulting, Llc

Middleburg Heights, Ohio, 44130, United States

Location

Local Institution - 087

Norman, Oklahoma, 73071, United States

Location

Local Institution - 294

Oklahoma City, Oklahoma, 73102, United States

Location

Local Institution - 185

Tulsa, Oklahoma, 74136, United States

Location

Local Institution - 217

Tulsa, Oklahoma, 74137, United States

Location

University of Pennsylvania Cancer Center

Philadelphia, Pennsylvania, 19104, United States

Location

Local Institution - 034

Fort Sam Houston, Texas, 78234, United States

Location

Local Institution - 079

Houston, Texas, 77058, United States

Location

Local Institution - 196

Houston, Texas, 77089, United States

Location

Gulf Coast Research Group LLC

Houston, Texas, 77098, United States

Location

Accurate Clinical Research Inc

Pasadena, Texas, 77505, United States

Location

Local Institution - 071

Richardson, Texas, 75082, United States

Location

Local Institution - 178

San Antonio, Texas, 78229, United States

Location

Local Institution - 181

Temple, Texas, 76508, United States

Location

Local Institution - 292

Riverton, Utah, 84065, United States

Location

Local Institution - 030

Lynchburg, Virginia, 24502, United States

Location

The Gastroenterology Group

Reston, Virginia, 20191, United States

Location

Local Institution - 072

Richmond, Virginia, 23249, United States

Location

Local Institution - 172

Roanoke, Virginia, 24016, United States

Location

Local Institution - 089

La Crosse, Wisconsin, 54601, United States

Location

Local Institution - 309

Liverpool, New South Wales, 2170, Australia

Location

Local Institution - 318

New Lambton Heights, New South Wales, 2305, Australia

Location

Local Institution - 328

Herston, Queensland, 4029, Australia

Location

Local Institution - 313

Maroorchydore, Queensland, 4558, Australia

Location

Local Institution - 321

North Mackay, Queensland, 4740, Australia

Location

Local Institution - 312

South Brisbane, Queensland, 4101, Australia

Location

Local Institution - 307

Bedford Park, South Australia, 5042, Australia

Location

Local Institution - 326

Elizabeth Vale, South Australia, 05112, Australia

Location

Local Institution - 317

Clayton, Victoria, 3168, Australia

Location

Local Institution - 305

Fitzroy, Victoria, 3065, Australia

Location

Local Institution - 329

Geelong, Victoria, 3220, Australia

Location

Local Institution - 327

Melbourne, Victoria, 3004, Australia

Location

Local Institution - 315

Subiaco, Western Australia, 6008, Australia

Location

Local Institution - 726

Innsbruck, 6020, Austria

Location

Local Institution - 727

Sankt Pölten, 3100, Austria

Location

Local Institution - 336

Vienna, 1020, Austria

Location

Local Institution - 725

Vienna, 1090, Austria

Location

Local Institution - 753

Rousse, 7002, Bulgaria

Location

Local Institution - 750

Sofia, 1407, Bulgaria

Location

Local Institution - 755

Sofia, 1407, Bulgaria

Location

Local Institution - 756

Sofia, 1431, Bulgaria

Location

Local Institution - 752

Sofia, 1527, Bulgaria

Location

Local Institution - 554

Sofia, 1784, Bulgaria

Location

Local Institution - 269

Edmonton, Alberta, T5R1W2, Canada

Location

Local Institution - 262

New Westminster, British Columbia, V3L 3W5, Canada

Location

Local Institution - 267

Vancouver, British Columbia, V6Z 2K5, Canada

Location

Local Institution - 256

Brandon, Manitoba, R7A 0N7, Canada

Location

Local Institution - 266

Greater Sudbury, Ontario, P3C 5K6, Canada

Location

Local Institution - 264

Toronto, Ontario, M5G 1X5, Canada

Location

Local Institution - 257

Toronto, Ontario, M5T 3A9, Canada

Location

Local Institution - 254

Montreal, Quebec, H1T 2M4, Canada

Location

Local Institution - 270

Ottawa, Quebec, K1H 8L6, Canada

Location

Local Institution - 423

Changzhou, Jiangsu, 213003, China

Location

Local Institution - 369

Shanghai, Shanghai Municipality, 200120, China

Location

Local Institution - 482

Beijing, 100050, China

Location

Local Institution - 467

Beijing, 100700, China

Location

Local Institution - 379

Bengbu, 233004, China

Location

Local Institution - 485

Changchun, 130021, China

Location

Local Institution - 376

Changchun, 130033, China

Location

Local Institution - 421

Changsha, 410008, China

Location

Local Institution - 378

Changsha, 450052, China

Location

Local Institution - 414

Changzhou, 213004, China

Location

Local Institution - 419

Chengdu, 610041, China

Location

Local Institution - 422

Fuzhou, 350005, China

Location

Local Institution - 478

Guangzhou, 510030, China

Location

Local Institution - 472

Guangzhou, 510180, China

Location

Local Institution - 486

Guangzhou, 510655, China

Location

Local Institution - 470

Hangzhou, Zhejiang, 100142, China

Location

Local Institution - 491

Hefei, 230001, China

Location

Local Institution - 374

Kunming, 650032, China

Location

Local Institution - 383

Luzhou, 646099, China

Location

Local Institution - 488

Nanchang, 330006, China

Location

Local Institution - 418

Nanjing, 210008, China

Location

Local Institution - 375

Nanjing, 210009, China

Location

Local Institution - 487

Nanjing, 210029, China

Location

Local Institution - 473

Shanghai, 200025, China

Location

Local Institution - 380

Shanghai, 200040, China

Location

Local Institution - 377

Shanghai, 200080, China

Location

Local Institution - 458

Taichung City, 40447, China

Location

Local Institution - 373

Tianjin, 300052, China

Location

Local Institution - 475

Wuhan, 430022, China

Location

Local Institution - 474

Wuhan, 430030, China

Location

Local Institution - 483

Wuhan, 430060, China

Location

Local Institution - 381

Wuxi, 214023, China

Location

Local Institution - 415

Xi'an, 710038, China

Location

Local Institution - 420

Xi'an, 710100, China

Location

Local Institution - 370

Zhengzhou, 450014, China

Location

Local Institution - 397

Armenia, 630004, Colombia

Location

Local Institution - 398

Barranquilla, 080020, Colombia

Location

Local Institution - 395

Bogotá, 110221, Colombia

Location

Local Institution - 396

Cali, 760026, Colombia

Location

Local Institution - 394

Medellín, 050034, Colombia

Location

Local Institution - 613

Helsinki, 00290, Finland

Location

Local Institution - 614

Turku, FI-20521, Finland

Location

Local Institution - 647

Neuilly-sur-Seine, Cedex, 92200, France

Location

Local Institution - 639

Béziers, 34525, France

Location

Local Institution - 635

Blois, 41016, France

Location

Local Institution - 634

Caen, 14000, France

Location

Local Institution - 644

Colombes, 92701, France

Location

Local Institution - 632

Nantes, 44093, France

Location

Local Institution - 630

Pierre-Bénite, 69495, France

Location

Local Institution - 631

Saint-Priest-en-Jarez, 42270, France

Location

Local Institution - 786

Batumi, 6010, Georgia

Location

Local Institution - 779

Kutaisi, 4600, Georgia

Location

Local Institution - 454

Tbilisi, 0101, Georgia

Location

Local Institution - 778

Tbilisi, 0112, Georgia

Location

Local Institution - 782

Tbilisi, 0131, Georgia

Location

Local Institution - 552

Tbilisi, 0144, Georgia

Location

Local Institution - 793

Tbilisi, 0159, Georgia

Location

Local Institution - 740

Tbilisi, 0160, Georgia

Location

Local Institution - 783

Tbilisi, 0160, Georgia

Location

Local Institution - 784

Tbilisi, 0160, Georgia

Location

Local Institution - 785

Tbilisi, 0160, Georgia

Location

Local Institution - 335

Tbilisi, 0179, Georgia

Location

Local Institution - 455

Tbilisi, 0180, Georgia

Location

Local Institution - 781

Tbilisi, 0186, Georgia

Location

Local Institution - 780

Telavi, 2200, Georgia

Location

Local Institution - 629

Berlin, 10787, Germany

Location

Local Institution - 653

Berlin, 12200, Germany

Location

Local Institution - 648

Berlin, 13353, Germany

Location

Local Institution - 628

Berlin, 14163, Germany

Location

Local Institution - 664

Brandenburg, 14770, Germany

Location

Local Institution - 732

Dachau, 85221, Germany

Location

Local Institution - 574

Frankfurt am Main, 60313, Germany

Location

Local Institution - 657

Frankfurt am Main, 60590, Germany

Location

Local Institution - 658

Halle, 06108, Germany

Location

Local Institution - 656

Halle, 06120, Germany

Location

Local Institution - 652

Hamburg, 22559, Germany

Location

Local Institution - 591

Hanover, 30625, Germany

Location

Local Institution - 649

Keil, 24105, Germany

Location

Local Institution - 337

Leipzig, 04103, Germany

Location

Local Institution - 660

Mainz, 55131, Germany

Location

Local Institution - 667

Münster, 48149, Germany

Location

Local Institution - 620

Neuruppin, 16816, Germany

Location

Local Institution - 584

Nürtingen, 72622, Germany

Location

Local Institution - 661

Stuttgart, 70376, Germany

Location

Local Institution - 790

Athens, 11 527, Greece

Location

Local Institution - 588

Athens, 115 28, Greece

Location

Local Institution - 791

Athens, 11527, Greece

Location

Local Institution - 792

Athens, 18536, Greece

Location

Local Institution - 592

Athens, Attiki, 15562, Greece

Location

Local Institution - 787

Heraklion, 71 110, Greece

Location

Local Institution - 789

Thessaloniki, 54642, Greece

Location

Local Institution - 788

Thessaloniki, 56429, Greece

Location

Local Institution - 404

Hong Kong, 0, Hong Kong

Location

Local Institution - 405

Kowloon, 0, Hong Kong

Location

Local Institution - 798

Békéscsaba, 5600, Hungary

Location

Local Institution - 803

Budapest, 1062, Hungary

Location

Local Institution - 804

Budapest, 1088, Hungary

Location

Local Institution - 556

Budapest, H-1036, Hungary

Location

Local Institution - 801

Győr, 9024, Hungary

Location

Local Institution - 555

Gyula, 5700, Hungary

Location

Local Institution - 797

Miskolc, 3529, Hungary

Location

Local Institution - 800

Nagykanizsa, H-8800, Hungary

Location

Local Institution - 816

Szekszárd, 7100, Hungary

Location

Local Institution - 805

Szentes, 6600, Hungary

Location

Local Institution - 799

Székesfehérvár, 8000, Hungary

Location

Local Institution - 343

Afula, 18341, Israel

Location

Local Institution - 346

Beer Jacob, 73100, Israel

Location

Local Institution - 350

Haifa, 3109601, Israel

Location

Local Institution - 347

Jerusalem, 9362410, Israel

Location

Local Institution - 349

Kfar Saba, 44281, Israel

Location

Local Institution - 341

Petah Tikva, 49100, Israel

Location

Local Institution - 340

Tel Aviv, 64239, Israel

Location

Local Institution - 605

Kaunas, LT-50009, Lithuania

Location

Local Institution - 603

Klaipėda, LT-5808, Lithuania

Location

Local Institution - 607

Vilnius, 08406, Lithuania

Location

Local Institution - 606

Vilnius, LT-08661, Lithuania

Location

Local Institution - 604

Vilnius, LT-10207, Lithuania

Location

Local Institution - 952

Amsterdam, 1081 HV, Netherlands

Location

Local Institution - 955

Amsterdam, 1105 AZ, Netherlands

Location

Local Institution - 956

Groningen, 9713 GZ, Netherlands

Location

Local Institution - 949

Nijmegen, 6525 GA, Netherlands

Location

Local Institution - 951

Sittard-Geleen, 6162 BG, Netherlands

Location

Local Institution - 954

Tilburg, 5022 GC, Netherlands

Location

Local Institution - 580

Częstochowa, 42-202, Poland

Location

Local Institution - 988

Elblag, 82-300, Poland

Location

Local Institution - 579

Gdansk, 80-382, Poland

Location

Local Institution - 978

Gdansk, 80-803, Poland

Location

Local Institution - 577

Gdynia, 81-537, Poland

Location

Local Institution - 906

Jelenia Góra, 58-500, Poland

Location

Local Institution - 757

Józefów, 05-410, Poland

Location

Local Institution - 578

Katowice, 40-040, Poland

Location

Local Institution - 834

Ksawerów, 95-054, Poland

Location

Local Institution - 581

Lodz, 90-127, Poland

Location

Local Institution - 981

Lodz, 93-034, Poland

Location

Local Institution - 976

Nowy Targ, 34-400, Poland

Location

Local Institution - 963

Rzeszów, 35-302, Poland

Location

Local Institution - 979

Sopot, 81-756, Poland

Location

Local Institution - 835

Szczecin, 71-270, Poland

Location

Local Institution - 586

Warsaw, 00-728, Poland

Location

Local Institution - 833

Warsaw, 02-018, Poland

Location

Local Institution - 989

Warsaw, 02-653, Poland

Location

Local Institution - 807

Warsaw, 04-730, Poland

Location

Local Institution - 893

Wierzchosławice, 33-122, Poland

Location

Local Institution - 983

Wroclaw, 50-053, Poland

Location

Local Institution - 984

Wroclaw, 50-367, Poland

Location

Local Institution - 582

Wroclaw, 50-381, Poland

Location

Local Institution - 982

Wroclaw, 51-162, Poland

Location

Local Institution - 831

Wroclaw, 53-114, Poland

Location

Local Institution - 987

Wroclaw, 53-333, Poland

Location

Local Institution - 832

Wroclaw, 54-144, Poland

Location

Local Institution - 959

Coimbra, 3000-075, Portugal

Location

Local Institution - 958

Guimarães, 4835-044, Portugal

Location

Local Institution - 961

Loures, 2674-514, Portugal

Location

Local Institution - 957

Viana do Castelo, 4904-858, Portugal

Location

Local Institution - 966

Barnaul, 656015, Russia

Location

Local Institution - 871

Barnaul, 656024, Russia

Location

Local Institution - 589

Bataysk, 346880, Russia

Location

Local Institution - 621

Chelyabinsk, 454021, Russia

Location

Local Institution - 991

Chelyabinsk, 454076, Russia

Location

Local Institution - 998

Kaliningrad, 236016, Russia

Location

Local Institution - 882

Kaluga, 248007, Russia

Location

Local Institution - 849

Kemerovo, 650066, Russia

Location

Local Institution - 566

Moscow, 105554, Russia

Location

Local Institution - 995

Moscow, 115516, Russia

Location

Local Institution - 873

Moscow, 117997, Russia

Location

Local Institution - 870

Moscow, 119192, Russia

Location

Local Institution - 869

Moscow, 123423, Russia

Location

Local Institution - 990

Nizhny Novgorod, 603140, Russia

Location

Local Institution - 853

Novosibirsk, 630091, Russia

Location

Local Institution - 876

Novosibirsk, 630117, Russia

Location

Local Institution - 996

Omsk, 644024, Russia

Location

Local Institution - 875

Orenburg, 460050, Russia

Location

Local Institution - 867

Penza, 440026, Russia

Location

Local Institution - 863

Saint Petersburg, 191015, Russia

Location

Local Institution - 993

Saint Petersburg, 191015, Russia

Location

Local Institution - 868

Saint Petersburg, 194044, Russia

Location

Local Institution - 857

Saint Petersburg, 195009, Russia

Location

Local Institution - 879

Saint Petersburg, 196143, Russia

Location

Local Institution - 878

Saint Petersburg, 196247, Russia

Location

Local Institution - 874

Saint Petersburg, 197110, Russia

Location

Local Institution - 865

Samara, 443001, Russia

Location

Local Institution - 992

Saratov, 410053, Russia

Location

Local Institution - 866

Sochi, 354207, Russia

Location

Local Institution - 877

Tomsk, 634063, Russia

Location

Local Institution - 881

Ufa, 450005, Russia

Location

Local Institution - 880

Volgograd, 400107, Russia

Location

Local Institution - 583

Yekaterinburg, 620075, Russia

Location

Local Institution - 872

Yekaterinburg, 620109, Russia

Location

Local Institution - 546

Cape Town, 7500, Senegal

Location

Local Institution - 887

Belgrade, 11 080, Serbia

Location

Local Institution - 596

Belgrade, 11000, Serbia

Location

Local Institution - 886

Belgrade, 11000, Serbia

Location

Local Institution - 890

Belgrade, 11000, Serbia

Location

Local Institution - 891

Kragujevac, 34000, Serbia

Location

Local Institution - 884

Novi Sad, 21 000, Serbia

Location

Local Institution - 885

Pančevo, 26000, Serbia

Location

Local Institution - 585

Vršac, 26300, Serbia

Location

Local Institution - 889

Zrenjanin, 23 000, Serbia

Location

Local Institution - 900

Bratislava, 820 07, Slovakia

Location

Local Institution - 894

Bratislava, 82606, Slovakia

Location

Local Institution - 895

Brezno, 97701, Slovakia

Location

Local Institution - 899

Nitra, 94901, Slovakia

Location

Local Institution - 897

Nové Zámky, 94002, Slovakia

Location

Local Institution - 898

Prešov, 080 01, Slovakia

Location

Local Institution - 896

Rimavská Sobota, 979 01, Slovakia

Location

Local Institution - 904

Celje, 3000, Slovenia

Location

Local Institution - 543

Gauteng, 1820, South Africa

Location

Local Institution - 545

Kempton Park, 1619, South Africa

Location

Local Institution - 544

Pretoria, 0001, South Africa

Location

Local Institution - 542

Pretoria, 0084, South Africa

Location

Local Institution - 549

Pretoria, 0181, South Africa

Location

Local Institution - 548

Somerset West, 7130, South Africa

Location

Local Institution - 547

Val de Grace, 0184, South Africa

Location

Local Institution - 434

Busan, 49241, South Korea

Location

Local Institution - 431

Busan, 612-030, South Korea

Location

Local Institution - 432

Daegu, 705-030, South Korea

Location

Local Institution - 438

Seoul, 3080, South Korea

Location

Local Institution - 429

Suwon, 442723, South Korea

Location

Teknon Medical Center

Barcelona, 08022, Spain

Location

University Hospital Reina Sofia

Córdoba, 14001, Spain

Location

University Hospital of Girona Dr. Josep Trueta

Girona, 17007, Spain

Location

Hospital Universitario De Gran Canaria Dr. Negrin

Las Palmas de Gran Canaria, 35012, Spain

Location

Local Institution - 695

Madrid, 28040, Spain

Location

University Hospital Puerta de Hierro Majadajonda

Majadahonda, Madrid, 28222, Spain

Location

University Hospital Marques de Valdecilla (HUMV)

Santander, 39008, Spain

Location

Local Institution - 697

Valencia, 46010, Spain

Location

Local Institution - 625

Stockholm, 112 81, Sweden

Location

Local Institution - 460

Kaohsiung City, 82445, Taiwan

Location

Local Institution - 463

Kaohsiung, San Ming Dist., 807, Taiwan

Location

Local Institution - 461

Niao-Sung Hsiang Kaohsiung County, 83301, Taiwan

Location

Local Institution - 459

Tainan, Taiana, 704, Taiwan

Location

Local Institution - 462

Taoyuan, 33305, Taiwan

Location

Local Institution - 464

Tapei, Beitou Dist., 11217, Taiwan

Location

Local Institution - 465

Tapei, 10002, Taiwan

Location

Local Institution - 357

Ankara, 01660, Turkey (Türkiye)

Location

Local Institution - 365

Elâzığ, 23119, Turkey (Türkiye)

Location

Local Institution - 358

Istanbul, 34098, Turkey (Türkiye)

Location

Local Institution - 361

Istanbul, 34668, Turkey (Türkiye)

Location

Local Institution - 353

Kadiköy/Istanbul, 41380, Turkey (Türkiye)

Location

Local Institution - 922

Chernivtsi, 58001, Ukraine

Location

Local Institution - 929

Ivano-Frankivsk, 76008, Ukraine

Location

Local Institution - 965

Kharkiv, 61037, Ukraine

Location

Local Institution - 920

Khmelnytskyi, 29000, Ukraine

Location

Local Institution - 933

Kropyvnytskyi, 25006, Ukraine

Location

Local Institution - 923

Kyiv, 01601, Ukraine

Location

Local Institution - 563

Kyiv, 02002, Ukraine

Location

Local Institution - 564

Kyiv, 03037, Ukraine

Location

Local Institution - 977

Kyiv, 04107, Ukraine

Location

Local Institution - 590

Lutsk, 43005, Ukraine

Location

Local Institution - 974

Lviv, 79010, Ukraine

Location

Local Institution - 902

Odesa, 65025, Ukraine

Location

Local Institution - 932

Vinnytsia, 21009, Ukraine

Location

Local Institution - 924

Vinnytsia, 21018, Ukraine

Location

Local Institution - 587

Zaporizhia, 69063, Ukraine

Location

Local Institution - 925

Zaporizhzhya, 69600, Ukraine

Location

Related Publications (1)

  • Feagan BG, Schreiber S, Afzali A, Rieder F, Hyams J, Kollengode K, Pearlman J, Son V, Marta C, Wolf DC, D'Haens GG. Ozanimod as a novel oral small molecule therapy for the treatment of Crohn's disease: The YELLOWSTONE clinical trial program. Contemp Clin Trials. 2022 Nov;122:106958. doi: 10.1016/j.cct.2022.106958. Epub 2022 Oct 5.

Related Links

MeSH Terms

Conditions

Crohn Disease

Interventions

ozanimod

Condition Hierarchy (Ancestors)

Inflammatory Bowel DiseasesGastroenteritisGastrointestinal DiseasesDigestive System DiseasesIntestinal Diseases

Results Point of Contact

Title
Bristol-Myers Squibb Study Director
Organization
Bristol-Myers Squibb

Study Officials

  • Bristol-Myers Squibb

    Bristol-Myers Squibb

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 14, 2018

First Posted

February 22, 2018

Study Start

March 7, 2018

Primary Completion

November 21, 2023

Study Completion

November 21, 2023

Last Updated

December 5, 2024

Results First Posted

December 5, 2024

Record last verified: 2024-11

Locations