The Modulatory Effect of Oxytocin on Interoception

NCT03074409 | Completed Results

• 1 other identifier: UESTC-neuSCAN-34
• Study Type: interventional
• Target: 83
• Locations: 1 country
• Sites: 1

Brief Summary

This study is designed to investigate oxytocin's effects on interoception and whether these effects vary as a function of different emotional valence.

Conditions

Interoception

Keywords

Oxytocin

Outcome Measures

Primary Outcomes (2)

• Heartbeat Detection (Interoception) Accuracy

  heartbeat detection (interoception) accuracy is calculated by the following equation: 1/N ∑ (1 - (\|recorded heartbeats - counted heartbeats\|)/recorded heartbeats). N was the number of blocks for the heartbeat detection task.

  45 minutes after oxytocin/placebo treatment

• Interoceptive Network Activity

  interoceptive network (including anterior insula and dorsal cingulate cortex) activity as measured by the functional MRI technique in the heartbeat detection task. In the heartbeat detection task participants were instructed to make a keypress each time they felt their heartbeat. The interoceptive network activity was indicated by the percentage of BOLD signal change. The value of the percentage of BOLD signal change indicates the level of a certain brain region activated (the involvement of a brain region in a specific cognitive process).

  45 minutes after oxytocin/placebo treatment

Study Arms (2)

oxytocin

EXPERIMENTAL

intranasal administration of oxytocin

Drug: oxytocin

placebo

PLACEBO COMPARATOR

intranasal administration of the same ingredient except oxytocin

Drug: placebo

Interventions

oxytocin DRUG

self-administration of oxytocin (nasal spray)

oxytocin

placebo DRUG

self-administration of placebo (nasal spray)

placebo

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy subjects

You may not qualify if:

• Subjects reported having any neurological problems, psychiatric illness or drug or alcohol abuse and none were currently taking any form of medication and had not drunk any caffeine-containing beverages on the day of the experiment.

Sponsors & Collaborators

• University of Electronic Science and Technology of China: lead

Study Sites (1)

University of Electronic Science and Technology of China

Chengdu, Sichuan, 611731, China

Location

MeSH Terms

Interventions

Oxytocin

Intervention Hierarchy (Ancestors)

Pituitary Hormones, Posterior; Pituitary Hormones; Peptide Hormones; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Peptides; Amino Acids, Peptides, and Proteins

Results Point of Contact

• Title: Dr. Shuxia Yao
• Organization: University of Electronic Science and Technology of China

yaoshuxia@uestc.edu.cn

+8618111297596

Study Officials

• Keith Kendrick, PhD

  University of Electronic Science and Technology of China

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 3, 2017
• First Posted: March 8, 2017
• Study Start: March 2, 2017
• Primary Completion: September 6, 2017
• Study Completion: September 12, 2017
• Last Updated: October 18, 2019
• Results First Posted: October 18, 2019

Record last verified: 2019-09

Locations

CN (1)