NCT04715737

Brief Summary

The main aim of the present study is to investigate whether intranasal vasopressin (20IU) and oxytocin (24IU) have differential effects on attention control in a social-emotional saccade/antisaccade eye-tracking paradigm.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
160

participants targeted

Target at P75+ for not_applicable healthy

Timeline
Completed

Started Dec 2017

Longer than P75 for not_applicable healthy

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 19, 2017

Completed
3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2021

Completed
13 days until next milestone

First Submitted

Initial submission to the registry

January 14, 2021

Completed
6 days until next milestone

First Posted

Study publicly available on registry

January 20, 2021

Completed
Last Updated

January 22, 2021

Status Verified

January 1, 2021

Enrollment Period

3 years

First QC Date

January 14, 2021

Last Update Submit

January 20, 2021

Conditions

Healthy

Keywords

VasopressinOxytocinEye-trackingAttention control

Outcome Measures

Primary Outcomes (2)

  • Differential effects of intranasal vasopressin and oxytocin administration on saccade/antisaccade latencies towards social (facial) versus non-social (shape) stimuli

    Comparison between social-specific saccade/antisaccade latencies (in milliseconds) between the vasopressin, oxytocin and placebo treatment conditions

    Time Frame: 45 minutes - 100 minutes after treatment

  • Differential effects of intranasal vasopressin and oxytocin administration on error rates of saccade/antisaccade for social (facial) versus non-social (shape) stimuli

    Comparison between social-specific error rates of saccade/antisaccade between the vasopressin, oxytocin and placebo treatment conditions

    Time Frame: 45 minutes - 100 minutes after treatment

Secondary Outcomes (2)

  • Emotion-specific effects of vasopressin and oxytocin administration on saccade/antisaccade latencies towards the separate facial emotions

    Time Frame: 45 minutes - 100 minutes after treatment

  • Emotion-specific effects of vasopressin and oxytocin administration on saccade/antisaccade error rates for the separate facial emotions

    Time Frame: 45 minutes - 100 minutes after treatment

Study Arms (3)

Vasopressin

EXPERIMENTAL

Vasopressin (20IU) intranasally

Drug: Vasopressin

Oxytocin

EXPERIMENTAL

Oxytocin (24IU) intranasally

Drug: Oxytocin

Placebo

PLACEBO COMPARATOR

Placebo intranasally

Drug: Placebo

Interventions

VasopressinDRUG

Administration of vasopressin (20IU) intranasally

Vasopressin
OxytocinDRUG

Administration of oxytocin (24IU) intranasally

Oxytocin
PlaceboDRUG

Administration of placebo intranasally

Placebo

Eligibility Criteria

Age18 Years - 30 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Male, healthy participants
  • Non smokers

You may not qualify if:

  • Previous or current medical, psychiatric, neurological disorder
  • Regular medication
  • Use of any psychoactive substances in the 24 hours before experiment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Electronic Science and Technology of China (UESTC)

Sichuan, Chengdu, 611731, China

Location

MeSH Terms

Conditions

Diabetes Insipidus

Interventions

VasopressinsOxytocin

Condition Hierarchy (Ancestors)

Kidney DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital DiseasesPituitary DiseasesEndocrine System Diseases

Intervention Hierarchy (Ancestors)

Pituitary Hormones, PosteriorPituitary HormonesPeptide HormonesHormonesHormones, Hormone Substitutes, and Hormone AntagonistsNeuropeptidesPeptidesAmino Acids, Peptides, and ProteinsOligopeptidesNerve Tissue ProteinsProteins

Study Officials

  • Keith Kendrick, PhD

    University of Electronic Science and Technology of China (UESTC)

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Model Details: Between-subject randomized placebo-controlled double-blind pharmacological eye-tracking design
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

January 14, 2021

First Posted

January 20, 2021

Study Start

December 19, 2017

Primary Completion

January 1, 2021

Study Completion

January 1, 2021

Last Updated

January 22, 2021

Record last verified: 2021-01

Data Sharing

IPD Sharing
Will not share

Locations

CN(1)