NCT03054142

Brief Summary

Acute kidney injury (AKI) is a common clinical syndrome, especially patients in the hospital. AKI has become a huge medical burden in China. Little information is available about this disease burden in our country. The investigators aimed to evaluate the burden of AKI and to analyze the related risk factors.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,000,000

participants targeted

Target at P75+ for all trials

Timeline
20mo left

Started Jan 2017

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress85%
Jan 2017Dec 2027

Study Start

First participant enrolled

January 1, 2017

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

February 13, 2017

Completed
2 days until next milestone

First Posted

Study publicly available on registry

February 15, 2017

Completed
10.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2027

Last Updated

December 13, 2022

Status Verified

December 1, 2022

Enrollment Period

11 years

First QC Date

February 13, 2017

Last Update Submit

December 10, 2022

Conditions

Outcome Measures

Primary Outcomes (1)

  • Incidence of AKI

    Jan. 2011 to Oct. 2016

Secondary Outcomes (5)

  • Recognition rate of AKI

    Jan. 2011 to Oct. 2016

  • Proportion of nephrology referral

    Jan. 2011 to Oct. 2016

  • In-hospital mortality

    Jan. 2011 to Oct. 2016

  • Longer ICU stay

    Jan. 2011 to Oct. 2016

  • Higher medical cost

    Jan. 2011 to Oct. 2016

Study Arms (2)

AKI

Other: no intervention

non-AKI

Other: no intervention

Interventions

AKInon-AKI

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

All inpatients (if outpatient identification is achieved, outpatient and inpatient patients can be judged to be the same individual, the outpatient electronic data is extracted at the same time)

You may qualify if:

  • The patients diagnosed on the basis of changes in serum creatinine according to the criteria of 2012 Kidney Disease Improving Global Outcomes(KDIGO)

You may not qualify if:

  • Serum creatinine record less than two times during hospitalization
  • Patients being diagnosed with End-stage kidney disease (chronic kidney disease stage 5)
  • Nephrectomy
  • Kidney transplantation
  • Peak serum creatinine of less than 53µ mol/L
  • Serum creatinine decrease after amputation

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Nephrology Dept,Guangdong General Hospital

Guangzhou, Guangdong, China

RECRUITING

Related Publications (1)

  • Xu L, Wu Y, Chen Y, Li R, Wang Z, Li Z, Liu G, Yu L, Shi W, Liang X; China collaborative study on AKI (CCS-AKI). Is acute kidney injury age-dependent in older adults: an observational study in two centers from North China. BMC Geriatr. 2021 Jan 6;21(1):7. doi: 10.1186/s12877-020-01906-z.

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal InsufficiencyKidney DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital Diseases

Study Officials

  • Liang Xinling, M.D.,Ph.D

    Nephrology Dept,Guangdong General Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Liang Xinling, M.D.,Ph.D

CONTACT

Liang Xinling, M.D.,Ph.D

CONTACT

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Director of Division of Nephrology and Blood Purification Center of Guangdong General Hospital

Study Record Dates

First Submitted

February 13, 2017

First Posted

February 15, 2017

Study Start

January 1, 2017

Primary Completion (Estimated)

December 31, 2027

Study Completion (Estimated)

December 31, 2027

Last Updated

December 13, 2022

Record last verified: 2022-12

Data Sharing

IPD Sharing
Will not share

Locations