Acute Kidney Injury Following Cardiac Surgery
Acute Kidney Injury After Cardiac Surgery - A Retrospective Single-center Study
1 other identifier
observational
495
0 countries
N/A
Brief Summary
Acute kidney injury (AKI) occurs in approximately one-third of patients undergoing cardiac surgery (CS), and represents one of the most significant negative predictors of patient outcome in this population. The investigators sought to examine the risk factors associated with the development of AKI and renal recovery in patients undergoing cardiac surgery at San Bortolo Hospital, Italy 2014-2015.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2014
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 31, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
June 20, 2016
CompletedFirst Submitted
Initial submission to the registry
March 30, 2017
CompletedFirst Posted
Study publicly available on registry
April 5, 2017
CompletedAugust 29, 2019
August 1, 2019
12 months
March 30, 2017
August 27, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Prevalence of acute kidney injury using full Kidney Disease Improving Global Outcomes criteria
Development of AKI within 7 days.
within 7 days
Secondary Outcomes (1)
Renal recovery
Within 1 month
Study Arms (1)
Cardiac Surgery Patients
All adult patients undergoing cardiac surgery (elective/emergent) at San Bortolo Hospital, Vicenza, Italy during November 2014 - October 2015
Interventions
Eligibility Criteria
Adult patients undergoing cardiac surgery (elective, urgent and emergent; coronary artery bypass, valve replacements, combined or other surgery, with cardiopulmonary bypass) between November 2014 and October 2015 at the Division of Cardiac Surgery, San Bortolo Hospital, in Vicenza, Italy
You may qualify if:
- \- Adult cardiac surgery
You may not qualify if:
- Missing baseline serum creatinine (defined as a serum creatinine value within 90 prior to surgery) or missing serum creatinine within 3 days before hospital discharge
- Stage 5 chronic kidney disease (estimated glomerular filtration rate \<15 ml/min/1.73 m2 or receipt of chronic dialysis)
- Solid organ transplant recipients
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (2)
Ryden L, Sartipy U, Evans M, Holzmann MJ. Acute kidney injury after coronary artery bypass grafting and long-term risk of end-stage renal disease. Circulation. 2014 Dec 2;130(23):2005-11. doi: 10.1161/CIRCULATIONAHA.114.010622. Epub 2014 Sep 19.
PMID: 25239439BACKGROUNDPickering JW, James MT, Palmer SC. Acute kidney injury and prognosis after cardiopulmonary bypass: a meta-analysis of cohort studies. Am J Kidney Dis. 2015 Feb;65(2):283-93. doi: 10.1053/j.ajkd.2014.09.008. Epub 2014 Nov 5.
PMID: 25445101BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Claudio Ronco, MD
International Renal Research Institute of Vicenza
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Senior Phyisician
Study Record Dates
First Submitted
March 30, 2017
First Posted
April 5, 2017
Study Start
November 1, 2014
Primary Completion
October 31, 2015
Study Completion
June 20, 2016
Last Updated
August 29, 2019
Record last verified: 2019-08
Data Sharing
- IPD Sharing
- Will not share