Effect of Exercise on Selected Anthropometric,Biochemical and Physiological Variables Among Hypertensive Patients

NCT03029767 | Completed DMC

• 1 other identifier: 213.55.94.37
• Study Type: interventional
• Target: 92
• Locations: 1 country
• Sites: 1

Brief Summary

Hypertension is the most common risk factor for development of stroke, congestive heart failure chronic kidney disease, and coronary artery disease in Sub Saharan Africa. The prevalence of hypertension will increase by 2025 in most parts of the world including Ethiopia according to World Health Organization. Physical inactivity has been identified as a stronger predictor of chronic diseases such as hypertension. Exercise as a lifestyle modification is beneficial to a wide variety of health conditions, specific to hypertension; the benefits of exercise have been promoted by a number of organizations and agencies including World Health Organization. According to the knowledge of the investigator there are no research works in relation to aerobic and resistance exercise effects among hypertensive patients generally in Ethiopia, and particularly in the area selected for the present research. Therefore the aim of this study is to assess the effect of aerobic and resistance exercises on selected anthropometric, biochemical and physiological variables among hypertensive patients in Hawassa University Referral Hospital.

Conditions

Hypertension

Keywords

Hypertension; Anthropometry; Aerobic exercise; Resistance exercise

Outcome Measures

Primary Outcomes (1)

• Effect of aerobic exercise training (as intervention measures) on resting systolic blood pressure will be assessed.

  Change rates of systolic blood pressure among intervention and control groups

  [ Time Frame: sixteen weeks ]

Secondary Outcomes (2)

• Effect of combined aerobic and resistance training on the reduction of body mass index among the hypertensive patients will be assessed

  [ Time Frame: Sixteen weeks ]

• Effect of combined aerobic and resistance training on the increasement of HDL-c level among the hypertensive patients will be assessed

  [ Time Frame: Sixteen weeks ]

Study Arms (4)

Aerobic exercise

EXPERIMENTAL

Aerobic exercise training will be carried out as an intervention activity

Other: Aerobic exercise .

Resistance exercise

EXPERIMENTAL

Resistance exercise training will be conducted as an intervention activity

Other: Resistance exercise

Aerobic and resistance exercise

EXPERIMENTAL

Aerobic and resistance training will be implemented

Other: Aerobic and resistance exercise

Control group

NO INTERVENTION

standard or usual activity carried out.Additional intervention will not be given.

Interventions

Aerobic exercise . OTHER

The aerobic exercise group will perform brisk walking. Intensity of the aerobic exercise program will be progressively increased throughout the 16-week program. Intensity of aerobic exercise will be 40-65% of maximum heart rate , which is low to moderate.Duration of each session will be 45 minutes. Aerobic exercise will be performed 3 days per week.

Also known as: Non pharmacological

Aerobic exercise

Resistance exercise OTHER

The resistance exercise group will perform 8 different exercises. Frequency of exercises per week is 3 days and duration of each exercise session is 45minutes. Interval rest among different exercises is 1minute.The intensity and repetition of resistance exercises is progressive. Participants will be exercised at 30% intensity (low intensity) for upper body and 50% intensity (moderate intensity) repetition voluntary maximum for lower body. Progressive, dynamic and rhythmical, alternative to upper-body and lower-body works and circuit resistance training of low to moderate intensity exercises will be executed.

Also known as: Non pharmacological

Resistance exercise

Aerobic and resistance exercise OTHER

The aerobic and resistance exercise group will perform 23 minutes aerobic exercises and 22 minutes resistance exercises. The exercises will be performed three days per week . Intensity of aerobic and resistance exercise group for aerobic and resistance exercises are similar with intensity of aerobic group and resistance group exercises respectively.

Also known as: Non pharmacological

Aerobic and resistance exercise

Eligibility Criteria

• Age: 31 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Hypertensive patients who will give a written consent to participate in the study
• Hypertensive patients who are going to stay in the area throughout the study period
• Hypertensive patients between the age range of 31 and 45 years old with essential mild hypertension (systolic blood pressure between 140-159 mmHg and diastolic blood pressure between 90 and 99 mm Hg)
• participants not participated in structured physical exercises for previous 3 months
• patients who are on single anti-hypertensive medication or unmedicated
• Body mass index(BMI) 18.5kg/m2-29.9kg/m2

You may not qualify if:

• participants who involved in any exercise program prior to study
• pregnant women
• women who are taking contraceptive drugs
• Participants who are taking lipid lowering drugs
• participants who are taking any medications except single anti-hypertensive medication
• participants with organ damage,
• secondary hypertension
• patients with known liver problem
• patients with renal disease ,heart disease, brain disease
• participants with age less than 31 and greater than 45 years
• diabetic patients

Sponsors & Collaborators

• Mekelle University: lead

Study Sites (1)

Hawassa University Referral Hospital

Awasa, Southern Nations Nationality Peoples Region, Ethiopia

Location

Related Publications (1)

• 1. Addo J, Smeeth L, Leon DA. Hypertension in sub Saharan Africa: a systematic review. Hypertension. 50(6):1012-8,2007. [PubMed/17954720] 2. Bacon SL, Sherwood A, Hinderliter A, Blumenthal JA. Effects of exercise, diet and weight loss on high blood pressure. Sports Medicine 35 (5), 307-316,2004. [PubMed/15107009] 3. Banz W, Maher M, Thompson W. Effects of resistance versus aerobic training on coronary artery disease risk factors. Exp Biol Med. 228(4):434-40,2003. [PubMed/12671188] 4. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jone JR, Materson BJ, Oparil S, Wright JT, Roccella EJ. Seventh Report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report.JAMA 289 (19):2560-72, 2003. [PubMed/12748199] 5. Cornelissen V, Fagard R. Effect of resistance training on resting blood pressure: a meta- analysis of randomized controlled trials. J Hypertens 23(2):251-9, 2005. [PubMed/15662209] 6. Cornelissen V, Fagard R. Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors. Hypertension 46 (4):667-75, 2005[PubMed/16157788] 7. Fagard RH, Cornelissen VA. Effect of exercise on blood pressure control in Hypertensive patients. Eur J Cardiovasc Prev Rehabil. 14:12-7, 2007. [PubMed/17301622] 8. Fagard RH. Exercise characteristics and the blood pressure response to dynamic physical training. Med Sci Sports Exerc 33: S484-492,2001. [PubMed/11427774] 9. Guidry, M.A., Blanchard ,B.E., Thompson ,P.D., Maresh, C.M., Seip, R.L., &Taylor, A.L. (2006). The influence of short and long duration on the blood pressure response to an acute bout of dynamic exercise. Am Heart J 151:1322.e5-12. [PubMed/16781245] 10. World Health Organization . Obesity: Preventing and Managing the Global Epidemic. WHO Technical Report 2000( 894). Geneva. 11. World Health Organization (2002). The world health report 2002: reducing risks, promoting healthy life. WHO, Geneva. 12. World Health Organization . The world health report 2002: reducing risks, promoting healthy life. WHO, Geneva 2000. 13. World Health Organization (WHO). A global brief on hypertension world health day. Geneva 2013. 14. Ha CH, So WY. Effects of combined exercise training on body composition and metabolic syndrome factors. Iran J Public Health. 41 (8):20-6,2012.[ PMC3469031]

  RESULT

MeSH Terms

Conditions

Hypertension

Interventions

Exercise; Resistance Training

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human

Study Officials

• Mitiku D Abebe, MSc

  College of Natural and Computational Sciences,Mekelle University Mekelle University

  PRINCIPAL INVESTIGATOR

• Soumatra K Mondal, PhD

  College of Natural and Computational Sciences, Mekelle University Mekelle University

  STUDY DIRECTOR

• Mahmud Ab Mahmud, PhD

  College of Health Sciences, Mekelle University

  STUDY CHAIR

• Palani B Kumar, PhD

  College of Natural and Computational Sciences, Mekelle University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Mitiku Daimo PhD scholar

Study Record Dates

• First Submitted: January 20, 2017
• First Posted: January 24, 2017
• Study Start: February 20, 2017
• Primary Completion: June 17, 2017
• Study Completion: June 17, 2017
• Last Updated: November 26, 2018

Record last verified: 2018-11

Data Sharing

• IPD Sharing: Will share

Locations

ET (1)