Acute Effects of Different Exercises on Blood Pressure in Hypertensive Subjects
Hemodynamic, Autonomic and Inflammatory Answers to Different Types of Exercises in Resistant Hypertensive Patients: an Metabolomic Approach
1 other identifier
interventional
30
0 countries
N/A
Brief Summary
Lifestyle changes might reduce cardiovascular risk due to the decrease in blood pressure (BP). However, whether combining aerobic and resistance exercises affect BP and hemodynamic parameters, as well as arterial stiffness and inflammation markers in resistant hypertensive (RHTN) patients, have not been investigated yet.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable hypertension
Started Jan 2017
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 6, 2016
CompletedFirst Posted
Study publicly available on registry
December 9, 2016
CompletedStudy Start
First participant enrolled
January 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2018
CompletedDecember 14, 2016
December 1, 2016
11 months
December 6, 2016
December 13, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
systolic blood pressure in mmHg
systolic blood pressure will be assessed for 15 minutes in baseline, 60 minutes and 24 hours post each interventions.
15 minutes
Secondary Outcomes (5)
arterial stiffness
baseline and 60 minutes post each intervention
ambulatory blood pressure monitoring
baseline and post each intervention
interleukin 6
baseline, 60 minutes and 24 hours post each intervention
interleukin 10
baseline, 60 minutes and 24 hours post each intervention
tumor necrosis factor alpha
baseline, 60 minutes and 24 hours post each intervention
Study Arms (3)
aerobic exercise
EXPERIMENTALAerobic exercise (EA): activity on a treadmill lasting 45 minutes with intensity of 50-60% of maximum heart rate (HR) obtained from ergometer test
resistance exercise
ACTIVE COMPARATORresistance exercise (RE): 4 series of 12 repetitions of resistance exercises at moderate intensity (until moderate fatigue), for 45 minutes
combined exercise
ACTIVE COMPARATORcombined exercise (CE): EA (25 minutes) + ER (20 minutes), with an interval of 2 minutes between sessions totalizing 45 minutes
Interventions
Aerobic exercise (EA): activity on a treadmill lasting 45 minutes with intensity of 50-60% of maximum heart rate (HR) obtained from ergometer test
resistance exercise (RE): 4 series of 12 repetitions of resistance exercises at moderate intensity (until moderate fatigue), for 45 minutes
combined exercise (CE): EA (25 minutes) + ER (20 minutes), with an interval of 2 minutes between sessions totalizing 45 minutes
Eligibility Criteria
You may qualify if:
- the diagnosis recommended by the AHA Statement on Resistant Hypertension (2008)
- a 6-month period clinic follow-up
- give written informed consent form
You may not qualify if:
- secondary Hypertension
- pseudoresistance hypertension (poor medication adherence and white coat hypertension)
- patients with symptomatic ischemic heart disease, impaired renal function, liver disease and history of stroke, myocardial infarction and peripheral vascular diseases, heart failure
- pregnant women
- smoking
- regular physical activity
- mental or physical limitation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Fraccari-Pires N, Coelho-Junior HJ, Gambassi BB, Cabral de Faria AP, Ritter AMV, Gasparetti CS, Pioli MR, Ruberti OM, Ferreira-Melo SE, Moreno H, Rodrigues B. Cardiovascular Autonomic Responses to Aerobic, Resistance and Combined Exercises in Resistance Hypertensive Patients. Biomed Res Int. 2022 Apr 20;2022:8202610. doi: 10.1155/2022/8202610. eCollection 2022.
PMID: 35496038DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Nayara F. Pires, PhD student
University of Campinas
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Full professor
Study Record Dates
First Submitted
December 6, 2016
First Posted
December 9, 2016
Study Start
January 1, 2017
Primary Completion
December 1, 2017
Study Completion
March 1, 2018
Last Updated
December 14, 2016
Record last verified: 2016-12
Data Sharing
- IPD Sharing
- Will not share