Post-Exercise Hypotension in Elderly Hypertensive Men

NCT02415582 | Completed

• 1 other identifier: 130484
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to compare the effects of two exercise protocols on post-exercise blood pressure versus a control group in elderly hypertensive men. Participants are allocated to all groups: control group and two experimental exercise protocols, in a random order. In the control group, participants remain resting sitting, and, in the exercise protocols, participants practice exercise bouts of aerobic exercise or a combination of resistance and aerobic exercises. In order to standardize baseline conditions, before the sessions subjects remain sitting quietly for 20 minutes. After each exercise protocol, participants have 60 minutes for recovery and, simultaneously, they have BP measured every 5 minutes. After the exercise sessions or control, an equipment for 24 hours ambulatory BP monitoring is installed in every participant.

Conditions

Hypertension

Keywords

Hypertension; Bloodpressure; Post-exercise hypotension; Combined exercise; Aerobic exercise; Resistance exercise; Aging; Elderly; Ambulatory blood pressure monitoring

Outcome Measures

Primary Outcomes (1)

• Ambulatory Blood Pressure Monitoring

  Ambulatory blood pressure monitoring following experimental protocols

  24 hours

Secondary Outcomes (1)

• Office Blood Pressure

  1 hour

Study Arms (3)

Aerobic exercise

EXPERIMENTAL

Aerobic exercise on treadmill at 65-70% of the heart rate reserve during a session.

Other: Aerobic exercise

Combined exercises

EXPERIMENTAL

A session combines resistance and aerobic exercises, with aerobic exercise on treadmill at 65-70% of the heart rate reserve, followed by 60 minutes for cardiorespiratory recovery, and resistance exercise.

Other: Combined exercises

Control

SHAM COMPARATOR

Participants do not exercise and remain sitting for 45 minutes

Other: Control

Interventions

Aerobic exercise OTHER

Aerobic exercise on treadmill

Aerobic exercise

Combined exercises OTHER

Combined resistance and aerobic exercise

Combined exercises

Control OTHER

45 minutes resting sitting

Control

Eligibility Criteria

• Age: 60 Years - 70 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Essential hypertension grade 1 - 2 with or without medical treatment:
• resting systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg

You may not qualify if:

• Smoking;
• Bone, joint, or muscle problems that could limit the performance of the exercises.
• BMI ≥ 30 kg/m2
• Heart Attack in the last year

Sponsors & Collaborators

• Hospital de Clinicas de Porto Alegre: lead
• Federal University of Rio Grande do Sul: collaborator

Study Sites (1)

Hospital de Clinicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

Location

MeSH Terms

Conditions

Hypertension; Post-Exercise Hypotension

Interventions

Exercise

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases; Orthostatic Intolerance; Primary Dysautonomias; Autonomic Nervous System Diseases; Nervous System Diseases; Hypotension

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Sandra C Fuchs, PhD

  Hospital de Clinicas de Porto Alegre

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 9, 2015
• First Posted: April 14, 2015
• Study Start: March 1, 2014
• Primary Completion: December 1, 2015
• Study Completion: December 1, 2015
• Last Updated: May 31, 2018

Record last verified: 2015-08

Locations

BR (1)