Aerobic Exercise in Postexercise Cardiovascular Responses in Resistant Hypertension: a Cross-over Trial
1 other identifier
interventional
22
1 country
1
Brief Summary
Aerobic exercise has the potential to diminish blood pressure values. The aim of this study is to determine whether this potential is also applicable for those with resistant hypertension and whether exercise intensity plays a role in this context. We hypothesize that performing an aerobic exercise session reduces blood pressure values in resistant hypertensive patients in a dose-response relation with exercise intensity.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable hypertension
Started Sep 2013
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2013
CompletedFirst Submitted
Initial submission to the registry
September 23, 2014
CompletedFirst Posted
Study publicly available on registry
September 25, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2015
CompletedAugust 20, 2015
August 1, 2015
1.7 years
September 23, 2014
August 19, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Ambulatory Blood Pressure Monitoring
22h
Secondary Outcomes (2)
Forearm blood flow
1h
Reactive hyperemia
pre and 30min post
Study Arms (3)
Control
NO INTERVENTIONsited rest for 45 minutes
higher intensity aerobic exercise
EXPERIMENTAL45 minutes of aerobic exercise at 75%HRmax
lower intensity aerobic exercise
EXPERIMENTAL45 minutes of aerobic exercise at 50%HRmax
Interventions
aerobic exercise (cycloergometer) at selected intensity (HRmax or equivalent)
Eligibility Criteria
You may qualify if:
- resistant-to-treatment hypertensive subjects (24h ambulatory BP above 130/80, or daytime ambulatory BP above 135/85, or night-time ambulatory BP above 120/70 in spite use of 3 anti-hypertensive medications of different classes, being one diuretic; or use of 4 or more anti-hypertensive medications).
You may not qualify if:
- Muscle or skeletal abnormalities that preclude effort, abnormal exercise stress test, major illnesses that would preclude exercise effort or could influence in the outcome variables (pulmonary disease, valve disease, renal insufficiency, etc.)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Daniel Umpierre, PhD
Federal University of Health Science of Porto Alegre
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 23, 2014
First Posted
September 25, 2014
Study Start
September 1, 2013
Primary Completion
May 1, 2015
Study Completion
May 1, 2015
Last Updated
August 20, 2015
Record last verified: 2015-08