Walking Exercise on Memory, Subjective Cognitive Complaint, and Brain-derived Neurotrophic Factor for Hypertension

NCT04930263 | Completed Results

• 1 other identifier: 201808096RINA
• Study Type: interventional
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine the effect of 6-month aerobic walking program on memory, subjective cognitive complaints, and brain-derived neurotrophic factor for older hypertensive women. Participants will be randomly assigned to the experimental group and the control group. The intervention group will last for 24 weeks. The outcome measurements included memory, subjective cognitive complaints, and brain-derived neurotrophic factor.

Conditions

Hypertension

Keywords

Walking exercise; Memory; Hypertension; Brain-derived neurotrophic factor; Subjective Cognitive Complaint; Women

Outcome Measures

Primary Outcomes (1)

• Memory Function

  The Hopkins Verbal Learning Test was administered to measure verbal learning and memory. The score is a sum of correct responses in each of three learning trial (encoding) (possible score 0 to 36 for summed recall of trials) and a delayed recall trial (possible score 0 to 12). Higher scores mean a better memory.

  outcome measure at 24th week

Secondary Outcomes (2)

• Brain-derived Neurotrophic Factor

  outcome measure at 24th week

• Subjective Cognitive Complaints

  outcome measure at 24th week

Study Arms (2)

Aerobic exercise

EXPERIMENTAL

Behavioral: walking exercise 1. The intervention was 24 weeks walking intervention program with moderate-intensity, 5 sessions a week for 30 minutes per section 2. individualized education 3. telephone and social media counselling 4. booklet guidance

Behavioral: Aerobic exercise

control group

ACTIVE COMPARATOR

Given routine care and life health manual for the participants.

Behavioral: control group

Interventions

Aerobic exercise BEHAVIORAL

The intervention was 24 weeks walking exercise program. Participants exercised frequency at 5 sessions a week for 30 minutes per section with moderate-intensity and wearable device assisted. Each session consisted of a 5 minutes warm-up, moderate-intensity walking exercises and 5 minutes cool-down. The program included individualized education, telephone and social media counselling, and booklet guidance

Aerobic exercise

control group BEHAVIORAL

control group received routine care and a manual on healthy living

control group

Eligibility Criteria

• Age: 60 Years - 80 Years
• Gender Eligibility Details: participant eligibility is based on self-representation of gender identity.
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• aged 60-80 years old,
• a diagnosed of hypertension ≥ 6 months
• self-reporting the signs of memory or thinking skills problems

You may not qualify if:

• probable cognitive impairment as assessed by Montreal Cognitive Assessment ( \< 24 points),
• significant conditions limiting walking ability (e.g. musculoskeletal problems, visual impairment, etc.),
• already participating in 30 minutes or more of moderate-intensity exercise five times a week
• a history of severe cardiovascular disease,
• a history of neurologic or psychiatric disorder such as stroke, head injury dementia, Parkinson disease, and depression.

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, 110, Taiwan

Location

MeSH Terms

Conditions

Hypertension

Interventions

Exercise; Control Groups

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods

Results Point of Contact

• Title: Mrs Cheng-Chen Chou
• Organization: National Yang Ming Chiao Tung University

chou8278@gmail.com

28267176

Study Officials

• Cheng-Chen Chou

  Nursing

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: We conduct a single-blinded, randomized controlled study. Sixty-six participants are randomly assigned to the experimental group and the control group.

Study Record Dates

• First Submitted: June 14, 2021
• First Posted: June 18, 2021
• Study Start: November 9, 2018
• Primary Completion: July 31, 2019
• Study Completion: July 31, 2019
• Last Updated: December 13, 2021
• Results First Posted: December 13, 2021

Record last verified: 2021-06

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)