NCT03025308

Brief Summary

The primary objective of this study is to evaluate the long-term safety and tolerability of filgotinib in participants who have completed one of the parent studies of filgotinib in rheumatoid arthritis (RA).

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
2,731

participants targeted

Target at P75+ for phase_3 rheumatoid-arthritis

Timeline
Completed

Started Feb 2017

Longer than P75 for phase_3 rheumatoid-arthritis

Geographic Reach
32 countries

345 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 17, 2017

Completed
2 days until next milestone

First Posted

Study publicly available on registry

January 19, 2017

Completed
1 month until next milestone

Study Start

First participant enrolled

February 28, 2017

Completed
8.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 16, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 16, 2025

Completed
Last Updated

July 3, 2025

Status Verified

July 1, 2025

Enrollment Period

8.2 years

First QC Date

January 17, 2017

Last Update Submit

July 1, 2025

Conditions

Outcome Measures

Primary Outcomes (2)

  • Proportion of Participants Experiencing Adverse Events (AEs)

    Up to 6 years

  • Proportion of Participants Experiencing Clinically Significant Laboratory Abnormalities

    Up to 6 years

Secondary Outcomes (1)

  • Proportion of Participants Achieving American College of Rheumatology- N (ACR-N) Response in Each Arm

    Up to 6 years

Study Arms (4)

Blinded Phase: Filgotinib 200 mg

EXPERIMENTAL

Filgotinib 200 mg plus placebo to match (PTM) filgotinib 100 mg for up to 6 years

Drug: FilgotinibDrug: Placebo to match filgotinib

Blinded Phase: Filgotinib 100 mg

EXPERIMENTAL

Filgotinib 100 mg plus PTM filgotinib 200 mg for up to 6 years

Drug: FilgotinibDrug: Placebo to match filgotinib

Open Label Phase: Filgotinib 200 mg

EXPERIMENTAL

Filgotinib 200 mg for up to 6 years

Drug: Filgotinib

Open Label Phase: Filgotinib 100 mg

EXPERIMENTAL

Filgotinib 100 mg for up to 6 years

Drug: Filgotinib

Interventions

Tablet(s) administered orally once daily

Also known as: GS-6034, GLPG0634
Blinded Phase: Filgotinib 100 mgBlinded Phase: Filgotinib 200 mgOpen Label Phase: Filgotinib 100 mgOpen Label Phase: Filgotinib 200 mg

Tablet(s) administered orally once daily

Blinded Phase: Filgotinib 100 mgBlinded Phase: Filgotinib 200 mg

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Males or females who may benefit from filgotinib as judged by the investigator AND who completed a Gilead sponsored filgotinib parent study for RA as outlined below:
  • Have completed GS-US-417-0301, GS-US-417-0302 or GS-US-417-0303 on study drug
  • Have completed GS-US-417-0302 on standard of care therapy due to RA non-responder status
  • Females of childbearing potential must have a negative pregnancy test prior to first dose of study drug in the long term extension (LTE)
  • Females of childbearing potential who engage in heterosexual intercourse must agree to protocol-approved methods of contraception

You may not qualify if:

  • Diagnosis of an autoimmune or inflammatory joint disease other than RA, which would put the participant at risk by participating in the study or would interfere with study assessments/data interpretation, per judgment of the investigator
  • Known hypersensitivity to the study drug or its excipients
  • Any medical condition which would put the participant at risk by participating in the study or would interfere with study assessments/data interpretation, per judgment of the investigator

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (345)

Rheumatology Associates of North Alabama, PC

Huntsville, Alabama, 35801, United States

Location

Arthrocare, Arthritis Care & Research PC

Gilbert, Arizona, 85234, United States

Location

Arizona Arthritis & Rheumatology Associates, P.C.

Phoenix, Arizona, 85037, United States

Location

Arizona Arthritis & Rheumatology Associates, P.C.

Tucson, Arizona, 85704, United States

Location

Medvin Clinical Research

Covina, California, 91722, United States

Location

C.V. Mehta M.D. Medical Corporation

Hemet, California, 92543, United States

Location

University of California San Diego (UCSD) - Perlman Ambulatory Clinic

La Jolla, California, 92037, United States

Location

Keck Medicine of USC- Division of Rheumatology

Los Angeles, California, 90033, United States

Location

Desert Medical Advances

Palm Desert, California, 92260, United States

Location

Stanford University Hospitals and Clinics (Immunology & Rheumatology)

Palo Alto, California, 94305, United States

Location

C.V. Mehta Medical Corporation

Riverside, California, 92518, United States

Location

Inland Rheumatology Clinical Trials, Inc.

Upland, California, 91786, United States

Location

Desert Valley Medical Group

Victorville, California, 92395, United States

Location

Medvin Clinical Research

Whittier, California, 90602, United States

Location

AARDS Research, Inc.

Aventura, Florida, 33180, United States

Location

Clinical Research of West Florida, Inc.

Clearwater, Florida, 33765, United States

Location

Omega Research Consultants, LLC

DeBary, Florida, 32713, United States

Location

University of Florida College of Medicine, Jacksonville - Rheumatology Research

Jacksonville, Florida, 32207, United States

Location

Suncoast Research Group, LLC

Miami, Florida, 33135, United States

Location

San Marcus Research Clinic, Inc.

Miami Lakes, Florida, 33014, United States

Location

Suncoast Clinical Research, Inc.

New Port Richey, Florida, 34652, United States

Location

Omega Research Consultants LLC

Orlando, Florida, 32804, United States

Location

IRIS Research and Development, LLC

Plantation, Florida, 33324, United States

Location

Jefrey D. Lieberman, MD, P.C.

Decatur, Georgia, 30033, United States

Location

Springfield Clinic

Springfield, Illinois, 62702, United States

Location

University of Kansas Medical Center

Kansas City, Kansas, 66160, United States

Location

Heartland Research Associates, LLC

Wichita, Kansas, 67207, United States

Location

Center For Arthritis and Osteoporosis

Elizabethtown, Kentucky, 42701, United States

Location

Bluegrass Community Research, Inc.

Lexington, Kentucky, 40504, United States

Location

Klein & Associates, M.D., P.A.

Cumberland, Maryland, 21502, United States

Location

Arthritis Treatment Center

Frederick, Maryland, 21702, United States

Location

Klein & Associates, M.D., P.A.

Hagerstown, Maryland, 21740, United States

Location

The Center For Rheumatology And Bone Research

Wheaton, Maryland, 20902, United States

Location

Clinical Pharmacology Study Group

Worcester, Massachusetts, 01605, United States

Location

Umass Memorial Medical Center- Memorial Campus

Worcester, Massachusetts, 01605, United States

Location

Henry Ford Health System

Detroit, Michigan, 48202, United States

Location

Shores Rheumatology, PC

Saint Clair Shores, Michigan, 48081, United States

Location

St. Paul Rheumatology, PA

Eagan, Minnesota, 55121, United States

Location

Arthritis Associates, PLLC

Hattiesburg, Mississippi, 39402, United States

Location

North Mississippi Medical Clinics, Inc.

Tupelo, Mississippi, 38801, United States

Location

Clayton Medical Research, P.C.

St Louis, Missouri, 63117, United States

Location

Arthritis Consultants, Inc.

St Louis, Missouri, 63141, United States

Location

Physician Research Collaboration, LLC

Lincoln, Nebraska, 68516, United States

Location

Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States

Location

Arthritis & Osteoporosis Associates

Freehold, New Jersey, 07728, United States

Location

Ocean Rheumatology, PA

Toms River, New Jersey, 08755, United States

Location

Albuquerque Clinical Trials, Inc.

Albuquerque, New Mexico, 87102, United States

Location

NYU Langone Ambulatory Care Brooklyn Heights

Brooklyn, New York, 11201, United States

Location

Weill Cornell Physicians At Brooklyn Heights

Brooklyn, New York, 11201, United States

Location

Joint And Muscle Research Institute

Charlotte, North Carolina, 28204, United States

Location

Physicians East, PA

Greenville, North Carolina, 27834, United States

Location

PMG Research of Salisbury

Salisbury, North Carolina, 28144, United States

Location

Paramount Medical Research & Consulting, LLC

Middleburg Heights, Ohio, 44130, United States

Location

Health Research of Oklahoma

Oklahoma City, Oklahoma, 73103, United States

Location

The Oklahoma Center For Arthritis Therapy & Research, Inc.

Tulsa, Oklahoma, 74104, United States

Location

East Penn Rheumatology Associates

Bethlehem, Pennsylvania, 18015, United States

Location

Altoona Center for Clinical Research

Duncansville, Pennsylvania, 16635, United States

Location

Arthritis Group, PC

Philadelphia, Pennsylvania, 19152, United States

Location

Clinical Research Center of Reading LLC

Wyomissing, Pennsylvania, 19610, United States

Location

PA Regional Center For Arthritis And Osteoporosis Research

Wyomissing, Pennsylvania, 19610, United States

Location

Articularis Healthcare Inc., dba Columbia Arthritis Center, PA

Columbia, South Carolina, 29204, United States

Location

Carolina Rheumatology & Neurology Assoc., PC

Myrtle Beach, South Carolina, 29572, United States

Location

Articularis Healthcare Group d/b/a ACME Research

Orangeburg, South Carolina, 29118, United States

Location

Articularis Healthcare Group d/b/a Low Country Rheumatology

Summerville, South Carolina, 29486, United States

Location

Ramesh C. Gupta, M.D.

Memphis, Tennessee, 38119, United States

Location

Diagnostic Group

Beaumont, Texas, 77701, United States

Location

Trinity Universal Research Associates, Inc

Carrollton, Texas, 75007, United States

Location

Adriana Pop-Moody MD Clinic PA

Corpus Christi, Texas, 78404, United States

Location

Arthritis Centers Of Texas

Dallas, Texas, 75246, United States

Location

Southwest Rheumatology Research, LLC

Mesquite, Texas, 75150, United States

Location

Trinity Universal Research Associates, Inc

Plano, Texas, 75024, United States

Location

Arthritis & Osteoporosis Center of South Texas

San Antonio, Texas, 78232, United States

Location

Ceim Investigaciones Medicas Srl

Ciudad Autonoma, Buenos Aires, 1425, Argentina

Location

CIMEL

Buenos Aires, B1824KAJ, Argentina

Location

Onganizacion Medica de Investigacion S.A (OMI)

Ciudad Autonoma Buenos Aires, C1015ABO, Argentina

Location

Mautalen Salud e Investigación

Ciudad Autonoma Buenos Aires, C1128AAF, Argentina

Location

Consultorios Reumatológicos Pampa

Ciudad Autonoma de Buenos Aire, C1428DZF, Argentina

Location

Investigaciones Reumatologicas Y Osteologicas (IRO) SRL

Ciudad Autonoma, C1114AHH, Argentina

Location

Instituto De Reumatologia

Mendoza, 5500, Argentina

Location

Instituto Médico Cer

Quilmes, B1878DVB, Argentina

Location

Instituto Iari

San Isidro, Argentina

Location

Cer San Juan, Centro Polivalente de Asistencia e Investigacion Clinica

San Juan, CP5400, Argentina

Location

Centro Medico Privado de Reumatología

San Miguel de Tucumán, T4000AXL, Argentina

Location

Rheumatology Research Unit

Maroochydore, Queensland, 4558, Australia

Location

RK Will Pty Ltd

Victoria Park, Western Australia, 6100, Australia

Location

Southern Clinical Research Pty Ltd

Hobart, 7000, Australia

Location

Cliniques Universitaires Saint-Luc

Brussels, 1200, Belgium

Location

Reumaclinic Genk

Genk, 3600, Belgium

Location

Universitaire Ziekenhuizen (UZ) Leuven - Gasthuisberg

Leuven, 3000, Belgium

Location

Zna Jan Palfijn

Merksem, 2170, Belgium

Location

"Medical Center Help" EOOD

Dobrich, 9300, Bulgaria

Location

"Medical Center- Hipokrat 2000" OOD

Haskovo, 6300, Bulgaria

Location

"UMHAT - Kaspela" EOOD

Plovdiv, 4001, Bulgaria

Location

"MHAT Lyulin" EAD, Department of Rheumatology

Sofia, 1336, Bulgaria

Location

Medical Center "N. I. Pirogov" EOOD

Sofia, 1612, Bulgaria

Location

"DCC Equita" EOOD

Varna, 9000, Bulgaria

Location

MHAT "Sveta Petka" AD, Department of Internal Diseases

Vidin, 3700, Bulgaria

Location

The Waterside Clinic

Barrie, L4M6L2, Canada

Location

Centre De Recherche Musculo Squelettique

Trois-Rivières, G8Z1Y2, Canada

Location

Quantum Research Santiago

Santiago, 7500588, Chile

Location

Someal SA

Santiago, 7510186, Chile

Location

Centro Medico De Reumatologia

Temuco, 4790928, Chile

Location

MUDr. Michaela Blahova, revmatologicka ambulance s.r.o.

Brno, 60200, Czechia

Location

L.K.N. Arthrocentrum, s.r.o.

Hlučín, 748 01, Czechia

Location

MUDr. Rosypalová, S.R.O.

Ostrava-Poruba, 70800, Czechia

Location

Revmatologicky ustav

Prague, 12850, Czechia

Location

Revmatologicka Ambulance

Prague, 140 00, Czechia

Location

Revmatologicka ambulance, Nuselska Poliklinika

Prague, 14000, Czechia

Location

Arthrocentrum spol.s.r.o.

Prague Praha 10, 10100, Czechia

Location

Medical Plus, S.R.O.

Uherské Hradiště, 68601, Czechia

Location

Hôpital Lapeyronie, Service d'Immuno-Rhumatologic

Montpellier, 34295, France

Location

Rheumapraxis Dr. med. Reiner Kurthen

Aachen, 52064, Germany

Location

Schlosspark-Klinik

Berlin, 14059, Germany

Location

Centrum f. inn. Diagn. und Therap. Rheumatologie/Immunologie

Frankfurt am Main, 60590, Germany

Location

HRF II, Hamburger Rheuma Forsch. Zentrum II, MVZ f. Rheumatologie und Autoimmuned. Hamb. GmbH/ Dr. A. Everding GbR

Hamburg, 20095, Germany

Location

Rheumazentrum Ratungen-Studienambulanz GbR

Ratingen, 40878, Germany

Location

Department of Medicine & Theraputics, The Chinese University of Hong Kong

Hong Kong, Hong Kong

Location

Department of Medicine, Queen Mary Hospital

Hong Kong, Hong Kong

Location

Tuen Mun Hospital

Hong Kong, Hong Kong

Location

Betegapolo-Irgalmasrend Budai Irgalmasrendi Korhaz

Budapest, 1023, Hungary

Location

Revita Reumatológiai Kft.

Budapest, 1027, Hungary

Location

Markhot Ferenc Oktatokorhaz es Rendelointezet; Reumatologiai Osztaly

Eger, 3300, Hungary

Location

Bekes Megyei Kozponti Korhaz, Pandy Kalman Tagkorhaz, Reumatologiai Osztaly

Gyula, 5700, Hungary

Location

Bacs Kiskun Megyei Korhaz Szedgedi Tudomanyegyetem Altalanos Orvostudomanyi Kar Oktatokorhaz Kalocsai Szent Kereszt Korh

Kalocsa, 6300, Hungary

Location

Pest Megyei Flor Ferenc Korhaz, Reumatologiai-es Fizioterapias Osztaly

Kistarcsa, 2143, Hungary

Location

Csongrad Megyei Dr. Bugyi Istvan Korhaz; Mozgasszervi Rehabilitacios Osztaly

Szentes, 6600, Hungary

Location

C-Med Rehabilitacios es Diagnosztikai Kozpont. Reumatologia

Székesfehérvár, 8000, Hungary

Location

Panchshil Hospital, Dep

Ahmedabad, 380005, India

Location

B.J. Medical College and Civil Hospital

Ahmedabad, 380016, India

Location

Chanre Rheumatology and Immunology Centre and Research

Bangalore, 560010, India

Location

Chennai Meenakshi Multispeciality Hospital Ltd

Chennai, 600004, India

Location

All India Institute of Medical Sciences

Delhi, 110029, India

Location

Medanta - The Medicity

Gūrgaon, 122001, India

Location

Gleneagles Global Hospitals

Hyderabad, 500004, India

Location

Nizams Institute of Medical Sciences

Hyderabad, 50082, India

Location

Shri Nidaan Hospital and Hope Fertility Centre

Jaipur, 302001, India

Location

SR Kalla Memorial Gastro and General Hospital

Jaipur, 302001, India

Location

Santokba Durlabhji Memorial Hospital Cum Medical Research Institute

Jaipur, 302015, India

Location

Apollo Gleneagles Hospitals, Kolkata

Kolkata, 700 054, India

Location

Medical College & Hospital, Kolkata

Kolkata, 700073, India

Location

Department of Rheumatology, KG Medical University

Lucknow, 226018, India

Location

Kasturba Medical College Hospital

Mangalore, 575001, India

Location

Vinaya Hospital and Research Centre

Mangalore, 575003, India

Location

JSS Medical College and Hospital

Mysuru, 570004, India

Location

Suretech Hospital and Research Centre Pvt Ltd

Nagpur, 440012, India

Location

Maharaja Agrasen Hospital

New Delhi, 110026, India

Location

Sir Ganga Ram Hospital

New Delhi, 110060, India

Location

Centre for Rheumatic Disease, Hermes Doctor House

Pune, 411001, India

Location

Deenanath Mangeshkar Hospital and Research Centre

Pune, 411004, India

Location

Krishna Institute of Medical Sciences

Secunderabad, India

Location

Rajiv Gandhi Institute of Medical Sciences and Government General Hospital

Srikakulam, 532001, India

Location

Nirmal Hospital Private Limited

Surat, 395002, India

Location

Medical College Baroda and Sir Sayajirao General Hospital

Vadodara, 390001, India

Location

King George Hospital

Visakhapatnam, 530002, India

Location

St Vincent's University Hospital

Dublin, Dublin 4, Ireland

Location

Bnai Zion Medical Center

Haifa, 3339419, Israel

Location

The Lady Davis Carmel Medical Center

Haifa, 3436212, Israel

Location

Rabin Medical Center

Petah Tikva, 4941492, Israel

Location

The Chaim Sheba Medical Center

Ramat Gan, 5265601, Israel

Location

Tel Aviv Medical Center

Tel Aviv, 6423906, Israel

Location

Departimento Cardio-toraco-vascolare Gestione delle Malattie Reumatiche e del Connettivo e Malattie Metaboliche dell'osso

Bologna, Bologna, 40138, Italy

Location

Reumatologia

Milan, 20157, Italy

Location

Chibaken Saiseikai Narashino Hospital

Narashino, Chiba, 275-8580, Japan

Location

Medical Corporation Kojyokai Hirose Clinic

Tokorozawa, Saitama, 359-1111, Japan

Location

Honjo Rheumatism Clinic

Takaoka, Toyama, 933-0874, Japan

Location

Chiba University Hospital

Chiba, 2608677, Japan

Location

Kyushu Medical Center

Fukuoka, 810-8563, Japan

Location

National Hospital Organization Kyushu Medical Center

Fukuoka, 810-8563, Japan

Location

Seirei Hamamatsu General Hospital

Hamamatsu, 430-8558, Japan

Location

Hiroshima Rheumatology Clinic

Hiroshima, 730-0017, Japan

Location

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital

Hiroshima, 730-8619, Japan

Location

Hiroshima University Hospital

Hiroshima, 734-8551, Japan

Location

Iizuka Hospital

Iizuka-shi, 820-8505, Japan

Location

Saitama Medical University Hospital

Iruma-gun, 350-0495, Japan

Location

Shimane University Hospital

Izumo, 693-8501, Japan

Location

Kagoshima red cross hospital

Kagoshima, 891-0133, Japan

Location

Matsubara Mayflower Hospital

Katō, 673-1462, Japan

Location

Saitama Medical Center

Kawagoe, 350-8550, Japan

Location

Hospital of the University of Occupational and Environmental Health, Japan

Kitakyushu-shi, 807-8556, Japan

Location

Kobe University Hospital

Kobe, 650-0017, Japan

Location

Kumamoto Orthopaedic Hospital

Kumamoto, 862-0975, Japan

Location

Kurume University Medical Center

Kurume-shi, 839-0863, Japan

Location

University Hospital, Kyoto Prefectural University of Medicine

Kyoto, 602-8566, Japan

Location

Kyoto University Hospital

Kyoto, 606-8507, Japan

Location

Yu Family Clinic

Miyagi-gun, 981-0112, Japan

Location

Zenjinkai Shiminnnomori Hospital

Miyazaki, 880-0122, Japan

Location

Yoshida orthopaedic and rheumatology Clinic

Morioka, 020-0015, Japan

Location

Nagaoka Red Cross Hospital

Nagaoka, 940-2085, Japan

Location

Nagasaki Medical Hospital of Rheumatology

Nagasaki, 850-0832, Japan

Location

Nagoya University Hospital

Nagoya, 466-8560, Japan

Location

The Hospital of Hyogo College of Medine

Nishinomiya, 663-8501, Japan

Location

Okayama Saiseikai General Hospital Outpatient Center

Okayama, 700-0013, Japan

Location

Okayama University Hospital

Okayama, 700-8558, Japan

Location

Ome Municipal General Hospital

Ōme, 198-0042, Japan

Location

National Hospital Organization Sagamihara National Hospital

Sagamihara, 252-0392, Japan

Location

Sanuki Municipal Hospital

Sanuki-shi, 769-2393, Japan

Location

Sagawa Akira Rheumatology Clinic

Sapporo, 060-0001, Japan

Location

Sapporo City General Hospital

Sapporo, 060-8604, Japan

Location

Hokkaido University Hospital

Sapporo, 060-8648, Japan

Location

Hokkaido Medical Center for Rheumatic Diseases

Sapporo, 063-0811, Japan

Location

Sasebo Chuo Hospital

Sasebo-shi, 857-1195, Japan

Location

Azuma Rheumatology Clinic

Sayama-shi, 350-1305, Japan

Location

Niigata Rheumatic Center

Shibata, 957-0054, Japan

Location

Shizuoka Welfare Hospital

Shizuoka, 420-8623, Japan

Location

Osaka University Hospital

Suita-shi, 565-0871, Japan

Location

Inoue Hospital

Takasaki-shi, 370-0053, Japan

Location

St. Luke's International Hospital

Tokyo, 104-8560, Japan

Location

Medical Corporation Uchida Clinic

Tokyo, 130-0013, Japan

Location

Showa University East Hospital

Tokyo, 142-0054, Japan

Location

Toho University Omori Medical Center

Tokyo, 143-8541, Japan

Location

Toho University Ohashi Medical Center

Tokyo, 153-8515, Japan

Location

Setagaya Rheumatic Clinic

Tokyo, 156-0052, Japan

Location

Keio University Hospital

Tokyo, 160-8582, Japan

Location

Teikyo University Hospital

Tokyo, 173-8606, Japan

Location

Yuuai Medical Center

Tomigusuku-shi, 901-0224, Japan

Location

University of Tsukuba Hospital

Tsukuba, 305-8576, Japan

Location

Wakayama Medical University Hospital

Wakayama, 641-8509, Japan

Location

Yokohama Minami Kyousai Hospital

Yokohama, 236-0037, Japan

Location

Hospital Selayang

Batu Caves, Selangor, 68100, Malaysia

Location

University Malaya Medical Centre

Kuala Lumpur, 59100, Malaysia

Location

Centro De Investigación Clínica De Morelia, Sc

Morelia, Michoacán, 58070, Mexico

Location

Kohler & Milstein Research S.A. de C.V.

Mérida, Yucatán, 97070, Mexico

Location

Investigacion y Biomedicina de Chihuahua, S.C.

Chihuahua City, 31000, Mexico

Location

Clinstile, S.A. De C.V.

Mexico City, 06700, Mexico

Location

Clinosar Mexico. S.A. de C. V.

Mexico City, 06760, Mexico

Location

Centro Peninsular De Investigacion Clinica S.C.P.

Mérida, 97000, Mexico

Location

Biologicos Especializados

México, 06700, Mexico

Location

Hospital Universitario Dr. Jose Eleuterio Gonzalez

Monterrey, 64460, Mexico

Location

Middlemore Clinical Trial

Papatoetoe, Auckland, 2025, New Zealand

Location

Optimal Clinical Trials, Level 2

Auckland, 1010, New Zealand

Location

Waikato Hospital

Hamilton, 3240, New Zealand

Location

Clinical Trial Unit, CCHDB, Wellington Hospital

Newtown, 6021, New Zealand

Location

Clinical Trials Unit, Timaru Hospital

Timaru, 7910, New Zealand

Location

Gabinet Internistyczno-Reumatologiczny Piotr Adrian Klimiuk

Bialystok, 15-099, Poland

Location

Clinicmed

Bialystok, 15-879, Poland

Location

Szpital Uniwersytecki Nr 2, Klinka Reumatologii I Ukladowych Chorob Tkanki Lacznej

Bydgoszcz, 85168, Poland

Location

Niepubliczny Zaklad Opieki Zdrowotnej BIF-MED S.C.

Bytom, 41-902, Poland

Location

Nszoz Unica Cr

Dabrówka, 62096, Poland

Location

Centrum Kliniczno-Badawcze J. Brzezicki

Elblag, 82300, Poland

Location

Centrum Medyczne Pratia Gdynia

Gdynia, 81-338, Poland

Location

NZOZ Centrum Medyczna Sw. Lukasza w Kartuzach

Kartuzy, 83300, Poland

Location

SILMEDIC Spolka z ograniczona odpowiedzialnoscia w Swindniku, Oddzial w Katowicach

Katowice, 40-282, Poland

Location

Nzoz Centrum Medyczne Promimed

Krakow, 31-637, Poland

Location

Twoja Przychodnia -Centrum Medyzcne Nowa Sol

Nowa Sól, 67-100, Poland

Location

Synexus Polska Sp. z.o.o. Oddzial w Porznaniu

Poznan, 60-702, Poland

Location

Centrum Badan Klinicznych S.C. Wieslawa Porawska, Lukasz Porawski

Poznan, 60-733, Poland

Location

Ai Centrum Medyczne

Poznan, 61-113, Poland

Location

Samodzielny Publiczny Zespol Opieki Zdrowotnej w Tomaszowie Lubelskim Lubelskim; Oddzial Reumatologiczy

Tomaszów Lubelski, 22-600, Poland

Location

Nasz Lekarz Przychodnie Medyczne

Torun, 87100, Poland

Location

Reumatika -Centrum Reumatologii NZOZ

Warsaw, 02-691, Poland

Location

Centrum Medyczne AMED Warszawa Targówek

Warsaw, 03291, Poland

Location

Centrum Medyczne Oporow

Wroclaw, 52416, Poland

Location

Spitalul Judetean de Urgenta Bacau, Sectia Reumatologie

Bacau, 600114, Romania

Location

S.C. Ianuli Med Consult S.R.L.

Bucharest, 010976, Romania

Location

Spitalul Clinic ,, Sf. Maria", Sectia Reumatologie

Bucharest, 011172, Romania

Location

Spitalul Clinic,, Sf. Maria"", Departamentul de Medicina Interna si Reumatologie

Bucharest, 011172, Romania

Location

Spitalul Clinic Judetean de Urgenta Tirgu Mures

Târgu Mureş, 540136, Romania

Location

Territorial State Budgetary Healthcare Institution "Territorial Clinical Hospital"

Barnaul, 656024, Russia

Location

State Budgetary Healthcare Institution, Chelyabinsk Regional Clinical Hospital

Chelyabinsk, 454076, Russia

Location

FSBEI of HE "Kazan State Medical University" of Ministry of Healthcare of the Russia Federation, Department of hospital therapy

Kazan', 420103, Russia

Location

Medical Center Maximum Zdorovia LLC

Kemerovo, 650066, Russia

Location

Kemerovo State Medical University on the base of Regional Clinical Hospital for War Veterans

Kemerovo, 650099, Russia

Location

Municipal Clinical Hospital No. 15 named after O.M. Filatov

Moscow, 111539, Russia

Location

City Clinical Hospital #4 of Department of Healthcare of Moscow City

Moscow, 115093, Russia

Location

M. Vladimirsky Moscow Regional Research Clinical Institute

Moscow, 129110, Russia

Location

Municipal Clinical Hospital No. 40 Department of healthcare of Moscow City

Moscow, 129301, Russia

Location

Nizhny Novgorod City Clinical Hospital #5

Nizhny Novgorod, 603005, Russia

Location

Saint-Petersburg State Budgetary Healthcare Institution "Clinical rheumatology hospital # 25"

Saint Petersburg, 190068, Russia

Location

LLC Polyclinic of Private Security Personnel

Saint Petersburg, 192007, Russia

Location

State Healthcare Institution, Regional Clinical Hospital

Saratov, 410053, Russia

Location

LLC BioMed

Vladimir, 600005, Russia

Location

State Autonomous Healthcare Institution of Yaroslavl region "Clinical Hospital for Emergency Medical Care n. a. N. V. Solovyev"

Yaroslavl, 150003, Russia

Location

Institute Of Rheumatology

Belgrade, 11000, Serbia

Location

Military Medical Academy, Clinic of Rheumatology

Belgrade, 11000, Serbia

Location

Clinical Hospital Center Bezanijska Kosa

Belgrade, 11080, Serbia

Location

Institute For Treatment And Rehabilitation Niska Banja

Niška Banja, 18205, Serbia

Location

Neštátna Reumatologická Ambulancia

Bratislava, 841 04, Slovakia

Location

Reumex S.R.O.

Rimavská Sobota, 97901, Slovakia

Location

LERAM s.r.o.

Topoľčany, 95501, Slovakia

Location

Arthritis Clinical Trial Centre

Cape Town, 7505, South Africa

Location

Netcare St. Augustine's Hospital

Durban, 4001, South Africa

Location

Umhlanga Netcare Medical Centre

Durban, 4319, South Africa

Location

Charlotte Maxeke Johannesburg Academic Hospital

Johannesburg, 2193, South Africa

Location

Winelands Medical Research Centre

Stellenbosch, South Africa

Location

Pusan National University Hospital

Busan, 49241, South Korea

Location

Kyungpook National University Hospital

Daegu, 41944, South Korea

Location

Daegu Catholic University Medical Center

Daegu, 42472, South Korea

Location

Chungnam National University Hospital

Daejeon, 35015, South Korea

Location

Eulji University Hospital

Daejeon, 35233, South Korea

Location

Chonnam National University Hospital

Gwangju, 61469, South Korea

Location

Inha University Hospital

Incheon, 22332, South Korea

Location

Chonbuk National University Medical School

Jeonju, 54907, South Korea

Location

Seoul National University Hospital

Seoul, 03080, South Korea

Location

Hanyang University Seoul Hospital

Seoul, 04763, South Korea

Location

Konkuk University Medical Center

Seoul, 05030, South Korea

Location

Asan Medical Center

Seoul, 05505, South Korea

Location

Chung-Ang University Hospital Institutional Review Board

Seoul, 06973, South Korea

Location

SMG-SNU Boramae Medical Center

Seoul, 07061, South Korea

Location

Complejo Hospitalario Universitario de Santiago

A Coruña, 15706, Spain

Location

Hospital Universitario Cruces

Barakaldo, 48903, Spain

Location

Hospital General Universitario Gregorio Maranon

Madrid, 28007, Spain

Location

Hospital Universitario Ramon y Cajal

Madrid, 28034, Spain

Location

Hospital Regional Universitario de Malaga

Málaga, 29009, Spain

Location

Corporacio Santiaria Parc Tauli

Sabadell, 08208, Spain

Location

Clínica Gaias

Santiago de Compostela, 15702, Spain

Location

Hospital HM Nuestra Senora de la Esperanza

Santiago de Compostela, 15705, Spain

Location

Hospital Clinico Universitario de Valencia

Valencia, 46010, Spain

Location

Changhua Christian Hospital

Changhua, 500, Taiwan

Location

Kaohsiung Veterans General Hospital

Kaohsiung City, 813, Taiwan

Location

Chang Gung Memorial Hospital, Keelung

Keelung, 204, Taiwan

Location

Chung Shan Medical University Hospital

Taichung, 40201, Taiwan

Location

China Medical University Hospital

Taichung, 404, Taiwan

Location

Chi Mei Hospital, Chi Mei Medical Center

Tainan, 710, Taiwan

Location

National Taiwan University Hospital

Taipei, 100, Taiwan

Location

Taipei Medical University Hospital

Taipei, 110, Taiwan

Location

Tri-Service General Hospital

Taipei, 11490, Taiwan

Location

Chang Gung Medical Foundation, Chang Gung Memorial Hospital, Linkou Branch

Taoyuan District, 333, Taiwan

Location

Phramongkutklao Hospital, Division of Rheumatology, Department of Medicine

Bangkok, 10400, Thailand

Location

Rajavithi Hospital, Rheumatology and Allergy Unit

Bangkok, 10400, Thailand

Location

Faculty of Medicine Siriraj Hospital, Mahidol University, Division of Rheumatology, Department of Medicine

Bangkok, 10700, Thailand

Location

Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Chiang Mai University

Chiang Mai, 50200, Thailand

Location

Faculty of Medicine, Prince of Songkla University, Songklanagarind Hospital

Songkhla, 90110, Thailand

Location

Municipal Institution Dnipropetrovsk 6th City Clinical Hospital of Dnipropetrovsk Regional Council

Dnipro, 49074, Ukraine

Location

Municipal Nonprofit Enterprise of the Kharkiv Regional Council, Regional Hospital for War Veterans, Department of Therapy #1

Kharkiv, 61019, Ukraine

Location

State Institution "National Institute of Therapy named after L.T. Maloyi" of National Academy of Medical Sciences of Ukraine"

Kharkiv, 61039, Ukraine

Location

Municipal Institution of Heath Care "Regional Clinical Hospital-Center Of Emergency Medicine & Disaster Medicine"

Kharkiv, 61058, Ukraine

Location

Municipal Nonprofit Enterprise "City Clinical Hospital #13" of the Kharkiv City Council, Department of Therapy

Kharkiv, 61124, Ukraine

Location

Minicipal Institution "Kherson City Clinical Hospital n. a. Afanasiy and Olga Tropinykh", Department of Therapy #1

Kherson, 73000, Ukraine

Location

Kyiv Oleksandrivska City Clinical Hospital, Department of Rheumatology # 2

Kyiv, 01601, Ukraine

Location

Kyiv City Clinical Hospital #6, Department of Therapy

Kyiv, 03126, Ukraine

Location

State Institution National Scientific Center M.D. Strazhesko Institute of Cardiology of NAMS of Ukraine

Kyiv, 03680, Ukraine

Location

Municipal Institution of Kyiv Regional Council "Kyiv Regional Clinical Hospital", Highly Specialized Therapeutic Department

Kyiv, 04107, Ukraine

Location

Lutsk City Clinical Hospital

Lutsk, 43024, Ukraine

Location

Municipal Institution of Lviv Regional Council "Lviv Regional Clinical Hospital" Department of Rheumatology

Lviv, 79010, Ukraine

Location

Municipal Nonprofit Enterprise "4-th City Clinical Hospital in Lviv", Department of Rheumatology

Lviv, 79011, Ukraine

Location

Municipal Institution Odesa Regional Clinical Hospital, Polyclinic Department

Odesa, 65025, Ukraine

Location

Vinnytsya Regional Clinical Hospital named after M. I. Pyrogova, Department of Rheumatology

Vinnytsia, 21018, Ukraine

Location

City Clinical Hospital #1, Department of Rheumatology

Vinnytsia, 21029, Ukraine

Location

Medical Centre Modern Clinic, LLC

Zaporizhzhya, 69005, Ukraine

Location

Municipal Institution "City Hospital #1", Department of Therapy

Zaporizhzhya, 69104, Ukraine

Location

Municipal Institution City Hospital #7, Department of Therapy

Zaporizhzhya, 69118, Ukraine

Location

NHS Lothian, Western General Hospital

Edinburgh, EH4 2XU, United Kingdom

Location

Princess Alexandra Hospital

Harlow, CM201QX, United Kingdom

Location

Northumbria Healthcare NHS Foundation Trust

North Shields, NE29 8NH, United Kingdom

Location

Warrington and Halton Hospitals Nhs Foundation Trust

Warrington, WA5 1QG, United Kingdom

Location

Related Publications (3)

  • Tanaka Y, Matsubara T, Atsumi T, Amano K, Ishiguro N, Hirata S, Yamaoka K, Combe BG, Nash P, Genovese M, Pechonkina A, Liu J, Kondo A, Fukada H, De Leonardis F, Takeuchi T. Safety and efficacy of filgotinib in Japanese patients with rheumatoid arthritis: Week 156 interim results in FINCH 4. Mod Rheumatol. 2025 Apr 8;35(3):425-433. doi: 10.1093/mr/roae099.

  • Balsa A, Wassenberg S, Tanaka Y, Tournadre A, Orzechowski HD, Rajendran V, Lendl U, Stiers PJ, Watson C, Caporali R, Galloway J, Verschueren P. Effect of Filgotinib on Body Mass Index (BMI) and Effect of Baseline BMI on the Efficacy and Safety of Filgotinib in Rheumatoid Arthritis. Rheumatol Ther. 2023 Dec;10(6):1555-1574. doi: 10.1007/s40744-023-00599-1. Epub 2023 Sep 25.

  • Combe B, Besuyen R, Gomez-Centeno A, Matsubara T, Sancho Jimenez JJ, Yin Z, Buch MH. Geographic Analysis of the Safety and Efficacy of Filgotinib in Rheumatoid Arthritis. Rheumatol Ther. 2023 Feb;10(1):35-51. doi: 10.1007/s40744-022-00494-1. Epub 2022 Oct 7.

MeSH Terms

Conditions

Arthritis, Rheumatoid

Interventions

GLPG0634

Condition Hierarchy (Ancestors)

ArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic DiseasesConnective Tissue DiseasesSkin and Connective Tissue DiseasesAutoimmune DiseasesImmune System Diseases

Study Officials

  • Alfasigma Study Director

    Alfasigma S.p.A.

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Masking Details
This study was originally designed and initiated as a double-blind study but the study design will change to open-label following implementation of the protocol amendment # 4.
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 17, 2017

First Posted

January 19, 2017

Study Start

February 28, 2017

Primary Completion

May 16, 2025

Study Completion

May 16, 2025

Last Updated

July 3, 2025

Record last verified: 2025-07

Data Sharing

IPD Sharing
Will not share

Locations