Testing the Addition of Atezolizumab to Combination Chemotherapy or Atezolizumab Alone for Metastatic Colon or Rectal Cancer, the COMMIT Study

NCT02997228 | Active Not Recruiting Phase 3 FDA Drug

• 4 other identifiers: NCI-2016-01961NRG-GI004/S1610NRG-GI004U10CA180868
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 445

Brief Summary

This phase III trial studies how well combination chemotherapy, bevacizumab, and/or atezolizumab work in treating patients with deficient deoxyribonucleic acid (DNA) mismatch repair colorectal cancer that has spread from where it first started (primary site) to other places in the body (metastatic). Chemotherapy drugs, such as fluorouracil, oxaliplatin, and leucovorin calcium, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of the tumor. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving combination chemotherapy, bevacizumab, and atezolizumab may work better in treating patients with colorectal cancer.

Conditions

Metastatic Colorectal Adenocarcinoma; Stage IV Colorectal Cancer AJCC v7

Outcome Measures

Primary Outcomes (1)

• Progression free survival (PFS)

  The analysis set is intent-to-treat (ITT). The experimental arms will be compared to the control arm by the log-rank test stratified by BRAF status (V600E mutation or not), metastatic disease: (liver-only, extra-hepatic), and prior adjuvant therapy for colon cancer (yes, no). Hazard ratios and associated confidence intervals from a stratified Cox regression model will also be reported along with estimates of the distributions of time to PFS event by the method of Kaplan and Meier. Sensitivity analyses accounting for 2 or more consecutively missed scheduled tumor imaging scans before progression/death will also be conducted.

  From the time from randomization until first confirmed progression or death from any cause, assessed up to 5 years

Secondary Outcomes (7)

• Overall survival (OS)

  The time from randomization to death from any cause, assessed up to 5 years

• Objective response rate (ORR) (complete response [CR] or partial response [PR])

  Up to 5 years

• Incidence of adverse events

  Up to 30 days after last cycle

• Rate of PFS

  At 12 months

• Disease control rate (CR + PR + stable disease [SD])

  At 12 months

Other Outcomes (13)

• Severity of fatigue

  At 16 weeks

• Physical functioning

  At 16 weeks

• Health utility scores

  Up to 5 years

Study Arms (3)

Arm I (bevacizumab, mFOLFOX6)

ACTIVE COMPARATOR

Patients receive bevacizumab intravenously (IV) over 30-90 minutes on day 1, oxaliplatin IV over 2 hours on day 1 of cycles 1-10, leucovorin calcium IV over 2 hours on day 1, and fluorouracil IV over 46-48 hours on days 1 and 2. Treatment with oxaliplatin repeats every 2 weeks for up to 10 cycles in the absence of disease progression or unacceptable toxicity. Treatment of bevacizumab, leucovorin calcium, and fluorouracil repeat every 2 weeks for up to 48 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT with or without PET or MRI throughout the trial. Patients may also undergo collection of optional blood samples throughout the trial. (CLOSED TO ACCRUAL)

Biological: Bevacizumab; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Drug: Fluorouracil; Drug: Leucovorin; Procedure: Magnetic Resonance Imaging; Drug: Oxaliplatin; Procedure: Positron Emission Tomography; Other: Quality-of-Life Assessment; Other: Questionnaire Administration

Arm II (atezolizumab)

EXPERIMENTAL

Patients receive atezolizumab IV over 30-60 minutes on day 1. Treatment repeats every 2 weeks for up to 48 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT with or without PET or MRI throughout the trial. Patients may also undergo collection of optional blood samples throughout the trial.

Drug: Atezolizumab; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Procedure: Magnetic Resonance Imaging; Procedure: Positron Emission Tomography; Other: Quality-of-Life Assessment; Other: Questionnaire Administration

Arm III (atezolizumab, bevacizumab, mFOLFOX6)

EXPERIMENTAL

Patients receive atezolizumab IV over 30-60 minutes on day 1. Treatment repeats every 2 weeks for up to 48 cycles in the absence of disease progression or unacceptable toxicity. Patients also receive bevacizumab IV over 30-90 minutes on day 1, oxaliplatin IV over 2 hours on day 1 cycles 1-10, leucovorin calcium IV over 2 hours on day 1, and fluorouracil IV over 46-48 hours on day 1. Treatment with oxaliplatin repeats every 2 weeks for up to 10 cycles in the absence of disease progression or unacceptable toxicity. Treatment of bevacizumab, leucovorin calcium, and fluorouracil repeat every 2 weeks for up to 48 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT with or without PET or MRI throughout the trial. Patients may also undergo collection of optional blood samples throughout the trial.

Drug: Atezolizumab; Biological: Bevacizumab; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Drug: Fluorouracil; Drug: Leucovorin; Procedure: Magnetic Resonance Imaging; Drug: Oxaliplatin; Procedure: Positron Emission Tomography; Other: Quality-of-Life Assessment; Other: Questionnaire Administration

Interventions

Atezolizumab DRUG

Given IV

Also known as: MPDL 3280A, MPDL 328OA, MPDL-3280A, MPDL3280A, MPDL328OA, RG 7446, RG-7446, RG7446, RO 5541267, RO-5541267, RO5541267, Tecentriq

Arm II (atezolizumab); Arm III (atezolizumab, bevacizumab, mFOLFOX6)

Bevacizumab BIOLOGICAL

Given IV

Also known as: ABP 215, ABP-215, ABP215, Alymsys, Anti-VEGF, Anti-VEGF Humanized Monoclonal Antibody, Anti-VEGF Monoclonal Antibody SIBP04, Anti-VEGF rhuMAb, Avastin, Avzivi, Aybintio, BAT 1706, BAT-1706, BAT1706, BAT1706 Biosimilar, Bevacizumab awwb, Bevacizumab Biosimilar ABP 215, Bevacizumab Biosimilar BAT1706, Bevacizumab Biosimilar BEVZ92, Bevacizumab Biosimilar BI 695502, Bevacizumab Biosimilar CBT 124, Bevacizumab Biosimilar CT-P16, Bevacizumab Biosimilar FKB238, Bevacizumab Biosimilar GB-222, Bevacizumab Biosimilar HD204, Bevacizumab Biosimilar HLX04, Bevacizumab Biosimilar IBI305, Bevacizumab Biosimilar LY01008, Bevacizumab Biosimilar MB02, Bevacizumab Biosimilar MIL60, Bevacizumab Biosimilar Mvasi, Bevacizumab Biosimilar MYL-1402O, Bevacizumab Biosimilar QL 1101, Bevacizumab Biosimilar QL1101, Bevacizumab Biosimilar RPH-001, Bevacizumab Biosimilar SCT501, Bevacizumab Biosimilar Zirabev, Bevacizumab-adcd, Bevacizumab-aveg, Bevacizumab-awwb, Bevacizumab-aybi, Bevacizumab-bvzr, Bevacizumab-byva, Bevacizumab-equi, Bevacizumab-maly, Bevacizumab-nwgd, Bevacizumab-onbe, Bevacizumab-tnjn, BP102, BP102 Biosimilar, CT P16, CT-P16, CTP16, Equidacent, FKB 238, FKB-238, FKB238, HD204, Immunoglobulin G1 (Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF Light Chain, Dimer, Jobevne, MB 02, MB-02, MB02, Mvasi, MYL-1402O, Onbevzi, Oyavas, PF 06439535, PF-06439535, PF06439535, QL1101, Recombinant Humanized Anti-VEGF Monoclonal Antibody, rhuMab-VEGF, SCT501, SIBP 04, SIBP-04, SIBP04, Vegzelma, Zirabev

Arm I (bevacizumab, mFOLFOX6); Arm III (atezolizumab, bevacizumab, mFOLFOX6)

Biospecimen Collection PROCEDURE

Undergo collection of blood samples

Also known as: Biological Sample Collection, Biospecimen Collected, Sample Collection, Specimen Collection

Arm I (bevacizumab, mFOLFOX6); Arm II (atezolizumab); Arm III (atezolizumab, bevacizumab, mFOLFOX6)

Computed Tomography PROCEDURE

Undergo CT or CT/PET

Also known as: CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, Diagnostic CAT Scan, Diagnostic CAT Scan Service Type, tomography

Arm I (bevacizumab, mFOLFOX6); Arm II (atezolizumab); Arm III (atezolizumab, bevacizumab, mFOLFOX6)

Fluorouracil DRUG

Given IV

Also known as: 5 Fluorouracil, 5 Fluorouracilum, 5 FU, 5-Fluoro-2,4(1H, 3H)-pyrimidinedione, 5-Fluorouracil, 5-Fluracil, 5-Fu, 5FU, AccuSite, Carac, Fluoro Uracil, Fluouracil, Flurablastin, Fluracedyl, Fluracil, Fluril, Fluroblastin, Ribofluor, Ro 2-9757, Ro-2-9757

Arm I (bevacizumab, mFOLFOX6); Arm III (atezolizumab, bevacizumab, mFOLFOX6)

Leucovorin DRUG

Given IV

Also known as: Folinic acid

Arm I (bevacizumab, mFOLFOX6); Arm III (atezolizumab, bevacizumab, mFOLFOX6)

Magnetic Resonance Imaging PROCEDURE

Undergo MRI

Also known as: Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI

Arm I (bevacizumab, mFOLFOX6); Arm II (atezolizumab); Arm III (atezolizumab, bevacizumab, mFOLFOX6)

Oxaliplatin DRUG

Given IV

Also known as: 1-OHP, Ai Heng, Aiheng, Dacotin, Dacplat, Diaminocyclohexane Oxalatoplatinum, Eloxatin, Eloxatine, Elplat, JM 83, JM-83, JM83, Oxalatoplatin, Oxalatoplatinum, RP 54780, RP-54780, RP54780, SR 96669, SR-96669, SR96669

Arm I (bevacizumab, mFOLFOX6); Arm III (atezolizumab, bevacizumab, mFOLFOX6)

Positron Emission Tomography PROCEDURE

Undergo CT/PET

Also known as: Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, PT

Arm I (bevacizumab, mFOLFOX6); Arm II (atezolizumab); Arm III (atezolizumab, bevacizumab, mFOLFOX6)

Quality-of-Life Assessment OTHER

Ancillary studies

Also known as: Quality of Life Assessment

Arm I (bevacizumab, mFOLFOX6); Arm II (atezolizumab); Arm III (atezolizumab, bevacizumab, mFOLFOX6)

Questionnaire Administration OTHER

Ancillary studies

Arm I (bevacizumab, mFOLFOX6); Arm II (atezolizumab); Arm III (atezolizumab, bevacizumab, mFOLFOX6)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
• Age \>= 18 years
• Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2
• Diagnosis of metastatic adenocarcinoma of colon or rectum without previous chemotherapy or any other systemic therapy for metastatic colorectal cancer except for one cycle of FOLFOX or capecitabine and oxaliplatin (CAPOX), either with or without bevacizumab prior to enrollment. Upon enrollment, the preceding single cycle of FOLFOX or FOLFOX + bevacizumab, if the patient received one, will not count towards patients' assessments per protocol. Cycle 1 day 1 (C1D1) of atezolizumab or C1D1 of mFOLFOX6/bevacizumab + atezolizumab will correspond to the first day the patient received therapy on trial
• Tumor determined to be mismatch-repair deficient (dMMR) by Clinical Laboratory Improvement Act (CLIA)-certified immunohistochemical (IHC) assay with a panel of all four IHC markers, including MLH1, MSH2, PMS2, and MSH6; alternatively, MSI-H diagnosed by polymerase chain reaction (PCR)-based assessment of microsatellite alterations (either Bethesda markers or Pentaplex panel) or by next-generation sequencing (NGS) are eligible
• Documentation by PET/CT scan, CT scan, or MRI that the patient has measurable metastatic disease per RECIST 1.1
• No immediate need for surgical intervention for the primary tumor or palliative diversion/bypass
• Absolute neutrophil count (ANC) must be \>= 1500/mm\^3 (obtained within 28 days prior randomization)
• Platelet count must be \>= 100,000/mm\^3 (obtained within 28 days prior randomization)
• Hemoglobin must be \>= 8 g/dL (obtained within 28 days prior randomization)
• Total bilirubin must be =\< 4 x ULN (upper limit of normal) (obtained within 28 days prior randomization); and
• Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) must be =\< 3 x ULN for the lab with the following exception: for patients with documented liver metastases, AST and ALT must be =\< 5 x ULN (obtained within 28 days prior randomization)
• Calculated creatinine clearance \>= 30 mL/min (obtained within 28 days prior randomization)
• A urine sample tested for proteinuria by either the dipstick method, urinalysis (UA), or a urine protein creatinine (UPC) ratio:
• The dipstick method must indicate 0-1+ protein; if dipstick reading is \>= 2+, a 24-hour urine must be done and it must demonstrate \< 1.0 g of protein per 24 hours or a UPC ratio \< 1.0

You may not qualify if:

• Known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies, fluoropyrimidines, folic acid derivatives or oxaliplatin
• Uncontrolled high blood pressure defined as systolic blood pressure (BP) \> 150 mmHg or diastolic BP \> 100 mmHg with or without anti-hypertensive medication; patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria
• Documented New York Heart Association (NYHA) class III or IV congestive heart failure
• Serious or non-healing wound, skin ulcer, or bone fracture
• History of inherited bleeding diathesis, gastrointestinal (GI) perforation, significant vascular disease (e.g., aortic aneurysm requiring surgical repair or recent arterial thrombosis or symptomatic peripheral ischemia, transient ischemic attack \[TIA\], cerebrovascular accident \[CVA\] or arterial thrombotic event), abdominal fistula, intra-abdominal abscess, or active GI bleeding (with cause not addressed) within 6 months prior to randomization, or other medical condition in the opinion of the treating oncologist that makes the risk of cardiovascular or bleeding complications with bevacizumab use unacceptably high
• Other malignancies are excluded unless the patient has completed therapy for the malignancy \>= 12 months prior to randomization and is considered disease-free; patients with the following cancers are eligible if diagnosed and treated within the past 12 months: in situ carcinomas or basal cell and squamous cell carcinoma of the skin
• Known DPD (dihydro pyrimidine dehydrogenase) deficiency
• Symptomatic peripheral sensory neuropathy \>= grade 2 (Common Terminology Criteria for Adverse Events \[CTCAE\] version \[v\] 5.0)
• Prior treatment with oxaliplatin chemotherapy within 6 months prior to randomization
• History of grade 2 hemoptysis (defined as 2.5 mL of bright red blood per episode) within 1 month prior to screening
• Prior treatment with anti-PD-1, or anti-PD-L1 therapeutic antibody or pathway-targeting agents; patients who have received prior treatment with anti-CTLA-4 may be enrolled provided the following requirements are met:
• Minimum of 12 weeks from the first dose of anti-CTLA-4 and \> 6 weeks from the last dose to randomization
• No history of severe immune-related adverse effects (CTCAE grade 3 and 4) from anti-CTLA-4
• Treatment with systemic immunosuppressive medications (including, but not limited to, prednisone, cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-tumor necrosis factor \[anti-TNF\] agents) within 14 days prior to randomization; however,
• Patients who have received acute, low dose, systemic immunosuppressant medications (e.g., a one-time dose of dexamethasone for nausea; or chronic daily treatment with corticosteroids with a dose of =\< 10 mg/day methylprednisolone equivalent) may be enrolled

Sponsors & Collaborators

• NRG Oncology: collaborator
• National Cancer Institute (NCI): lead

Study Sites (445)

Kingman Regional Medical Center

Kingman, Arizona, 86401, United States

Location

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

Jonesboro, Arkansas, 72401, United States

Location

Kaiser Permanente-Anaheim

Anaheim, California, 92806, United States

Location

Kaiser Permanente-Baldwin Park

Baldwin Park, California, 91706, United States

Location

Kaiser Permanente-Bellflower

Bellflower, California, 90706, United States

Location

Alta Bates Summit Medical Center-Herrick Campus

Berkeley, California, 94704, United States

Location

John Muir Medical Center-Concord

Concord, California, 94520, United States

Location

Kaiser Permanente-Fontana

Fontana, California, 92335, United States

Location

Kaiser Permanente South Bay

Harbor City, California, 90710, United States

Location

Kaiser Permanente-Irvine

Irvine, California, 92618, United States

Location

Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, 90027, United States

Location

Kaiser Permanente West Los Angeles

Los Angeles, California, 90034, United States

Location

Fremont - Rideout Cancer Center

Marysville, California, 95901, United States

Location

Memorial Medical Center

Modesto, California, 95355, United States

Location

Kaiser Permanente-Ontario

Ontario, California, 91761, United States

Location

Saint Joseph Hospital - Orange

Orange, California, 92868, United States

Location

UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States

Location

Kaiser Permanente - Panorama City

Panorama City, California, 91402, United States

Location

Kaiser Permanente-Riverside

Riverside, California, 92505, United States

Location

Sutter Medical Center Sacramento

Sacramento, California, 95816, United States

Location

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States

Location

Salinas Valley Memorial

Salinas, California, 93901, United States

Location

Kaiser Permanente-San Diego Mission

San Diego, California, 92108, United States

Location

Kaiser Permanente-San Diego Zion

San Diego, California, 92120, United States

Location

Kaiser Permanente-San Marcos

San Marcos, California, 92078, United States

Location

John Muir Medical Center-Walnut Creek

Walnut Creek, California, 94598, United States

Location

Presbyterian Intercommunity Hospital

Whittier, California, 90602, United States

Location

Kaiser Permanente-Woodland Hills

Woodland Hills, California, 91367, United States

Location

Rocky Mountain Cancer Centers-Aurora

Aurora, Colorado, 80012, United States

Location

UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States

Location

Boulder Community Foothills Hospital

Boulder, Colorado, 80303, United States

Location

Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, 80304, United States

Location

Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States

Location

UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909, United States

Location

Memorial Hospital North

Colorado Springs, Colorado, 80920, United States

Location

Denver Health Medical Center

Denver, Colorado, 80204, United States

Location

National Jewish Health-Main Campus

Denver, Colorado, 80206, United States

Location

AdventHealth Porter

Denver, Colorado, 80210, United States

Location

Rocky Mountain Cancer Centers-Midtown

Denver, Colorado, 80218, United States

Location

Saint Joseph Hospital - Cancer Centers of Colorado

Denver, Colorado, 80218, United States

Location

Rocky Mountain Cancer Centers-Rose

Denver, Colorado, 80220, United States

Location

Mountain Blue Cancer Care Center - Swedish

Englewood, Colorado, 80113, United States

Location

Swedish Medical Center

Englewood, Colorado, 80113, United States

Location

Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States

Location

Cancer Care and Hematology-Fort Collins

Fort Collins, Colorado, 80528, United States

Location

National Jewish Health-Western Hematology Oncology

Golden, Colorado, 80401, United States

Location

Banner North Colorado Medical Center

Greeley, Colorado, 80631, United States

Location

UCHealth Greeley Hospital

Greeley, Colorado, 80631, United States

Location

Rocky Mountain Cancer Centers-Littleton

Littleton, Colorado, 80120, United States

Location

Rocky Mountain Cancer Centers-Sky Ridge

Lone Tree, Colorado, 80124, United States

Location

Medical Center of the Rockies

Loveland, Colorado, 80538, United States

Location

Banner North Colorado Medical Center - Loveland Campus

Loveland, Colorado, 80539, United States

Location

National Jewish Health-Northern Hematology Oncology

Thornton, Colorado, 80260, United States

Location

Intermountain Health Lutheran Hospital

Wheat Ridge, Colorado, 80401, United States

Location

Danbury Hospital

Danbury, Connecticut, 06810, United States

Location

Hartford Hospital

Hartford, Connecticut, 06102, United States

Location

Midstate Medical Center

Meriden, Connecticut, 06451, United States

Location

The Hospital of Central Connecticut

New Britain, Connecticut, 06050, United States

Location

William Backus Hospital

Norwich, Connecticut, 06360, United States

Location

Beebe South Coastal Health Campus

Millville, Delaware, 19967, United States

Location

Helen F Graham Cancer Center

Newark, Delaware, 19713, United States

Location

Medical Oncology Hematology Consultants PA

Newark, Delaware, 19713, United States

Location

Beebe Health Campus

Rehoboth Beach, Delaware, 19971, United States

Location

Kaiser Permanente-Capitol Hill Medical Center

Washington D.C., District of Columbia, 20002, United States

Location

Broward Health Medical Center

Fort Lauderdale, Florida, 33316, United States

Location

Regional Cancer Center-Lee Memorial Health System

Fort Myers, Florida, 33905, United States

Location

UF Health Cancer Institute - Gainesville

Gainesville, Florida, 32610, United States

Location

Baptist MD Anderson Cancer Center

Jacksonville, Florida, 32207, United States

Location

AdventHealth Orlando

Orlando, Florida, 32803, United States

Location

Phoebe Putney Memorial Hospital

Albany, Georgia, 31701, United States

Location

University Cancer and Blood Center LLC

Athens, Georgia, 30607, United States

Location

Augusta Oncology Associates PC-D'Antignac

Augusta, Georgia, 30901, United States

Location

Augusta Oncology Associates PC-Wheeler

Augusta, Georgia, 30909, United States

Location

Augusta University Medical Center

Augusta, Georgia, 30912, United States

Location

CTCA at Southeastern Regional Medical Center

Newnan, Georgia, 30265, United States

Location

Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States

Location

Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States

Location

Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605, United States

Location

Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814, United States

Location

Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States

Location

Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States

Location

Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687, United States

Location

Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687, United States

Location

Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States

Location

Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, Idaho, 83864, United States

Location

Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States

Location

Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States

Location

Illinois CancerCare-Canton

Canton, Illinois, 61520, United States

Location

Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States

Location

Centralia Oncology Clinic

Centralia, Illinois, 62801, United States

Location

Rush MD Anderson Cancer Center

Chicago, Illinois, 60612, United States

Location

University of Illinois

Chicago, Illinois, 60612, United States

Location

Carle at The Riverfront

Danville, Illinois, 61832, United States

Location

Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States

Location

Illinois CancerCare-Dixon

Dixon, Illinois, 61021, United States

Location

Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States

Location

Crossroads Cancer Center

Effingham, Illinois, 62401, United States

Location

Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States

Location

NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201, United States

Location

Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States

Location

NorthShore University HealthSystem-Glenbrook Hospital

Glenview, Illinois, 60026, United States

Location

NorthShore University HealthSystem-Highland Park Hospital

Highland Park, Illinois, 60035, United States

Location

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States

Location

Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States

Location

Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States

Location

Loyola University Medical Center

Maywood, Illinois, 60153, United States

Location

SSM Health Good Samaritan

Mount Vernon, Illinois, 62864, United States

Location

Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States

Location

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States

Location

Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States

Location

Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States

Location

Illinois CancerCare-Peru

Peru, Illinois, 61354, United States

Location

Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States

Location

Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States

Location

Springfield Clinic

Springfield, Illinois, 62702, United States

Location

Carle Cancer Center

Urbana, Illinois, 61801, United States

Location

Illinois CancerCare - Washington

Washington, Illinois, 61571, United States

Location

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States

Location

Community Cancer Center East

Indianapolis, Indiana, 46219, United States

Location

Community Cancer Center South

Indianapolis, Indiana, 46227, United States

Location

Franciscan Health Indianapolis

Indianapolis, Indiana, 46237, United States

Location

Community Cancer Center North

Indianapolis, Indiana, 46256, United States

Location

Community Howard Regional Health

Kokomo, Indiana, 46904, United States

Location

Franciscan Saint Elizabeth Health - Lafayette East

Lafayette, Indiana, 47905, United States

Location

Woodland Cancer Care Center

Michigan City, Indiana, 46360, United States

Location

Franciscan Health Mooresville

Mooresville, Indiana, 46158, United States

Location

Union Hospital

Terre Haute, Indiana, 47804, United States

Location

Mary Greeley Medical Center

Ames, Iowa, 50010, United States

Location

McFarland Clinic - Ames

Ames, Iowa, 50010, United States

Location

University of Iowa Healthcare Cancer Services Quad Cities

Bettendorf, Iowa, 52722, United States

Location

McFarland Clinic - Boone

Boone, Iowa, 50036, United States

Location

Mercy Hospital

Cedar Rapids, Iowa, 52403, United States

Location

Oncology Associates at Mercy Medical Center

Cedar Rapids, Iowa, 52403, United States

Location

Mercy Cancer Center-West Lakes

Clive, Iowa, 50325, United States

Location

UI Health Care Mission Cancer and Blood - West Des Moines Clinic

Clive, Iowa, 50325, United States

Location

UI Health Care Mission Cancer and Blood - Des Moines Clinic

Des Moines, Iowa, 50309, United States

Location

Broadlawns Medical Center

Des Moines, Iowa, 50314, United States

Location

Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States

Location

UI Health Care Mission Cancer and Blood - Laurel Clinic

Des Moines, Iowa, 50314, United States

Location

McFarland Clinic - Trinity Cancer Center

Fort Dodge, Iowa, 50501, United States

Location

UI Healthcare Mission Cancer and Blood - Fort Dodge

Fort Dodge, Iowa, 50501, United States

Location

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States

Location

McFarland Clinic - Jefferson

Jefferson, Iowa, 50129, United States

Location

McFarland Clinic - Marshalltown

Marshalltown, Iowa, 50158, United States

Location

Mercy Medical Center-West Lakes

West Des Moines, Iowa, 50266, United States

Location

HaysMed

Hays, Kansas, 67601, United States

Location

Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States

Location

The University of Kansas Cancer Center - Olathe

Olathe, Kansas, 66061, United States

Location

Salina Regional Health Center

Salina, Kansas, 67401, United States

Location

University of Kansas Health System Saint Francis Campus

Topeka, Kansas, 66606, United States

Location

University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States

Location

Cancer Center of Kansas-Wichita Medical Arts Tower

Wichita, Kansas, 67208, United States

Location

Cancer Center of Kansas - Wichita

Wichita, Kansas, 67214, United States

Location

Flaget Memorial Hospital

Bardstown, Kentucky, 40004, United States

Location

Baptist Health Lexington

Lexington, Kentucky, 40503, United States

Location

Saint Joseph Hospital East

Lexington, Kentucky, 40509, United States

Location

University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States

Location

Norton Hospital Pavilion and Medical Campus

Louisville, Kentucky, 40202, United States

Location

Norton Audubon Hospital and Medical Campus

Louisville, Kentucky, 40217, United States

Location

Norton Brownsboro Hospital and Medical Campus

Louisville, Kentucky, 40241, United States

Location

Ochsner Medical Center Kenner

Kenner, Louisiana, 70065, United States

Location

Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121, United States

Location

Harold Alfond Center for Cancer Care

Augusta, Maine, 04330, United States

Location

Eastern Maine Medical Center

Bangor, Maine, 04401, United States

Location

MaineHealth Waldo Hospital

Belfast, Maine, 04915, United States

Location

MaineHealth Maine Medical Center - Biddeford

Biddeford, Maine, 04005, United States

Location

Lafayette Family Cancer Center-EMMC

Brewer, Maine, 04412, United States

Location

Penobscot Bay Medical Center

Rockport, Maine, 04856, United States

Location

MaineHealth Cancer Care and IV Therapy - Sanford

Sanford, Maine, 04073, United States

Location

MaineHealth Cancer Care and IV Therapy - South Portland

South Portland, Maine, 04106, United States

Location

Kaiser Permanente-Woodlawn Medical Center

Baltimore, Maryland, 21244, United States

Location

University of Maryland Shore Medical Center at Easton

Easton, Maryland, 21601, United States

Location

Kaiser Permanente-Gaithersburg Medical Center

Gaithersburg, Maryland, 20879, United States

Location

Kaiser Permanente - Largo Medical Center

Largo, Maryland, 20774, United States

Location

Kaiser Permanente Lutherville - Timonium Medical Center

Lutherville, Maryland, 21093, United States

Location

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States

Location

Lowell General Hospital

Lowell, Massachusetts, 01854, United States

Location

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States

Location

McLaren Cancer Institute-Bay City

Bay City, Michigan, 48706, United States

Location

McLaren Cancer Institute-Bloomfield

Bloomfield, Michigan, 48302, United States

Location

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114, United States

Location

Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114, United States

Location

Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, 48183, United States

Location

Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, 48188, United States

Location

Trinity Health Medical Center - Canton

Canton, Michigan, 48188, United States

Location

Chelsea Hospital

Chelsea, Michigan, 48118, United States

Location

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, 48118, United States

Location

Hematology Oncology Consultants-Clarkston

Clarkston, Michigan, 48346, United States

Location

McLaren Cancer Institute-Clarkston

Clarkston, Michigan, 48346, United States

Location

Newland Medical Associates-Clarkston

Clarkston, Michigan, 48346, United States

Location

Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, 48038, United States

Location

Henry Ford Medical Center-Fairlane

Dearborn, Michigan, 48126, United States

Location

Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States

Location

Henry Ford Hospital

Detroit, Michigan, 48202, United States

Location

Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States

Location

McLaren Cancer Institute-Flint

Flint, Michigan, 48532, United States

Location

Singh and Arora Hematology Oncology PC

Flint, Michigan, 48532, United States

Location

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States

Location

Allegiance Health

Jackson, Michigan, 49201, United States

Location

West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States

Location

Karmanos Cancer Institute at McLaren Greater Lansing

Lansing, Michigan, 48910, United States

Location

University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912, United States

Location

McLaren Cancer Institute-Lapeer Region

Lapeer, Michigan, 48446, United States

Location

Hope Cancer Clinic

Livonia, Michigan, 48154, United States

Location

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States

Location

McLaren Cancer Institute-Macomb

Mount Clemens, Michigan, 48043, United States

Location

McLaren Cancer Institute-Central Michigan

Mount Pleasant, Michigan, 48858, United States

Location

Henry Ford Medical Center-Columbus

Novi, Michigan, 48377, United States

Location

McLaren Cancer Institute-Northern Michigan

Petoskey, Michigan, 49770, United States

Location

Newland Medical Associates-Pontiac

Pontiac, Michigan, 48341, United States

Location

Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341, United States

Location

McLaren-Port Huron

Port Huron, Michigan, 48060, United States

Location

MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601, United States

Location

Oncology Hematology Associates of Saginaw Valley PC

Saginaw, Michigan, 48604, United States

Location

MyMichigan Medical Center Tawas

Tawas City, Michigan, 48764, United States

Location

Munson Medical Center

Traverse City, Michigan, 49684, United States

Location

Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322, United States

Location

Saint Mary's Oncology/Hematology Associates of West Branch

West Branch, Michigan, 48661, United States

Location

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, 48197, United States

Location

Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, 56601, United States

Location

Minnesota Oncology - Burnsville

Burnsville, Minnesota, 55337, United States

Location

Essentia Health - Deer River Clinic

Deer River, Minnesota, 56636, United States

Location

Essentia Health Cancer Center

Duluth, Minnesota, 55805, United States

Location

Essentia Health Hibbing Clinic

Hibbing, Minnesota, 55746, United States

Location

Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States

Location

Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States

Location

Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States

Location

Health Partners Inc

Minneapolis, Minnesota, 55454, United States

Location

Regions Hospital

Saint Paul, Minnesota, 55101, United States

Location

United Hospital

Saint Paul, Minnesota, 55102, United States

Location

Essentia Health Sandstone

Sandstone, Minnesota, 55072, United States

Location

Essentia Health Virginia Clinic

Virginia, Minnesota, 55792, United States

Location

Baptist Cancer Center-Grenada

Grenada, Mississippi, 38901, United States

Location

Baptist Memorial Hospital and Cancer Center-Union County

New Albany, Mississippi, 38652, United States

Location

Baptist Memorial Hospital and Cancer Center-Oxford

Oxford, Mississippi, 38655, United States

Location

Baptist Memorial Hospital and Cancer Center-Desoto

Southhaven, Mississippi, 38671, United States

Location

Mercy Oncology and Hematology - Clayton-Clarkson

Ballwin, Missouri, 63011, United States

Location

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States

Location

MU Health - University Hospital/Ellis Fischel Cancer Center

Columbia, Missouri, 65212, United States

Location

Freeman Health System

Joplin, Missouri, 64804, United States

Location

Mercy Hospital Joplin

Joplin, Missouri, 64804, United States

Location

University Health Truman Medical Center

Kansas City, Missouri, 64108, United States

Location

Mercy Infusion Center - Chippewa

St Louis, Missouri, 63109, United States

Location

Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States

Location

Community Hospital of Anaconda

Anaconda, Montana, 59711, United States

Location

Billings Clinic Cancer Center

Billings, Montana, 59101, United States

Location

Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States

Location

Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States

Location

Great Falls Clinic

Great Falls, Montana, 59405, United States

Location

Saint Peter's Community Hospital

Helena, Montana, 59601, United States

Location

Logan Health Medical Center

Kalispell, Montana, 59901, United States

Location

Community Medical Center

Missoula, Montana, 59804, United States

Location

Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States

Location

OptumCare Cancer Care at Charleston

Las Vegas, Nevada, 89102, United States

Location

OptumCare Cancer Care at MountainView

Las Vegas, Nevada, 89128, United States

Location

OptumCare Cancer Care at Fort Apache

Las Vegas, Nevada, 89183, United States

Location

Renown Regional Medical Center

Reno, Nevada, 89502, United States

Location

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States

Location

Dartmouth Cancer Center - Manchester/ DCC Manchester

Manchester, New Hampshire, 03104, United States

Location

Dartmouth Cancer Center - Nashua

Nashua, New Hampshire, 03063, United States

Location

The Cancer Institute of New Jersey Hamilton

Hamilton, New Jersey, 08690, United States

Location

Morristown Medical Center

Morristown, New Jersey, 07960, United States

Location

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States

Location

The Valley Hospital - Luckow Pavilion

Paramus, New Jersey, 07652, United States

Location

Valley Health System Ridgewood Campus

Ridgewood, New Jersey, 07450, United States

Location

Robert Wood Johnson University Hospital Somerset

Somerville, New Jersey, 08876, United States

Location

Overlook Hospital

Summit, New Jersey, 07902, United States

Location

University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States

Location

Presbyterian Kaseman Hospital

Albuquerque, New Mexico, 87110, United States

Location

Memorial Medical Center-Las Cruces

Las Cruces, New Mexico, 88011, United States

Location

Presbyterian Rust Medical Center/Jorgensen Cancer Center

Rio Rancho, New Mexico, 87124, United States

Location

Roswell Park Cancer Institute

Buffalo, New York, 14263, United States

Location

Arnot Ogden Medical Center/Falck Cancer Center

Elmira, New York, 14905, United States

Location

Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042, United States

Location

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States

Location

University of Rochester

Rochester, New York, 14642, United States

Location

Dickstein Cancer Treatment Center

White Plains, New York, 10601, United States

Location

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States

Location

Southeastern Medical Oncology Center-Clinton

Clinton, North Carolina, 28328, United States

Location

Southeastern Medical Oncology Center-Goldsboro

Goldsboro, North Carolina, 27534, United States

Location

Margaret R Pardee Memorial Hospital

Hendersonville, North Carolina, 28791, United States

Location

Southeastern Medical Oncology Center-Jacksonville

Jacksonville, North Carolina, 28546, United States

Location

ECU Health Oncology Kenansville

Kenansville, North Carolina, 28349, United States

Location

ECU Health Oncology Kinston

Kinston, North Carolina, 28501, United States

Location

FirstHealth of the Carolinas-Moore Regional Hospital

Pinehurst, North Carolina, 28374, United States

Location

ECU Health Oncology Richlands

Richlands, North Carolina, 28574, United States

Location

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States

Location

Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501, United States

Location

Sanford Broadway Medical Center

Fargo, North Dakota, 58122, United States

Location

Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States

Location

Altru Cancer Center

Grand Forks, North Dakota, 58201, United States

Location

Cleveland Clinic Akron General

Akron, Ohio, 44307, United States

Location

Strecker Cancer Center-Belpre

Belpre, Ohio, 45714, United States

Location

Dayton Physicians LLC-Miami Valley South

Centerville, Ohio, 45459, United States

Location

Miami Valley Hospital South

Centerville, Ohio, 45459, United States

Location

Adena Regional Medical Center

Chillicothe, Ohio, 45601, United States

Location

University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States

Location

Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111, United States

Location

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

Location

Mount Carmel East Hospital

Columbus, Ohio, 43213, United States

Location

Columbus Oncology and Hematology Associates Inc

Columbus, Ohio, 43214, United States

Location

Riverside Methodist Hospital

Columbus, Ohio, 43214, United States

Location

Grant Medical Center

Columbus, Ohio, 43215, United States

Location

The Mark H Zangmeister Center

Columbus, Ohio, 43219, United States

Location

Mount Carmel Health Center West

Columbus, Ohio, 43222, United States

Location

Doctors Hospital

Columbus, Ohio, 43228, United States

Location

Miami Valley Hospital

Dayton, Ohio, 45409, United States

Location

Delaware Health Center-Grady Cancer Center

Delaware, Ohio, 43015, United States

Location

Grady Memorial Hospital

Delaware, Ohio, 43015, United States

Location

Greater Dayton Cancer Center

Kettering, Ohio, 45409, United States

Location

Fairfield Medical Center

Lancaster, Ohio, 43130, United States

Location

OhioHealth Mansfield Hospital

Mansfield, Ohio, 44903, United States

Location

Cleveland Clinic Cancer Center Mansfield

Mansfield, Ohio, 44906, United States

Location

Marietta Memorial Hospital

Marietta, Ohio, 45750, United States

Location

OhioHealth Marion General Hospital

Marion, Ohio, 43302, United States

Location

Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, 44124, United States

Location

Knox Community Hospital

Mount Vernon, Ohio, 43050, United States

Location

Licking Memorial Hospital

Newark, Ohio, 43055, United States

Location

Southern Ohio Medical Center

Portsmouth, Ohio, 45662, United States

Location

North Coast Cancer Care

Sandusky, Ohio, 44870, United States

Location

ProMedica Flower Hospital

Sylvania, Ohio, 43560, United States

Location

South Pointe Hospital

Warrensville Heights, Ohio, 44122, United States

Location

University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069, United States

Location

Saint Ann's Hospital

Westerville, Ohio, 43081, United States

Location

Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, 43701, United States

Location

Cancer Centers of Southwest Oklahoma Research

Lawton, Oklahoma, 73505, United States

Location

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States

Location

Cancer Treatment Centers of America

Tulsa, Oklahoma, 74133, United States

Location

Oklahoma Cancer Specialists and Research Institute-Tulsa

Tulsa, Oklahoma, 74146, United States

Location

Saint Charles Health System

Bend, Oregon, 97701, United States

Location

Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States

Location

Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015, United States

Location

Providence Newberg Medical Center

Newberg, Oregon, 97132, United States

Location

Saint Alphonsus Cancer Care Center-Ontario

Ontario, Oregon, 97914, United States

Location

Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045, United States

Location

Providence Portland Medical Center

Portland, Oregon, 97213, United States

Location

Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States

Location

Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States

Location

Saint Luke's Cancer Center - Allentown

Allentown, Pennsylvania, 18104, United States

Location

Saint Luke's University Hospital-Bethlehem Campus

Bethlehem, Pennsylvania, 18015, United States

Location

Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, 18017, United States

Location

Saint Luke's Hospital-Anderson Campus

Easton, Pennsylvania, 18045, United States

Location

Saint Vincent Hospital

Erie, Pennsylvania, 16544, United States

Location

UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, Pennsylvania, 17109, United States

Location

Jefferson Hospital

Jefferson Hills, Pennsylvania, 15025, United States

Location

Forbes Hospital

Monroeville, Pennsylvania, 15146, United States

Location

Allegheny Valley Hospital

Natrona Heights, Pennsylvania, 15065, United States

Location

Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212, United States

Location

West Penn Hospital

Pittsburgh, Pennsylvania, 15224, United States

Location

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232, United States

Location

Saint Luke's Hospital-Quakertown Campus

Quakertown, Pennsylvania, 18951, United States

Location

Reading Hospital

West Reading, Pennsylvania, 19611, United States

Location

Wexford Health and Wellness Pavilion

Wexford, Pennsylvania, 15090, United States

Location

Asplundh Cancer Pavilion

Willow Grove, Pennsylvania, 19090, United States

Location

AnMed Health Cancer Center

Anderson, South Carolina, 29621, United States

Location

Beaufort Memorial Hospital

Beaufort, South Carolina, 29902, United States

Location

Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States

Location

Prisma Health Cancer Institute - Easley

Easley, South Carolina, 29640, United States

Location

Saint Francis Hospital

Greenville, South Carolina, 29601, United States

Location

Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605, United States

Location

Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States

Location

Saint Francis Cancer Center

Greenville, South Carolina, 29607, United States

Location

Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States

Location

Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States

Location

Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States

Location

Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States

Location

Avera Cancer Institute-Aberdeen

Aberdeen, South Dakota, 57401, United States

Location

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104, United States

Location

Avera Cancer Institute

Sioux Falls, South Dakota, 57105, United States

Location

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States

Location

Bristol Regional Medical Center

Bristol, Tennessee, 37620, United States

Location

Baptist Memorial Hospital and Cancer Center-Collierville

Collierville, Tennessee, 38017, United States

Location

Cookeville Regional Medical Center

Cookeville, Tennessee, 38501, United States

Location

Wellmont Medical Associates Oncology and Hematology-Johnson City

Johnson City, Tennessee, 37604, United States

Location

Ballad Health Cancer Care - Kingsport

Kingsport, Tennessee, 37660, United States

Location

Wellmont Holston Valley Hospital and Medical Center

Kingsport, Tennessee, 37660, United States

Location

Baptist Memorial Hospital and Cancer Center-Memphis

Memphis, Tennessee, 38120, United States

Location

The Don and Sybil Harrington Cancer Center

Amarillo, Texas, 79106, United States

Location

Baptist Hospitals of Southeast Texas Cancer Center

Beaumont, Texas, 77701, United States

Location

MD Anderson in The Woodlands

Conroe, Texas, 77384, United States

Location

Parkland Memorial Hospital

Dallas, Texas, 75235, United States

Location

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States

Location

STCC at DHR Health Institute for Research and Development

Edinburg, Texas, 78539, United States

Location

Lyndon Baines Johnson General Hospital

Houston, Texas, 77026-1967, United States

Location

Houston Methodist Hospital

Houston, Texas, 77030, United States

Location

M D Anderson Cancer Center

Houston, Texas, 77030, United States

Location

MD Anderson West Houston

Houston, Texas, 77079, United States

Location

MD Anderson League City

League City, Texas, 77573, United States

Location

Baptist Regional Cancer Network-Cancer Center of Southeast Texas

Port Arthur, Texas, 77642, United States

Location

MD Anderson in Sugar Land

Sugar Land, Texas, 77478, United States

Location

Scott and White Memorial Hospital

Temple, Texas, 76508, United States

Location

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States

Location

Dartmouth Cancer Center - North

Saint Johnsbury, Vermont, 05819, United States

Location

Ballad Health Cancer Care - Bristol

Bristol, Virginia, 24201, United States

Location

Kaiser Permanente-Burke Medical Center

Burke, Virginia, 22015, United States

Location

Augusta Health Center for Cancer and Blood Disorders

Fishersville, Virginia, 22939, United States

Location

Centra Alan B Pearson Regional Cancer Center

Lynchburg, Virginia, 24501, United States

Location

Kaiser Permanente Tysons Corner Medical Center

McLean, Virginia, 22102, United States

Location

Ballad Health Cancer Care - Norton

Norton, Virginia, 24273, United States

Location

Virginia Cancer Institute

Richmond, Virginia, 23229, United States

Location

VCU Massey Cancer Center at Stony Point

Richmond, Virginia, 23235, United States

Location

VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States

Location

VCU Community Memorial Health Center

South Hill, Virginia, 23970, United States

Location

Kaiser Permanente-Caton Hill Medical Center

Woodbridge, Virginia, 22192, United States

Location

Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States

Location

Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States

Location

Jefferson Healthcare

Port Townsend, Washington, 98368, United States

Location

Swedish Medical Center-First Hill

Seattle, Washington, 98122, United States

Location

MultiCare Deaconess Cancer and Blood Specialty Center - Downtown

Spokane, Washington, 99204, United States

Location

MultiCare Deaconess Cancer and Blood Specialty Center - North

Spokane, Washington, 99218, United States

Location

West Virginia University Charleston Division

Charleston, West Virginia, 25304, United States

Location

West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States

Location

Camden Clark Medical Center

Parkersburg, West Virginia, 26101, United States

Location

Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409, United States

Location

ThedaCare Regional Cancer Center

Appleton, Wisconsin, 54911, United States

Location

Ascension Saint Elizabeth Hospital

Appleton, Wisconsin, 54915, United States

Location

Duluth Clinic Ashland

Ashland, Wisconsin, 54806, United States

Location

Ascension Southeast Wisconsin Hospital - Elmbrook Campus

Brookfield, Wisconsin, 53045, United States

Location

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States

Location

Ascension Saint Francis - Reiman Cancer Center

Franklin, Wisconsin, 53132, United States

Location

Bellin Memorial Hospital

Green Bay, Wisconsin, 54301, United States

Location

Mercyhealth Hospital and Cancer Center - Janesville

Janesville, Wisconsin, 53548, United States

Location

University of Wisconsin Carbone Cancer Center - Johnson Creek

Johnson Creek, Wisconsin, 53038, United States

Location

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States

Location

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Madison, Wisconsin, 53718, United States

Location

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States

Location

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States

Location

Aspirus Medford Hospital

Medford, Wisconsin, 54451, United States

Location

Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States

Location

ProHealth D N Greenwald Center

Mukwonago, Wisconsin, 53149, United States

Location

Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017, United States

Location

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066, United States

Location

Ascension Mercy Hospital

Oshkosh, Wisconsin, 54904, United States

Location

Ascension All Saints Hospital

Racine, Wisconsin, 53405, United States

Location

Aspirus Cancer Care - James Beck Cancer Center

Rhinelander, Wisconsin, 54501, United States

Location

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States

Location

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States

Location

ProHealth Waukesha Memorial Hospital

Waukesha, Wisconsin, 53188, United States

Location

UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188, United States

Location

Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401, United States

Location

Ascension Medical Group Southeast Wisconsin - Mayfair Road

Wauwatosa, Wisconsin, 53226, United States

Location

Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States

Location

Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494, United States

Location

Cheyenne Regional Medical Center-West

Cheyenne, Wyoming, 82001, United States

Location

Billings Clinic-Cody

Cody, Wyoming, 82414, United States

Location

MeSH Terms

Conditions

Colorectal Neoplasms

Interventions

atezolizumab; Bevacizumab; Immunoglobulin G; Disulfides; Specimen Handling; Fluorouracil; dehydroftorafur; Leucovorin; Magnetic Resonance Spectroscopy; Oxaliplatin

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases

Intervention Hierarchy (Ancestors)

Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal; Antibodies; Immunoglobulins; Immunoproteins; Blood Proteins; Proteins; Amino Acids, Peptides, and Proteins; Serum Globulins; Globulins; Immunoglobulin Isotypes; Sulfides; Anions; Ions; Electrolytes; Inorganic Chemicals; Hydrogen Sulfide; Sulfur Compounds; Organic Chemicals; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques; Uracil; Pyrimidinones; Pyrimidines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Formyltetrahydrofolates; Tetrahydrofolates; Folic Acid; Pterins; Pteridines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Coenzymes; Enzymes and Coenzymes; Spectrum Analysis; Chemistry Techniques, Analytical; Coordination Complexes

Study Officials

• Caio Max S Rocha Lima

  NRG Oncology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 19, 2016
• First Posted: December 20, 2016
• Study Start: January 19, 2018
• Primary Completion (Estimated): June 1, 2027
• Study Completion (Estimated): June 1, 2027
• Last Updated: June 3, 2026

Record last verified: 2026-03

Locations

US (445)