NCT02930980

Brief Summary

The purpose of the MASS2 is to characterize accelerometer signals of Micra implantable device during different postures and activities and to understand the source of the sensed motion, in order to test feasibility for future enhancements in device functionalities.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
43

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Oct 2016

Shorter than P25 for not_applicable

Geographic Reach
3 countries

4 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 6, 2016

Completed
6 days until next milestone

First Posted

Study publicly available on registry

October 12, 2016

Completed
2 days until next milestone

Study Start

First participant enrolled

October 14, 2016

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 25, 2017

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 25, 2017

Completed
1.9 years until next milestone

Results Posted

Study results publicly available

March 11, 2019

Completed
Last Updated

March 11, 2019

Status Verified

November 1, 2018

Enrollment Period

6 months

First QC Date

October 6, 2016

Results QC Date

January 30, 2018

Last Update Submit

November 26, 2018

Conditions

Outcome Measures

Primary Outcomes (1)

  • Waveform and Components of Accelerometer Signal

    Accelerometer signal was measured using the 3 axis Micra accelerometer (Vector 1 was labelled as V1, Vector 2 as V2, Vector 3 as V3). Components of the accelerometer signals (unit (g) represent acceleration)were identified and labelled as A1 (acceleration associated with ventricular systole), A2 (ventricular diastole), A3 (early passive filling), and A4 (active filling). The A4 signal is associated with atrial contraction and active filling.

    For approximately two hours after software download

Study Arms (1)

Investigational Software

EXPERIMENTAL

Investigational Software loaded on Micra device

Device: Investigational Software loaded on Micra device

Interventions

Subject will receive an investigational software loaded on subject's Micra device

Investigational Software

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Subject is ≥ 18 years old
  • Subject is implanted with a Micra device
  • Subject or witness (if applicable as per local regulation) is able and willing to provide Informed Consent

You may not qualify if:

  • Subject is in atrial fibrillation
  • Subject is not able to perform study requirements

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

Kepler Universitätsklinikum

Linz, 4020, Austria

Location

Hôpital cardiologique du Haut-Lévêque

Pessac, France

Location

CHRU Tours - Hopital Trousseau

Tours, France

Location

Hospital Clinic

Barcelona, Spain

Location

Related Publications (1)

  • Chinitz L, Ritter P, Khelae SK, Iacopino S, Garweg C, Grazia-Bongiorni M, Neuzil P, Johansen JB, Mont L, Gonzalez E, Sagi V, Duray GZ, Clementy N, Sheldon T, Splett V, Stromberg K, Wood N, Steinwender C. Accelerometer-based atrioventricular synchronous pacing with a ventricular leadless pacemaker: Results from the Micra atrioventricular feasibility studies. Heart Rhythm. 2018 Sep;15(9):1363-1371. doi: 10.1016/j.hrthm.2018.05.004. Epub 2018 May 11.

MeSH Terms

Conditions

Bradycardia

Condition Hierarchy (Ancestors)

Arrhythmias, CardiacHeart DiseasesCardiovascular DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Results Point of Contact

Title
Valentina Amori, Medical Writer
Organization
Medtronic EMEA RCC

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
LTE60
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 6, 2016

First Posted

October 12, 2016

Study Start

October 14, 2016

Primary Completion

April 25, 2017

Study Completion

April 25, 2017

Last Updated

March 11, 2019

Results First Posted

March 11, 2019

Record last verified: 2018-11

Locations