Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia
1 other identifier
observational
400
1 country
2
Brief Summary
Bradyarrhythmia, including sinus node dysfunction and atrioventricular block, is a major cause necessitating pacemaker implantation. In contrast to familial bradyarrhythmia known as by mutations at particular ion channels, limited information is available for the mechanistic study in non-familial bradyarrhythmia. Possible gene polymorphisms related to non-familial bradyarrhythmia were studied. Comparison of multi-locus analysis and single-locus analysis will be analyzed between the cases and controls. Functional studies will perform to clarify the results of association study.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
2 active sites
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Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2011
CompletedFirst Submitted
Initial submission to the registry
March 6, 2011
CompletedFirst Posted
Study publicly available on registry
March 9, 2011
CompletedMarch 9, 2011
March 1, 2011
March 6, 2011
March 6, 2011
Conditions
Study Arms (3)
sinus node dysfunction
Atrioventricular block
control
Eligibility Criteria
The case group include 200 patients and the control group include 200 patients.
You may qualify if:
- The patients with non-familial bradyarrhythmia
You may not qualify if:
- Familial bradyarrhythmia Reversible bradyarrhythmia Bradyarrhythmia after open heart surgery and severe organic heart diseases
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- China Medical University Hospitallead
- China Medical University, Chinacollaborator
Study Sites (2)
China Medical University Hospital
Taichung, Taiwan, 404, Taiwan
China Medical University Hospital
Taichung, Taiwan, 404, Taiwan
Related Publications (1)
Mangrum JM, DiMarco JP. The evaluation and management of bradycardia. N Engl J Med. 2000 Mar 9;342(10):703-9. doi: 10.1056/NEJM200003093421006. No abstract available.
PMID: 10706901BACKGROUND
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jan-Yow Chen, MD
China Medical University Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
March 6, 2011
First Posted
March 9, 2011
Study Start
February 1, 2011
Last Updated
March 9, 2011
Record last verified: 2011-03