The Effects of Mastication on Energy Release From Walnuts
The Effects of Mastication and Digestion on the Bio Accessibility of Energy From Walnuts
1 other identifier
interventional
50
1 country
1
Brief Summary
With an emphasis on oral processing, this study seeks to characterize the mechanisms that account for the high satiation properties of walnuts and low energy yield during digestion.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable obesity
Started Aug 2015
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2015
CompletedFirst Submitted
Initial submission to the registry
October 14, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 30, 2016
CompletedFirst Posted
Study publicly available on registry
October 6, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
December 30, 2016
CompletedDecember 12, 2023
December 1, 2023
8 months
October 14, 2015
December 11, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Effects of oral processing on the energy yield from walnuts.
Released fat concentration following chewing.
7 months
Secondary Outcomes (1)
Particle size disruption
7 months
Other Outcomes (8)
Cell staining and counting
7 months
Appetite ratings
7 months
In vitro digestion
7 months
- +5 more other outcomes
Study Arms (1)
Chewing group
OTHER50 individuals, both male and female, between the ages of 18 and 60 years old, with a BMI between 18-35 kg/m2 from any ethnic/racial background will be recruited. Participants must have natural dentition and rate the hedonic value of all study foods between 3 and 7 on a 9-point category scale.
Interventions
On the first visit, the random nut treatments will include chewing walnuts, almonds and pistachios. The chewing conditions will include: 1) 5 g nuts alone, 2) 5 g nuts with 5 ml water, 3) 5 g nuts with 5 ml apple juice, 4) 5 g nuts with 5 g plain yogurt, 5) 5 g nuts with 5 g sweet yogurt. On visits 2 and 3 the treatments of either 28 g of walnuts or walnut butter will be presented.
Eligibility Criteria
You may qualify if:
- Natural dentition and no oral pathology
- Rate hedonic value of all study foods between 3 and 7 on a 9-point category scale.
You may not qualify if:
- BMI between 18-35 kg/m2
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Purdue Universitylead
- California Walnut Commissioncollaborator
Study Sites (1)
Purdue University
West Lafayette, Indiana, 47906, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Richard D Mattes, PhD
Purdue University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Distinguished Professor
Study Record Dates
First Submitted
October 14, 2015
First Posted
October 6, 2016
Study Start
August 1, 2015
Primary Completion
March 30, 2016
Study Completion
December 30, 2016
Last Updated
December 12, 2023
Record last verified: 2023-12