Brief Summary

The purpose of this study is to compare the acute metabolic responses and time-trial performance following the ingestion of carbohydrate solutions containing either maple syrup, maple sap, corn syrup, a commercial sport drink or water.

Trial Health

On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment

participants targeted

Target at P50-P75 for not_applicable

Timeline

Completed

Started Jul 2016

Geographic Reach

1 country

1 active site

Status

completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

1.7 years study duration

Study Start

First participant enrolled

July 11, 2016

Completed

19 days until next milestone

First Submitted

Initial submission to the registry

July 30, 2016

Completed

27 days until next milestone

First Posted

Study publicly available on registry

August 26, 2016

Completed

1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 22, 2017

Completed

3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 30, 2018

Completed

Last Updated

August 21, 2019

Status Verified

August 1, 2019

Enrollment Period

1.4 years

First QC Date

July 30, 2016

Last Update Submit

August 19, 2019

Conditions

Carbohydrate Ingestion Fuel Selection Athletic Performance

Keywords

Isotope Labeling, StableExercise, PhysicalCalorimetry, IndirectAthletic PerformanceSugar Maple

Outcome Measures

Primary Outcomes (2)

Exogenous carbohydrate oxidation
Measured by indirect respiratory calorimetry combined with tracer techniques.
Every 30 minutes during the exercise protocol, during 3 minutes of expired gas collection.
Exercise performance in the 20-km time trial
Duration to complete distance and mean power sustained during the performance
At the end of 2 hours of exercise

Secondary Outcomes (7)

Blood insulin concentration
Every 30 minutes during the exercise protocol
Blood glucose concentration
Every 30 minutes during the exercise protocol
Blood free fatty acid concentration
Every 30 minutes during the exercise protocol
Blood lactate concentration
Every 30 minutes during the exercise protocol
Muscle glycogen oxidation
Every 30 minutes during the exercise protocol, during 3 minutes of expired gas collection.
+2 more secondary outcomes

Other Outcomes (2)

Palatability score
Within 5 minutes after the first ingestion and within 5 minutes after the last ingestion.
Score of gastrointestinal symptoms
Within 5 minutes after the end of exercise

Study Arms (5)

Maple syrup

EXPERIMENTAL

A maple syrup solution of 6% carbohydrate per volume labeled with 13C-sucrose will be ingested 30 min prior to starting exercise and every 30 min thereafter (solution ingestion), until 2h of the constant load cycling exercise is completed. Starting 4 min before each solution ingested over the protocol, indirect respiratory calorimetry, expired gas sampling, blood sampling will occur. After completing the 2h of exercise, subjects will be given a few minutes of rest (5-min) during which the catheter will be removed, after which the 20-km time trial will be initiated on the same ergometer. Palatability of the solution will be assessed after the first ingestion and after ingesting the last solution. Gastrointestinal symptoms will be assessed after the time trial.

Dietary Supplement: Solution ingestionBehavioral: Constant load cyclingProcedure: Expired gas samplingProcedure: Indirect respiratory calorimetryOther: PalatabilityOther: GastrointestinalProcedure: Blood samplingBehavioral: Time trial

Maple sap

EXPERIMENTAL

A maple sap solution of 6% carbohydrate per volume labeled with 13C-sucrose will be ingested 30 min prior to starting exercise and every 30 min thereafter (solution ingestion), until 2h of the constant load cycling exercise is completed. Starting 4 min before each solution ingested over the protocol, indirect respiratory calorimetry, expired gas sampling, blood sampling will occur. After completing the 2h of exercise, subjects will be given a few minutes of rest (5-min) during which the catheter will be removed, after which the 20-km time trial will be initiated on the same ergometer. Palatability of the solution will be assessed after the first ingestion and after ingesting the last solution. Gastrointestinal symptoms will be assessed after the time trial.

Glucose

ACTIVE COMPARATOR

A glucose solution of 6% carbohydrate per volume labeled with 13C-sucrose will be ingested 30 min prior to starting exercise and every 30 min thereafter (solution ingestion), until 2h of the constant load cycling exercise is completed. Starting 4 min before each solution ingested over the protocol, indirect respiratory calorimetry, expired gas sampling, blood sampling will occur. After completing the 2h of exercise, subjects will be given a few minutes of rest (5-min) during which the catheter will be removed, after which the 20-km time trial will be initiated on the same ergometer. Palatability of the solution will be assessed after the first ingestion and after ingesting the last solution. Gastrointestinal symptoms will be assessed after the time trial.

Sport drink

ACTIVE COMPARATOR

A Gatorade (TM) solution of 6% carbohydrate per volume labeled with 13C-sucrose will be ingested 30 min prior to starting exercise and every 30 min thereafter (solution ingestion), until 2h of the constant load cycling exercise is completed. Starting 4 min before each solution ingested over the protocol, indirect respiratory calorimetry, expired gas sampling, blood sampling will occur. After completing the 2h of exercise, subjects will be given a few minutes of rest (5-min) during which the catheter will be removed, after which the 20-km time trial will be initiated on the same ergometer. Palatability of the solution will be assessed after the first ingestion and after ingesting the last solution. Gastrointestinal symptoms will be assessed after the time trial.

Trace

PLACEBO COMPARATOR

A solution containing stevia (sugar substitute) and trace amounts of glucose (3g) labeled with 13C-sucrose will be ingested 30 min prior to starting exercise and every 30 min thereafter (solution ingestion), until 2h of the constant load cycling exercise is completed. Starting 4 min before each solution ingested over the protocol, indirect respiratory calorimetry, expired gas sampling, blood sampling will occur. After completing the 2h of exercise, subjects will be given a few minutes of rest (5-min) during which the catheter will be removed, after which the 20-km time trial will be initiated on the same ergometer. Palatability of the solution will be assessed after the first ingestion and after ingesting the last solution. Gastrointestinal symptoms will be assessed after the time trial.

Interventions

Solution ingestionDIETARY_SUPPLEMENT

Subjects will be required to ingest 2 litres of the experimental solution, spread over the 2 hours of exercise. A first ingestion of 572 mL of solution will be made at rest, 30 minutes before starting exercise, and 286 mL will be ingested immediately before the start of exercise and every 30 minutes during the exercise period.