Power Spectral Analysis of EEG During Equi-MAC Inhalation Anesthesia
Power Spectral Analysis of the Electroencephalogram During Equi-MAC Sevoflurane vs. Desflurane Anesthesia: A Randomized Controlled Trial
1 other identifier
interventional
90
1 country
1
Brief Summary
The purpose of this clinical trial is to compare hypnotic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using power spectral analysis of the electroencephalogram.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_3
Started Aug 2016
Shorter than P25 for phase_3
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 10, 2016
CompletedStudy Start
First participant enrolled
August 16, 2016
CompletedFirst Posted
Study publicly available on registry
August 19, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 6, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
December 6, 2016
CompletedSeptember 3, 2020
September 1, 2020
4 months
August 10, 2016
September 2, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
Spectral edge frequency 95% value
EEG variables were measured after meeting steady-state anesthesia of 1 MAC.
During about 30 min study period
Secondary Outcomes (1)
Bispectral index
During about 30 min study period
Study Arms (2)
Sevoflurane
EXPERIMENTALAnesthesia was maintained with sevoflurane.
Desflurane
EXPERIMENTALAnesthesia was maintained with desflurane.
Interventions
Anesthesia was maintained with sevoflurane in patients undergoing arthroscopic knee surgery under general anesthesia. End-tidal concentration of sevoflurane was maintained at age-corrected 1 minimum alveolar concentration throughout the study period.
Anesthesia was maintained with desflurane in patients undergoing arthroscopic knee surgery under general anesthesia. End-tidal concentration of desflurane was maintained at age-corrected 1 minimum alveolar concentration throughout the study period.
Eligibility Criteria
You may qualify if:
- patients undergoing arthroscopic knee surgery under general anesthesia using volatile anesthetics
- patients with american society of anesthesiologist physical status I, II
- patients aged 19-65 years
- patients obtaining written informed consent
You may not qualify if:
- patients with a history of any psychiatric or neurological disease
- patients who had received any medication affecting the central nervous system
- patients who had received medication affecting the sympathetic or parasympathetic nervous systems
- patients undergoing tracheal intubation for airway management
- pregnant women
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Kangbuk Samsung Hospital
Seoul, 03181, South Korea
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Kyoungho Ryu, M.D.
Kangbuk Samsung Hospital
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Clinical assistant professor
Study Record Dates
First Submitted
August 10, 2016
First Posted
August 19, 2016
Study Start
August 16, 2016
Primary Completion
December 6, 2016
Study Completion
December 6, 2016
Last Updated
September 3, 2020
Record last verified: 2020-09