Hemodynamics for Equi-MAC Anesthesia
Comparison of Vasodilative Effects Between Sevoflurane and Desflurane Using Peripheral Perfusion Index
1 other identifier
interventional
70
1 country
1
Brief Summary
The aim of this study is to compare the peripheral perfusion index values produced by equi-MAC of sevoflurane and desflurane in patients undergoing single-agent inhalation anesthesia.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jun 2018
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 15, 2018
CompletedStudy Start
First participant enrolled
June 18, 2018
CompletedFirst Posted
Study publicly available on registry
June 26, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 13, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
November 13, 2018
CompletedOctober 21, 2019
October 1, 2019
5 months
June 15, 2018
October 18, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
peripheral perfusion index
peripheral perfusion index value at a steady-state anesthesia of age-corrected 1.0 MAC
After a 30-min waiting period from the induction of anesthesia
Secondary Outcomes (2)
mean arterial pressure
After a 30-min waiting period from the induction of anesthesia
heart rate
After a 30-min waiting period from the induction of anesthesia
Study Arms (2)
Sevoflurane
EXPERIMENTALAnesthesia is maintained with sevoflurane.
Desflurane
EXPERIMENTALAnesthesia is maintained with desflurane.
Interventions
End-tidal concentration of sevoflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.
End-tidal concentration of desflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.
Eligibility Criteria
You may qualify if:
- patients aged between 19 and 65 yr
- patients with American Society of Anesthesiologists physical status classification I or II
- patients scheduled for elective arthroscopic knee surgery under general anesthesia
- patients obtaining written informed consent
You may not qualify if:
- patients with a history of any disease associated with the autonomic nervous system
- patients receiving any medication affecting the sympathetic or parasympathetic nervous systems
- patients with cardiac arrhythmia, diabetes mellitus, and alcohol or drug abuse
- pregnant women
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Kangbuk Samsung Hospital
Seoul, 03181, South Korea
Related Publications (1)
Ryu KH, Hwang SH, Shim JG, Ahn JH, Cho EA, Lee SH, Byun JH. Comparison of vasodilatory properties between desflurane and sevoflurane using perfusion index: a randomised controlled trial. Br J Anaesth. 2020 Dec;125(6):935-942. doi: 10.1016/j.bja.2020.07.050. Epub 2020 Sep 18.
PMID: 32958203DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Kyoung-Ho Ryu, M.D.
Kangbuk Samsung Hospital
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant professor
Study Record Dates
First Submitted
June 15, 2018
First Posted
June 26, 2018
Study Start
June 18, 2018
Primary Completion
November 13, 2018
Study Completion
November 13, 2018
Last Updated
October 21, 2019
Record last verified: 2019-10
Data Sharing
- IPD Sharing
- Will not share