The Ratio of Hypnotic to Analgesic Potency of Volatile Anesthetics
1 other identifier
interventional
90
1 country
1
Brief Summary
The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and isoflurane at equi-minimum alveolar concentration using EEG analysis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_3
Started Jan 2020
Shorter than P25 for phase_3
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 6, 2018
CompletedFirst Posted
Study publicly available on registry
July 17, 2018
CompletedStudy Start
First participant enrolled
January 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2020
CompletedApril 9, 2024
August 1, 2018
7 months
July 6, 2018
April 8, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
qCON index
The hypnotic potency of volatile anesthetics was evaluated by qCON index during standardized nociceptive stimulus (30 s, 50 mA, 50 Hz tetanic stimulation).
the 10 min at steady-state anesthesia after endotracheal intubation
Secondary Outcomes (1)
qNOX index
the 10 min at steady-state anesthesia after endotracheal intubation
Study Arms (2)
Sevoflurane
EXPERIMENTALAnesthesia was maintained with sevoflurane.
Isoflurane
EXPERIMENTALAnesthesia was maintained with isoflurane.
Interventions
Anesthesia was maintained with sevoflurane in patients undergoing standardized nociceptive stimulus (long-lasting tetanic stimulus of the ulnar nerve; 30 s, 50 mA, 50 Hz, square-wave).
Anesthesia was maintained with isoflurane in patients undergoing standardized nociceptive stimulus (long-lasting tetanic stimulus of the ulnar nerve; 30 s, 50 mA, 50 Hz, square-wave).
Eligibility Criteria
You may qualify if:
- patients undergoing general anesthesia using volatile anesthetics and intubation
- patients with american society of anesthesiologist physical status I, II
- patients obtaining written informed consent
You may not qualify if:
- patients with a history of any psychiatric or neurological disease
- patients who had received any medication affecting the central nervous system
- patients who had received medication affecting the sympathetic or parasympathetic nervous systems
- patients undergoing supraglottic airway for airway management
- pregnant women
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine
Cangzhou, Hebei, 061001, China
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ruizhao Lv, M.D
Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 6, 2018
First Posted
July 17, 2018
Study Start
January 1, 2020
Primary Completion
August 1, 2020
Study Completion
December 1, 2020
Last Updated
April 9, 2024
Record last verified: 2018-08