Endophenotype Characterization of a Family Psychiatric Disorder

NCT02843997 | Unknown

• 1 other identifier: 38RC14.321
• Study Type: interventional
• Target: 29
• Locations: 1 country
• Sites: 1

Brief Summary

Bipolar disorder is a chronic and frequent mood pathology, that impacts on emotional and socio-professional life of sick subjects, and also increase mortality by suicide. Suicide is considered as a bipolar disorder result. The main goal of this study is the endophenotype characterization from a clinical and cognitive point of view, of a bipolar spectrum's disorder present in a family, and then highlight a mutation of one of the genes involved is this disorder.

Conditions

Healthy Volunteer

Keywords

Bipolar disorder; Endophenotype; Family; Autosomal dominant expression; Sequencing; Heritability

Outcome Measures

Primary Outcomes (3)

• Neuropsychological evaluations tests

  Neuropsychological evaluations (about one hour) : TMT (Trail Making Test) A and B, Stroop VFT (Visual Field Testing), DST (Dyslexia Screening Test) Tower of London test Hayling, CPT (continuous performance task) CVLT (California Verbal Learning Test) tests.

  One day

• Eye tracking.

  The volunteer will follow an instruction according to the color seen on a screen. This instruction is to look at the side where there is a flashlight and to look at the opopsite if the light is unbroken. Mistakes will be count.

  One hour

• Blood sampling

  Genetic sample for extraction of DNA.

  3 minutes

Study Arms (1)

Healthy volunteers

OTHER

Members of a family

Genetic: Endophenotype and sequencing

Interventions

Endophenotype and sequencing GENETIC

Draw an endophenotype and genetic study

Healthy volunteers

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Members of a family adult (more than 18 years)
• Signed informed consents
• Registered to a French social security or possesor of the European Health Insurance Card

You may not qualify if:

• Clinical part :
• Refusal to sign the participation study consent.
• Organic affection likely to affect cognitive abilities and brain structures or acute decompensation of a bipolar disorder.
• Genetic part :
• Refusal to sign the genetic sample consent.

Sponsors & Collaborators

• University Hospital, Grenoble: lead

Study Sites (1)

UniversityHospitalGrenoble

La Tronche, 38700, France

RECRUITING

Related Publications (55)

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  BACKGROUND

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MeSH Terms

Conditions

Bipolar Disorder

Interventions

Endophenotypes; Base Sequence

Condition Hierarchy (Ancestors)

Bipolar and Related Disorders; Mood Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Phenotype; Genetic Phenomena; Molecular Structure; Biochemical Phenomena; Chemical Phenomena; Genetic Structures

Study Officials

• Jérôme Holtzmann, Doctor

  Grenoble Hospital University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jérôme Holtzmann, Doctor

CONTACT

04 76 76 54 14; jholtzmann@chu-grenoble.fr

John Rendu, Doctor

CONTACT

04 76 76 55 73; jrendu@chu-grenoble.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 11, 2016
• First Posted: July 26, 2016
• Study Start: February 1, 2015
• Primary Completion: February 1, 2018
• Study Completion: February 1, 2018
• Last Updated: July 26, 2016

Record last verified: 2016-07

Locations

FR (1)