Cortical Excitability Using Transcranial Magnetic Stimulation and Neuronavigation Device
RC-TMS
Study of Cortical Excitability in Healthy Subjects With Transcranial Magnetic Stimulation (TMS) and a Neuronavigation Device
1 other identifier
interventional
75
1 country
1
Brief Summary
This study has two main goals :
- to investigate the impact of aging on cortical excitability (CE)
- to investigate the impact of "state dependency" on CE, using a cognitive task and an emotional one. A Neuronavigation system of transcranial magnetic stimulation is used, and electromyographic response are recorded.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable healthy-volunteers
Started Jun 2012
Longer than P75 for not_applicable healthy-volunteers
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2012
CompletedFirst Submitted
Initial submission to the registry
July 23, 2014
CompletedFirst Posted
Study publicly available on registry
November 4, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2016
CompletedMay 8, 2017
May 1, 2017
4 years
July 23, 2014
May 3, 2017
Conditions
Outcome Measures
Primary Outcomes (2)
Amplitudes of Motor evoked Potentials (µV) for ICI and ICF.
Motor Evoked Potential (MEP) from the first dorsal interosseous are register during the stimulations. Intracortical Inhibition (ICI) and Facilitation (ICF) are a paired-pulse TMS measure of cortical excitability. A short Interval interstimuli (2ms) leads to a cortical inhibition, which reflects the GABAergic neurotransmission; whereas a longer interval interstimuli leads to a cortical facilitation, which reflects glutamatergic neurotransmission.
Participants will be followed for an expected average of one month
Durations of Cortical Silent Period (ms)
Cortical Silent Period (CSP) is a single-pulse TMS measure of cortical inhibition, stimulations are applied while subjects are exerting a muscular contraction of the thum-index pinch and lead to a muscular cancellation. Duration of this silence is measured.
Participants will be followed for an expected average of one month
Study Arms (1)
state dependency TMS
OTHERTMS performed at rest and during a cognitive/emotional task
Interventions
Eligibility Criteria
You may qualify if:
- male or female
- age 18-75
- signed informed consent
- normal physical examination
You may not qualify if:
- less 18 or more 75 years of age
- contra indication to TMS: epilepsia or seizures, metallic head devices, cardiac pacemaker, pregnancy, jet lag or severe insomnia the night before
- severe physical disease
- treatment with psychotropic drugs
- overt psychiatric disease
- alcohol consumption before the examination
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Psychiatry & Neurology - University Hospital Grenoble
Grenoble, 38000, France
Study Officials
- PRINCIPAL INVESTIGATOR
Thierry BOUGEROL, MD, PhD
University of Grenoble
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 23, 2014
First Posted
November 4, 2015
Study Start
June 1, 2012
Primary Completion
June 1, 2016
Study Completion
June 1, 2016
Last Updated
May 8, 2017
Record last verified: 2017-05