Brain Bases of Natural Scenes's Visual Perception of Natural Scenes

NCT02840305 | Completed

• 1 other identifier: 38RC11.221
• Study Type: interventional
• Target: 141
• Locations: 1 country
• Sites: 1

Brief Summary

Using the available data from psychophysics, cellular electrophysiology and functionnal neuroanatomy of visual pathway, current models of visual recognition suppose that the perception of scenes start with a parallel extraction of differents elementary visual characteristics to different spatial frequencies according to a default processing principle named : 'coarse-to-fine'. According to this principle, the visual scene's analysis would be decomposed in two steps. Fisrt, the fast analysis of the global information borne by low frequency of the scene will provide an overview of the scene's structure and would enable a first perceptive categorisation which would be then refined, approved or denied by the latest analysis of the most local, detailed and precise information, carried by the very high spatial frequency of the scene. The research carried out since several years is preparing a biologically plausible model and to find brain bases by different imaging techniques among healthy subjects but also patients with a brain lesion and patients with a peripheral lesion. The main goal of this Magnetic Resonance Imaging study is to find brain bases of natural scenes's visual perception of the natural scenes. Three studies in Magnetic Resonance Imaging will be conducted, during which subjects will have to categorize pictures of natural scenes filtered in spatial frequencies. The outcome of this study will allow to refine models of visual recognition, most of them based on analysis of spatial frequencies.

Conditions

Healthy Volunteer

Keywords

Natural scenes; Brain bases; Visual perception; MRI

Outcome Measures

Primary Outcomes (1)

• Identify brain bases of natural scenes's visual perception of the natural scenes

  Evaluation 1 = Visual tasks Experience 1 : Brain bases of spatial frequencies treatment Experience 2 : Brain bases of Computer to Film (CtF) natural scenes analysis MRI exam Experience 3 : Part of parahippocampal gyrus in Computer to Film (CtF) natural scenes analysis MRI exam About 30 minutes Evaluation 2 = Retinotopy : only adults that have shown activations inside occipital cortex during evaluation 1 MRI exam about 50 minutes

  About 80 minutes

Study Arms (3)

Expérience 1

OTHER

Brain bases of spatial frequencies treatment 30 young adults, 20 old adults 20 children between 4 and 6 years, 20 children between 6 and 12 years and 20 young adults

Other: Evaluation of visual function; Other: Magnetic Resonance Imaging

Expérience 2

OTHER

Brain bases of Computer to Film (CtF) analysis 30 young adults, 20 old adults

Other: Evaluation of visual function; Other: Magnetic Resonance Imaging

Expérience 3

OTHER

Part of parahippocampal gyrus in Computer to Film (CtF) analysis 30 young adults, 20 old adults.

Other: Evaluation of visual function; Other: Magnetic Resonance Imaging

Interventions

Evaluation of visual function OTHER

Expérience 1; Expérience 2; Expérience 3

Magnetic Resonance Imaging OTHER

Also known as: MRI

Expérience 1; Expérience 2; Expérience 3

Eligibility Criteria

• Age: 4 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Subjet over 18 years and less than 30 years
• Affiliation to a social security
• Free signed consent
• Medical exam done before participation to the study
• Normal or corrected visual acuity

You may not qualify if:

• Counter-argument to MRI
• Pregnant, breast-feeding or parturient women
• Adults non protected or unable to express their consent
• Adults protected
• Important earing or visual disorder
• Neuropsychiatric disorder current or past passée ou présente (exept benign epilepsy)
• Severe affection on a general level (cardiac, respiratory, hematologic, renal, hépatic, cancerous)
• Drug treatment in progress (exept anti-epileptic drug) likely to de modulate brain activity
• Subjet over 50 years
• Affiliation to a social security
• Free signed consent
• Medical exam done before participation to the study
• Normal or corrected visual acuity
• Counter-argument to MRI
• Pregnant, breast-feeding or parturient women

Sponsors & Collaborators

• University Hospital, Grenoble: lead

Study Sites (1)

UniversityHospitalGrenoble

La Tronche, 38700, France

Location

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MeSH Terms

Interventions

Magnetic Resonance Spectroscopy

Intervention Hierarchy (Ancestors)

Spectrum Analysis; Chemistry Techniques, Analytical; Investigative Techniques

Study Officials

• Alexandre Krainik, Professor

  Grenoble Hospital University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 18, 2016
• First Posted: July 21, 2016
• Study Start: April 1, 2012
• Primary Completion: March 1, 2016
• Study Completion: August 1, 2016
• Last Updated: January 18, 2017

Record last verified: 2017-01

Locations

FR (1)