NCT02830100

Brief Summary

The goal is to define what is the nature of intern speech, how it manifests itself, who deal with agency in intern speech and finally what is the role of intern speech in attention tasks.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
25

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jul 2015

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 23, 2015

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 12, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 12, 2015

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

July 8, 2016

Completed
4 days until next milestone

First Posted

Study publicly available on registry

July 12, 2016

Completed
Last Updated

October 15, 2018

Status Verified

October 1, 2018

Enrollment Period

5 months

First QC Date

July 8, 2016

Last Update Submit

October 10, 2018

Conditions

Healthy Volunteer

Keywords

Intern speechSpeech and visual imagingMind and oral driftCognitive performanceMagnetic Resonance Imaging

Outcome Measures

Primary Outcomes (1)

  • Study intern speech

    Magnetic Resonance Imaging while talking, thinking, listening

    About an hour

Study Arms (1)

Healthy volunteers

OTHER
Other: Healthy volunteersDevice: MRI

Interventions

Healthy volunteersOTHER

Magnetic Resonance Imaging during intern speech, listening, talking, thinking.

Healthy volunteers
MRIDEVICE
Healthy volunteers

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Between 18 and 65 years
  • Right-handed
  • French as mother tongue
  • Visual acuity that allow to read stimulis (contact lens authorized)
  • Healthy subject

You may not qualify if:

  • Respiratory or cardio-vascular pathology
  • Claustrophobia

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

UniversityHospitalGrenoble

La Tronche, 38700, France

Location

Related Publications (21)

  • Baciu MV, Rubin C, Decorps MA, Segebarth CM. fMRI assessment of hemispheric language dominance using a simple inner speech paradigm. NMR Biomed. 1999 Aug;12(5):293-8. doi: 10.1002/(sici)1099-1492(199908)12:53.0.co;2-6.

    PMID: 10484818BACKGROUND

  • Basho S, Palmer ED, Rubio MA, Wulfeck B, Muller RA. Effects of generation mode in fMRI adaptations of semantic fluency: paced production and overt speech. Neuropsychologia. 2007 Apr 9;45(8):1697-706. doi: 10.1016/j.neuropsychologia.2007.01.007. Epub 2007 Jan 16.

    PMID: 17292926BACKGROUND

  • Bookheimer SY, Zeffiro TA, Blaxton T, Gaillard W, Theodore W. Regional cerebral blood flow during object naming and word reading. Human Brain Mapping. 1995;3:93-106.

    BACKGROUND

  • Clark A, Karmiloff-Smith A. The cognizer's innards: a psychological and philosophical perspective on the development of thought. Mind & Language. 1993;8:487-519.

    BACKGROUND

  • Conrad B, Schonle P. Speech and respiration. Arch Psychiatr Nervenkr (1970). 1979 Apr 12;226(4):251-68. doi: 10.1007/BF00342238.

    PMID: 454139BACKGROUND

  • Davis RN, Nolen-Hoeksema S. Cognitive inflexibility among ruminators and nonruminators. Cognitive Therapy and Research. 2000;24:699-711.

    BACKGROUND

  • Frings M, Dimitrova A, Schorn CF, Elles HG, Hein-Kropp C, Gizewski ER, Diener HC, Timmann D. Cerebellar involvement in verb generation: an fMRI study. Neurosci Lett. 2006 Nov 27;409(1):19-23. doi: 10.1016/j.neulet.2006.08.058. Epub 2006 Oct 12.

    PMID: 17046160BACKGROUND

  • Huang J, Carr TH, Cao Y. Comparing cortical activations for silent and overt speech using event-related fMRI. Hum Brain Mapp. 2002 Jan;15(1):39-53. doi: 10.1002/hbm.1060.

    PMID: 11747099BACKGROUND

  • Lupyan G. Extracommunicative functions of language: verbal interference causes selective categorization impairments. Psychon Bull Rev. 2009 Aug;16(4):711-8. doi: 10.3758/PBR.16.4.711.

    PMID: 19648457BACKGROUND

  • McGuire PK, Silbersweig DA, Murray RM, David AS, Frackowiak RS, Frith CD. Functional anatomy of inner speech and auditory verbal imagery. Psychol Med. 1996 Jan;26(1):29-38. doi: 10.1017/s0033291700033699.

    PMID: 8643761BACKGROUND

  • Morin A. Inner Speech Encyclopedia of Human Behavior. 2012;Elsevier:436-43.

    BACKGROUND

  • Netsell R, Ashley E, Bakker K. The Inner Speech of Persons who Stutter. Proceedings of the International Motor Speech Conference. Savannah, Georgia2010

    BACKGROUND

  • Olivers CN, Nieuwenhuis S. The beneficial effects of additional task load, positive affect, and instruction on the attentional blink. J Exp Psychol Hum Percept Perform. 2006 Apr;32(2):364-79. doi: 10.1037/0096-1523.32.2.364.

    PMID: 16634676BACKGROUND

  • Owen WJ, Borowsky R, Sarty GE. FMRI of two measures of phonological processing in visual word recognition: ecological validity matters. Brain Lang. 2004 Jul-Sep;90(1-3):40-6. doi: 10.1016/S0093-934X(03)00418-8.

    PMID: 15172523BACKGROUND

  • Palmer ED, Rosen HJ, Ojemann JG, Buckner RL, Kelley WM, Petersen SE. An event-related fMRI study of overt and covert word stem completion. Neuroimage. 2001 Jul;14(1 Pt 1):182-93. doi: 10.1006/nimg.2001.0779.

    PMID: 11525327BACKGROUND

  • Partovi S, Konrad F, Karimi S, Rengier F, Lyo JK, Zipp L, Nennig E, Stippich C. Effects of covert and overt paradigms in clinical language fMRI. Acad Radiol. 2012 May;19(5):518-25. doi: 10.1016/j.acra.2011.12.017. Epub 2012 Jan 27.

    PMID: 22281389BACKGROUND

  • Rosen HJ, Ojemann JG, Ollinger JM, Petersen SE. Comparison of brain activation during word retrieval done silently and aloud using fMRI. Brain Cogn. 2000 Mar;42(2):201-17. doi: 10.1006/brcg.1999.1100.

    PMID: 10744920BACKGROUND

  • Shergill SS, Bullmore ET, Brammer MJ, Williams SC, Murray RM, McGuire PK. A functional study of auditory verbal imagery. Psychol Med. 2001 Feb;31(2):241-53. doi: 10.1017/s003329170100335x.

    PMID: 11232912BACKGROUND

  • Shuster LI, Lemieux SK. An fMRI investigation of covertly and overtly produced mono- and multisyllabic words. Brain Lang. 2005 Apr;93(1):20-31. doi: 10.1016/j.bandl.2004.07.007.

    PMID: 15766765BACKGROUND

  • Uttl B, Morin A, Faulds TJ, Hall T, Wilson JM. Sampling Inner Speech Using Text Messaging. Proceedings of the Canadian Society for Brain, Behavior, and Cognitive Science. Kingston2012. p. 287.

    BACKGROUND

  • Roger E, Rodrigues De Almeida L, Loevenbruck H, Perrone-Bertolotti M, Cousin E, Schwartz JL, Perrier P, Dohen M, Vilain A, Baraduc P, Achard S, Baciu M. Unraveling the functional attributes of the language connectome: crucial subnetworks, flexibility and variability. Neuroimage. 2022 Nov;263:119672. doi: 10.1016/j.neuroimage.2022.119672. Epub 2022 Oct 6.

    PMID: 36209795DERIVED

MeSH Terms

Conditions

Speech

Condition Hierarchy (Ancestors)

Verbal BehaviorCommunicationBehavior

Study Officials

  • Alexandre Krainik, Professor

    Grenoble Hospital University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 8, 2016

First Posted

July 12, 2016

Study Start

July 23, 2015

Primary Completion

December 12, 2015

Study Completion

December 12, 2015

Last Updated

October 15, 2018

Record last verified: 2018-10

Locations

FR(1)