Impact of Sleep Restriction in Women

NCT02835261 | Completed DMC

• 1 other identifier: AAAQ7638
• Study Type: interventional
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

The overall goal of this project is to test the hypothesis that long-term, sustained sleep restriction (SR), in women, will lead to increased cardio-metabolic risk. This will be characterized by increases in visceral adiposity, unhealthy lifestyle behaviors (poor dietary quality and low physical activity) and cardio-metabolic risk factors (blood pressure, glucose intolerance) relative to habitual sleep (HS). The investigators expect these changes to be worse in pre- compared to post-menopausal women.

Conditions

Sleep; Cardiovascular Disease; Obesity

Keywords

Obesity; Metabolic Disorders

Outcome Measures

Primary Outcomes (3)

• Change in glucose tolerance

  Oral glucose tolerance test

  baseline to 6 weeks

• Change in blood pressure

  24-hour ambulatory blood pressure; weekly office blood pressure

  baseline to 6 weeks

• Flow-mediated dilatation

  Endpoint FMD

  baseline to 6 weeks

Secondary Outcomes (10)

• Change in Adiposity

  baseline to 6 weeks

• Change in physical activity levels

  baseline to 6 weeks

• C-reactive protein

  Weeks 0, 3, 4, and 6

• Interleukin-6

  Weeks 0, 3, 4, and 6

• Tumor necrosis factor

  Weeks 0, 3, 4, and 6

Other Outcomes (1)

• NIH Toolbox® for Assessment of Neurological and Behavioral Function (NIH Toolbox)

  Weeks 0 and 6

Study Arms (2)

Habitual Sleep (HS)

NO INTERVENTION

During the HS phase, participants will be asked to follow a fixed bedtime routine based on their screening sleep schedule.

Sleep Restriction (SR)

EXPERIMENTAL

During the SR phase, participants will be asked to keep their habitual wake time constant but delay their bedtime to achieve a reduction of 1.5 h in total sleep time. A delay in bedtimes was chosen rather than advancing wakeup time because it most closely reflects differences in sleep timing behavior between short and normal sleepers.

Other: Sleep Restriction

Interventions

Sleep Restriction OTHER

Mild sleep restriction (-1.5 h/night) over a period of 6 weeks

Sleep Restriction (SR)

Eligibility Criteria

• Age: 20 Years - 75 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 20-75 years old
• All racial/ethnic groups
• Body mass index 18.5-34.9 kg/m2
• Sleep 7-9 h in bed/night with no daytime nap
• Normal scores on:
• Pittsburgh Quality of Sleep Questionnaire Epworth Sleepiness Scale, Berlin Questionnaire, Sleep Disorders Inventory Questionnaire, Beck Depression Inventory, Composite Scale of Morningness/Eveningness, Three Factor Eating Questionnaire

You may not qualify if:

• Smokers (any cigarettes or ex-smoker \<3 years)
• Neurological, medical or psychiatric disorder
• Diabetics
• Regular use of any medication or supplement
• Eating and/or sleep disorders
• Contraindications for MRI scanning
• Travel across time zones within 4 wk
• History of drug and alcohol abuse
• Shift worker (or rotating shift worker)
• Caffeine intake \>300 mg/d
• Oral contraceptive use or hormone replacement therapy
• Heavy equipment operators
• Commercial long-distance drivers.

Sponsors & Collaborators

• Columbia University: lead
• American Heart Association: collaborator

Study Sites (1)

New York Obesity Nutrition Research Center

New York, New York, 10032, United States

Location

Related Publications (84)

• Jackowska M, Steptoe A. Sleep and future cardiovascular risk: prospective analysis from the English Longitudinal Study of Ageing. Sleep Med. 2015 Jun;16(6):768-74. doi: 10.1016/j.sleep.2015.02.530. Epub 2015 Mar 9.

  PMID: 25934538 BACKGROUND

• Wu MC, Yang YC, Wu JS, Wang RH, Lu FH, Chang CJ. Short sleep duration associated with a higher prevalence of metabolic syndrome in an apparently healthy population. Prev Med. 2012 Oct;55(4):305-309. doi: 10.1016/j.ypmed.2012.07.013. Epub 2012 Jul 27.

  PMID: 22846501 BACKGROUND

• Ohkuma T, Fujii H, Iwase M, Ogata-Kaizu S, Ide H, Kikuchi Y, Idewaki Y, Jodai T, Hirakawa Y, Nakamura U, Kitazono T. U-shaped association of sleep duration with metabolic syndrome and insulin resistance in patients with type 2 diabetes: the Fukuoka Diabetes Registry. Metabolism. 2014 Apr;63(4):484-91. doi: 10.1016/j.metabol.2013.12.001. Epub 2013 Dec 7.

  PMID: 24411997 BACKGROUND

• Chaput JP, McNeil J, Despres JP, Bouchard C, Tremblay A. Seven to eight hours of sleep a night is associated with a lower prevalence of the metabolic syndrome and reduced overall cardiometabolic risk in adults. PLoS One. 2013 Sep 5;8(9):e72832. doi: 10.1371/journal.pone.0072832. eCollection 2013.

  PMID: 24039808 BACKGROUND

• Hall MH, Muldoon MF, Jennings JR, Buysse DJ, Flory JD, Manuck SB. Self-reported sleep duration is associated with the metabolic syndrome in midlife adults. Sleep. 2008 May;31(5):635-43. doi: 10.1093/sleep/31.5.635.

  PMID: 18517034 BACKGROUND

• Chaput JP, McNeil J, Despres JP, Bouchard C, Tremblay A. Short sleep duration as a risk factor for the development of the metabolic syndrome in adults. Prev Med. 2013 Dec;57(6):872-7. doi: 10.1016/j.ypmed.2013.09.022. Epub 2013 Oct 5.

  PMID: 24099879 BACKGROUND

• Cappuccio FP, Taggart FM, Kandala NB, Currie A, Peile E, Stranges S, Miller MA. Meta-analysis of short sleep duration and obesity in children and adults. Sleep. 2008 May;31(5):619-26. doi: 10.1093/sleep/31.5.619.

  PMID: 18517032 BACKGROUND

• Redline S, Foody J. Sleep disturbances: time to join the top 10 potentially modifiable cardiovascular risk factors? Circulation. 2011 Nov 8;124(19):2049-51. doi: 10.1161/CIRCULATIONAHA.111.062190. No abstract available.

  PMID: 22064955 BACKGROUND

• Robertson MD, Russell-Jones D, Umpleby AM, Dijk DJ. Effects of three weeks of mild sleep restriction implemented in the home environment on multiple metabolic and endocrine markers in healthy young men. Metabolism. 2013 Feb;62(2):204-11. doi: 10.1016/j.metabol.2012.07.016. Epub 2012 Sep 15.

  PMID: 22985906 BACKGROUND

• Hoevenaar-Blom MP, Spijkerman AM, Kromhout D, Verschuren WM. Sufficient sleep duration contributes to lower cardiovascular disease risk in addition to four traditional lifestyle factors: the MORGEN study. Eur J Prev Cardiol. 2014 Nov;21(11):1367-75. doi: 10.1177/2047487313493057. Epub 2013 Jul 3.

  PMID: 23823570 BACKGROUND

• Ford ES. Habitual sleep duration and predicted 10-year cardiovascular risk using the pooled cohort risk equations among US adults. J Am Heart Assoc. 2014 Dec 2;3(6):e001454. doi: 10.1161/JAHA.114.001454.

  PMID: 25468656 BACKGROUND

• Canivet C, Nilsson PM, Lindeberg SI, Karasek R, Ostergren PO. Insomnia increases risk for cardiovascular events in women and in men with low socioeconomic status: a longitudinal, register-based study. J Psychosom Res. 2014 Apr;76(4):292-9. doi: 10.1016/j.jpsychores.2014.02.001. Epub 2014 Feb 11.

  PMID: 24630179 BACKGROUND

• Sands-Lincoln M, Loucks EB, Lu B, Carskadon MA, Sharkey K, Stefanick ML, Ockene J, Shah N, Hairston KG, Robinson JG, Limacher M, Hale L, Eaton CB. Sleep duration, insomnia, and coronary heart disease among postmenopausal women in the Women's Health Initiative. J Womens Health (Larchmt). 2013 Jun;22(6):477-86. doi: 10.1089/jwh.2012.3918. Epub 2013 May 7.

  PMID: 23651054 BACKGROUND

• Cappuccio FP, Cooper D, D'Elia L, Strazzullo P, Miller MA. Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Eur Heart J. 2011 Jun;32(12):1484-92. doi: 10.1093/eurheartj/ehr007. Epub 2011 Feb 7.

  PMID: 21300732 BACKGROUND

• Cappuccio FP, Stranges S, Kandala NB, Miller MA, Taggart FM, Kumari M, Ferrie JE, Shipley MJ, Brunner EJ, Marmot MG. Gender-specific associations of short sleep duration with prevalent and incident hypertension: the Whitehall II Study. Hypertension. 2007 Oct;50(4):693-700. doi: 10.1161/HYPERTENSIONAHA.107.095471. Epub 2007 Sep 4.

  PMID: 17785629 BACKGROUND

• Stranges S, Dorn JM, Cappuccio FP, Donahue RP, Rafalson LB, Hovey KM, Freudenheim JL, Kandala NB, Miller MA, Trevisan M. A population-based study of reduced sleep duration and hypertension: the strongest association may be in premenopausal women. J Hypertens. 2010 May;28(5):896-902. doi: 10.1097/HJH.0b013e328335d076.

  PMID: 20040890 BACKGROUND

• Gangwisch JE, Feskanich D, Malaspina D, Shen S, Forman JP. Sleep duration and risk for hypertension in women: results from the nurses' health study. Am J Hypertens. 2013 Jul;26(7):903-11. doi: 10.1093/ajh/hpt044. Epub 2013 Apr 4.

  PMID: 23564028 BACKGROUND

• Choi JK, Kim MY, Kim JK, Park JK, Oh SS, Koh SB, Eom A. Association between short sleep duration and high incidence of metabolic syndrome in midlife women. Tohoku J Exp Med. 2011 Nov;225(3):187-93. doi: 10.1620/tjem.225.187.

  PMID: 22001675 BACKGROUND

• Miller MA, Kandala NB, Kivimaki M, Kumari M, Brunner EJ, Lowe GD, Marmot MG, Cappuccio FP. Gender differences in the cross-sectional relationships between sleep duration and markers of inflammation: Whitehall II study. Sleep. 2009 Jul;32(7):857-64.

  PMID: 19639748 BACKGROUND

• Matthews KA, Zheng H, Kravitz HM, Sowers M, Bromberger JT, Buysse DJ, Owens JF, Sanders M, Hall M. Are inflammatory and coagulation biomarkers related to sleep characteristics in mid-life women?: Study of Women's Health across the Nation sleep study. Sleep. 2010 Dec;33(12):1649-55. doi: 10.1093/sleep/33.12.1649.

  PMID: 21120127 BACKGROUND

• St-Onge MP, Perumean-Chaney S, Desmond R, Lewis CE, Yan LL, Person SD, Allison DB. Gender Differences in the Association between Sleep Duration and Body Composition: The Cardia Study. Int J Endocrinol. 2010;2010:726071. doi: 10.1155/2010/726071. Epub 2009 Nov 12.

  PMID: 20049158 BACKGROUND

• Mezick EJ, Wing RR, McCaffery JM. Associations of self-reported and actigraphy-assessed sleep characteristics with body mass index and waist circumference in adults: moderation by gender. Sleep Med. 2014 Jan;15(1):64-70. doi: 10.1016/j.sleep.2013.08.784. Epub 2013 Oct 14.

  PMID: 24239499 BACKGROUND

• Bosy-Westphal A, Hinrichs S, Jauch-Chara K, Hitze B, Later W, Wilms B, Settler U, Peters A, Kiosz D, Muller MJ. Influence of partial sleep deprivation on energy balance and insulin sensitivity in healthy women. Obes Facts. 2008;1(5):266-73. doi: 10.1159/000158874. Epub 2008 Oct 23.

  PMID: 20054188 BACKGROUND

• Markwald RR, Melanson EL, Smith MR, Higgins J, Perreault L, Eckel RH, Wright KP Jr. Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5695-700. doi: 10.1073/pnas.1216951110. Epub 2013 Mar 11.

  PMID: 23479616 BACKGROUND

• Spaeth AM, Dinges DF, Goel N. Effects of Experimental Sleep Restriction on Weight Gain, Caloric Intake, and Meal Timing in Healthy Adults. Sleep. 2013 Jul 1;36(7):981-990. doi: 10.5665/sleep.2792.

  PMID: 23814334 BACKGROUND

• Nedeltcheva AV, Kilkus JM, Imperial J, Kasza K, Schoeller DA, Penev PD. Sleep curtailment is accompanied by increased intake of calories from snacks. Am J Clin Nutr. 2009 Jan;89(1):126-33. doi: 10.3945/ajcn.2008.26574. Epub 2008 Dec 3.

  PMID: 19056602 BACKGROUND

• St-Onge MP, Roberts AL, Chen J, Kelleman M, O'Keeffe M, RoyChoudhury A, Jones PJ. Short sleep duration increases energy intakes but does not change energy expenditure in normal-weight individuals. Am J Clin Nutr. 2011 Aug;94(2):410-6. doi: 10.3945/ajcn.111.013904. Epub 2011 Jun 29.

  PMID: 21715510 BACKGROUND

• Shechter A, Rising R, Albu JB, St-Onge MP. Experimental sleep curtailment causes wake-dependent increases in 24-h energy expenditure as measured by whole-room indirect calorimetry. Am J Clin Nutr. 2013 Dec;98(6):1433-9. doi: 10.3945/ajcn.113.069427. Epub 2013 Oct 2.

  PMID: 24088722 BACKGROUND

• Haack M, Sanchez E, Mullington JM. Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. Sleep. 2007 Sep;30(9):1145-52. doi: 10.1093/sleep/30.9.1145.

  PMID: 17910386 BACKGROUND

• van Leeuwen WM, Lehto M, Karisola P, Lindholm H, Luukkonen R, Sallinen M, Harma M, Porkka-Heiskanen T, Alenius H. Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through IL-17 and CRP. PLoS One. 2009;4(2):e4589. doi: 10.1371/journal.pone.0004589. Epub 2009 Feb 25.

  PMID: 19240794 BACKGROUND

• Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges DF, Mullington JM. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol. 2004 Feb 18;43(4):678-83. doi: 10.1016/j.jacc.2003.07.050.

  PMID: 14975482 BACKGROUND

• Frey DJ, Fleshner M, Wright KP Jr. The effects of 40 hours of total sleep deprivation on inflammatory markers in healthy young adults. Brain Behav Immun. 2007 Nov;21(8):1050-7. doi: 10.1016/j.bbi.2007.04.003. Epub 2007 May 23.

  PMID: 17524614 BACKGROUND

• Kerkhofs M, Boudjeltia KZ, Stenuit P, Brohee D, Cauchie P, Vanhaeverbeek M. Sleep restriction increases blood neutrophils, total cholesterol and low density lipoprotein cholesterol in postmenopausal women: A preliminary study. Maturitas. 2007 Feb 20;56(2):212-5. doi: 10.1016/j.maturitas.2006.07.007. Epub 2006 Sep 1.

  PMID: 16950577 BACKGROUND

• O'Keeffe M, Roberts AL, Kelleman M, Roychoudhury A, St-Onge MP. No effects of short-term sleep restriction, in a controlled feeding setting, on lipid profiles in normal-weight adults. J Sleep Res. 2013 Dec;22(6):717-20. doi: 10.1111/jsr.12060. Epub 2013 May 20.

  PMID: 23682639 BACKGROUND

• Spiegel K, Leproult R, Van Cauter E. Impact of sleep debt on metabolic and endocrine function. Lancet. 1999 Oct 23;354(9188):1435-9. doi: 10.1016/S0140-6736(99)01376-8.

  PMID: 10543671 BACKGROUND

• Spiegel K, Knutson K, Leproult R, Tasali E, Van Cauter E. Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes. J Appl Physiol (1985). 2005 Nov;99(5):2008-19. doi: 10.1152/japplphysiol.00660.2005.

  PMID: 16227462 BACKGROUND

• Van Cauter E, Spiegel K, Tasali E, Leproult R. Metabolic consequences of sleep and sleep loss. Sleep Med. 2008 Sep;9 Suppl 1(0 1):S23-8. doi: 10.1016/S1389-9457(08)70013-3.

  PMID: 18929315 BACKGROUND

• Donga E, van Dijk M, van Dijk JG, Biermasz NR, Lammers GJ, van Kralingen KW, Corssmit EP, Romijn JA. A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects. J Clin Endocrinol Metab. 2010 Jun;95(6):2963-8. doi: 10.1210/jc.2009-2430. Epub 2010 Apr 6.

  PMID: 20371664 BACKGROUND

• Schmid SM, Hallschmid M, Jauch-Chara K, Wilms B, Lehnert H, Born J, Schultes B. Disturbed glucoregulatory response to food intake after moderate sleep restriction. Sleep. 2011 Mar 1;34(3):371-7. doi: 10.1093/sleep/34.3.371.

  PMID: 21358855 BACKGROUND

• Buxton OM, Pavlova M, Reid EW, Wang W, Simonson DC, Adler GK. Sleep restriction for 1 week reduces insulin sensitivity in healthy men. Diabetes. 2010 Sep;59(9):2126-33. doi: 10.2337/db09-0699. Epub 2010 Jun 28.

  PMID: 20585000 BACKGROUND

• Nedeltcheva AV, Kessler L, Imperial J, Penev PD. Exposure to recurrent sleep restriction in the setting of high caloric intake and physical inactivity results in increased insulin resistance and reduced glucose tolerance. J Clin Endocrinol Metab. 2009 Sep;94(9):3242-50. doi: 10.1210/jc.2009-0483. Epub 2009 Jun 30.

  PMID: 19567526 BACKGROUND

• Mosca M, Aggarwal B. Sleep duration, snoring habits, and cardiovascular disease risk factors in an ethnically diverse population. J Cardiovasc Nurs. 2012 May-Jun;27(3):263-9. doi: 10.1097/JCN.0b013e31821e7ad1.

  PMID: 21743341 BACKGROUND

• Prather AA, Epel ES, Cohen BE, Neylan TC, Whooley MA. Gender differences in the prospective associations of self-reported sleep quality with biomarkers of systemic inflammation and coagulation: findings from the Heart and Soul Study. J Psychiatr Res. 2013 Sep;47(9):1228-35. doi: 10.1016/j.jpsychires.2013.05.004. Epub 2013 Jun 5.

  PMID: 23746737 BACKGROUND

• St-Onge MP, O'Keeffe M, Roberts AL, RoyChoudhury A, Laferrere B. Short sleep duration, glucose dysregulation and hormonal regulation of appetite in men and women. Sleep. 2012 Nov 1;35(11):1503-10. doi: 10.5665/sleep.2198.

  PMID: 23115399 BACKGROUND

• Shechter A, Rising R, Wolfe S, Albu JB, St-Onge MP. Postprandial thermogenesis and substrate oxidation are unaffected by sleep restriction. Int J Obes (Lond). 2014 Sep;38(9):1153-8. doi: 10.1038/ijo.2013.239. Epub 2013 Dec 19.

  PMID: 24352294 BACKGROUND

• St-Onge MP, Shechter A, Shlisky J, Tam CS, Gao S, Ravussin E, Butler AA. Fasting plasma adropin concentrations correlate with fat consumption in human females. Obesity (Silver Spring). 2014 Apr;22(4):1056-63. doi: 10.1002/oby.20631. Epub 2013 Oct 17.

  PMID: 24115373 BACKGROUND

• St-Onge MP, Wolfe S, Sy M, Shechter A, Hirsch J. Sleep restriction increases the neuronal response to unhealthy food in normal-weight individuals. Int J Obes (Lond). 2014 Mar;38(3):411-6. doi: 10.1038/ijo.2013.114. Epub 2013 Jun 19.

  PMID: 23779051 BACKGROUND

• Shechter A, O'Keeffe M, Roberts AL, Zammit GK, RoyChoudhury A, St-Onge MP. Alterations in sleep architecture in response to experimental sleep curtailment are associated with signs of positive energy balance. Am J Physiol Regul Integr Comp Physiol. 2012 Nov 1;303(9):R883-9. doi: 10.1152/ajpregu.00222.2012. Epub 2012 Sep 12.

  PMID: 22972835 BACKGROUND

• St-Onge MP, McReynolds A, Trivedi ZB, Roberts AL, Sy M, Hirsch J. Sleep restriction leads to increased activation of brain regions sensitive to food stimuli. Am J Clin Nutr. 2012 Apr;95(4):818-24. doi: 10.3945/ajcn.111.027383. Epub 2012 Feb 22.

  PMID: 22357722 BACKGROUND

• St-Onge MP, Roberts A, Shechter A, Choudhury AR. Fiber and Saturated Fat Are Associated with Sleep Arousals and Slow Wave Sleep. J Clin Sleep Med. 2016 Jan;12(1):19-24. doi: 10.5664/jcsm.5384.

  PMID: 26156950 BACKGROUND

• St-Onge MP. The role of sleep duration in the regulation of energy balance: effects on energy intakes and expenditure. J Clin Sleep Med. 2013 Jan 15;9(1):73-80. doi: 10.5664/jcsm.2348.

  PMID: 23319909 BACKGROUND

• Shechter A, Grandner MA, St-Onge MP. The Role of Sleep in the Control of Food Intake. Am J Lifestyle Med. 2014 Nov 1;8(6):371-374. doi: 10.1177/1559827614545315. Epub 2014 Aug 6.

  PMID: 27065757 BACKGROUND

• St-Onge MP, Shechter A. Sleep disturbances, body fat distribution, food intake and/or energy expenditure: pathophysiological aspects. Horm Mol Biol Clin Investig. 2014 Jan;17(1):29-37. doi: 10.1515/hmbci-2013-0066.

  PMID: 25372728 BACKGROUND

• Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989 May;28(2):193-213. doi: 10.1016/0165-1781(89)90047-4.

  PMID: 2748771 BACKGROUND

• Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991 Dec;14(6):540-5. doi: 10.1093/sleep/14.6.540.

  PMID: 1798888 BACKGROUND

• Netzer NC, Stoohs RA, Netzer CM, Clark K, Strohl KP. Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome. Ann Intern Med. 1999 Oct 5;131(7):485-91. doi: 10.7326/0003-4819-131-7-199910050-00002.

  PMID: 10507956 BACKGROUND

• Douglass AB, Bornstein R, Nino-Murcia G, Keenan S, Miles L, Zarcone VP Jr, Guilleminault C, Dement WC. The Sleep Disorders Questionnaire. I: Creation and multivariate structure of SDQ. Sleep. 1994 Mar;17(2):160-7. doi: 10.1093/sleep/17.2.160.

  PMID: 8036370 BACKGROUND

• Arnau RC, Meagher MW, Norris MP, Bramson R. Psychometric evaluation of the Beck Depression Inventory-II with primary care medical patients. Health Psychol. 2001 Mar;20(2):112-9. doi: 10.1037//0278-6133.20.2.112.

  PMID: 11315728 BACKGROUND

• Smith CS, Reilly C, Midkiff K. Evaluation of three circadian rhythm questionnaires with suggestions for an improved measure of morningness. J Appl Psychol. 1989 Oct;74(5):728-38. doi: 10.1037/0021-9010.74.5.728.

  PMID: 2793773 BACKGROUND

• Stunkard AJ, Messick S. The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychosom Res. 1985;29(1):71-83. doi: 10.1016/0022-3999(85)90010-8.

  PMID: 3981480 BACKGROUND

• Silva GE, Goodwin JL, Sherrill DL, Arnold JL, Bootzin RR, Smith T, Walsleben JA, Baldwin CM, Quan SF. Relationship between reported and measured sleep times: the sleep heart health study (SHHS). J Clin Sleep Med. 2007 Oct 15;3(6):622-30.

  PMID: 17993045 BACKGROUND

• Basner M, Dinges DF. Dubious bargain: trading sleep for Leno and Letterman. Sleep. 2009 Jun;32(6):747-52. doi: 10.1093/sleep/32.6.747.

  PMID: 19544750 BACKGROUND

• Asarnow LD, McGlinchey E, Harvey AG. The effects of bedtime and sleep duration on academic and emotional outcomes in a nationally representative sample of adolescents. J Adolesc Health. 2014 Mar;54(3):350-6. doi: 10.1016/j.jadohealth.2013.09.004. Epub 2013 Nov 10.

  PMID: 24225447 BACKGROUND

• Reid KJ, Santostasi G, Baron KG, Wilson J, Kang J, Zee PC. Timing and intensity of light correlate with body weight in adults. PLoS One. 2014 Apr 2;9(4):e92251. doi: 10.1371/journal.pone.0092251. eCollection 2014.

  PMID: 24694994 BACKGROUND

• Spaeth AM, Dinges DF, Goel N. Sex and race differences in caloric intake during sleep restriction in healthy adults. Am J Clin Nutr. 2014 Aug;100(2):559-66. doi: 10.3945/ajcn.114.086579. Epub 2014 Jun 25.

  PMID: 24965304 BACKGROUND

• Shen W, Chen J, Kwak S, Punyanitya M, Heymsfield SB. Between-slice intervals in quantification of adipose tissue and muscle in children. Int J Pediatr Obes. 2011 Apr;6(2):149-56. doi: 10.3109/17477166.2010.486833. Epub 2010 Jun 7.

  PMID: 20528126 BACKGROUND

• Gallagher D, Kuznia P, Heshka S, Albu J, Heymsfield SB, Goodpaster B, Visser M, Harris TB. Adipose tissue in muscle: a novel depot similar in size to visceral adipose tissue. Am J Clin Nutr. 2005 Apr;81(4):903-10. doi: 10.1093/ajcn/81.4.903.

  PMID: 15817870 BACKGROUND

• St-Onge MP, Bourque C, Jones PJ, Ross R, Parsons WE. Medium- versus long-chain triglycerides for 27 days increases fat oxidation and energy expenditure without resulting in changes in body composition in overweight women. Int J Obes Relat Metab Disord. 2003 Jan;27(1):95-102. doi: 10.1038/sj.ijo.0802169.

  PMID: 12532160 BACKGROUND

• St-Onge MP, Ross R, Parsons WD, Jones PJ. Medium-chain triglycerides increase energy expenditure and decrease adiposity in overweight men. Obes Res. 2003 Mar;11(3):395-402. doi: 10.1038/oby.2003.53.

  PMID: 12634436 BACKGROUND

• Shen W, Chen J, Gantz M, Velasquez G, Punyanitya M, Heymsfield SB. A single MRI slice does not accurately predict visceral and subcutaneous adipose tissue changes during weight loss. Obesity (Silver Spring). 2012 Dec;20(12):2458-63. doi: 10.1038/oby.2012.168. Epub 2012 Jun 25.

  PMID: 22728693 BACKGROUND

• Dhurandhar NV, Schoeller D, Brown AW, Heymsfield SB, Thomas D, Sorensen TI, Speakman JR, Jeansonne M, Allison DB; Energy Balance Measurement Working Group. Energy balance measurement: when something is not better than nothing. Int J Obes (Lond). 2015 Jul;39(7):1109-13. doi: 10.1038/ijo.2014.199. Epub 2014 Nov 13.

  PMID: 25394308 BACKGROUND

• Berk ES, Kovera AJ, Boozer CN, Pi-Sunyer FX, Albu JB. Metabolic inflexibility in substrate use is present in African-American but not Caucasian healthy, premenopausal, nondiabetic women. J Clin Endocrinol Metab. 2006 Oct;91(10):4099-106. doi: 10.1210/jc.2005-2411. Epub 2006 Jul 25.

  PMID: 16868062 BACKGROUND

• St-Onge MP, Campbell A, Aggarwal B, Taylor JL, Spruill TM, RoyChoudhury A. Mild sleep restriction increases 24-hour ambulatory blood pressure in premenopausal women with no indication of mediation by psychological effects. Am Heart J. 2020 May;223:12-22. doi: 10.1016/j.ahj.2020.02.006. Epub 2020 Feb 8.

  PMID: 32135337 RESULT

• St-Onge MP, Campbell A, Salazar I, Pizinger T, Liao M, Aggarwal B. Information on Bedtimes and Wake Times Improves the Relation Between Self-Reported and Objective Assessments of Sleep in Adults. J Clin Sleep Med. 2019 Jul 15;15(7):1031-1036. doi: 10.5664/jcsm.7888.

  PMID: 31383241 RESULT

• St-Onge MP, Campbell A, Zuraikat F, Cheng B, Shah R, Berger JS, Sampogna RV, Jelic S. Impact of change in bedtime variability on body composition and inflammation: secondary findings from the Go Red for Women Strategically Focused Research Network. Int J Obes (Lond). 2020 Aug;44(8):1803-1806. doi: 10.1038/s41366-020-0555-1. Epub 2020 Mar 5.

  PMID: 32132641 RESULT

• Aggarwal B, Makarem N, Shah R, Emin M, Wei Y, St-Onge MP, Jelic S. Effects of Inadequate Sleep on Blood Pressure and Endothelial Inflammation in Women: Findings From the American Heart Association Go Red for Women Strategically Focused Research Network. J Am Heart Assoc. 2018 Jun 9;7(12):e008590. doi: 10.1161/JAHA.118.008590.

  PMID: 29886425 RESULT

• Makarem N, Zuraikat FM, Scaccia SE, RoyChoudhury A, St-Onge MP. Sustained Mild Sleep Restriction Increases Blood Pressure in Women: An Update From the American Heart Association Go Red for Women Strategically Focused Research Network. Hypertension. 2021 May 5;77(5):e50-e52. doi: 10.1161/HYPERTENSIONAHA.120.16370. Epub 2021 Mar 29. No abstract available.

  PMID: 33775114 RESULT

• Barragan R, Zuraikat FM, Tam V, Scaccia S, Cochran J, Li S, Cheng B, St-Onge MP. Actigraphy-Derived Sleep Is Associated with Eating Behavior Characteristics. Nutrients. 2021 Mar 5;13(3):852. doi: 10.3390/nu13030852.

  PMID: 33807690 RESULT

• St-Onge MP, Aggarwal B, Allison MA, Berger JS, Castaneda SF, Catov J, Hochman JS, Hubel CA, Jelic S, Kass DA, Makarem N, Michos ED, Mosca L, Ouyang P, Park C, Post WS, Powers RW, Reynolds HR, Sears DD, Shah SJ, Sharma K, Spruill T, Talavera GA, Vaidya D. Go Red for Women Strategically Focused Research Network: Summary of Findings and Network Outcomes. J Am Heart Assoc. 2021 Feb;10(5):e019519. doi: 10.1161/JAHA.120.019519. Epub 2021 Feb 23.

  PMID: 33619972 RESULT

• Petrov ME, Zuraikat FM, Cheng B, Aggarwal B, Jelic S, Laferrere B, St-Onge MP. Impact of sleep restriction on biomarkers of thyroid function: Two pooled randomized trials. Sleep Med. 2024 Dec;124:606-612. doi: 10.1016/j.sleep.2024.10.035. Epub 2024 Oct 30.

  PMID: 39488926 DERIVED

• Zimmerman ME, Benasi G, Hale C, Yeung LK, Cochran J, Brickman AM, St-Onge MP. The effects of insufficient sleep and adequate sleep on cognitive function in healthy adults. Sleep Health. 2024 Apr;10(2):229-236. doi: 10.1016/j.sleh.2023.11.011. Epub 2024 Jan 16.

  PMID: 38233280 DERIVED

• Barragan R, Zuraikat FM, Cheng B, Scaccia SE, Cochran J, Aggarwal B, Jelic S, St-Onge MP. Paradoxical Effects of Prolonged Insufficient Sleep on Lipid Profile: A Pooled Analysis of 2 Randomized Trials. J Am Heart Assoc. 2023 Oct 17;12(20):e032078. doi: 10.1161/JAHA.123.032078. Epub 2023 Oct 10.

  PMID: 37815115 DERIVED

• Shah R, Shah VK, Emin M, Gao S, Sampogna RV, Aggarwal B, Chang A, St-Onge MP, Malik V, Wang J, Wei Y, Jelic S. Mild sleep restriction increases endothelial oxidative stress in female persons. Sci Rep. 2023 Sep 16;13(1):15360. doi: 10.1038/s41598-023-42758-y.

  PMID: 37717072 DERIVED

• Barragan R, Zuraikat FM, Tam V, RoyChoudhury A, St-Onge MP. Changes in eating patterns in response to chronic insufficient sleep and their associations with diet quality: a randomized trial. J Clin Sleep Med. 2023 Nov 1;19(11):1867-1875. doi: 10.5664/jcsm.10696.

  PMID: 37409467 DERIVED

MeSH Terms

Conditions

Cardiovascular Diseases; Obesity; Metabolic Diseases

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Marie-Pierre St-Onge, PhD

  Columbia University-New York Obesity Nutrition Research Center

  PRINCIPAL INVESTIGATOR

• Sanja Jelic, MD

  Columbia University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Nutritional Medicine

Study Record Dates

• First Submitted: June 21, 2016
• First Posted: July 18, 2016
• Study Start: September 1, 2016
• Primary Completion: February 25, 2021
• Study Completion: February 25, 2021
• Last Updated: October 14, 2025

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: Upon study completion, after publication of main research aims.
• Access Criteria: Contact PI directly

Locations

US (1)