Sleep and Social Experiences Study 2

NCT05166590 | Completed DMC

• 2 other identifiers: 18-251695R01HL142051-03
• Study Type: interventional
• Target: 77
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to to test effects of sleep loss on perceived discrimination and cardiovascular functioning as well as identify moderators of the racial discrimination and objective sleep link in a sample of 80 African Americans.

Conditions

Sleep; Blood Pressure

Keywords

sleep; heart; stress

Outcome Measures

Primary Outcomes (1)

• Change in blood pressure post-rejection

  Both systolic and diastolic blood pressure is measured via blood pressure arm cuff, taken after a 5-minute resting period and after each social interaction task

  Baseline to post final rejection (cooperative task) an average of 32 minutes

Secondary Outcomes (5)

• Change in pre-ejection period (PEP) in response to rejection task

  Baseline to Post-rejection task, anticipated average of 42 minutes

• Change in heart rate variability (HRV) in response to rejection task

  Baseline to Post-rejection task, anticipated average of 42 minutes

• Change in affect

  Evening baseline to post-rejection task, time period of approximately 13 hours

• Risk-taking

  Immediately after final social rejection task, approximately at hour 13 of the overnight in-lab visit

• Trust (of outgroup partner)

  Public Goods game will be played after the Columbia Card Task, post-social rejection, approximately at hour 13 of the overnight in-lab visit

Study Arms (2)

Normal Sleep

NO INTERVENTION

Participants will sleep in the laboratory for 8 hours and then undergo the same social-rejection paradigm as the experimental group to serve as a control comparison.

Total Sleep Restriction

EXPERIMENTAL

Participants will experience a night of total sleep restriction and then undergo a social-rejection task in the morning.

Behavioral: Sleep Restriction

Interventions

Sleep Restriction BEHAVIORAL

Sleep Deprivation

Total Sleep Restriction

Eligibility Criteria

• Age: 18 Years - 64 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age: 18 to old 64 years old
• Self-identified African American/Black
• English speaking, able to provide informed consent
• Self-reported bedtime between 10 PM and 12 AM for 5/7 nights for the past 3-months (stability to be confirmed by actigraphy and sleep diary)
• Self-reported sleep duration of between 6.5 and 8.5 hours for 5/7 nights for the last month (duration to be confirmed by actigraphy and sleep diary)

You may not qualify if:

• Aged greater than 64 years (to minimize age-related differences in sleep quantity and architecture).
• Body mass index of 40 or above (to exclude for obesity, which can impair physiologic recording and confound study outcomes).
• Presence of any clinical sleep disorder, including insomnia and obstructive sleep apnea (OSA), as assessed by validated screening measure. OSA will also be assessed objectively during the Sleep Screening period.
• Medical or psychiatric condition, as assessed by self-report and clinical interview, that is likely to affect sleep/wake function or cardiovascular functioning, including doctor diagnosed arrhythmia, hypertension, congestive heart failure, major depression, bipolar disorder, post-traumatic stress disorder.
• Medication use that is likely to affect sleep/wake function or cardiovascular functioning, including antidepressants, anxiolytic or soporific medication, and beta-blockers.

Sponsors & Collaborators

• University of California, San Francisco: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Study Sites (1)

University of California, San Francisco

San Francisco, California, 94118, United States

Location

Study Officials

• Aric A Prather, PhD

  University of California, San Francisco

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Participants will be blind to their condition up until right before they begin their night of normal sleep or total restriction. Participants will also be blind to the nature of the social-rejection task until the debriefing.
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: All participants will be randomized to a night of normal sleep (8 hours) or total sleep restriction.

Study Record Dates

• First Submitted: December 8, 2021
• First Posted: December 22, 2021
• Study Start: June 1, 2021
• Primary Completion: May 31, 2025
• Study Completion: October 15, 2025
• Last Updated: November 6, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ANALYTIC CODE
• Time Frame: All processed data should be available within 5 years of completion of the study
• Access Criteria: Consistent with NIH guidelines

Locations

US (1)