Impact of Sleep Restriction on Performance in Adults

NCT02960776 | Completed Results

• 2 other identifiers: AAAQ77461R01HL128226-01A1
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

The overall goal of this project is to look at the effects of long-term, sustained sleep restriction (SR) in adults, and assess the effects on mood and cognitive and physical performance.

Conditions

Sleep; Obesity; Sleep Restriction

Keywords

Body Weight; Habitual sleep

Outcome Measures

Primary Outcomes (1)

• Endpoint Fat Volume

  Body composition (specifically fat volume) will be measured by MRI at baseline and endpoint.

  Week 6 (endpoint)

Secondary Outcomes (9)

• Energy Expenditure (EE)

  Measured over 14 days at the end of each phase (weeks 5 and 6; endpoint)

• Physical Activity

  Average over 6 weeks (measured daily)

• Ghrelin

  6 weeks

• Regional Brain Activation in Response to Food Stimuli

  Week 6

• Sedentary Behavior

  Average over 6 weeks (measured daily)

Other Outcomes (5)

• NIH Toolbox®

  Week 6 (endpoint)

• Neuro-behavioral Measures

  Week 6 (endpoint)

• Immune Function

  Week 5 (endpoint)

Study Arms (2)

Habitual Sleep (HS)

NO INTERVENTION

Participants will be asked to follow a fixed bedtime routine based on the participant's regular bed- and wake-times during the habitual sleep (HS) phase.

Sleep Restriction (SR)

EXPERIMENTAL

Participants will be asked to keep their habitual wake time constant but delay their bedtime to achieve a reduction of 1.5 hours in total sleep time during the sleep restriction (SR) phase.

Behavioral: Sleep Restriction (SR)

Interventions

Sleep Restriction (SR) BEHAVIORAL

Participants will be asked to keep their habitual wake time constant but delay their bedtime to achieve a reduction of 1.5 hours in total sleep time. A delay in bedtimes was chosen rather than advancing wake-up time because it most closely reflects differences in sleep timing behavior between short and normal sleepers.

Sleep Restriction (SR)

Eligibility Criteria

• Age: 20 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• BMI 25-29.9 kg/m2
• Have at least one obese parent
• Habitually sleep 7-9 hours a night
• Free of any current and past sleep and psychiatric disorders, including eating disorders, diabetes or Cardiovascular disease (CVD) (i.e., normal scores on: Pittsburgh Quality of Sleep Questionnaire Epworth Sleepiness Scale, Berlin Questionnaire, Sleep Disorders Inventory Questionnaire, Beck Depression Inventory, Composite Scale of Morningness/Eveningness, Three Factor Eating Questionnaire)
• All racial/ethnic groups

You may not qualify if:

• Smokers (any cigarettes or ex-smoker \< 3 years)
• Neurological, medical or psychiatric disorder
• Diabetics
• Eating and/or sleep disorders
• Contraindications for MRI scanning
• Travel across time zones within 4 weeks
• History of drug and alcohol abuse
• Shift worker (or rotating shift worker)
• Caffeine intake \> 300 mg/d
• Heavy equipment operators
• Commercial long-distance drivers

Sponsors & Collaborators

• Columbia University: lead
• NYU Langone Health: collaborator
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Study Sites (1)

New York Nutrition Obesity Research Center

New York, New York, 10032, United States

Location

Related Publications (14)

• Luckhaupt SE, Tak S, Calvert GM. The prevalence of short sleep duration by industry and occupation in the National Health Interview Survey. Sleep. 2010 Feb;33(2):149-59. doi: 10.1093/sleep/33.2.149.

  PMID: 20175398 BACKGROUND

• Keith SW, Redden DT, Katzmarzyk PT, Boggiano MM, Hanlon EC, Benca RM, Ruden D, Pietrobelli A, Barger JL, Fontaine KR, Wang C, Aronne LJ, Wright SM, Baskin M, Dhurandhar NV, Lijoi MC, Grilo CM, DeLuca M, Westfall AO, Allison DB. Putative contributors to the secular increase in obesity: exploring the roads less traveled. Int J Obes (Lond). 2006 Nov;30(11):1585-94. doi: 10.1038/sj.ijo.0803326. Epub 2006 Jun 27.

  PMID: 16801930 BACKGROUND

• Zuraikat FM, Makarem N, Redline S, Aggarwal B, Jelic S, St-Onge MP. Sleep Regularity and Cardiometabolic Heath: Is Variability in Sleep Patterns a Risk Factor for Excess Adiposity and Glycemic Dysregulation? Curr Diab Rep. 2020 Jul 23;20(8):38. doi: 10.1007/s11892-020-01324-w.

  PMID: 32700156 BACKGROUND

• Makarem N, Zuraikat FM, Aggarwal B, Jelic S, St-Onge MP. Variability in Sleep Patterns: an Emerging Risk Factor for Hypertension. Curr Hypertens Rep. 2020 Feb 21;22(2):19. doi: 10.1007/s11906-020-1025-9.

  PMID: 32086595 BACKGROUND

• Smith I, Salazar I, RoyChoudhury A, St-Onge MP. Sleep restriction and testosterone concentrations in young healthy males: randomized controlled studies of acute and chronic short sleep. Sleep Health. 2019 Dec;5(6):580-586. doi: 10.1016/j.sleh.2019.07.003. Epub 2019 Aug 12.

  PMID: 31416797 RESULT

• St-Onge MP, Campbell A, Salazar I, Pizinger T, Liao M, Aggarwal B. Information on Bedtimes and Wake Times Improves the Relation Between Self-Reported and Objective Assessments of Sleep in Adults. J Clin Sleep Med. 2019 Jul 15;15(7):1031-1036. doi: 10.5664/jcsm.7888.

  PMID: 31383241 RESULT

• Barragan R, Zuraikat FM, Tam V, Scaccia S, Cochran J, Li S, Cheng B, St-Onge MP. Actigraphy-Derived Sleep Is Associated with Eating Behavior Characteristics. Nutrients. 2021 Mar 5;13(3):852. doi: 10.3390/nu13030852.

  PMID: 33807690 RESULT

• Benasi G, Cheng B, Aggarwal B, St-Onge MP. The effects of sustained mild sleep restriction on stress and distress among healthy adults: Findings from two randomized crossover studies. Sleep Med. 2024 Mar;115:83-87. doi: 10.1016/j.sleep.2024.02.001. Epub 2024 Feb 2.

  PMID: 38342031 RESULT

• Zimmerman ME, Benasi G, Hale C, Yeung LK, Cochran J, Brickman AM, St-Onge MP. The effects of insufficient sleep and adequate sleep on cognitive function in healthy adults. Sleep Health. 2024 Apr;10(2):229-236. doi: 10.1016/j.sleh.2023.11.011. Epub 2024 Jan 16.

  PMID: 38233280 RESULT

• Li XY, Yoncheva Y, Yan CG, Castellanos FX, St-Onge MP. Chronic Mild Sleep Restriction Does Not Lead to Marked Neuronal Alterations Compared With Maintained Adequate Sleep in Adults. J Nutr. 2024 Feb;154(2):446-454. doi: 10.1016/j.tjnut.2023.12.016. Epub 2023 Dec 16.

  PMID: 38104943 RESULT

• Barragan R, Zuraikat FM, Cheng B, Scaccia SE, Cochran J, Aggarwal B, Jelic S, St-Onge MP. Paradoxical Effects of Prolonged Insufficient Sleep on Lipid Profile: A Pooled Analysis of 2 Randomized Trials. J Am Heart Assoc. 2023 Oct 17;12(20):e032078. doi: 10.1161/JAHA.123.032078. Epub 2023 Oct 10.

  PMID: 37815115 RESULT

• Barragan R, Zuraikat FM, Tam V, RoyChoudhury A, St-Onge MP. Changes in eating patterns in response to chronic insufficient sleep and their associations with diet quality: a randomized trial. J Clin Sleep Med. 2023 Nov 1;19(11):1867-1875. doi: 10.5664/jcsm.10696.

  PMID: 37409467 RESULT

• McAlpine CS, Kiss MG, Zuraikat FM, Cheek D, Schiroli G, Amatullah H, Huynh P, Bhatti MZ, Wong LP, Yates AG, Poller WC, Mindur JE, Chan CT, Janssen H, Downey J, Singh S, Sadreyev RI, Nahrendorf M, Jeffrey KL, Scadden DT, Naxerova K, St-Onge MP, Swirski FK. Sleep exerts lasting effects on hematopoietic stem cell function and diversity. J Exp Med. 2022 Nov 7;219(11):e20220081. doi: 10.1084/jem.20220081. Epub 2022 Sep 21.

  PMID: 36129517 RESULT

• Petrov ME, Zuraikat FM, Cheng B, Aggarwal B, Jelic S, Laferrere B, St-Onge MP. Impact of sleep restriction on biomarkers of thyroid function: Two pooled randomized trials. Sleep Med. 2024 Dec;124:606-612. doi: 10.1016/j.sleep.2024.10.035. Epub 2024 Oct 30.

  PMID: 39488926 DERIVED

MeSH Terms

Conditions

Obesity; Body Weight

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Results Point of Contact

• Title: Marie-Pierre St-Onge
• Organization: Columbia University Irving Medical Center

ms2554@cumc.columbia.edu

212-305-9379

Study Officials

• Marie-Pierre St-Onge, PhD

  Columbia University

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Nutritional Medicine

Study Record Dates

• First Submitted: November 7, 2016
• First Posted: November 10, 2016
• Study Start: November 1, 2016
• Primary Completion: July 5, 2023
• Study Completion: July 5, 2023
• Last Updated: April 3, 2025
• Results First Posted: July 9, 2024

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: After study completion and publication of main findings.
• Access Criteria: Contact PI for information

Locations

US (1)