Cryo Global Registry
1 other identifier
observational
5,385
38 countries
163
Brief Summary
Cryo Global Registry a prospective, global, multi-center, observational Post-Market Registry
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started May 2016
Longer than P75 for all trials
163 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 25, 2016
CompletedFirst Posted
Study publicly available on registry
April 27, 2016
CompletedStudy Start
First participant enrolled
May 2, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 29, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
November 29, 2024
CompletedJuly 30, 2025
February 1, 2025
8.6 years
April 25, 2016
July 29, 2025
Conditions
Outcome Measures
Primary Outcomes (4)
Freedom from Atrial Fibrillation (AF) Recurrence at 12 Months
Estimate the 12 month freedom from AF recurrence using the Arctic Front™ Cardiac Cryoablation Catheter System
12 Months
Freedom from Atrial Arrhythmia at 12 Months
Estimate the 12 month freedom from AF / Atrial Flutter (AFL)/ Atrial Tachycardia (AT) using the Arctic Front™ Cardiac Cryoablation Catheter System.
12 Months
Freedom from Arrythmias at 12 months
Estimate the 12-month freedom from arrythmias treated using the Freezor™ Family of Cardiac Cryoablation Catheters.
12 Months
Freedom from Device / Procedure Related Adverse Events
Estimate device and procedure-related adverse events for cryoablation using the Arctic Front™ Cardiac Cryoablation Catheter System through 12 months.
12 Months
Eligibility Criteria
Subjects 18 years or older with a planned procedure using commercially available Arctic Front™ Cardiac Cryoablation Catheter.
You may qualify if:
- Subject is ≥ 18 years of age or minimum age as required by local regulations
- Planned procedure using commercially available Arctic Front™ Cardiac Cryoablation Catheter
- Willing to comply with study requirements and give informed consent (defined as legally effective, documented confirmation of a subject's voluntary agreement to participate in this clinical study) or authorization per institution and geographical requirements
You may not qualify if:
- Subject is enrolled in a concurrent study that has not been approved for concurrent enrollment by the global study manager
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (163)
Carle Foundation Hospital
Urbana, Illinois, 61801, United States
Spectrum Health Hospitals
Grand Rapids, Michigan, 49503-2560, United States
The Lindner Research Center
Cincinnati, Ohio, 45219, United States
Doylestown Health Cardiology
Doylestown, Pennsylvania, 18901, United States
Texas Cardiac Arrhythmia Research Foundation
Austin, Texas, 78705-1852, United States
Texas Health Research & Education Institute
Dallas, Texas, 75231, United States
Instituto Cardiovascular de Buenos Aires (ICBA)
Buenos Aires, C1428DCO, Argentina
Institituo Cardiovascular Buenos Aires (ICBA)
Buenos Aires, CP:1428, Argentina
Hospital Universitario Fundación Favaloro
Buenos Aires, Argentina
Kepler Universitätsklinikum Med Campus III.
Linz, 4021, Austria
Centre Hospitalier Régional de la Citadelle
Liège, Liege, 4000, Belgium
Onze-Lieve-Vrouwziekenhuis-Campus Aalst
Aalst, Belgium
Gleneagles Jerudong Park Medical Centre
Bandar Seri Begawan, Brunei, BG3122, Brunei
Clínica Dávila
Santiago, Chile
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450052, China
Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College
Beijing, 100037, China
West China Hospital of Sichuan University
Chengdu, 610041, China
Shanghai Tenth People's Hospital
Shanghai, 200072, China
Ruijin Hospital Shanghai Jiao Tong University School of Medicine
Shanghai, China
Tianjin Chest Hospital
Tianjin, 300051, China
Fundacion Clinica Shaio
Bogotá, Colombia
Clinica Ces
Medellín, Colombia
Nemocnice Na Homolce
Prague, 150 30, Czechia
Märkische Gesundheitsholding GmbH & Co. KG - Klinikum Lüdenscheid
Lüdenscheid, North Rhine-Westphalia, 58515, Germany
Herz- und Gefässzentrum Bad Bevensen
Bad Bevensen, 29549, Germany
Segeberger Kliniken GmbH - Herzzentrum
Bad Segeberg, 23795, Germany
Sana Klinikum Lichtenberg
Berlin, 10365, Germany
Städtische Kliniken Bielefeld
Bielefeld, 33604, Germany
Klinikum Coburg GmbH
Coburg, 69450, Germany
St. Vinzenz-Hospital Köln
Cologne, 50733, Germany
Cardioangiologisches Centrum Bethanien
Frankfurt, 60389, Germany
Klinikum Lüdenscheid
Lüdenscheid, 58515, Germany
Kliniken Maria Hilf GmbH Mönchengladbach - Krankenhaus St. Franziskus
Mönchengladbach, 41063, Germany
Städtische Kliniken München GmbH - Klinikum Bogenhausen
München, Germany
Oberschwaben-Klinik GmbH - Krankenhaus St. Elisabeth
Ravensburg, 88212, Germany
St. Josephs Hospital Wiesbaden
Wiesbaden, 65189, Germany
Hellenic Airforce 251 General Hospital
Athens, 11525, Greece
Gottsegen György Országos Kardiológiai Intézet
Budapest, Hungary
Debreceni Egyetem
Debrecen, Hungary
Landspitali - National Hospital of Iceland
Reykjavik, Iceland, 108, Iceland
Aster Medcity
Kochi, Kerala, 682027, India
Sree Chitra Tirunal Institute for Medical Sciences & Technology
Thiruvananthapuram, Kerala, 695011, India
Eternal Hospital
Jaipur, Rajasthan, 302017, India
Apollo Hospital (Chennai)
Chennai, Tamil Nadu, 600006, India
Aig Hospital
Hyderabad, India
Max Super Speciality Hospital
New Delhi, 110017, India
National Cardiovascular Center Harapan Kita
Jakarta, 11420, Indonesia
National Cardiovascular Center Harapan Kita
Jakarta, Indonesia
Humanitas Mater Domini
Castellanza, 21053, Italy
Fondazione IRCCS Policlinico San
Pavia, Italy
Ospedale S. Maria della Misericordia
Perugia, 06129, Italy
Azienda Ospedaliero-Universitaria Pisana - Stabilimento di Cisanello
Pisa, 56100, Italy
Nagoya University Hospital
Nagoya, Aichi-ken, 466-8560, Japan
Japanese Red Cross Nagoya Daini Hospital
Nagoya, Aichi-ken, 466-8650, Japan
Fukuoka Sanno Hospital
Fukuoka, Fukuoka, 814-0001, Japan
Ogaki Municipal Hospital
Ōgaki, Gifu, 503-8502, Japan
Hiroshima City Hospital
Hiroshima, Hiroshima, 730-8518, Japan
Hiroshima Prefectural Hospital
Hiroshima, Hiroshima, 734-8530, Japan
Hiroshima University Hospital
Hiroshima, Hiroshima, 734-8551, Japan
Hokkaido Ohno Memorial Hospital
Sapporo, Hokkaido, 063-0052, Japan
Caress Sapporo Hokko Memorial Hospital
Sapporo, Hokkaido, 065-0027, Japan
Tsuchiura Kyodo General Hospital
Tsuchiura, Ibaraki, 300-0028, Japan
Tokai University Hospital
Isehara, Kanagawa, 259-1193, Japan
Shonan Kamakura General Hospital
Kamakura, Kanagawa, 247-8533, Japan
Japanese Red Cross Wakayama Medical Center
Wakayama, Kansai, 640-8558, Japan
Miyazaki Medical Association Hospital
Miyazaki, Miyazaki, 880-0834, Japan
Sakurabashi Watanabe Hospital
Osaka, Osaka, 530-0001, Japan
Osaka Rosai Hospital
Sakai, Osaka, 591-8025, Japan
Osaka General Medical Center
Sumiyoshi-ku, Osaka, 558-8558, Japan
Tokyo University Hospital
Bunkyo-Ku, Tokyo, 113-8655, Japan
Sakakibara Heart Institute
Fuchū, Tokyo, 183-0003, Japan
Hyogo Prefectural Amagasaki General Medical Center
Amagasaki, Japan
Kansai Rosai Hospital
Amagasaki, Japan
Anjo Kosei Hospital
Anjo, Japan
Tokyo Medical and Dental University, Medical Hospital
Bunkyō City, 113-8519, Japan
Nippon Medical School Hospital
Bunkyō City, Japan
Chiba University Hospital
Chiba, Japan
Tokai University Hachioji Hospital
Hachiōji, Japan
Saitama Medical University International Medical Center
Hidaka, Japan
Hirosaki University Hospital
Hirosaki, 036-8563, Japan
Hiroshima City Hospital
Hiroshima, Japan
Kanazawa University Hospital
Ishikawa, Japan
Nihon University Itabashi Hospital
Itabashi-ku, Japan
National Hospital Organization Kagoshima MC
Kagoshima, Japan
Kokura Kinen Hospital
Kitakyushu, 802-8555, Japan
Kobe City Medical Center General Hospital
Kobe, 650-0047, Japan
Dokkyo Medical University Saitama Medical Center
Koshigaya, Japan
Saiseikai Kumamoto Hospital
Kumamoto, Japan
Kyoto University Hospital
Kyoto, 606-8507, Japan
The Jikei University School of Medicine Hospital
Minatoku, Japan
Kyorin University Hospital
Mitaka, Japan
Mie Heart Center
Miwa, Japan
Nagoya City University East Medical Center
Nagoya, Japan
Kochi Medical School Hospital
Nankoku, Japan
Kurashiki Central Hospital
Okayama, Japan
Kindai University Hospital
Ōsaka-sayama, 589-8511, Japan
Toho University Omori Medical Center
Ōta-ku, Japan
Kitasato University Hospital
Sagamihara, Japan
Japanese Red Cross Saitama Hospital
Saitama, 330-8553, Japan
Sendai City Hospital
Sendai, Japan
Jichi Medical University Hospital
Shimotsuke-shi, Japan
National Cerebral and Cardiovascular Center
Suita, Japan
Tenri Hospital
Tenri, Japan
Showa University Toyosu Hospital
Tokyo, 135-8577, Japan
Tokyo Medical Center
Tokyo, Japan
Tokyo Metropolitan Hiroo Hospital
Tokyo, Japan
Toyama Prefectural Central Hospital
Toyama, Japan
Fujita Health University Hospital
Toyoake, Japan
University of Tsukuba Hospital
Tsukuba, Japan
Yamagata University Hospital
Yamagata, 990-9585, Japan
Yokkaichi Municipal Hospital
Yokkaichi, Japan
Yokohama City Minato Red Cross Hospital
Yokohama, 231-8682, Japan
University of Fukui Hospital
Yoshida, Japan
National Research Cardiac Surgery Center
Astana, Kazakhstan
Salman Al Abdallah Al Dabbous Cardiac Center (DCC) - Al Adan Hospital
Al Ahmadi, Kuwait
Chest Diseases Hospital
Kuwait City, Kuwait
Cardiac Vascular Sentral Kuala Lumpur (CVSKL)
Kuala Lumpur, Malaysia, 50470, Malaysia
Sarawak Heart Centre
Kuching, Sarawak, 94300, Malaysia
Hospital Serdang
Sepang, Selangor, 43000, Malaysia
Institut Jantung Negara
Kuala Lumpur, 50400, Malaysia
Hospital Angeles Lomas
Huixquilucan, State of Mexico, 52763, Mexico
Centro Médico Nacional Siglo XXI
Mexico City, 06720, Mexico
Hospital San Angel Inn Universidad
México, 03330, Mexico
The Royal Hospital
Muscat, Oman
Saint Lukes Medical Center (SLMC)
City of Taguig, National Capital Region, 1634, Philippines
The Medical City
Pasig, National Capital Region, 1603, Philippines
Spital Wojewodzki nr 2
Rzeszów, Poland, 35-301, Poland
Krakowski Szpital Specjalistyczny im. Jana Pawla II
Krakow, Poland
Centralny Szpital Kliniczny Uniwersytetu Medycznego w Łodzi
Lodz, Poland
Kliniczny Szpital Wojewódzki Nr 2 im. Św. Jadwigi Królowej w Rzeszowie
Rzeszów, Poland
Centro hospitalar Vila Nova de Gaia/Espinho-Unidade I
Vila Nova de Gaia, 4434-502, Portugal
Russian Scientific Center of Surgery by B.V. Petrovskiy, RAMN
Moscow, Russia
Tomsk National Research Medical Center of the Russian Academy of Sciences
Tomsk, Russia
State Budgetary Healthcare Institution of Sverdlovsk region for "Sverdlovsk Regional Clinical Hospital #1"
Yekaterinburg, 620102, Russia
King Fahad Medical City (KFMC)
Riyadh, 11433, Saudi Arabia
Institute for Cardiovascular Disease (ICVD) Dedinje
Belgrade, Serbia, 11040, Serbia
National University Hospital
Singapore, 119074, Singapore
National Heart Centre Singapore
Singapore, 169609, Singapore
National University Hospital
Singapore, Singapore
Stredoslovensky Ustav Srdcovych a Cievnych Chorob a.s
Banská Bystrica, 97401, Slovakia
Narodny ustav srdcovych a cievnych chorob, a.s. (NUSCH)
Bratislava, 83348, Slovakia
Vychodoslovensky ustav srdcovych a cievnych chorob, a.s.
Košice, 04011, Slovakia
Netcare Sunninghill Hospital
Johannesburg, South Africa
Busamed Gateway Hospital
Umhlanga, 4319, South Africa
Seoul National University Bundang Hospital
Seoul, Gyeonggi-do, 463-707, South Korea
Hallym University Sacred Heart Hospital
Seoul, 152-703, South Korea
Samsung Medical Center
Seoul, South Korea
Hospital Universitario Moncloa
Madrid, 28008, Spain
Centre Hospitalier Universitaire Vaudois
Lausanne, Switzerland
Taichung Veterans General Hospital
Taichung, Taiwan, 40705, Taiwan
Mackay Memorial Hospital
Taipei, Taiwan, 10491, Taiwan
Cheng-Hsin General Hospital
Taipei, Taiwan, 112, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
Siriraj Hospital
Bangkok, Thailand, 10700, Thailand
Phramongkutklao Hospital
Bangkok, Thailand
Ramathibodi Hospital
Bangkok, Thailand
Cleveland Clinic Abu Dhabi
Abu Dhabi, United Arab Emirates
Sheikh Khalifa Medical City
Abu Dhabi, United Arab Emirates
The Newcastle upon Tyne Hospitals NHS Foundation Trust - Freeman Hospital
Newcastle upon Tyne, United Kingdom, NE7 7DN, United Kingdom
Liverpool Heart and Chest Hospital NHS Foundation Trust
Liverpool, L14 3PE, United Kingdom
St George's University Hospitals - NHS Trust
London, SW17 0QT, United Kingdom
St. George's Hospital-NHS Trust
London, SW17 0QT, United Kingdom
St. Bartholomew's Hospital
London, United Kingdom
Related Publications (9)
Abdrakhmanov A, Nuralinov O, Rashbayeva G, Tursunbekov A, Bagibayev S, Bakytzhanuly A, Yessilbayev Z, Chinybayeva A, Abdrakhmanova Z, Salustri A, Suleymen Z, Kirkimbayeva R. Cryoballoon ablation for the treatment of atrial fibrillation in Kazakhstan: One year outcome from the Cryo Global Registry. Indian Pacing Electrophysiol J. 2025 Sep-Oct;25(5):294-301. doi: 10.1016/j.ipej.2025.06.008. Epub 2025 Jun 20.
PMID: 40545038DERIVEDKhelae SK, Chun KRJ, Drephal C, Scazzuso F, Kueffer FJ, van Bragt KA, Lawrenz T, Todd D, Ptaszynski P, Foldesi C. Real-world sex differences in healthcare utilization after cryoballoon ablation: 2-year outcomes from the Cryo Global Registry. Front Cardiovasc Med. 2025 Jun 3;12:1549002. doi: 10.3389/fcvm.2025.1549002. eCollection 2025.
PMID: 40529551DERIVEDLawin D, Stellbrink C, Chun KJ, Li CH, van Bragt KA, Kueffer F, Selma JM, Oh IY, Herzet JM, Nitta J, Chang TY, Lawrenz T. Impact of atrial fibrillation diagnosis-to-ablation time on 24-month efficacy and safety outcomes in the Cryo Global Registry. Europace. 2025 Feb 5;27(2):euaf008. doi: 10.1093/europace/euaf008.
PMID: 39836630DERIVEDAhn H, Lim HE, On YK, Selma JM, Kueffer FJ, van Bragt KA, Obidigbo V, Oh IY. Long-term Outcome of Cryoballoon Ablation in Korean Patients With Atrial Fibrillation: Real-World Experience From the Cryo Global Registry. Korean Circ J. 2024 Oct;54(10):619-633. doi: 10.4070/kcj.2024.0044. Epub 2024 Jun 10.
PMID: 38956935DERIVEDLawin D, Lawrenz T, Chun KRJ, Lim HE, Obidigbo V, Selma JM, Peytchev P, Nguyen DQ, Foldesi C, Stellbrink C; the Cryo AF Global Registry Investigators. Cryoballoon ablation of atrial fibrillation in octogenarians: one year outcomes from the cryo global registry. J Interv Card Electrophysiol. 2024 Sep;67(6):1341-1351. doi: 10.1007/s10840-023-01680-z. Epub 2023 Dec 12.
PMID: 38082096DERIVEDScazzuso F, Ptaszynski P, Kaczmarek K, Chun KRJ, Khelae SK, Foldesi C, Obidigbo V, van Bragt KA, On YK, Al-Kandari F, Okumura K; Cryo Global Registry Investigators. Regional variations in patient selection and procedural characteristics for cryoballoon ablation of atrial fibrillation in the cryo global registry. J Interv Card Electrophysiol. 2024 Apr;67(3):493-501. doi: 10.1007/s10840-023-01582-0. Epub 2023 Jul 28.
PMID: 37505337DERIVEDZucchelli G, Chun KRJ, Khelae SK, Foldesi C, Kueffer FJ, van Bragt KA, Scazzuso F, On YK, Al-Kandari F, Okumura K; Cryo Global Registry Investigators. Impact of first-line cryoablation for atrial fibrillation on healthcare utilization, arrhythmia disease burden and efficacy outcomes: real-world evidence from the Cryo Global Registry. J Interv Card Electrophysiol. 2023 Apr;66(3):711-722. doi: 10.1007/s10840-022-01388-6. Epub 2022 Nov 4.
PMID: 36331681DERIVEDLim HE, Oh IY, Kueffer FJ, van Bragt KA, On YK. Cryoballoon Catheter Ablation in Korean Patients With Paroxysmal and Persistent Atrial Fibrillation: One Year Outcome From the Cryo Global Registry. Korean Circ J. 2022 Oct;52(10):755-767. doi: 10.4070/kcj.2022.0127. Epub 2022 Aug 12.
PMID: 36097833DERIVEDRordorf R, Scazzuso F, Chun KRJ, Khelae SK, Kueffer FJ, Braegelmann KM, Okumura K, Al-Kandari F, On YK, Foldesi C; Cryo AF Global Registry Investigators. Cryoballoon Ablation for the Treatment of Atrial Fibrillation in Patients With Concomitant Heart Failure and Either Reduced or Preserved Left Ventricular Ejection Fraction: Results From the Cryo AF Global Registry. J Am Heart Assoc. 2021 Dec 21;10(24):e021323. doi: 10.1161/JAHA.121.021323. Epub 2021 Dec 10.
PMID: 34889108DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Khaldoun Tarakji, MD
Medtronic CAS Chief Medical Officer
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 12 Months
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 25, 2016
First Posted
April 27, 2016
Study Start
May 2, 2016
Primary Completion
November 29, 2024
Study Completion
November 29, 2024
Last Updated
July 30, 2025
Record last verified: 2025-02
Data Sharing
- IPD Sharing
- Will not share