NCT06026345

Brief Summary

The Affera Global Registry is a prospective, global, multi-center, observational post-market registry (PMR). The purpose of this study is to describe clinical performance and safety data in a broad patient population treated with the Affera Platform.

Trial Health

83
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
540

participants targeted

Target at P75+ for all trials

Timeline
26mo left

Started Dec 2023

Longer than P75 for all trials

Geographic Reach
7 countries

12 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress53%
Dec 2023Jul 2028

First Submitted

Initial submission to the registry

August 30, 2023

Completed
8 days until next milestone

First Posted

Study publicly available on registry

September 7, 2023

Completed
4 months until next milestone

Study Start

First participant enrolled

December 22, 2023

Completed
4.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2028

Expected
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2028

Last Updated

October 7, 2025

Status Verified

October 1, 2025

Enrollment Period

4.3 years

First QC Date

August 30, 2023

Last Update Submit

October 2, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Primary Objective #1 (Efficacy)

    Estimate freedom from recurrence of the arrhythmia(s) treated at the study index ablation procedure using the Affera Platform.

    12 Month Post Proceedure

Secondary Outcomes (1)

  • Primary Objective #2 (Safety)

    90 Days Post Proceedure

Study Arms (1)

Treatment Arm

Patients enrolled and treated with the Affera Platform

Device: Affera Platform

Interventions

A cardiac ablation will be performed using the Affera Platform

Treatment Arm

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Subjects ≥ 18 years of age (or minimum age as required by local regulations) who have a recommendation for an ablation with the Affera Platform may be approached regarding enrollment in this study.

You may qualify if:

  • Subject is ≥ 18 years of age or minimum age as required by local regulations
  • Planned procedure using the commercially available Affera Platform
  • Willing and able to comply with study requirements and give IC (defined as legally effective, documented confirmation of a subject's voluntary agreement to participate in this clinical study) or authorization per institution and geographical requirements

You may not qualify if:

  • Subject is enrolled in a concurrent study that has not been approved for concurrent enrollment by the global study manager

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (12)

Universitair Ziekenhuis Brussel

Brussels, 1090, Belgium

RECRUITING

IKEM - Institut Klinické a Experimentální Medicíny

Prague, 14021, Czechia

RECRUITING

Nemocnice Na Homolce

Prague, 15030, Czechia

RECRUITING

Hôpital Haut-Lévêque - CHU de Bordeaux

Bordeaux, 33604, France

RECRUITING

Clinique Pasteur

Toulouse, 31076, France

RECRUITING

Charité Universitätsmedizin Berlin, DHZC - Campus Charité Mitte

Berlin, 10117, Germany

RECRUITING

MVZ CCB Frankfurt und Main Taunus GbR

Frankfurt, 60431, Germany

RECRUITING

Universitäres Herzzentrum

Hamburg, 20246, Germany

RECRUITING

Beacon Hospital

Dublin, D18 AK68, Ireland

RECRUITING

Inselspital - Universitätsspital Bern

Bern, 3010, Switzerland

RECRUITING

Royal Papworth Hospital NHS Foundation Trust

Cambridge, CB2 0AY, United Kingdom

RECRUITING

Imperial College Healthcare NHS Trust - Hammersmith Hospital

London, W12 0HS, United Kingdom

RECRUITING

MeSH Terms

Conditions

Atrial Fibrillation

Condition Hierarchy (Ancestors)

Arrhythmias, CardiacHeart DiseasesCardiovascular DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Central Study Contacts

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
2 Years
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 30, 2023

First Posted

September 7, 2023

Study Start

December 22, 2023

Primary Completion (Estimated)

April 1, 2028

Study Completion (Estimated)

July 1, 2028

Last Updated

October 7, 2025

Record last verified: 2025-10

Data Sharing

IPD Sharing
Will not share

Locations