The Influence of day-to Day BPV on Long-term Adverse Outcomes in Patients Ischemic Stroke

NCT02663557 | Completed DMC

• 2 other identifiers: 2008105150027A2013836
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

Stroke is one of the most devastating disorder worldwide. Hypertension has been confirmed to be a major modifiable risk factor for stroke.Even the casual visit hypertension has been managed ideally,there is still surplus risk for stroke re-attack.The purpose of this study is to explore whether variation of 24-hour ambulatory and visit-to-visit blood pressure variability (BPV) contribute to recurrent stroke.

Conditions

Stroke

Keywords

stroke, blood pressure, prognosis

Outcome Measures

Primary Outcomes (1)

• mortality

  all cause death

  12 months

Secondary Outcomes (2)

• macrovascular events

  12 months

• microvascular events

  12 months

Other Outcomes (1)

• non-cardiovascular events

  12 months

Study Arms (4)

non-hypertension with lower BPV

patients meeting to flowing two criteria: 1. mean SBP\<140 mmHg; 2. Systolic blood pressure-coefficient variation (SBP-CV) \< Median SBP-CV

non-hypertension with higher BPV

patients meeting to flowing two criteria: 1. mean SBP\< 140 mmHg; 2. SBP-CV \> Median SBP-CV

hypertension with lower BPV

patients meeting to flowing two criteria: 1. mean SBP\> 140 mmHg; 2. SBP-CV \< Median SBP-CV

hypertension with higher BPV

patients meeting to flowing two criteria: 1. mean SBP\> 140 mmHg; 2. SBP-CV \> Median SBP-CV

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with acute ischemic stroke, which should be verified by define radiological evidences and acute onset of clinical manifestations.

You may not qualify if:

• comorbidity of dementia ( including AD, PDD, FTLD, VaD and so on )
• coexisting severe systematic diseases on admission such as acute coronary syndrome, malignant tumor, plasma dialysis therapy for renal failure, cirrhosis, rheumatic disease that would influence mortality.
• discharge with severe sequelae with mRS\>5

Sponsors & Collaborators

• Zhu Shi: lead

Study Sites (1)

Dongguan Peoples' Hospital

Dongguan, Guangdong, 523029, China

Location

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Zhu Shi, MD,PhD

  dongguan peoples' hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: deputy director of neurology department

Study Record Dates

• First Submitted: January 21, 2016
• First Posted: January 26, 2016
• Study Start: July 1, 2014
• Primary Completion: June 1, 2016
• Study Completion: March 1, 2017
• Last Updated: May 19, 2017

Record last verified: 2017-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)