Stroke Mechanism Evolution in Intracranial Atherosclerotic Stenosis

NCT02705599 | Completed

• 1 other identifier: HRMRI-NM-Tiantan
• Study Type: observational
• Target: 230
• Locations: 1 country
• Sites: 2

Brief Summary

Predictors of the risk of recurrent stroke for patients with symptomatic intracranial atherosclerotic stenosis (ICAS) remain unknown. The study will be to explore the stroke mechanism evolution in patients with ICAS by multi-model magnetic resonance imaging (MRI) which consists of diffusion-weighted imaging (DWI) and high-resolution MRI (HRMRI). The patients with symptomatic ICAS will undergo multi-model MRI. The baseline data, infarct patterns on DWI, and plaque features on HRMRI will be collected. The stroke mechanisms will be determined by the infarct patterns. During the 2 years follow-up, the recurrent ischemic events will be recorded. By comparing the baseline data, infarct patterns, and plaque features in patients with and without recurrent strokes, the high-risk features of patients with symptomatic ICAS will be identified. The evaluation of stroke mechanisms of patients with symptomatic ICAS will be summarized.

Conditions

Stroke

Keywords

Ischemic stroke; High resolution MRI; Perfusion; Mechanism

Outcome Measures

Primary Outcomes (1)

• Ischemic stroke event (in the stenotic vascular territory)

  The primary outcome will include ischemic stroke (in the stenotic vascular territory) and vascular death.

  To 2 years

Secondary Outcomes (1)

• Ischemic stroke event (in the non-stenotic vascular territory)

  To 2 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Symtomatic patients with intracranial atherosclerostic stenosis

You may not qualify if:

• Non-atherosclerosis vasculopathy such as vasculitis and arterial dissection diagnosed by comprehensive laboratory work (such as erythrocyte sedimentation rate or C-reactive protein elevations, antinuclear antibody, or antiphospholipid antibody positivity), vascular imaging, and clinical evaluation;
• Contraindication to MR examination, medical instability precluding MR examination.

Sponsors & Collaborators

• Chinese PLA General Hospital: lead
• Beijing Tiantan Hospital: collaborator

Study Sites (2)

Chinese PLA General Hospital

Beijing, Beijing Municipality, 100853, China

Location

Beijing Tiantan Hospital

Beijing, 100853, China

Location

Related Publications (8)

• Lyu J, Ma N, Liebeskind DS, Wang DJ, Ma L, Xu Y, Wang T, Miao Z, Lou X. Arterial Spin Labeling Magnetic Resonance Imaging Estimation of Antegrade and Collateral Flow in Unilateral Middle Cerebral Artery Stenosis. Stroke. 2016 Feb;47(2):428-33. doi: 10.1161/STROKEAHA.115.011057. Epub 2016 Jan 5.

  PMID: 26732570 BACKGROUND

• Ma N, Jiang WJ, Lou X, Ma L, Du B, Cai JF, Zhao TQ. Arterial remodeling of advanced basilar atherosclerosis: a 3-tesla MRI study. Neurology. 2010 Jul 20;75(3):253-8. doi: 10.1212/WNL.0b013e3181e8e714.

  PMID: 20644151 BACKGROUND

• Lopez-Cancio E, Matheus MG, Romano JG, Liebeskind DS, Prabhakaran S, Turan TN, Cotsonis GA, Lynn MJ, Rumboldt Z, Chimowitz MI. Infarct patterns, collaterals and likely causative mechanisms of stroke in symptomatic intracranial atherosclerosis. Cerebrovasc Dis. 2014;37(6):417-22. doi: 10.1159/000362922. Epub 2014 Jul 4.

  PMID: 25011483 BACKGROUND

• Hou Z, Li M, Lyu J, Xu Z, Liu Y, He J, Jing J, Wang R, Wang Y, Lou X, Miao Z, Ma N. Intraplaque Enhancement Is Associated With Artery-to-Artery Embolism in Symptomatic Vertebrobasilar Atherosclerotic Diseases. Front Neurol. 2021 Sep 1;12:680827. doi: 10.3389/fneur.2021.680827. eCollection 2021.

  PMID: 34539546 DERIVED

• Yang M, Ma N, Liu L, Wang A, Jing J, Hou Z, Liu Y, Lou X, Miao Z, Wang Y. Intracranial collaterals and arterial wall features in severe symptomatic vertebrobasilar stenosis. Neurol Res. 2020 Aug;42(8):649-656. doi: 10.1080/01616412.2020.1782081. Epub 2020 Jun 23.

  PMID: 32573371 DERIVED

• Xu Z, Li M, Lyu J, Hou Z, He J, Mo D, Gao F, Liu X, Sui B, Shen M, Pan Y, Wang Y, Lou X, Miao Z, Luo B, Ma N. Different risk factors in identical features of intracranial atherosclerosis plaques in the posterior and anterior circulation in high-resolution MRI. Ther Adv Neurol Disord. 2020 Mar 13;13:1756286420909991. doi: 10.1177/1756286420909991. eCollection 2020.

  PMID: 32206091 DERIVED

• Xu Z, Li M, Hou Z, Lyu J, Zhang N, Lou X, Miao Z, Ma N. Association between basilar artery configuration and Vessel Wall features: a prospective high-resolution magnetic resonance imaging study. BMC Med Imaging. 2019 Dec 26;19(1):99. doi: 10.1186/s12880-019-0388-3.

  PMID: 31878890 DERIVED

• Ma N, Xu Z, Lyu J, Li M, Hou Z, Liu Y, Yang M, Mo D, Gao F, Song L, Sun X, Liu L, Liu X, Sui B, Shen M, Ma L, Wang Y, Wang Y, Miao Z, Lou X. Association of Perforator Stroke After Basilar Artery Stenting With Negative Remodeling. Stroke. 2019 Mar;50(3):745-749. doi: 10.1161/STROKEAHA.118.023838.

  PMID: 30661491 DERIVED

MeSH Terms

Conditions

Stroke; Ischemic Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Xin Lou, M.D. Ph.D.

  Chinese PLA General Hospital

  PRINCIPAL INVESTIGATOR

• Ning Ma, M.D. Ph.D.

  Beijing Tiantan Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Deputy Chief

Study Record Dates

• First Submitted: March 7, 2016
• First Posted: March 10, 2016
• Study Start: August 1, 2014
• Primary Completion: December 1, 2020
• Study Completion: December 1, 2020
• Last Updated: April 4, 2023

Record last verified: 2023-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (2)