Which Parameters of Short-term Blood Pressure Variability Best Predict Early Outcomes in Acute Ischemic Stroke

NCT02675972 | Completed DMC

• 1 other identifier: DongguanPeoplesH
• Study Type: observational
• Target: 260
• Locations: 1 country
• Sites: 1

Brief Summary

Previous studies on the association between blood pressure variation (BPV) in acute ischemic stroke and functional outcomes yield conflicting result. The obscured definition and measurement of BPV engenders considerable confounding factors, making it difficult to interpret. We aim to investigate the predictive role of 24-hour BPV on early outcomes in acute non-cardiogenic ischemic stroke.

Conditions

Stroke

Keywords

stroke, blood pressure, prognosis

Outcome Measures

Primary Outcomes (1)

• early neurological deterioration

  NIHSS increase by 4 points or continuous consciousness deterioration

  7 days after admission

Secondary Outcomes (2)

• good functional outcome at 14 days

  up to 14 days in-hospital

• good functional outcome at 3 months

  3 months

Study Arms (2)

patient with poor outcome

modified Rankin scale≥3

patients with favorable outcome

modified Rankin scale\<3

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

acute ischemic stroke patients with 72 hour after onset

You may qualify if:

• acute ischemic stroke

You may not qualify if:

• cardiogenic cerebral embolisms due to atrial fibrillation, pronounced heart valve diseases or valve replacement operation;
• isolated sensory symptoms, isolated visual changes, isolated dizziness, or vertigo, without explicit MRI-DWI evidence for acute cerebral infarcts;
• coexisting severe systematic diseases on admission such as acute coronary syndrome, malignant tumor, plasma dialysis therapy for renal failure, cirrhosis, rheumatic disease which would influence patients' independent functions .

Sponsors & Collaborators

• Dongguan People's Hospital: lead

Study Sites (1)

Dongguan Peoples' Hospital

Dongguan, Guangdong, 523029, China

Location

Related Publications (1)

• Shi Z, Li ES, Zhong JS, Yuan JL, Li LR, Zheng CW. Predictive Significance of Day-to-Day Blood Pressure Variability in Acute Ischemic Stroke for 12-Month Functional Outcomes. Am J Hypertens. 2017 May 1;30(5):524-531. doi: 10.1093/ajh/hpx005.

  PMID: 28203689 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

fasting glucose, creatine, BNP, CRP,BUN,cholesterol, LDL,HDL

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• zhu Shi, PhD,MD

  dongguan peoples' hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: deputy director of neurology department

Study Record Dates

• First Submitted: January 27, 2016
• First Posted: February 5, 2016
• Study Start: January 1, 2014
• Primary Completion: May 1, 2015
• Study Completion: April 1, 2016
• Last Updated: May 17, 2017

Record last verified: 2017-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)