The Effect of Blood Volume Changes on the Glucose Tolerance
BV-GT
1 other identifier
interventional
20
1 country
1
Brief Summary
In this study the investigators would like to elaborate on the mechanisms that lead to a higher insulin sensitivity after exercise training and a lower insulin sensitivity after bedrest. The investigators speculate that the concomitant chances in blood volume during training and bedrest might explain the changed insulin sensitivity because with a changing blood volume also the dilution space of the glucose will change. Furthermore, the investigators would like to work on the influence of a changed capacity of skeletal muscle for glucose uptake and glycogen storage on the glucose sensitivity. Therefore, A) a bed rest study with healthy untrained subjects and B) a training study with obese pre-diabetic patients will be conducted.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable healthy
Started Jan 2015
Typical duration for not_applicable healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2015
CompletedFirst Submitted
Initial submission to the registry
November 13, 2015
CompletedFirst Posted
Study publicly available on registry
November 24, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2016
CompletedNovember 24, 2015
November 1, 2015
1.2 years
November 13, 2015
November 19, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
Change in blood volume
Baseline and 4 days
Change in glucose tolerance
Baseline and 4 days
Change in blood volume
Baseline and 6 weeks
Change in glucose tolerance
Baseline and 6 weeks
Study Arms (2)
Bedrest
EXPERIMENTAL4 days of bedrest
Exercise Training
EXPERIMENTAL6 weeks of aerobic endurance exercise training with 4 supervised sessions per week at an average intensity of 65 % of maximal heart rate
Interventions
Eligibility Criteria
You may qualify if:
- Informed consent as documented by signature
- Age: 18-35
- healthy (no chronic diseases)
- BMI: 19-25
- maximal oxygen uptake: 35-50 ml O2/min/kg
You may not qualify if:
- chronic diseases
- any health problems that do not allow the subjects to participate in the measurements (i.e. heart defect)
- History of familiar history (1st grade relatives) of venous thrombic-embolism or renal insufficiency
- Blood donation in the last month
- Any medication with known influence on blood volume, glucose metabolism and body weight
- Stay above 2500 m for more than 1 day
- Known allergies against Fragmin or Heparin
- Training:
- Informed consent as documented by signature
- Age: 35-50
- BMI: 30-40
- Fat%: 30-40 %
- maximal oxygen uptake: 20-35 ml O2/min/kg
- HbA1c: 5.5 - 7.0 %
- Chronic diseases
- +4 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Carsten Lundbylead
Study Sites (1)
Institute of Physiology, University of Zurich
Zurich, Canton of Zurich, 8057, Switzerland
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Carsten Lundby, Prof. Dr.
Institute of Physiology, University of Zurich
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Prof. Dr.
Study Record Dates
First Submitted
November 13, 2015
First Posted
November 24, 2015
Study Start
January 1, 2015
Primary Completion
April 1, 2016
Study Completion
April 1, 2016
Last Updated
November 24, 2015
Record last verified: 2015-11